Ultraviolet Light-Induced Immune Tolerance Is Mediated via the Fas/Fas-Ligand System
Open accessAbstract
Hapten sensitization through UV-exposed skin induces tolerance that is mediated via the induction of hapten-specific T suppressor cells. However, the detailed mechanisms underlying tolerance induction remain unclear to date. We show here that the apoptosis-related surface Ag Fas (APO-1, CD95) and its ligand, Fas ligand (FasL) are critically involved, since Fas-deficient lpr mice and FasL-deficient gld mice do not develop UV-induced tolerance. Adoptive transfer experiments revealed that the mediation of tolerance does not require the expression of Fas or FasL by the T suppressor cells but does require the expression of both molecules by the cells of mice receiving the T suppressor cells. To identify the mechanisms involved, the effect of suppressor cells on Ag-presenting dendritic cells (DC) was studied. Coincubation of hapten-pulsed DC with T cells that were obtained from UV-tolerized mice resulted in an enhanced death rate of DC, and this cell death was dependent upon Fas expression. The addition of IL-12, which recently was found to break established tolerance in vivo, prevented DC death. Moreover, IL-12 did not only rescue DC from T suppressor cell-induced death but also from apoptosis induced by rFasL, suggesting that IL-12 may interfere with the Fas/FasL system. Together, these data indicate a crucial role for the Fas/FasL system in UV-induced tolerance, and suggest that UV-induced T suppressor cells may act by inducing the cell death of APCs via the Fas pathway. The ability of IL-12 to break established tolerance may be due to the prevention of DC death induced by T suppressor cells.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Tolerance induction by apoptotic cells depends on MHC class I molecules and involves immune suppression by CD8+ T cells.
“Perhaps paradoxically, tolerance induction by apoptotic cells depends on MHC class I molecules and involves immune suppression by CD8+ T cells10,24,25.”
From Immunogenic and tolerogenic cell death (2009) · cites this paper as [24]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Inaba, K., Inaba, M., Romani, N., Aya, H., Deguchi, M., Ikehara, S., Muramatsu, S., & Steinman, R. M. (1992) · The Journal of Experimental Medicine · doi:10.1084/jem.176.6.1693 · Cited by 3,741 · see citing works
Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis
Watanabe‐Fukunaga, R., Brannan, C., Copeland, N., Jenkins, N., & Nagata, S. (1992) · Nature · doi:10.1038/356314a0 · Cited by 3,153 · see citing works
The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis
Itoh, N., Yonehara, S., Ishii, A., Yonehara, M., Mizushima, S.-I., Sameshima, M., Hase, A., Seto, Y., & Nagata, S. (1991) · Cell · doi:10.1016/0092-8674(91)90614-5 · Cited by 2,736 · see citing works
Koopman, G., Reutelingsperger, C. P. M., Kuijten, G., Keehnen, R. M. J., Pals, S. T., & van Oers, M. H. J. (1994) · Blood · doi:10.1182/blood.v84.5.1415.1415 · Cited by 2,687 · see citing works
Inhibition of death receptor signals by cellular FLIP
Irmler, M., Thome, M., Hahne, M., Schneider, P., Hofmann, K., Steiner, V., Bodmer, J.-L., Schröter, M., Burns, K., Mattmann, C., et al. (1997) · Nature · doi:10.1038/40657 · Cited by 2,548 · see citing works
Suda, T., Takahashi, T., Golstein, P., & Nagata, S. (1993) · Cell · doi:10.1016/0092-8674(93)90326-l · Cited by 2,488 · see citing works
Fas Ligand-Induced Apoptosis as a Mechanism of Immune Privilege
Griffith, T. S., Brunner, T., Fletcher, S. M., Green, D. R., & Ferguson, T. A. (1995) · Science · doi:10.1126/science.270.5239.1189 · Cited by 1,990 · see citing works
Monoclonal Antibody-Mediated Tumor Regression by Induction of Apoptosis
Trauth, B. C., Klas, C., Peters, A. M. J., Matzku, S., Mӧller, P., Falk, W., Debatin, K., & Krammer, P. H. (1989) · Science · doi:10.1126/science.2787530 · Cited by 1,716 · see citing works
Fas(CD95)/FasL interactions required for programmed cell death after T-cell activation
