Induction of Th2 Responses and IgE Is Largely Due to Carbohydrates Functioning as Adjuvants on Schistosoma mansoni Egg Antigens

Lymphokine Control of In Vivo Immunoglobulin Isotype Selection

Finkelman, F. D., Holmes, J. M., Katona, I. M., Urban, J. F., Beckmann, M. P., Park, L. S., Schooley, K., Coffman, R. L., Mosmann, T. R., & Paul, W. E. (1990) · Annual Review of Immunology · doi:10.1146/annurev.iy.08.040190.001511 · Cited by 1,301

The receptor DEC-205 expressed by dendritic cells and thymic epithelial cells is involved in antigen processing

Jiang, W., Swiggard, W. J., Heufler, C., Peng, M., Mirza, A., Steinman, R. M., & Nussenzweig, M. C. (1995) · Nature · doi:10.1038/375151a0 · Cited by 966

Mannose-binding lectin: the pluripotent molecule of the innate immune system

TURNER, M. W. (1996) · Immunology Today · doi:10.1016/s0167-5699(96)80908-x · Cited by 709

Purified interleukin 5 supports the terminal differentiation and proliferation of murine eosinophilic precursors

Yamaguchi, Y., Suda, T., Suda, J., Eguchi, M., Miura, Y., Harada, N., Tominaga, A., & Takatsu, K. (1988) · Journal of Experimental Medicine · doi:10.1084/jem.167.1.43 · Cited by 566

Cytokine messenger RNA expression for IL-3, IL-4, IL-5, and granulocyte/macrophage-colony-stimulating factor in the nasal mucosa after local allergen provocation: relationship to tissue eosinophilia

Durham, S. R., Ying, S., Varney, V. A., Jacobson, M. R., Sudderick, R. M., Mackay, I. S., Kay, A. B., & Hamid, Q. A. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.148.8.2390 · Cited by 557

Egg deposition is the major stimulus for the production of Th2 cytokines in murine schistosomiasis mansoni

Grzych, J., Pearce, E. J., Cheever, A. W., Caulada-Benedetti, Z., Caspar, P., Heiny, S. R., Lewis, F. A., & Sher, A. (1991) · The Journal of Immunology · doi:10.4049/jimmunol.146.4.1322 · Cited by 542

Uptake of Pneumocystis carinii mediated by the macrophage mannose receptor

Ezekowitz, R. A. B., Williams, D., Koziel, H., Armstrong, M. Y. K., Warner, A., Richards, F. F., & Rose, R. M. (1991) · Nature · doi:10.1038/351155a0 · Cited by 447

Oligosaccharide-specific induction of interleukin 10 production by B220+ cells from schistosome-infected mice: a mechanism for regulation of CD4+ T-cell subsets

Velupillai, P., & Harn, D. A. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.1.18 · Cited by 299

The mannose receptor and other macrophage lectins

Stahl, P. D. (1992) · Current Opinion in Immunology · doi:10.1016/0952-7915(92)90123-v · Cited by 245

The structure of a neural specific carbohydrate epitope of horseradish peroxidase recognized by anti-horseradish peroxidase antiserum

Kurosaka, A., Yano, A., Itoh, N., Kuroda, Y., Nakagawa, T., & Kawasaki, T. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)64302-2 · Cited by 202

Alternative activation of macrophages

Gordon, S. (2003) · Nature Reviews Immunology · doi:10.1038/nri978 · Cited by 6,189

The immunobiology of schistosomiasis

Pearce, E. J., & MacDonald, A. S. (2002) · Nature reviews. Immunology · doi:10.1038/nri843 · Cited by 1,170

Protective immune mechanisms in helminth infection

Anthony, R. M., Rutitzky, L. I., Urban, J. F., Stadecker, M. J., & Gause, W. C. (2007) · Nature reviews. Immunology · doi:10.1038/nri2199 · Cited by 959

DC-SIGN: escape mechanism for pathogens

van Kooyk, Y., & Geijtenbeek, T. B. H. (2003) · Nature reviews. Immunology · doi:10.1038/nri1182 · Cited by 939

Modulation of Host Immunity by Helminths: The Expanding Repertoire of Parasite Effector Molecules

Maizels, R. M., Smits, H. H., & McSorley, H. J. (2018) · Immunity · doi:10.1016/j.immuni.2018.10.016 · Cited by 435

Cutting Edge: Carbohydrate Profiling Identifies New Pathogens That Interact with Dendritic Cell-Specific ICAM-3-Grabbing Nonintegrin on Dendritic Cells

Appelmelk, B. J., van Die, I., van Vliet, S. J., Vandenbroucke‐Grauls, C. M. J. E., Geijtenbeek, T. B. H., & van Kooyk, Y. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.4.1635 · Cited by 432

Parasites and the Hygiene Hypothesis: Regulating the Immune System?

