The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Tissue-Specific Segregation of CD1d-Dependent and CD1d-Independent NK T Cells
Abstract
NKT cells, defined as T cells expressing the NK cell marker NK1.1, are involved in tumor rejection and regulation of autoimmunity via the production of cytokines. We show in this study that two types of NKT cells can be defined on the basis of their reactivity to the monomorphic MHC class I-like molecule CD1d. One type of NKT cell is positively selected by CD1d and expresses a biased TCR repertoire together with a phenotype found on activated T cells. A second type of NKT cell, in contrast, develops in the absence of CD1d, and expresses a diverse TCR repertoire and a phenotype found on naive T cells and NK cells. Importantly, the two types of NKT cells segregate in distinct tissues. Whereas thymus and liver contain primarily CD1d-dependent NKT cells, spleen and bone marrow are enriched in CD1d-independent NKT cells. Collectively, our data suggest that recognition of tissue-specific ligands by the TCR controls localization and activation of NKT cells.
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Cites
Adhesion between epithelial cells and T lymphocytes mediated by E-cadherin and the αEβ7 integrin
Cepek, K. L., Shaw, S. K., Parker, C. M., Russell, G. J., Morrow, J. S., Rimm, D. L., & Brenner, M. B. (1994) · Nature · doi:10.1038/372190a0 · Cited by 1,178
Burdin, N., Brossay, L., Koezuka, Y., Smiley, S. T., Grusby, M. J., Gui, M., Taniguchi, M., Hayakawa, K., & Kronenberg, M. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.7.3271 · Cited by 334
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Cited by
Carnaud, C., Lee, D., Donnars, O., Park, S.-H., Beavis, A., Koezuka, Y., & Bendelac, A. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.9.4647 · Cited by 854
Hepatic T cells and liver tolerance
Crispe, I. N. (2003) · Nature Reviews Immunology · doi:10.1038/nri981 · Cited by 661
Pellicci, D. G., Hammond, K. J. L., Uldrich, A. P., Baxter, A. G., Smyth, M. J., & Godfrey, D. I. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20011544 · Cited by 371
Cardiolipin Binds to CD1d and Stimulates CD1d-Restricted γδ T Cells in the Normal Murine Repertoire
Dieudé, M., Striegl, H., Tyznik, A. J., Wang, J., Behar, S. M., Piccirillo, C. A., Levine, J. S., Zajonc, D. M., & Rauch, J. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1000921 · Cited by 121
The immune landscape in nonalcoholic steatohepatitis
Narayanan, S., Surette, F. A., & Hahn, Y. S. (2016) · Immune Network · doi:10.4110/in.2016.16.3.147 · Cited by 64
Metadata
- Authors
- Eberl, G., Lees, R., Smiley, S. T., Taniguchi, M., Grusby, M. J., & MacDonald, H. R.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1999-06-01
- Volume
- 162
- Issue
- 11
- Pages
- 6410-6419
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2150967155
- Cited by
- 324
- References
- 2
- FWCI
- 11.43
- Type
- journal article
- Language
- en
- Open access
- closed
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- Eberl, G., Lees, R., Smiley, S. T., Taniguchi, M., Grusby, M. J., & MacDonald, H. R. (1999). Tissue-Specific Segregation of CD1d-Dependent and CD1d-Independent NK T Cells. The Journal of Immunology. https://doi.org/10.4049/jimmunol.162.11.6410
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