Cited by 170T-cell and B-cell ImmunologyHematopoietic Stem Cell TransplantationLymphoma Diagnosis and Treatment

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B Cell Maintenance in Aged Mice Reflects Both Increased B Cell Longevity and Decreased B Cell Generation

Kline, Gregory H, Hayden, Tracy A, Klinman, Norman R·1999·The Journal of Immunology

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Abstract

In aged mice the population of mature peripheral B cells is maintained despite a severalfold decrease in the population of bone marrow B cell progenitors. The analysis of the rate of accumulation of 5′-bromo-2-deoxyuridine (BrdU)-labeled splenic B cells in mice fed BrdU for 8 days to 8 wk demonstrated a severalfold increase in the half-life of mature B cells in aged mice. Consistent with a role for decreased B cell turnover in maintaining the mature B cell population of aged mice, several findings indicate that fewer newly generated B cells enter the spleen from the bone marrow in aged vs young adult mice. These include 1) a fourfold decrease in the population of relatively immature splenic B cells, defined as cells that express high levels of heat-stable Ag and accumulate BrdU within 8 wk of labeling; and 2) an equivalent decrease in the population of bone marrow cells representative of later stages of B cell maturation (sIgD−sIgMint-high). Surprisingly, despite a four- to sixfold decrease in pre-B cells, the population of least mature bone marrow B cells (IgD−sIgMvery low) remains intact. Because this population accumulates BrdU-labeled cells more slowly in aged mice than in younger mice, and bone marrow B cells at more mature developmental stages are diminished, it appears that in aged mice B cell development beyond the sIgMvery low stage may be retarded and that cells, therefore, accumulate within this population.

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Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow.
Hardy, R. R., Carmack, C. E., Shinton, S. A., Kemp, J. D., & Hayakawa, K. (1991) · The Journal of Experimental Medicine · doi:10.1084/jem.173.5.1213 · Cited by 1,604
Handbook of the Biology of Aging
Finch, C. E., & Schneider, E. L. (1990) · DigitalGeorgetown (Georgetown University Library) · Cited by 1,210
Receptor editing in self-reactive bone marrow B cells.
Tiegs, S. L., Russell, D. M., & Nemazee, D. A. (1993) · The Journal of Experimental Medicine · doi:10.1084/jem.177.4.1009 · Cited by 1,033
Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes
Nemazee, D. A., & Bürki, K. (1989) · Nature · doi:10.1038/337562a0 · Cited by 1,019
A monoclonal antibody discriminating between subsets of T and B cells.
BRUCE, J. S., Symington, F. W., McKearn, T. J., & Sprent, J. (1981) · The Journal of Immunology · doi:10.4049/jimmunol.127.6.2496 · Cited by 542
Elimination of self-reactive B lymphocytes proceeds in two stages: Arrested development and cell death
Hartley, S. B., Cooke, M. P., Fulcher, D. A., Harris, A. W., Cory, S., Basten, A., & Goodnow, C. C. (1993) · Cell · doi:10.1016/0092-8674(93)90111-3 · Cited by 509
Peripheral B cell maturation. II. Heat-stable antigenhi splenic B cells are an immature developmental intermediate in the production of long-lived marrow-derived B cells.
Allman, D., Ferguson, S. E., Lentz, V. M., & Cancro, M. P. (1993) · The Journal of Immunology · doi:10.4049/jimmunol.151.9.4431 · Cited by 408
Lymphocyte life-span and memory
Sprent, J., & Tough, D. F. (1994) · Science · doi:10.1126/science.8073282 · Cited by 398
Protein Splicing of Inteins and Hedgehog Autoproteolysis: Structure, Function, and Evolution
Perler, F. B. (1998) · Cell · doi:10.1016/s0092-8674(00)80892-2 · Cited by 370
Transitional B cells are the target of negative selection in the B cell compartment.
Carsetti, R., Köhler, G., & Lamers, M. C. (1995) · The Journal of Experimental Medicine · doi:10.1084/jem.181.6.2129 · Cited by 358

Flagged first, then by citations

Show all 48 references

Research works printed but not linked: 43

1977, Cell. Immunol., 26
1997, Immunol. Rev., 79
1997, Immunol. Rev., 55
1981, J. Exp. Med., 547
1982, Cell. Immunol., 34
1980, Nature, 164
1983, J. Exp. Med., 1300
1986, Cell. Immunol., 452
1976, J. Exp. Med., 1037
1997, Immunol. Rev., 103
1986, J. Immunol., 368
1989, J. Immunol., 3798
1991, J. Immunol., 2750
1994, J. Immunol., 2214
1993, J. Cell. Biochem., F404
1986, Immunol. Rev., 159
1993, Curr. Opin. Immunol., 433
1975, Cell Tissue Kinet., 97
1997, Eur. J. Immunol., 1188
1982, Immunol. Rev., 81
1988, J. Immunol., 1863
1991, Clin. Immunol. Immunopathol., 301
1993, Blood, 2290
1993, Curr. Opin. Immunol., 207
1996, Int. Immunol., 509
1992, J. Immunol., 2533
1993, J. Immunol., 4431
1981, J. Immunol., 2496
1994, Science, 1395
1992, J. Immunol. Methods, 225
1995, Methods Companion Methods Enzymol., 3
1991, J. Exp. Med., 1213
1981, J. Immunol., 2027
1995, J. Exp. Med., 2129
1989, Nature, 562
1993, Cell, 325
1993, J. Exp. Med., 1009
1998, Cell, 1
1997, Immunity, 97
1991, J. Exp. Med., 717
1997, Eur. J. Immunol., 1801
1998, J. Immunol., 4472
1989, J. Immunol., 3833

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Authors: Kline, G. H., Hayden, T. A., & Klinman, N. R.
Affiliations: Scripps Research Institute (US)
Venue: The Journal of Immunology
Publisher: Oxford University Press (OUP)
Published: 1999-03
Volume: 162
Issue: 6
Pages: 3342-3349
ISSN: 0022-1767 (ISSN-L)
1550-6606
DOI: 10.4049/jimmunol.162.6.3342
OpenAlex: W2156242308
Cited by: 170
References: 48
Citations by year: 2026: 1 · 2025: 3 · 2024: 2 · 2023: 3 · 2022: 3 · 2021: 5 · 2020: 6 · 2019: 9 · 2018: 3 · 2017: 6 · 2016: 3 · 2015: 5 · 2014: 3 · 2013: 5 · 2012: 9
FWCI: 1.94
Type: journal article
Language: en
Open access: closed
Licence: academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: The Journal of Immunology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Aging (P01AG001743, T32AG000080, AG-01743, T32 AG-00080)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
Health Sciences › Medicine › Pathology and Forensic Medicine › Lymphoma Diagnosis and Treatment
Keywords: B cell aging, splenic B cells, B cell maturation, pre-B cells, CD24, BrdU labeling, immunosenescence
MeSH terms: Aging, Animals, B-Lymphocytes, Bone Marrow Cells, Bromodeoxyuridine, Cell Cycle, Cell Differentiation, Cell Survival, Immunoglobulin M, Lymphocyte Activation, Receptors, Antigen, B-Cell, Spleen, Stem Cells, Cell Lineage, Mice

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B Cell Maintenance in Aged Mice Reflects Both Increased B Cell Longevity and Decreased B Cell Generation

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