Fetal liver development and implications for liver disease pathogenesis

Neutrophil Emigration in the Skin, Lungs, and Peritoneum: Different Requirements for CD11/CD18 Revealed by CD18-deficient Mice

Mizgerd, J. P., Kubo, H., Kutkoski, G. J., Bhagwan, S. D., Scharffetter-Kochanek, K., Beaudet, A. L., & Doerschuk, C. M. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.186.8.1357 · Cited by 7,332 · see citing works

Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors

Gomez Perdiguero, E., Klapproth, K., Schulz, C., Busch, K., Azzoni, E., Crozet, L., Garner, H., Trouillet, C., de Bruijn, M. F., Geissmann, F., et al. (2015) · Nature · doi:10.1038/nature13989 · Cited by 2,339 · see citing works

Vascularized and functional human liver from an iPSC-derived organ bud transplant

Takebe, T., Sekine, K., Enomura, M., Koike, H., Kimura, M., Ogaeri, T., Zhang, R.-R., Ueno, Y., Zheng, Y.-W., Koike, N., et al. (2013) · Nature · doi:10.1038/nature12271 · Cited by 2,170 · see citing works

Landscape of Infiltrating T Cells in Liver Cancer Revealed by Single-Cell Sequencing

Zheng, C., Zheng, L., Yoo, J.-K., Guo, H., Zhang, Y., Guo, X., Kang, B., Hu, R., Huang, J. Y., Zhang, Q., et al. (2017) · Cell · doi:10.1016/j.cell.2017.05.035 · Cited by 2,152 · see citing works

Endothelial and perivascular cells maintain haematopoietic stem cells

Ding, L., Saunders, T. L., Enikolopov, G., & Morrison, S. J. (2012) · Nature · doi:10.1038/nature10783 · Cited by 1,934 · see citing works

Resolving the fibrotic niche of human liver cirrhosis at single-cell level

Ramachandran, P., Dobie, R., Wilson-Kanamori, J. R., Dora, E. F., Henderson, B. E. P., Luu, N. T., Portman, J. R., Matchett, K. P., Brice, M., Marwick, J. A., et al. (2019) · Nature · doi:10.1038/s41586-019-1631-3 · Cited by 1,784 · see citing works

Exploring tissue architecture using spatial transcriptomics

Rao, A., Barkley, D., França, G. S., & Yanai, I. (2021) · Nature · doi:10.1038/s41586-021-03634-9 · Cited by 1,700 · see citing works

SoupX removes ambient RNA contamination from droplet-based single-cell RNA sequencing data

Young, M. D., & Behjati, S. (2020) · GigaScience · doi:10.1093/gigascience/giaa151 · Cited by 1,619 · see citing works

Pioneer transcription factors: establishing competence for gene expression

Zaret, K. S., & Carroll, J. S. (2011) · Genes & Development · doi:10.1101/gad.176826.111 · Cited by 1,589 · see citing works

Single cell RNA sequencing of human liver reveals distinct intrahepatic macrophage populations

MacParland, S. A., Liu, J. C., Ma, X.-Z., Innes, B. T., Bartczak, A. M., Gage, B. K., Manuel, J., Khuu, N., Echeverri, J., Linares, I., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-06318-7 · Cited by 1,552 · see citing works

Definitive Hematopoiesis Is Autonomously Initiated by the AGM Region

Medvinsky, A., & Dzierzak, E. A. (1996) · Cell · doi:10.1016/s0092-8674(00)80165-8 · Cited by 1,548 · see citing works

Fate tracing reveals hepatic stellate cells as dominant contributors to liver fibrosis independent of its aetiology

Mederacke, I., Hsu, C. C., Troeger, J. S., Huebener, P., Mu, X., Dapito, D. H., Pradere, J.-P., & Schwabe, R. F. (2013) · Nature Communications · doi:10.1038/ncomms3823 · Cited by 1,443 · see citing works

Highly efficient generation of human hepatocyte-like cells from induced pluripotent stem cells

Si-Tayeb, K., Noto, F. K., Nagaoka, M., Li, J., Battle, M. A., Duris, C., North, P. E., Dalton, S., & Duncan, S. A. (2010) · Hepatology · doi:10.1002/hep.23354 · Cited by 1,282 · see citing works

Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1

Li, L., Krantz, I. D., Deng, Y., Genin, A., Banta, A. B., Collins, C. C., Qi, M., Trask, B. J., Kuo, W. L., Cochran, J., et al. (1997) · Nature Genetics · doi:10.1038/ng0797-243 · Cited by 1,277 · see citing works

Tie2-Cre Transgenic Mice: A New Model for Endothelial Cell-Lineage Analysis in Vivo