Yazdanbakhsh, M., & Matricardi, P. M. (2004) · Clinical Reviews in Allergy & Immunology · doi:10.1385/criai:26:1:15 · Cited by 429

Omega-1, a glycoprotein secreted by Schistosoma mansoni eggs, drives Th2 responses

Everts, B., Perona‐Wright, G., Smits, H. H., Hokke, C. H., van der Ham, A. J., Fitzsimmons, C. M., Doenhoff, M. J., van der Bosch, J., Mohrs, K., Haas, H., et al. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20082460 · Cited by 335

Control of adaptive immune responses by Toll-like receptors

Barton, G. M., & Medzhitov, R. M. (2002) · Current Opinion in Immunology · doi:10.1016/s0952-7915(02)00343-6 · Cited by 327

Schistosoma mansoni antigens modulate the activity of the innate immune response and prevent onset of type 1 diabetes

Zaccone, P., Fehervari, Z. T., Jones, F. M., Sidobre, S., Kronenberg, M., Dunne, D. W., & Cooke, A. (2003) · European Journal of Immunology · doi:10.1002/eji.200323910 · Cited by 317

Maturation of Dendritic Cell 2 Phenotype by a Helminth Glycan Uses a Toll-Like Receptor 4-Dependent Mechanism

Thomas, P. G., Carter, M. R., Atochina, O., Da’dara, A. A., Piskorska, D., McGuire, E., & Harn, D. A. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.11.5837 · Cited by 303

CD8− Dendritic Cell Activation Status Plays an Integral Role in Influencing Th2 Response Development

MacDonald, A. S., Straw, A. D., Bauman, B. E., & Pearce, E. J. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.4.1982 · Cited by 280

The Major Glycoprotein Allergen from Arachis hypogaea, Ara h 1, Is a Ligand of Dendritic Cell-Specific ICAM-Grabbing Nonintegrin and Acts as a Th2 Adjuvant In Vitro

Shreffler, W. G., Castro, R., Kucuk, Z. Y., Charlop–Powers, Z., Grishina, G. T., Yoo, S., Burks, A. W., & Sampson, H. A. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.6.3677 · Cited by 273

Thioredoxin Peroxidase Secreted by Fasciola hepatica Induces the Alternative Activation of Macrophages

Donnelly, S., O’Neill, S. M., Sekiya, M., Mulcahy, G. M., & Dalton, J. P. (2004) · Infection and Immunity · doi:10.1128/iai.73.1.166-173.2005 · Cited by 265

Schistosoma mansoni soluble egg antigens are internalized by human dendritic cells through multiple C-type lectins and suppress TLR-induced dendritic cell activation

van Liempt, E., van Vliet, S. J., Engering, A. J., García-Vallejo, J. J., Bank, C. M. C., Sánchez‐Hernández, M., van Kooyk, Y., & van Die, I. (2007) · Molecular Immunology · doi:10.1016/j.molimm.2006.12.012 · Cited by 255

Dectin-2 Recognition of House Dust Mite Triggers Cysteinyl Leukotriene Generation by Dendritic Cells

Barrett, N. A., Maekawa, A., Rahman, O. M., Austen, K. F., & Kanaoka, Y. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.182.2.1119 · Cited by 247

Macrophage galactose-type C-type lectins as novel markers for alternatively activated macrophages elicited by parasitic infections and allergic airway inflammation

Raes, G., Brys, L., Dahal, B. K., Brandt, J., Grooten, J., Brombacher, F., Vanham, G., Noël, W., Bogaert, P., Boonefaes, T., et al. (2004) · Journal of Leukocyte Biology · doi:10.1189/jlb.0304212 · Cited by 246

C-type lectin DC-SIGN: An adhesion, signalling and antigen-uptake molecule that guides dendritic cells in immunity

Švajger, U., Anderluh, M., Jeras, M., & Obermajer, N. (2010) · Cellular Signalling · doi:10.1016/j.cellsig.2010.03.018 · Cited by 256

Schistosome-derived omega-1 drives Th2 polarization by suppressing protein synthesis following internalization by the mannose receptor

Everts, B., Hussaarts, L., Driessen, N. N., Meevissen, M. H. J., Schramm, G., van der Ham, A. J., van der Hoeven, B., Scholzen, T., Burgdorf, S., Mohrs, M., et al. (2012) · Journal of Experimental Medicine · doi:10.1084/jem.20111381 · Cited by 236

