Aging and developmental transitions in the B cell lineage
Abstract
One explanation for the deterioration of the humoral immune response in elderly individuals is that B lymphopoiesis declines with increasing age. Recent studies report a dramatic decline in pre-B cell numbers in old mice. Surprisingly, the number of mature B cells does not decline with age. To determine if new B cells are made in aged animals despite the drop in pre-B cells, we used 5'-bromo-2-deoxyuridine labeling to determine the production rate of B cells in the bone marrow and spleen of young and old mice. Because of the great variability in the number of early B lineage cells in old mice, we acquired data on >60 young and 50 old mice throughout these experiments. The transitional and mature B cell compartments in the spleen have slower labeling kinetics in old mice as compared to young. By the end of 4 weeks of labeling, an average of only 15% of the mature B cell compartment consists of newly made cells compared to 30% in young mice. However, in contrast to an earlier report, our results indicate that there is no statistical difference in the rate of production of new immature B cells in the marrow of young and old animals. In total, our results confirm previous work showing that mature B cells in old mice have a slower turnover, but more importantly suggest that the defect in mature B cell turnover is not due to a decline in B lymphopoiesis, but rather an inability of the newly made cells to replenish the peripheral compartments.
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In mice, the turnover of mature spleen B cells decreases with age.
“In mice, the turnover of mature spleen B cells also decreases with age [143, 144].”
From Immunosenescence: a key player in cancer development (2020) · cites this paper as [143]
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- Authors
- Johnson, K. M.
- Affiliations
- Loyola University Medical Center (US)
- Corresponding author
- Johnson, K. M.
- Venue
- International Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2002-11-01
- Volume
- 14
- Issue
- 11
- Pages
- 1313-1323
- ISSN
- 0953-8178 (ISSN-L)
- 1460-2377
- OpenAlex
- W2137896220
- Cited by
- 128
- References
- 35
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 5 · 2023: 1 · 2022: 6 · 2021: 4 · 2020: 2 · 2019: 6 · 2018: 5 · 2017: 5 · 2016: 3 · 2015: 2 · 2014: 1 · 2013: 10 · 2012: 6
- FWCI
- 2.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (K07AG000997, R01AG13874, K07 AG00997, R01AG013874)
- National Institute of Allergy and Infectious Diseases (T32AI007508, T32 AI 07508)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Health Sciences › Medicine › Pathology and Forensic Medicine › Lymphoma Diagnosis and Treatment
- Keywords
- B cell aging, B cell development, pre-B cells, mature B cells, bone marrow, spleen, 5-bromo-2'-deoxyuridine labeling, developmental transitions, aged mice
- MeSH terms
- Aging, Animals, B-Lymphocytes, Bone Marrow, Bromodeoxyuridine, Cell Differentiation, Female, Flow Cytometry, Kinetics, Mice, Inbred BALB C, Spleen, Staining and Labeling, Cellular Senescence, Mice
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