Kisanuki, Y. Y., Hammer, R. E., Miyazaki, J.-I., Williams, S. C., Richardson, J. A., & Yanagisawa, M. (2001) · Developmental Biology · doi:10.1006/dbio.2000.0106 · Cited by 1,241 · see citing works

A human liver cell atlas reveals heterogeneity and epithelial progenitors

Aizarani, N., Saviano, A., Sagar, Mailly, L., Durand, S., Herman, J. S., Pessaux, P., Baumert, T. F., & Grün, D. (2019) · Nature · doi:10.1038/s41586-019-1373-2 · Cited by 1,147 · see citing works

Hepatocyte Nuclear Factor 4α (Nuclear Receptor 2A1) Is Essential for Maintenance of Hepatic Gene Expression and Lipid Homeostasis

Hayhurst, G. P., Lee, Y.-H., Lambert, G., Ward, J. M., & Gonzalez, F. J. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.4.1393-1403.2001 · Cited by 1,107 · see citing works

Single-cell spatial reconstruction reveals global division of labour in the mammalian liver

Halpern, K. B., Shenhav, R., Matcovitch-Natan, O., Tóth, B., Lemze, D., Golan, M., Massasa, E. E., Baydatch, S., Landen, S., Moor, A. E., et al. (2017) · Nature · doi:10.1038/nature21065 · Cited by 1,059 · see citing works

A single-cell molecular map of mouse gastrulation and early organogenesis

Pijuan-Sala, B., Griffiths, J. A., Guibentif, C., Hiscock, T. W., Jawaid, W., Calero-Nieto, F. J., Mulas, C., Ibarra-Soria, X., Tyser, R. C. V., Ho, D. L. L., et al. (2019) · Nature · doi:10.1038/s41586-019-0933-9 · Cited by 1,033 · see citing works

Human MAIT cells are xenobiotic-resistant, tissue-targeted, CD161hi IL-17–secreting T cells

Dusséaux, M., Martin, E., Serriari, N., Péguillet, I., Prémel, V., Louis, D., Milder, M., Bourhis, L. L., Soudais, C., Treiner, E., et al. (2010) · Blood · doi:10.1182/blood-2010-08-303339 · Cited by 1,031 · see citing works

Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart

Zhou, B., Ma, Q., Rajagopal, S., Wu, S. M., Domian, I., Rivera-Feliciano, J., Jiang, D., von Gise, A., Ikeda, S., Chien, K. R., et al. (2008) · Nature · doi:10.1038/nature07060 · Cited by 1,019 · see citing works

Runx1 is required for the endothelial to haematopoietic cell transition but not thereafter

Chen, M. J., Yokomizo, T., Zeigler, B. M., Dzierzak, E. A., & Speck, N. A. (2009) · Nature · doi:10.1038/nature07619 · Cited by 1,016 · see citing works

Liver regeneration: biological and pathological mechanisms and implications

Michalopoulos, G. K., & Bhushan, B. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-020-0342-4 · Cited by 998 · see citing works

Deterministically patterned biomimetic human iPSC-derived hepatic model via rapid 3D bioprinting

Ma, X., Qu, X., Zhu, W. Z., Li, Y.-S. J., Yuan, S., Zhang, H., Liu, J., Wang, P., Lai, C. S. E., Zanella, F., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1524510113 · Cited by 881 · see citing works

Biliary atresia

Hartley, J., Davenport, M., & Kelly, D. A. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60946-6 · Cited by 880 · see citing works

Liver Organogenesis Promoted by Endothelial Cells Prior to Vascular Function

Matsumoto, K., Yoshitomi, H., Rossant, J., & Zaret, K. S. (2001) · Science · doi:10.1126/science.1063889 · Cited by 877 · see citing works

Bone marrow-derived monocytes give rise to self-renewing and fully differentiated Kupffer cells

Scott, C. L., Zheng, F., De Baetselier, P., Martens, L., Saeys, Y., De Prijck, S., Lippens, S., Abels, C., Schoonooghe, S., Raes, G., et al. (2016) · Nature Communications · doi:10.1038/ncomms10321 · Cited by 860 · see citing works

Role of Kupffer cells in host defense and liver disease

Bilzer, M., Roggel, F., & Gerbes, A. L. (2006) · Liver International · doi:10.1111/j.1478-3231.2006.01342.x · Cited by 857 · see citing works

Long-Term Expansion of Functional Mouse and Human Hepatocytes as 3D Organoids

Hu, H., Gehart, H., Artegiani, B., LÖpez-Iglesias, C., Dekkers, F., Basak, O., van Es, J., Chuva de Sousa Lopes, S. M., Begthel, H., Korving, J., et al. (2018) · Cell · doi:10.1016/j.cell.2018.11.013 · Cited by 837 · see citing works

Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis

Kisseleva, T., Cong, M., Paik, Y., Scholten, D., Jiang, C., Benner, C., Iwaisako, K., Moore-Morris, T., Scott, B., Tsukamoto, H., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1201840109 · Cited by 805 · see citing works

