Cited by 170T-cell and B-cell ImmunologyHematopoietic Stem Cell TransplantationLymphoma Diagnosis and Treatment

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B Cell Maintenance in Aged Mice Reflects Both Increased B Cell Longevity and Decreased B Cell Generation

Kline, Gregory H, Hayden, Tracy A, Klinman, Norman R·1999·The Journal of Immunology

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Abstract

In aged mice the population of mature peripheral B cells is maintained despite a severalfold decrease in the population of bone marrow B cell progenitors. The analysis of the rate of accumulation of 5′-bromo-2-deoxyuridine (BrdU)-labeled splenic B cells in mice fed BrdU for 8 days to 8 wk demonstrated a severalfold increase in the half-life of mature B cells in aged mice. Consistent with a role for decreased B cell turnover in maintaining the mature B cell population of aged mice, several findings indicate that fewer newly generated B cells enter the spleen from the bone marrow in aged vs young adult mice. These include 1) a fourfold decrease in the population of relatively immature splenic B cells, defined as cells that express high levels of heat-stable Ag and accumulate BrdU within 8 wk of labeling; and 2) an equivalent decrease in the population of bone marrow cells representative of later stages of B cell maturation (sIgD−sIgMint-high). Surprisingly, despite a four- to sixfold decrease in pre-B cells, the population of least mature bone marrow B cells (IgD−sIgMvery low) remains intact. Because this population accumulates BrdU-labeled cells more slowly in aged mice than in younger mice, and bone marrow B cells at more mature developmental stages are diminished, it appears that in aged mice B cell development beyond the sIgMvery low stage may be retarded and that cells, therefore, accumulate within this population.

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Authors: Kline, G. H., Hayden, T. A., & Klinman, N. R.
Affiliations: Scripps Research Institute (US)
Venue: The Journal of Immunology
Publisher: Oxford University Press (OUP)
Published: 1999-03
Volume: 162
Issue: 6
Pages: 3342-3349
ISSN: 0022-1767 (ISSN-L)
1550-6606
DOI: 10.4049/jimmunol.162.6.3342
OpenAlex: W2156242308
Cited by: 170
References: 48
Citations by year: 2026: 1 · 2025: 3 · 2024: 2 · 2023: 3 · 2022: 3 · 2021: 5 · 2020: 6 · 2019: 9 · 2018: 3 · 2017: 6 · 2016: 3 · 2015: 5 · 2014: 3 · 2013: 5 · 2012: 9
FWCI: 1.94
Type: journal article
Language: en
Open access: closed
Licence: academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: The Journal of Immunology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Aging (P01AG001743, T32AG000080, AG-01743, T32 AG-00080)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
Health Sciences › Medicine › Pathology and Forensic Medicine › Lymphoma Diagnosis and Treatment
Keywords: B cell aging, splenic B cells, B cell maturation, pre-B cells, CD24, BrdU labeling, immunosenescence
MeSH terms: Aging, Animals, B-Lymphocytes, Bone Marrow Cells, Bromodeoxyuridine, Cell Cycle, Cell Differentiation, Cell Survival, Immunoglobulin M, Lymphocyte Activation, Receptors, Antigen, B-Cell, Spleen, Stem Cells, Cell Lineage, Mice

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B Cell Maintenance in Aged Mice Reflects Both Increased B Cell Longevity and Decreased B Cell Generation

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