Ju, S., Panka, D., Cui, H., Ettinger, R., EI-Khatib, M., Sherr, D., Stanger, B., & Marshak-Rothstein, A. (1995) · Nature · doi:10.1038/373444a0 · Cited by 1,709 · see citing works
Generalized lymphoproliferative disease in mice, caused by a point mutation in the fas ligand
Takahashi, T., Tanaka, M., Brannan, C. I., Jenkins, N. A., Copeland, N. G., Suda, T., & Nagata, S. (1994) · Cell · doi:10.1016/0092-8674(94)90375-1 · Cited by 1,527 · see citing works
Molecular basis of sun-induced premature skin ageing and retinoid antagonism
Fisher, G. J., Datta, S. C., Talwar, H. S., Wang, Z.-Q., Varani, J., Kang, S., & Voorhees, J. J. (1996) · Nature · doi:10.1038/379335a0 · Cited by 1,410 · see citing works
Brunner, T., Mogil, R. J., LaFace, D., Yoo, N. J., Mahboubi, A., Echeverri, F., Martin, S. J., Force, W. R., Lynch, D. H., Ware, C. F., et al. (1995) · Nature · doi:10.1038/373441a0 · Cited by 1,314 · see citing works
A role for CD95 ligand in preventing graft rejection
Bellgrau, D., Gold, D. P., Selawry, H. P., Moore, J. K., Franzusoff, A., & Duke, R. C. (1995) · Nature · doi:10.1038/377630a0 · Cited by 1,147 · see citing works
Toews, G., Bergstresser, P., & Streilein, J. (1980) · Journal of Immunology · doi:10.4049/jimmunol.124.1.445 · Cited by 963 · see citing works
Maturation Stages of Mouse Dendritic Cells in Growth Factor–dependent Long-Term Cultures
Winzler, C., Rovere, P. Q., Rescigno, M., Granucci, F., Penna, G., Adorini, L., Zimmermann, V. S., Davoust, J. M., & Ricciardi‐Castagnoli, P. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.185.2.317 · Cited by 848 · see citing works
Expression of the functional soluble form of human fas ligand in activated lymphocytes.
Tanaka, M., Suda, T., Takahashi, T., & Nagata, S. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb07096.x · Cited by 639 · see citing works
A subclass of dendritic cells kills CD4 T cells via Fas/Fas-ligand-induced apoptosis.
Süss, G., & Shortman, K. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.183.4.1789 · Cited by 622 · see citing works
Kinetics of Response in Lymphoid Tissues to Antiretroviral Therapy of HIV-1 Infection
Cavert, W. P., Notermans, D. W., Staskus, K., Wietgrefe, S. W., Zupancic, M., Gebhard, K. H., Henry, K., Zhang, Z.-Q., Mills, R., McDade, H., et al. (1997) · Science · doi:10.1126/science.276.5314.960 · Cited by 622 · see citing works
Fas and FasL in the homeostatic regulation of immune responses
Lynch, D. H., Ramsdell, F., & Alderson, M. R. (1995) · Immunology Today · doi:10.1016/0167-5699(95)80079-4 · Cited by 573 · see citing works
Potential Involvement of Fas and Its Ligand in the Pathogenesis of Hashimoto's Thyroiditis
Giordano, C. S. D. S., Stassi, G., Maria, R. D., Todaro, M., Richiusa, P., Papoff, G., Ruberti, G., Bagnasco, M., Testi, R., & Galluzzo, A. (1997) · Science · doi:10.1126/science.275.5302.960 · Cited by 572 · see citing works
Zhang, X. M., Brunner, T., Carter, L., Dutton, R. W., Rogers, P., Bradley, L. M., Sato, T., Reed, J. C., Green, D. R., & Swain, S. L. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.185.10.1837 · Cited by 459 · see citing works
Elmets, C. A., Bergstresser, P. R., Tigelaar, R. E., Wood, P. J., & Streilein, J. W. (1983) · The Journal of experimental medicine · doi:10.1084/jem.158.3.781 · Cited by 392 · see citing works
CD95-Induced Apoptosis of Lymphocytes in an Immune Privileged Site Induces Immunological Tolerance
Griffith, T. S., Yu, X., Herndon, J. M., Green, D. R., & Ferguson, T. A. (1996) · Immunity · doi:10.1016/s1074-7613(00)80305-2 · Cited by 382 · see citing works
Cooper, K. D., Oberhelman, L., HAMILTON, T. A., Baadsgaard, O., Terhune, M. H., LeVee, G. J., Anderson, T. J., & Koren, H. S. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.18.8497 · Cited by 368 · see citing works
FLAME-1, a Novel FADD-like Anti-apoptotic Molecule That Regulates Fas/TNFR1-induced Apoptosis
Srinivasula, S. M., Ahmad, M., Ottilie, S., Bullrich, F., Banks, S., Wang, Y., Fernandes‐Alnemri, T., Croce, C. M., Litwack, G., Tomaselli, K. J., et al. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.30.18542 · Cited by 335 · see citing works
Enhanced and accelerated lymphoproliferation in Fas-null mice.