NOTCH2 Mutations Cause Alagille Syndrome, a Heterogeneous Disorder of the Notch Signaling Pathway

McDaniell, R. M., Warthen, D. M., Sanchez-Lara, P. A., Pai, A. A., Krantz, I. D., Piccoli, D. A., & Spinner, N. B. (2006) · The American Journal of Human Genetics · doi:10.1086/505332 · Cited by 747 · see citing works

Multipotent Flk-1+ Cardiovascular Progenitor Cells Give Rise to the Cardiomyocyte, Endothelial, and Vascular Smooth Muscle Lineages

Kattman, S. J., Huber, T. L., & Keller, G. M. (2006) · Developmental Cell · doi:10.1016/j.devcel.2006.10.002 · Cited by 730 · see citing works

Initiation of Mammalian Liver Development from Endoderm by Fibroblast Growth Factors

Jung, J., Zheng, M., Goldfarb, M., & Zaret, K. S. (1999) · Science · doi:10.1126/science.284.5422.1998 · Cited by 721 · see citing works

The Liver Sieve: Considerations Concerning the Structure and Function of Endothelial Fenestrae, the Sinusoidal Wall and the Space of Disse

Wisse, E., Zanger, R. D., Charels, K., Smissen, P. V. D., & McCuskey, R. S. (1985) · Hepatology · doi:10.1002/hep.1840050427 · Cited by 712 · see citing works

Hepatic ductular hypoplasia associated with characteristic facies, vertebral malformations, retarded physical, mental, and sexual development, and cardiac murmur

Alagille, D., Odièvre, M., Gautier, M., et al. (1975) · The Journal of Pediatrics · doi:10.1016/s0022-3476(75)80706-2 · Cited by 696 · see citing works

Fate tracing reveals the endothelial origin of hematopoietic stem cells

Zovein, A. C., Hofmann, J. J., Lynch, M., French, W. J., Turlo, K. A., Yang, Y., Becker, M. S., Zanetta, L., Dejana, E., Gasson, J. C., et al. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2008.09.018 · Cited by 691 · see citing works

Onco-fetal Reprogramming of Endothelial Cells Drives Immunosuppressive Macrophages in Hepatocellular Carcinoma

Sharma, A., Seow, J. J. W., Dutertre, C.-A., Pai, R., Blériot, C., Mishra, A., Wong, R. M. M., Singh, G. S. N., Sudhagar, S., Khalilnezhad, S., et al. (2020) · Cell · doi:10.1016/j.cell.2020.08.040 · Cited by 677 · see citing works

An electron microscopic study of the fenestrated endothelial lining of rat liver sinusoids

Wisse, E. (1970) · Journal of Ultrastructure Research · doi:10.1016/s0022-5320(70)90150-4 · Cited by 655 · see citing works

Syndromic paucity of interlobular bile ducts (Alagille syndrome or arteriohepatic dysplasia): Review of 80 cases

Alagille, D., Estrada, A., Hadchouel, M., Gautler, M., Odièvre, M., & Dommergues, J. P. (1987) · The Journal of Pediatrics · doi:10.1016/s0022-3476(87)80153-1 · Cited by 650 · see citing works

Distinct mesodermal signals, including BMPs from the septum transversum mesenchyme, are required in combination for hepatogenesis from the endodermPreprint

Rossi, J. M., Dunn, N. R., Hogan, B. L. M., & Zaret, K. S. (2001) · Genes & Development · doi:10.1101/gad.904601 · Cited by 646 · see citing works

Decoding human fetal liver haematopoiesis

Popescu, D.-M., Botting, R. A., Stephenson, E., Green, K., Webb, S., Jardine, L., Calderbank, E. F., Polanski, K., Goh, I., Efremova, M., et al. (2019) · Nature · doi:10.1038/s41586-019-1652-y · Cited by 606 · see citing works

Hepatic specification of the gut endoderm in vitro: cell signaling and transcriptional control.Preprint

Gualdi, R., Bossard, P., Zheng, M., Hamada, Y., Coleman, J. R., & Zaret, K. S. (1996) · Genes & Development · doi:10.1101/gad.10.13.1670 · Cited by 590 · see citing works

The initiation of liver development is dependent on Foxa transcription factors

Lee, C. S., Friedman, J. R., Fulmer, J. T., & Kaestner, K. H. (2005) · Nature · doi:10.1038/nature03649 · Cited by 581 · see citing works

Lineage tracing demonstrates the venous origin of the mammalian lymphatic vasculaturePreprint

Srinivasan, R. S., Dillard, M. E., Lagutin, O. V., Lin, F., Tsai, S. Y., Tsai, M., Samokhvalov, I. M., & Oliver, G. C. (2007) · Genes & Development · doi:10.1101/gad.1588407 · Cited by 580 · see citing works

Global Epidemiology of Chronic Liver Disease

Cheemerla, S., & Balakrishnan, M. (2021) · Clinical Liver Disease · doi:10.1002/cld.1061 · Cited by 571 · see citing works

Immunomodulation by endothelial cells — partnering up with the immune system?

