The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Inducing Mucosal IgA: A Challenge for Vaccine Adjuvants and Delivery Systems
Open accessAbstract
Mucosal IgA or secretory IgA (SIgA) are structurally equipped to resist chemical degradation in the harsh environment of mucosal surfaces and enzymes of host or microbial origin. Production of SIgA is finely regulated, and distinct T-independent and T-dependent mechanisms orchestrate Ig α class switching and SIgA responses against commensal and pathogenic microbes. Most infectious pathogens enter the host via mucosal surfaces. To provide a first line of protection at these entry ports, vaccines are being developed to induce pathogen-specific SIgA in addition to systemic immunity achieved by injected vaccines. Mucosal or epicutaneous delivery of vaccines helps target the inductive sites for SIgA responses. The efficacy of such vaccines relies on the identification and/or engineering of vaccine adjuvants capable of supporting the development of SIgA alongside systemic immunity and delivery systems that improve vaccine delivery to the targeted anatomic sites and immune cells.
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Cites
New concepts in the generation and functions of IgA
Pabst, O. (2012) · Nature reviews. Immunology · doi:10.1038/nri3322 · Cited by 656
Intestinal IgA production and its role in host-microbe interaction
Gutzeit, C., Magri, G., & Cerutti, A. (2014) · Immunological Reviews · doi:10.1111/imr.12189 · Cited by 332
MyD88 Signaling in T Cells Directs IgA-Mediated Control of the Microbiota to Promote Health
Kubinak, J. L., Petersen, C., Stephens, W. Z., Soto, R., Bake, E., O’Connell, R. M., & Round, J. L. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2014.12.009 · Cited by 328
Norton, E. B., Lawson, L. B., Freytag, L. C., & Clements, J. D. (2011) · Clinical and Vaccine Immunology · doi:10.1128/cvi.00538-10 · Cited by 221
Wang, Y., Liu, L., Moore, D. J., Shen, X., Peek, R. M., Acra, S. A., Li, H., Ren, X., Polk, D. B., & Yan, F. (2017) · Mucosal Immunology · doi:10.1038/mi.2016.57 · Cited by 149
The kinase TBK1 controls IgA class switching by negatively regulating noncanonical NF-κB signaling
Jin, J., Xiao, Y., Chang, J.-H., Yu, J., Hu, H., Starr, R., Brittain, G. C., Chang, M., Cheng, X., & Sun, S.-C. (2012) · Nature Immunology · doi:10.1038/ni.2423 · Cited by 136
Cited by
COVID-19 Vaccine Frontrunners and Their Nanotechnology Design
Chung, Y. H., Beiss, V., Fiering, S. N., & Steinmetz, N. F. (2020) · ACS Nano · doi:10.1021/acsnano.0c07197 · Cited by 346
The Effects of Secretory IgA in the Mucosal Immune System
Li, Y., Jin, L., & Chen, T. (2020) · BioMed Research International · doi:10.1155/2020/2032057 · Cited by 336
The inflammatory function of human IgA
Hansen, I. S., Baeten, D. L. P., & den Dunnen, J. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-018-2976-8 · Cited by 170
The protozoan commensal Tritrichomonas musculis is a natural adjuvant for mucosal IgA
Cao, E. Y., Burrows, K., Chiaranunt, P., Popovic, A., Zhou, X., Xie, C., Thakur, A., Britton, G., Spindler, M., Ngai, L., et al. (2024) · Journal of Experimental Medicine · doi:10.1084/jem.20221727 · Cited by 8
Metadata
- Authors
- Boyaka, P. N.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2017-07-01
- Volume
- 199
- Issue
- 1
- Pages
- 9-16
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2723539103
- Cited by
- 257
- References
- 6
- FWCI
- 7.33
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