Lacto- N -fucopentaose III Found on Schitosoma mansoni Egg Antigens Functions as Adjuvant for Proteins by Inducing Th2-Type Response

Okano, M., Satoskar, A. R., Nishizaki, K., & Harn, D. A. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.1.442 · Cited by 210

Glycan gimmickry by parasitic helminths: A strategy for modulating the host immune response?

van Die, I., & Cummings, R. D. (2010) · Glycobiology · doi:10.1093/glycob/cwp140 · Cited by 199

Immunology of Parasitic Helminth Infections

MacDonald, A. S., Araújo, M. I., & Pearce, E. J. (2002) · Infection and Immunity · doi:10.1128/iai.70.2.427-433.2002 · Cited by 202

Dectin-2 mediates Th2 immunity through the generation of cysteinyl leukotrienes

Barrett, N. A., Rahman, O. M., Fernandez, J., Parsons, M. W., Xing, W., Austen, K. F., & Kanaoka, Y. (2011) · The Journal of Experimental Medicine · doi:10.1084/jem.20100793 · Cited by 196

Chronic helminth infection and helminth‐derived egg antigens promote adipose tissue M2 macrophages and improve insulin sensitivity in obese mice

Hussaarts, L., García‐Tardón, N., van Beek, L., Heemskerk, M. M., Haeberlein, S., van der Zon, G. C. M., Ozir‐Fazalalikhan, A., Berbée, J. F. P., van Dijk, K. W., van Harmelen, V., et al. (2015) · The FASEB Journal · doi:10.1096/fj.14-266239 · Cited by 198

Th2 response polarization during infection with the helminth parasite Schistosoma mansoni

Pearce, E. J., Kane, C. M., Sun, J., Taylor, J. J., McKee, A. S., & Cervi, L. (2004) · Immunological Reviews · doi:10.1111/j.0105-2896.2004.00187.x · Cited by 190

Molecular Characterization of an Interleukin-4-inducing Factor from Schistosoma mansoni Eggs

Schramm, G., Falcone, F. H., Gronow, A., Haisch, K., Mamat, U., Doenhoff, M. J., Oliveira, G., Galle, J., Dahinden, C. A., & Haas, H. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300497200 · Cited by 178

The Schistosome Oligosaccharide Lacto- N -neotetraose Expands Gr1+ Cells That Secrete Anti-inflammatory Cytokines and Inhibit Proliferation of Naive CD4+ Cells: A Potential Mechanism for Immune Polarization in Helminth Infections

Terrazas, L. I., Walsh, K. L., Piskorska, D., McGuire, E., & Harn, D. A. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.9.5294 · Cited by 169

Chronic Helminth Infections Protect Against Allergic Diseases by Active Regulatory Processes

Smits, H. H., Everts, B., Hartgers, F. C., & Yazdanbakhsh, M. (2010) · Current Allergy and Asthma Reports · doi:10.1007/s11882-009-0085-3 · Cited by 158

Update on trematode infections in sheep

Rojo-Vázquez, F. A., Meana, A., Sancho, F. V., & Valladares, M. M. (2012) · Veterinary Parasitology · doi:10.1016/j.vetpar.2012.03.029 · Cited by 153

Survey of immune-related, mannose/fucose-binding C-type lectin receptors reveals widely divergent sugar-binding specificities

Lee, R. T., Hsu, T.-L., Huang, S. K., Hsieh, S.-L., Wong, C., & Lee, Y. C. (2010) · Glycobiology · doi:10.1093/glycob/cwq193 · Cited by 149

Immunology of Alveolar and Cystic Echinococcosis (AE and CE)

Gottstein, B., Soboslay, P. T., Ortona, E., Wang, J., Siracusano, A., & Vuitton, D. A. (2016) · Advances in Parasitology/Advances in parasitology · doi:10.1016/bs.apar.2016.09.005 · Cited by 149

Chronic Helminth Infection Induces Alternatively Activated Macrophages Expressing High Levels of CCR5 with Low Interleukin-12 Production and Th2-Biasing Ability

Rodríguez‐Sosa, M., Satoskar, A. R., Calderón, R., Gómez-García, L., Saavedra, R., Bojalil, R., & Terrazas, L. I. (2002) · Infection and Immunity · doi:10.1128/iai.70.7.3656-3664.2002 · Cited by 149

Priming of the immune response by schistosome eggs

Pearce, E. J. (2005) · Parasite Immunology · doi:10.1111/j.1365-3024.2005.00765.x · Cited by 137

