Cited by 206Parasites and Host InteractionsAllergic Rhinitis and SensitizationAsthma and respiratory diseases

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Induction of Th2 Responses and IgE Is Largely Due to Carbohydrates Functioning as Adjuvants on Schistosoma mansoni Egg Antigens

Okano, Mitsuhiro, Satoskar, Abhay R, Nishizaki, Kazunori, Abe, Mie, Harn, Donald A·1999·The Journal of Immunology

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Abstract

Infection with the helminth parasite Schistosoma mansoni induces a pronounced Th2-type response that is associated with significant IgE production. To better understand how the parasite drives these responses, we investigated the relative roles of proteins and carbohydrates in driving Th2-type and/or IgE responses using a murine model of intranasal sensitization with soluble egg Ags (SEA) of Schistosoma mansoni. We found that repeated intranasal sensitization with soluble egg Ags led to the induction of both total and specific IgE production and nasal eosinophilia. By comparing the responses of mice sensitized with SEA or metaperiodate-treated SEA we were able to demonstrate that carbohydrates on SEA are the major inducers of IgE production and nasal recruitment of eosinophils. Mice sensitized with periodate-treated SEA displayed a significant decrease in both total and specific IgE levels in comparison to mice sensitized with native SEA. Furthermore, sensitization of mice with periodate-treated SEA significantly reduced levels of Ag-specific IgG1, but had no effect on IgG2a production. Nasal lymphocytes from mice sensitized with native SEA, but not with periodate-treated SEA, produced IL-4, IL-5, and IL-10 when restimulated with native SEA in vitro. On the other hand, lymphocytes from mice sensitized with periodate-treated SEA did not produce any of these same cytokines following in vitro restimulation, suggesting that carbohydrates were required for in vivo induction of Th2 response and for that of associated cytokine responses in this model. Lastly, competitive inhibition ELISA showed that although carbohydrates are required for SEA-specific IgE induction, they are not targets of the induced IgE response.

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The receptor DEC-205 expressed by dendritic cells and thymic epithelial cells is involved in antigen processing
Jiang, W., Swiggard, W. J., Heufler, C., Peng, M., Mirza, A., Steinman, R. M., & Nussenzweig, M. C. (1995) · Nature · doi:10.1038/375151a0 · Cited by 966
Mannose-binding lectin: the pluripotent molecule of the innate immune system
TURNER, M. W. (1996) · Immunology Today · doi:10.1016/s0167-5699(96)80908-x · Cited by 709
Purified interleukin 5 supports the terminal differentiation and proliferation of murine eosinophilic precursors
Yamaguchi, Y., Suda, T., Suda, J., Eguchi, M., Miura, Y., Harada, N., Tominaga, A., & Takatsu, K. (1988) · Journal of Experimental Medicine · doi:10.1084/jem.167.1.43 · Cited by 566
Cytokine messenger RNA expression for IL-3, IL-4, IL-5, and granulocyte/macrophage-colony-stimulating factor in the nasal mucosa after local allergen provocation: relationship to tissue eosinophilia
Durham, S. R., Ying, S., Varney, V. A., Jacobson, M. R., Sudderick, R. M., Mackay, I. S., Kay, A. B., & Hamid, Q. A. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.148.8.2390 · Cited by 557
Egg deposition is the major stimulus for the production of Th2 cytokines in murine schistosomiasis mansoni
Grzych, J., Pearce, E. J., Cheever, A. W., Caulada-Benedetti, Z., Caspar, P., Heiny, S. R., Lewis, F. A., & Sher, A. (1991) · The Journal of Immunology · doi:10.4049/jimmunol.146.4.1322 · Cited by 542
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Ezekowitz, R. A. B., Williams, D., Koziel, H., Armstrong, M. Y. K., Warner, A., Richards, F. F., & Rose, R. M. (1991) · Nature · doi:10.1038/351155a0 · Cited by 447
Oligosaccharide-specific induction of interleukin 10 production by B220+ cells from schistosome-infected mice: a mechanism for regulation of CD4+ T-cell subsets
Velupillai, P., & Harn, D. A. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.1.18 · Cited by 299
Self-citation
The mannose receptor and other macrophage lectins
Stahl, P. D. (1992) · Current Opinion in Immunology · doi:10.1016/0952-7915(92)90123-v · Cited by 245
The structure of a neural specific carbohydrate epitope of horseradish peroxidase recognized by anti-horseradish peroxidase antiserum
Kurosaka, A., Yano, A., Itoh, N., Kuroda, Y., Nakagawa, T., & Kawasaki, T. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)64302-2 · Cited by 202