Adachi, M., Suematsu, S., Suda, T., Watanabe, D., Fukuyama, H., Ogasawara, J., Tanaka, T., Yoshida, N., & Nagata, S. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.5.2131 · Cited by 200 · see citing works
Effect of IL-12 on immune suppression and suppressor cell induction by ultraviolet radiation.
Schmitt, D. A., Owen‐Schaub, L. B., & Ullrich, S. E. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.154.10.5114 · Cited by 166 · see citing works
Successive generation of antigen-presenting, dendritic cell lines from murine epidermis.
Xu, S., Ariizumi, K., Càceres‐Dittmar, G., Edelbaum, D., Hashimoto, K., Bergstresser, P. R., & Takashima, A. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.154.6.2697 · Cited by 153 · see citing works
CD40 ligation counteracts Fas-induced apoptosis of human dendritic cells
Björck, P. (1997) · International Immunology · doi:10.1093/intimm/9.3.365 · Cited by 153 · see citing works
IL-12 as mediator and adjuvant for the induction of contact sensitivity in vivo
Müller, G., Saloga, J., Germann, T., Schuler, G., KNOP, J., & Enk, A. H. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.155.10.4661 · Cited by 136 · see citing works
Schwarz, A., Grabbe, S., Aragane, Y., Sandkuhl, K., Riemann, H., Luger, T. A., Kubin, M. Z., Trinchieri, G., & Schwarz, T. (1996) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12347944 · Cited by 135 · see citing works
Self-citationGenetic basis of ultraviolet-B effects on contact hypersensitivity
Streilein, J. W., & Bergstresser, P. R. (1988) · Immunogenetics · doi:10.1007/bf00376119 · Cited by 111 · see citing works
Cutaneous Malignant Melanoma and Sun Exposure
Katsambas, A. (1996) · Archives of Dermatology · doi:10.1001/archderm.1996.03890280106015 · Cited by 108 · see citing works
Analysis of the Role of bcl‐2 in Apoptosis
Hawkins, C. J., & Vaux, D. L. (1994) · Immunological Reviews · doi:10.1111/j.1600-065x.1994.tb00886.x · Cited by 79 · see citing works
SOLAR ULTRAVIOLET RADIATION AND THE RISK OF INFECTIOUS DISEASE: SUMMARY OF A WORKSHOP*†
Chapman, R. S., Cooper, K. D., Fabo, E. C. D., et al. (1995) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1995.tb03966.x · Cited by 77 · see citing works
UVB Radiation and DNFB Skin Painting Induce Suppressor Cells Universally in Mice
Glass, M. J., Bergstresser, P. R., Tigelaar, R. E., et al. (1990) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12874117 · Cited by 60 · see citing works
Shimizu, T., & Streilein, J. W. (1994) · PubMed · Cited by 39 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Immunogenic and tolerogenic cell death
Green, D. R., Ferguson, T., Zitvogel, L., & Kroemer, G. (2009) · Nature Reviews Immunology · doi:10.1038/nri2545 · Cited by 1,176 · see citing works
Hill, L. L., Shreedhar, V. K., Kripke, M. L., & Owen-Schaub, L. B. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.189.8.1285 · Cited by 75 · see citing works
Pradhan, S., Kim, H. K., Thrash, C. J., Cox, M. A., Mantena, S. K., Wu, J.-H., Athar, M., Katiyar, S. K., Elmets, C. A., & Timares, L. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.5.3077 · Cited by 28 · see citing works
“The nature of the relevant qualitative changes are under investigation by several laboratories, and a role for apoptosis has been implicated (37).”
BackgroundResult
- Authors
- Schwarz, A., Grabbe, S., Grosse-Heitmeyer, K., Roters, B., Riemann, H., Luger, T. A., Trinchieri, G., & Schwarz, T.
- Affiliations
- University of Münster (DE)
- The Wistar Institute (US)
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1998-05-01
- Volume
- 160
- Issue
- 9
- Pages
- 4262-4270
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1679015646
- Cited by
- 73
- References
- 37
- Citations by year
- 2024: 1 · 2023: 2 · 2021: 1 · 2020: 1 · 2013: 1 · 2012: 3
- FWCI
- 1.68
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- National Institutes of Health (5r01ca032898-13)
- National Cancer Institute (CA 32898, CA-20833, CA-10815, P30CA010815)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- Fas/Fas ligand, hapten sensitization, regulatory T cells, dendritic cell apoptosis, IL-12, lpr mice, gld mice, adoptive transfer, antigen-presenting cells, skin immunology
- MeSH terms
- Animals, Dendritic Cells, Dermatitis, Contact, Haptens, Immune Tolerance, Membrane Glycoproteins, Mice, Inbred C3H, T-Lymphocytes, Ultraviolet Rays, Apoptosis, fas Receptor, Mice, Fas Ligand Protein
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