Immune biasing by helminth glycans

Thomas, P. G., & Harn, D. A. (2003) · Cellular Microbiology · doi:10.1046/j.1462-5822.2003.00337.x · Cited by 137

Role of the programmed Death-1 pathway in the suppressive activity of alternatively activated macrophages in experimental cysticercosis

Terrazas, L. I., Montero, D., Terrazas, C. A., Reyes, J. L., & Rodríguez‐Sosa, M. (2005) · International Journal for Parasitology · doi:10.1016/j.ijpara.2005.06.003 · Cited by 136

Delayed Anaphylaxis to Red Meat in Patients with IgE Specific for Galactose alpha-1,3-Galactose (alpha-gal)

Commins, S. P., & Platts‐Mills, T. A. E. (2012) · Current Allergy and Asthma Reports · doi:10.1007/s11882-012-0315-y · Cited by 134

Predictive values of alpha‐gal IgE levels and alpha‐gal IgE: Total IgE ratio and oral food challenge‐proven meat allergy in a population with a high prevalence of reported red meat allergy

Mabelane, T., Basera, W., Botha, M., Thomas, H., Ramjith, J., & Levin, M. (2018) · Pediatric Allergy and Immunology · doi:10.1111/pai.12969 · Cited by 114

Pathogens target DC‐SIGN to influence their fate DC‐SIGN functions as a pathogen receptor with broad specificity

Geijtenbeek, T. B. H., & van Kooyk, Y. (2003) · Apmis · doi:10.1034/j.1600-0463.2003.11107803.x · Cited by 129

Re‐examination of the immunosuppressive mechanisms mediating non‐cure of Leishmania infection in mice

Sacks, D. L., & Anderson, C. (2004) · Immunological Reviews · doi:10.1111/j.0105-2896.2004.00185.x · Cited by 126

Both Free-Living and Parasitic Nematodes Induce a Characteristic Th2 Response That Is Dependent on the Presence of Intact Glycans

Tawill, S. A., Goff, L. L., Ali, F., Blaxter, M., & Allen, J. E. (2003) · Infection and Immunity · doi:10.1128/iai.72.1.398-407.2004 · Cited by 126

Cytokine-mediated host responses during schistosome infections; walking the fine line between immunological control and immunopathology

HOFFMANN, K., Wynn, T. A., & Dunne, D. W. (2002) · Advances in Parasitology/Advances in parasitology · doi:10.1016/s0065-308x(02)52014-5 · Cited by 127

Immunomodulatory glycan LNFPIII alleviates hepatosteatosis and insulin resistance through direct and indirect control of metabolic pathways

Bhargava, P., Li, C., Stanya, K. J., Jacobi, D., Dai, L., Liu, S., Gangl, M. R., Harn, D. A., & Lee, C. (2012) · Nature Medicine · doi:10.1038/nm.2962 · Cited by 124

Th2 responses in schistosomiasis

Fairfax, K. C., Nascimento, M., Huang, S. C., Everts, B., & Pearce, E. J. (2012) · Seminars in Immunopathology · doi:10.1007/s00281-012-0354-4 · Cited by 121

Atopy, asthma, and antibodies to Ascaris among rural and urban children in Kenya

Perzanowski, M. S., Nganga, L., Carter, M. C., Odhiambo, J. A., Ngari, P., Vaughan, J., Chapman, M. D., Kennedy, M. W., & Platts‐Mills, T. A. E. (2002) · The Journal of Pediatrics · doi:10.1067/mpd.2002.122937 · Cited by 122

Glycomics Analysis of Schistosoma mansoni Egg and Cercarial Secretions*S

Jang-Lee, J., Curwen, R. S., Ashton, P. D., Tissot, B., Mathieson, W., Panico, M., Dell, A., Wilson, R. A., & Haslam, S. (2007) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m700004-mcp200 · Cited by 124

Helminths and dendritic cells: Sensing and regulating via pattern recognition receptors, Th2 and Treg responses

Everts, B., Smits, H. H., Hokke, C. H., & Yazdanbakhsh, M. (2010) · European Journal of Immunology · doi:10.1002/eji.200940109 · Cited by 121

Schistosome N‐glycans containing core α3‐fucose and core β2‐xylose epitopes are strong inducers of Th2 responses in mice

Faveeuw, C., Mallevaey, T., Paschinger, K., Wilson, I. B. H., Fontaine, J., Mollicone, R., Oriol, R., Altmann, F., Lerouge, P., Capron, M., et al. (2003) · European Journal of Immunology · doi:10.1002/eji.200323717 · Cited by 117

