The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
IL-1 and TNF Antagonists Inhibit the Inflammatory Response and Bone Loss in Experimental Periodontitis
Abstract
Periodontal disease is the most frequent cause of tooth loss in humans and is the most prevalent disease associated with bone loss, including osteoporosis. Periodontal destruction is initiated by bacteria that colonize the tooth surface, leading to inflammation and bone resorption. To assess the roles of IL-1 and TNF in this process, studies were conducted in a Macaca fascicularis primate model of experimental periodontitis. Function-blocking soluble receptors to IL-1 and TNF were applied by local injection to sites with induced periodontal destruction and compared with similar sites injected with vehicle alone. The results indicate that injection of soluble receptors to IL-1 and TNF inhibited by approximately 80% the recruitment of inflammatory cells in close proximity to bone. The formation of osteoclasts was reduced by 67% at the experimental sites compared with that at the control sites, and the amount of bone loss was reduced by 60%. All results were statistically significant (p < 0.01). These findings indicate that a significant component of the pathologic process of periodontitis is due to IL-1/TNF activity, since inhibiting IL-1/TNF reduces both inflammatory cell recruitment and bone loss. The data also suggest that inflammation associated with gingivitis is actively protective, since blocking further up-regulation of the host response with IL-1/TNF inhibitors does not cause periodontal damage. Furthermore, these results coupled with recent evidence that IL-1 and TNF participate in endocrine-associated osteoporosis suggest that multiple pathologies involving excessive loss of bone may operate through a common mechanism involving IL-1 and/or TNF.
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Cites
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Cited by
The Oral Microbiota: Dynamic Communities and Host Interactions
Lamont, R. J., Koo, H., & Hajishengallis, G. (2018) · Nature Reviews Microbiology · doi:10.1038/s41579-018-0089-x · Cited by 2,217
Periodontitis: a polymicrobial disruption of host homeostasis
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Inflammation and Bone Loss in Periodontal Disease
Cochran, D. L. (2008) · Journal of Periodontology · doi:10.1902/jop.2008.080233 · Cited by 732
Self-citationThe role of the microbiota in periodontal disease
Curtis, M. A., Diaz, P. I., & Van Dyke, T. E. (2020) · Periodontology 2000 · doi:10.1111/prd.12296 · Cited by 698
Metadata
- Authors
- Assuma, R., Oates, T., Cochran, D., Amar, S., & Graves, D. T.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1998-01-01
- Volume
- 160
- Issue
- 1
- Pages
- 403-409
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1525531948
- Cited by
- 600
- References
- 35
- FWCI
- 24.75
- Type
- journal article
- Language
- en
- Open access
- closed
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- Assuma, R., Oates, T., Cochran, D., Amar, S., & Graves, D. T. (1998). IL-1 and TNF Antagonists Inhibit the Inflammatory Response and Bone Loss in Experimental Periodontitis. The Journal of Immunology. https://doi.org/10.4049/jimmunol.160.1.403
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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