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Show all 32 references

Research works printed but not linked: 30

1991, J. Biol. Chem., 4168
1991, Arch. Biochem. Biophys., 474
1995, Eur. J. Immunol., 538
1997, J. Exp. Med., 899
1991, Nature, 155
1996, Immunol. Today, 532
1998, Semin. Immunol., 355
1991, J. Immunol., 1322
1997, J. Immunol., 4398
1990, Proc. Natl. Acad. Sci. USA, 4159
1994, Proc. Natl. Acad. Sci. USA, 18
1997, J. Immunol., 338
1999, Allergy, 593
1984, J. Exp. Med., 1371
1999, Allergy, 811
1995, J. Immunol. Methods, 41
1997, J. Infect. Dis., 1649
1990, Annu. Rev. Immunol., 303
1992, Curr. Opin. Immunol., 49
1995, Nature, 151
1996, Eur. J. Immunol., 394
1994, J. Exp. Med., 203
1993, Regional Immunol., 69
1996, Proc. Natl. Acad. Sci USA, 7944
1996, Immunology, 493
1993, Laryngoscope, 189
1996, J. Allergy Clin. Immunol., 489
1995, J. Allergy Clin. Immunol., 396
1988, J. Exp. Med., 43
1992, J. Immunol., 2390

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Self-citation
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Thors, C. (2006) · Figshare
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Bantleon, F. I. (2014)
The Immunobiology of Urogenital Schistosomiasis
(2014) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/9781608059850114020008
From Microbiology and Tumor Biology Center Karolinska Institutet, Stockholm, Sweden Serodiagnostics of schistosomiasis using keyhole limpet hemocyanin (KLH) as antigen
Thors, C. (2006)

Authors: Okano, M., Satoskar, A. R., Nishizaki, K., Abe, M., & Harn, D. A.
Affiliations: Harvard University (US)
Okayama University (JP)
ORCID: Okano, Mitsuhiro
Satoskar, Abhay R
Nishizaki, Kazunori
Venue: The Journal of Immunology
Publisher: Oxford University Press (OUP)
Published: 1999-12
Volume: 163
Issue: 12
Pages: 6712-6717
ISSN: 0022-1767 (ISSN-L)
1550-6606
DOI: 10.4049/jimmunol.163.12.6712
OpenAlex: W2097456894
Cited by: 206
References: 32
Citations by year: 2025: 2 · 2024: 1 · 2023: 6 · 2022: 1 · 2021: 6 · 2020: 3 · 2019: 6 · 2018: 6 · 2017: 4 · 2016: 5 · 2015: 6 · 2014: 10 · 2013: 4 · 2012: 13
FWCI: 7.28
Type: journal article
Language: en
Open access: closed
Licence: academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: The Journal of Immunology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Allergy and Infectious Diseases (AI-16305-18)
Topics: Life Sciences › Immunology and Microbiology › Parasitology › Parasites and Host Interactions
Health Sciences › Medicine › Immunology and Allergy › Allergic Rhinitis and Sensitization
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
Keywords: Schistosoma mansoni, soluble egg antigen, Th2 immune response, eosinophilia, periodate treatment, intranasal sensitization, IL-4, IL-5, IL-10, IgG1, IgG2a, helminthiasis
MeSH terms: Adjuvants, Immunologic, Administration, Intranasal, Animals, Antibodies, Helminth, Antigens, Helminth, Carbohydrates, Cells, Cultured, Eosinophilia, Female, Immunoglobulin E, Mice, Inbred BALB C, Nasal Mucosa, Ovum, Periodic Acid, Schistosoma mansoni, Cytokines, Th2 Cells, Epitopes, T-Lymphocyte, Carbohydrate Metabolism, Mice

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Induction of Th2 Responses and IgE Is Largely Due to Carbohydrates Functioning as Adjuvants on Schistosoma mansoni Egg Antigens

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