IgE cross‐reactivity between Ascaris and domestic mite allergens: the role of tropomyosin and the nematode polyprotein ABA‐1

Acevedo, N., Sánchez, J., Erler, A., Mercado, D., Briza, P., Kennedy, M. W., Fernández, A., Gutierrez, M., Chua, K. Y., Cheong, N., et al. (2009) · Allergy · doi:10.1111/j.1398-9995.2009.02084.x · Cited by 115

Trichuris suis-induced modulation of human dendritic cell function is glycan-mediated

Klaver, E. J., Kuijk, L. M., Laan, L. C., Kringel, H., van Vliet, S. J., Bouma, G., Cummings, R. D., Kraal, G., & van Die, I. (2012) · International Journal for Parasitology · doi:10.1016/j.ijpara.2012.10.021 · Cited by 107

IPSE/alpha-1: A major immunogenic component secreted from Schistosoma mansoni eggs

Schramm, G., Gronow, A., Knobloch, J., Wippersteg, V., Grevelding, C. G., Galle, J., Fuller, H. R., STANLEY, R. G., Chiodini, P. L., Haas, H., et al. (2006) · Molecular and Biochemical Parasitology · doi:10.1016/j.molbiopara.2006.01.003 · Cited by 102

DC-SIGN Mediates Binding of Dendritic Cells to Authentic Pseudo-LewisY Glycolipids of Schistosoma mansoni Cercariae, the First Parasite-specific Ligand of DC-SIGN

Meyer, S., van Liempt, E., Imberty, A., van Kooyk, Y., Geyer, H., Geyer, R., & van Die, I. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m507100200 · Cited by 102

Soluble egg antigen from Schistosoma japonicum modulates the progression of chronic progressive experimental autoimmune encephalomyelitis via Th2-shift response

Zheng, X., Hu, X., Zhou, G., Lu, Z., Qiu, W., Bao, J., & Dai, Y. (2008) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2007.12.001 · Cited by 101

A fatal attraction: Mycobacterium tuberculosis and HIV-1 target DC-SIGN to escape immune surveillance

van Kooyk, Y., Appelmelk, B. J., & Geijtenbeek, T. B. H. (2003) · Trends in Molecular Medicine · doi:10.1016/s1471-4914(03)00027-3 · Cited by 101

Schistosome glycoconjugates in host-parasite interplay

Hokke, C. H., & Deelder, A. M. (2001) · Glycoconjugate Journal · doi:10.1023/a:1020634602161 · Cited by 101

Parasitic helminths: a pharmacopeia of anti-inflammatory molecules

Johnston, M. J., MacDonald, J. A., & McKay, D. M. (2008) · Parasitology · doi:10.1017/s0031182008005210 · Cited by 103

Immunity to schistosomiasis: glycans are potential antigenic targets for immune intervention

Nyame, A. K., Lewis, F. A., Doughty, B. L., Corrêa‐Oliveira, R., & Cummings, R. D. (2003) · Experimental Parasitology · doi:10.1016/s0014-4894(03)00110-3 · Cited by 92

Th1/Th2 effector choice in parasitic infection: decision making by committee

Jankovic, D. L., Sher, A., & Yap, G. S. (2001) · Current Opinion in Immunology · doi:10.1016/s0952-7915(00)00234-x · Cited by 91

Modulation of host immune responses by helminth glycans

Harn, D. A., McDonald, J. A., Atochina, O., & Da’dara, A. A. (2009) · Immunological Reviews · doi:10.1111/j.1600-065x.2009.00799.x · Cited by 90

Antigen Presentation by CD1d Contributes to the Amplification of Th2 Responses to Schistosoma mansoni Glycoconjugates in Mice

Faveeuw, C., Angeli, V., Fontaine, J., Maliszewski, C. R., Capron, A., Kaer, L. V., Moser, M., Capron, M., & Trottein, F. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.2.906 · Cited by 87

Review series on helminths, immune modulation and the hygiene hypothesis: Mechanisms underlying helminth modulation of dendritic cell function

Carvalho, L., Sun, J., Kane, C., Marshall, F., Krawczyk, C., & Pearce, E. J. (2009) · Immunology · doi:10.1111/j.1365-2567.2008.03008.x · Cited by 85

IPSE/alpha‐1, a major secretory glycoprotein antigen from schistosome eggs, expresses the Lewis X motif on core‐difucosylated N‐glycans

