A critical role for the proapoptotic protein bid in ultraviolet-induced immune suppression and cutaneous apoptosis
Open accessAbstract
Apoptosis plays an important role in eliminating UV-damaged keratinocytes, but its role in UV-induced immune suppression is not clear. Langerhans cells (LCs) may function as inducers of immune suppression. We have shown that LCs derived from mice deficient in the proapoptotic Bid (BH3-interacting death domain protein) gene (Bid KO) resist apoptosis and induce amplified immune responses. In this report, we examined responses in Bid KO mice to UVB exposure. Acute UV exposure led Bid KO mice to develop fewer apoptotic cells and retain a greater fraction of LCs in the epidermal layer of skin in comparison to wild-type mice. Bid KO mice were also markedly resistant to local and systemic UV tolerance induction to hapten sensitization and contact hypersensitivity responses. Elicitation responses and inflammation at skin sensitization sites in UV-treated Bid KO mice were equal to or greater than nonsuppressed control responses. In Bid KO mice, LCs accumulated in lymph nodes to greater numbers, demonstrated longer lifespans, and contained fewer DNA-damaged cells. These studies provide evidence that Bid activation is a critical upstream mediator in UV-induced keratinocyte and LC apoptosis and that its absence abrogates UV-induced immune tolerance.
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Langerhans cells derived from mice deficient in the pro-apoptotic Bid gene resist apoptosis and can induce amplified contact hypersensitivity reactions; Bid activation is a critical upstream mediator in UV-induced keratinocyte and LC apoptosis and its absence abrogates UV-induced immune tolerance.
“In fact, LCs derived from mice deficient in the pro-apoptotic Bid (BH3-interacting death domain protein) gene resist apoptosis and can induce amplified contact hypersensitivity reactions. Bid activation is a critical upstream mediator in UV-induced keratinocyte and LC apoptosis and its absence abrogates UV-induced immune tolerance [74].”
From Molecular Mechanisms of UV-Induced Apoptosis and Its Effects on Skin Residential Cells: The Implication in UV-Based Phototherapy (2013) · cites this paper as [74]
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- Authors
- Pradhan, S., Kim, H. K., Thrash, C. J., Cox, M. A., Mantena, S. K., Wu, J.-H., Athar, M., Katiyar, S. K., Elmets, C. A., & Timares, L.
- Affiliations
- University of Alabama at Birmingham (US)
- Department of Dermatology
- Department of Cell Biology
- Corresponding author
- Pradhan, Sanjay
- Athar, Mohammad
- Timares, Laura
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-09-01
- Volume
- 181
- Issue
- 5
- Pages
- 3077-3088
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- PMC
- PMC2659735
- OpenAlex
- W1954540631
- Cited by
- 28
- References
- 45
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 1 · 2021: 1 · 2020: 1 · 2019: 1 · 2017: 2 · 2016: 1 · 2014: 1 · 2013: 3 · 2012: 3
- FWCI
- 4.29
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The Journal of Immunology (publishedVersion, public-domain)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- University of Alabama at Birmingham
- National Institutes of Health
- National Cancer Institute (R01-CA86172, R01CA086172)
- National Institute of Allergy and Infectious Diseases (R01-AI50150, R01AI050150)
- National Institute of Environmental Health Sciences (R01ES015323)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R21AR055252, P30AR050948, P30AR048311)
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- Bid, Langerhans cells, keratinocyte apoptosis, contact hypersensitivity, hapten sensitization, UV resistance, DNA damage, skin inflammation
- MeSH terms
- Animals, Immune Tolerance, Immunosuppression Therapy, Langerhans Cells, Skin, Ultraviolet Rays, Keratinocytes, Apoptosis, Mice, Knockout, Apoptosis Regulatory Proteins, BH3 Interacting Domain Death Agonist Protein, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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