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Cited by 170T-cell and B-cell ImmunologyHematopoietic Stem Cell TransplantationLymphoma Diagnosis and Treatment

The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.

B Cell Maintenance in Aged Mice Reflects Both Increased B Cell Longevity and Decreased B Cell Generation

Kline, Gregory H, Hayden, Tracy A, Klinman, Norman R·1999·The Journal of Immunology
DOI 10.4049/jimmunol.162.6.3342
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Abstract

In aged mice the population of mature peripheral B cells is maintained despite a severalfold decrease in the population of bone marrow B cell progenitors. The analysis of the rate of accumulation of 5′-bromo-2-deoxyuridine (BrdU)-labeled splenic B cells in mice fed BrdU for 8 days to 8 wk demonstrated a severalfold increase in the half-life of mature B cells in aged mice. Consistent with a role for decreased B cell turnover in maintaining the mature B cell population of aged mice, several findings indicate that fewer newly generated B cells enter the spleen from the bone marrow in aged vs young adult mice. These include 1) a fourfold decrease in the population of relatively immature splenic B cells, defined as cells that express high levels of heat-stable Ag and accumulate BrdU within 8 wk of labeling; and 2) an equivalent decrease in the population of bone marrow cells representative of later stages of B cell maturation (sIgD−sIgMint-high). Surprisingly, despite a four- to sixfold decrease in pre-B cells, the population of least mature bone marrow B cells (IgD−sIgMvery low) remains intact. Because this population accumulates BrdU-labeled cells more slowly in aged mice than in younger mice, and bone marrow B cells at more mature developmental stages are diminished, it appears that in aged mice B cell development beyond the sIgMvery low stage may be retarded and that cells, therefore, accumulate within this population.

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Citations

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Research works printed but not linked: 43

  1. 1977, Cell. Immunol., 26
  2. 1997, Immunol. Rev., 79
  3. 1997, Immunol. Rev., 55
  4. 1981, J. Exp. Med., 547
  5. 1982, Cell. Immunol., 34
  6. 1980, Nature, 164
  7. 1983, J. Exp. Med., 1300
  8. 1986, Cell. Immunol., 452
  9. 1976, J. Exp. Med., 1037
  10. 1997, Immunol. Rev., 103
  11. 1986, J. Immunol., 368
  12. 1989, J. Immunol., 3798
  13. 1991, J. Immunol., 2750
  14. 1994, J. Immunol., 2214
  15. 1993, J. Cell. Biochem., F404
  16. 1986, Immunol. Rev., 159
  17. 1993, Curr. Opin. Immunol., 433
  18. 1975, Cell Tissue Kinet., 97
  19. 1997, Eur. J. Immunol., 1188
  20. 1982, Immunol. Rev., 81
  21. 1988, J. Immunol., 1863
  22. 1991, Clin. Immunol. Immunopathol., 301
  23. 1993, Blood, 2290
  24. 1993, Curr. Opin. Immunol., 207
  25. 1996, Int. Immunol., 509
  26. 1992, J. Immunol., 2533
  27. 1993, J. Immunol., 4431
  28. 1981, J. Immunol., 2496
  29. 1994, Science, 1395
  30. 1992, J. Immunol. Methods, 225
  31. 1995, Methods Companion Methods Enzymol., 3
  32. 1991, J. Exp. Med., 1213
  33. 1981, J. Immunol., 2027
  34. 1995, J. Exp. Med., 2129
  35. 1989, Nature, 562
  36. 1993, Cell, 325
  37. 1993, J. Exp. Med., 1009
  38. 1998, Cell, 1
  39. 1997, Immunity, 97
  40. 1991, J. Exp. Med., 717
  41. 1997, Eur. J. Immunol., 1801
  42. 1998, J. Immunol., 4472
  43. 1989, J. Immunol., 3833

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Metadata

Authors
Kline, G. H., Hayden, T. A., & Klinman, N. R.
Affiliations
Scripps Research Institute (US)
Venue
The Journal of Immunology
Publisher
Oxford University Press (OUP)
Published
1999-03
Volume
162
Issue
6
Pages
3342-3349
ISSN
  • 0022-1767 (ISSN-L)
  • 1550-6606
DOI
10.4049/jimmunol.162.6.3342
OpenAlex
W2156242308
Cited by
170
References
48
Citations by year
2026: 1 · 2025: 3 · 2024: 2 · 2023: 3 · 2022: 3 · 2021: 5 · 2020: 6 · 2019: 9 · 2018: 3 · 2017: 6 · 2016: 3 · 2015: 5 · 2014: 3 · 2013: 5 · 2012: 9
FWCI
1.94
Type
journal article
Language
en
Open access
closed
Licence
academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations
  • The Journal of Immunology (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute on Aging (P01AG001743, T32AG000080, AG-01743, T32 AG-00080)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Lymphoma Diagnosis and Treatment
Keywords
B cell aging, splenic B cells, B cell maturation, pre-B cells, CD24, BrdU labeling, immunosenescence
MeSH terms
Aging, Animals, B-Lymphocytes, Bone Marrow Cells, Bromodeoxyuridine, Cell Cycle, Cell Differentiation, Cell Survival, Immunoglobulin M, Lymphocyte Activation, Receptors, Antigen, B-Cell, Spleen, Stem Cells, Cell Lineage, Mice

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