Wuhrer, M., Balog, C. I. A., Catalina, M., Jones, F. M., Schramm, G., Haas, H., Doenhoff, M., Dunne, D. W., Deelder, A., & Hokke, C. (2006) · The FEBS Journal · doi:10.1111/j.1742-4658.2006.05242.x · Cited by 92

LNFPIII/LeX-Stimulated Macrophages Activate Natural Killer Cells via CD40-CD40L Interaction

Atochina, O., & Harn, D. A. (2005) · Clinical and Vaccine Immunology · doi:10.1128/cdli.12.9.1041-1049.2005 · Cited by 84

Glycoconjugates in Host-Helminth Interactions

Prasanphanich, N. S., Mickum, M. L., Heimburg‐Molinaro, J., & Cummings, R. D. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00240 · Cited by 84

The Glycosylation Pattern of Common Allergens: The Recognition and Uptake of Der p 1 by Epithelial and Dendritic Cells Is Carbohydrate Dependent

Al-Ghouleh, A., Johal, R., Sharquie, I. K., Emara, M., Harrington, H., Shakib, F., & Ghaemmaghami, A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033929 · Cited by 83

CD154 Plays a Central Role in Regulating Dendritic Cell Activation During Infections That Induce Th1 or Th2 Responses

Straw, A. D., MacDonald, A. S., Denkers, E., & Pearce, E. J. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.2.727 · Cited by 83

Contribution of dust mite and cat specific IgE to total IgE: Relevance to asthma prevalence

Erwin, E. A., Rönmark, E., Wickens, K. L., Perzanowski, M. S., Barry, D., Lundbäck, B., Crane, J., & Platts‐Mills, T. A. E. (2007) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2006.12.648 · Cited by 82

Glycomics-driven discoveries in schistosome research

Hokke, C. H., Deelder, A. M., Hoffmann, K. F., & Wuhrer, M. (2007) · Experimental Parasitology · doi:10.1016/j.exppara.2007.06.003 · Cited by 80

Cutting Edge: Polarized Th Cell Response Induction by Transferred Antigen-Pulsed Dendritic Cells Is Dependent on IL-4 or IL-12 Production by Recipient Cells

MacDonald, A. S., & Pearce, E. J. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.7.3127 · Cited by 80

Schistosome larvae stimulate macrophage cytokine production through TLR4-dependent and -independent pathways

Jenkins, S., Hewitson, J. P., Ferret-Bernard, S., & Mountford, A. (2005) · International Immunology · doi:10.1093/intimm/dxh319 · Cited by 91

Glycans Modulate Immune Responses in Helminth Infections and Allergy

van Die, I., & Cummings, R. D. (2005) · KARGER eBooks · doi:10.1159/000088883 · Cited by 78

Integrating transcriptome, proteome and glycome analyses of Schistosoma biology.

Hokke, C., Fitzpatrick, J. M., & Hoffmann, K. (2007) · Trends in Parasitology · doi:10.1016/j.pt.2007.02.007 · Cited by 76

Antibody Responses to the Fucosylated LacdiNAc Glycan Antigen in Schistosoma mansoni-Infected Mice and Expression of the Glycan among Schistosomes

Nyame, A. K., Leppänen, A., Bogitsh, B. J., & Cummings, R. D. (2000) · Experimental Parasitology · doi:10.1006/expr.2000.4573 · Cited by 72

Polarization of host immune responses by helminth‐expressed glycans

Tundup, S., Srivastava, L., & Harn, Jr. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2012.06618.x · Cited by 71

Glycans and glycan-specific IgE in clinical and molecular allergology: Sensitization, diagnostics, and clinical symptoms.

Homann, A., Schramm, G., & Jappe, U. (2017) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2017.04.019 · Cited by 68

Schistosomal-derived lysophosphatidylcholine triggers M2 polarization of macrophages through PPARγ dependent mechanisms

Assunção, L. S., Magalhães, K. G., Carneiro, A. B., Molinaro, R., de Almeida, P. E., Atella, G. C., Castro-Faria-Neto, H. C., & Bozza, P. T. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2016.11.006 · Cited by 69

Mapping fucosylated epitopes on glycoproteins and glycolipids ofSchistosoma mansonicercariae, adult worms and eggs

Robijn, M. L. M., Wuhrer, M., Kornelis, D., Deelder, A. M., Geyer, R., & Hokke, C. H. (2004) · Parasitology · doi:10.1017/s0031182004006390 · Cited by 64

Vaccination-induced protection of lambs against the parasitic nematode Haemonchus contortus correlates with high IgG antibody responses to the LDNF glycan antigen

Vervelde, L., Bakker, N., Kooyman, F. N. J., Cornelissen, A. W. C. A., Bank, C. M. C., Nyame, A. K., Cummings, R. D., & van Die, I. (2003) · Glycobiology · doi:10.1093/glycob/cwg107 · Cited by 60

Sex‐related differences in the initiation of allergic rhinitis in mice

Yamatomo, T., Okano, M., Ono, T., Nakayama, E., Yoshino, T., Satoskar, A. R., Harn, D. A., & Nishizaki, K. (2001) · Allergy · doi:10.1034/j.1398-9995.2001.056006525.x · Cited by 60

Helminth‐excreted/secreted products are recognized by multiple receptors on DCs to block the TLR response and bias Th2 polarization in a cRAF dependent pathway

Terrazas, C. A., Alcántara‐Hernández, M., Bonifaz, L. C., Terrazas, L. I., & Satoskar, A. R. (2013) · The FASEB Journal · doi:10.1096/fj.13-228932 · Cited by 58

Intact glycans from cestode antigens are involved in innate activation of myeloid suppressor cells

Gómez-García, L., Lopez-Marin, L. M., Saavedra, R., Reyes, J. L., Rodríguez‐Sosa, M., & Terrazas, L. I. (2005) · Parasite Immunology · doi:10.1111/j.1365-3024.2005.00790.x · Cited by 57

Gender-specific expression of complex-type N-glycans in schistosomes.

Wuhrer, M., Koeleman, C., Fitzpatrick, J. M., Hoffmann, K., Deelder, A., & Hokke, C. (2006) · Glycobiology · doi:10.1093/glycob/cwl020 · Cited by 65

Dendritic cell activation and function in response to Schistosoma mansoni

Perona‐Wright, G., Jenkins, S. J., & MacDonald, A. S. (2006) · International Journal for Parasitology · doi:10.1016/j.ijpara.2006.02.003 · Cited by 56

Structural Characterization of Glycans on Omega-1, a Major Schistosoma mansoni Egg Glycoprotein That Drives Th2 Responses

Meevissen, M. H. J., Wuhrer, M., Doenhoff, M. J., Schramm, G., Haas, H., Deelder, A. M., & Hokke, C. H. (2010) · Journal of Proteome Research · doi:10.1021/pr100081c · Cited by 54

Immune modulation by Lacto-N-fucopentaose III in experimental autoimmune encephalomyelitis

Zhu, B., Trikudanathan, S., Zozulya, A. L., Sandoval-Garcia, C., Kennedy, J. K., Atochina, O., Norberg, T., Castagner, B., Seeberger, P. H., Fábry, Z., et al. (2011) · Clinical Immunology · doi:10.1016/j.clim.2011.12.006 · Cited by 53

TLRs, Treg, and B Cells, an Interplay of Regulation during Helminth Infection

Ludwig‐Portugall, I., & Layland, L. E. (2012) · Frontiers in Immunology · doi:10.3389/fimmu.2012.00008 · Cited by 53

Vaccines against veterinary helminths

Hein, W., & Harrison, G. B. L. (2005) · Veterinary Parasitology · doi:10.1016/j.vetpar.2005.07.006 · Cited by 53

Prevention of psoriasis‐like lesions development in fsn/fsn mice by helminth glycans

Atochina, O., & Harn, D. A. (2006) · Experimental Dermatology · doi:10.1111/j.1600-0625.2006.00431.x · Cited by 53

Impaired pro-inflammatory cytokine production and increased Th2-biasing ability of dendritic cells exposed to Taenia excreted/secreted antigens: A critical role for carbohydrates but not for STAT6 signaling

Terrazas, C. A., Gómez-García, L., & Terrazas, L. I. (2010) · International Journal for Parasitology · doi:10.1016/j.ijpara.2010.02.016 · Cited by 52

Complexity and function of cytokine responses in experimental infection by Echinococcus granulosus

Baz, A., Mourglia‐Ettlin, G., & Dematteis, S. (2006) · Immunobiology · doi:10.1016/j.imbio.2005.09.001 · Cited by 51

Protection studies with recombinant excretory/secretory proteins of Haemonchus contortus

Vervelde, L., van Leeuwen, M. A. W., Kruidenier, M., Kooyman, F. N. J., Huntley, J. F., van Die, I., & Cornelissen, A. W. C. A. (2002) · Parasite Immunology · doi:10.1046/j.1365-3024.2002.00454.x · Cited by 51

The schistosome in the mammalian host: understanding the mechanisms of adaptation

Kusel, J. R., Al-Adhami, B. H., & Doenhoff, M. J. (2007) · Parasitology · doi:10.1017/s0031182007002971 · Cited by 50

Specific glycan elements determine differential binding of individual egg glycoproteins of the human parasite Schistosoma mansoni by host C-type lectin receptors

Meevissen, M. H. J., Driessen, N. N., Smits, H. H., Versteegh, R., van Vliet, S. J., van Kooyk, Y., Schramm, G., Deelder, A. M., Haas, H., Yazdanbakhsh, M., et al. (2012) · International Journal for Parasitology · doi:10.1016/j.ijpara.2012.01.004 · Cited by 48

Schistosoma mansoni egg glycoproteins and C-type lectins of host immune cells: molecular partners that shape immune responses.

Meevissen, M. H. J., Yazdanbakhsh, M., & Hokke, C. (2012) · Experimental parasitology · doi:10.1016/j.exppara.2011.05.005 · Cited by 56

Worms to the rescue: Can worm glycans protect from autoimmune diseases?

Kuijk, L. M., & van Die, I. (2010) · IUBMB Life · doi:10.1002/iub.304 · Cited by 47

The Schistosoma mansoni Hepatic Egg Granuloma Provides a Favorable Microenvironment for Sustained Growth of Leishmania donovani

Hassan, M. F., Zhang, Y., Engwerda, C. R., Kaye, P. M., Sharp, H., & Bickle, Q. D. (2006) · American Journal Of Pathology · doi:10.2353/ajpath.2006.051319 · Cited by 45

Transmission Intensity Determines Lymphocyte Responsiveness and Cytokine Bias in Human Lymphatic Filariasis

King, C. L., Connelly, M., Alpers, M. P., Bockarie, M. J., & Kazura, J. W. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.12.7427 · Cited by 43

Immunoregulation byTaenia crassicepsand Its Antigens

Peón, A. N., Espinoza-Jiménez, A., & Terrazas, L. I. (2012) · BioMed Research International · doi:10.1155/2013/498583 · Cited by 42

Carbohydrate components of Taenia crassiceps metacestodes display Th2-adjuvant and anti-inflammatory properties when co-injected with bystander antigen

Gómez-García, L., Rivera-Montoya, I., Rodríguez‐Sosa, M., & Terrazas, L. I. (2006) · Parasitology Research · doi:10.1007/s00436-006-0159-2 · Cited by 42

Vaccination-induced IgG response to Galα1–3GalNAc glycan epitopes in lambs protected against Haemonchus contortus challenge infection

van Stijn, C. M. W., van den Broek, M., Vervelde, L., Alvarez, R., Cummings, R. D., Tefsen, B., & van Die, I. (2009) · International Journal for Parasitology · doi:10.1016/j.ijpara.2009.07.009 · Cited by 42

Ascaris lumbricoides and ticks associated with sensitization to galactose α1,3-galactose and elicitation of the alpha-gal syndrome

Murangi, T., Prakash, P. S., Moreira, B. P., Basera, W., Botha, M., Cunningham, S., Facey‐Thomas, H. E., Halajian, A., Joshi, L., Ramjith, J., et al. (2021) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2021.07.018 · Cited by 41

Omega-1, a glycoprotein secreted by Schistosoma mansoni eggs, drives Th2 responses

Everts, B., Perona‐Wright, G., Smits, H. H., Hokke, C. H., van der Ham, A. J., Fitzsimmons, C. M., Doenhoff, M. J., van der Bosch, J., Mohrs, K., Haas, H., et al. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20082460 · Cited by 335

High-mannose glycans from Schistosoma mansoni eggs are important for priming of Th2 responses via Dectin-2 and prostaglandin E2

Almeida, L., van Roey, R., Patente, T. A., Otto, F., Veldhuizen, T., Ghorasaini, M., van Diepen, A., Schramm, G., Liu, J., Idborg, H., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1372927 · Cited by 8

Th2 immune response against Schistosoma mansoni infection

Schramm, G., & Haas, H. (2010) · Microbes and Infection · doi:10.1016/j.micinf.2010.06.001 · Cited by 62

CD4+ Th2 response induced by Schistosoma mansoni eggs develops rapidly, through an early, transient, Th0-like stage

Vella, A. T., & Pearce, E. J. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.148.7.2283 · Cited by 167

Lacto- N -fucopentaose III Found on Schitosoma mansoni Egg Antigens Functions as Adjuvant for Proteins by Inducing Th2-Type Response

Okano, M., Satoskar, A. R., Nishizaki, K., & Harn, D. A. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.1.442 · Cited by 210