Amersfoort, J., Eelen, G., & Carmeliet, P. (2022) · Nature reviews. Immunology · doi:10.1038/s41577-022-00694-4 · Cited by 549 · see citing works

Modeling Steatohepatitis in Humans with Pluripotent Stem Cell-Derived Organoids

Ouchi, R., Togo, S., Kimura, M., Shinozawa, T., Koido, M., Koike, H., Thompson, W., Karns, R. A., Mayhew, C. N., McGrath, P. S., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.05.007 · Cited by 537 · see citing works

Bipotential Adult Liver Progenitors Are Derived from Chronically Injured Mature Hepatocytes

Tarlow, B. D., Pelz, C., Naugler, W. E., Wakefield, L., Wilson, E. M., Finegold, M. J., & Grompe, M. (2014) · Cell Stem Cell · doi:10.1016/j.stem.2014.09.008 · Cited by 533 · see citing works

Cholangiocarcinomas can originate from hepatocytes in mice

Fan, B., Malato, Y., Calvisi, D. F., Naqvi, S., Razumilava, N., Ribback, S., Gores, G. J., Dombrowski, F., Evert, M., Chen, X., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci63212 · Cited by 529 · see citing works

Pancreatic exocrine duct cells give rise to insulin-producing beta cells during embryogenesis but not after birth.

Solar, M., Cardalda, C., Houbracken, I., Martín, M., Maestro, M., Demedts, N., Xu, X.-B., Grau, V., Heimberg, H., Bouwens, L., et al. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.11.003 · Cited by 516 · see citing works

Mammalian hepatocyte differentiation requires the transcription factor HNF-4alpha.

(2000) · PubMed Central · Cited by 489 · see citing works

Hybrid Periportal Hepatocytes Regenerate the Injured Liver without Giving Rise to Cancer

Font-Burgada, J., Shalapour, S., Ramaswamy, S., Hsueh, B., Rossell, D., Umemura, A., Taniguchi, K., Nakagawa, H., Valasek, M. A., Ye, L., et al. (2015) · Cell · doi:10.1016/j.cell.2015.07.026 · Cited by 486 · see citing works

Spatial heterogeneity in the mammalian liver

Ben-Moshe, S., & Itzkovitz, S. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0134-x · Cited by 485 · see citing works

Robust cellular reprogramming occurs spontaneously during liver regeneration

Yanger, K., Zong, Y., Maggs, L. R., Shapira, S. N., Maddipati, R., Aiello, N. M., Thung, S. N., Wells, R. G., Greenbaum, L. E., & Stanger, B. Z. (2013) · Genes & Development · doi:10.1101/gad.207803.112 · Cited by 484 · see citing works

Deciphering human macrophage development at single-cell resolution

Bian, Z., Gong, Y., Huang, T., Lee, C., Bian, L., Bai, Z., Shi, H., Zeng, Y., Liu, C., He, J., et al. (2020) · Nature · doi:10.1038/s41586-020-2316-7 · Cited by 478 · see citing works

Identification of Liver Cancer Progenitors Whose Malignant Progression Depends on Autocrine IL-6 Signaling

He, G., Dhar, D., Nakagawa, H., Font-Burgada, J., Ogata, H., Jiang, Y., Shalapour, S., Seki, E., Yost, S. E., Jepsen, K., et al. (2013) · Cell · doi:10.1016/j.cell.2013.09.031 · Cited by 469 · see citing works

Reversal of Left-Right Asymmetry: a Situs Inversus Mutation

Yokoyama, T., Copeland, N. G., Jenkins, N. A., Montgomery, C. A., Elder, F. F. B., & Overbeek, P. A. (1993) · Science · doi:10.1126/science.8480178 · Cited by 462 · see citing works

Mammalian hepatocyte differentiation requires the transcription factor HNF-4αPreprint

Li, J., Ning, G., & Duncan, S. A. (2000) · Genes & Development · doi:10.1101/gad.14.4.464 · Cited by 458 · see citing works

Notch signaling controls liver development by regulating biliary differentiation

Zong, Y., Panikkar, A., Xu, J., Antoniou, A., Raynaud, P., Lemaigre, F. P., & Stanger, B. Z. (2009) · Development · doi:10.1242/dev.029140 · Cited by 443 · see citing works

Expansion of hematopoietic stem cells in the developing liver of a mouse embryo

Ema, H., & Nakauchi, H. (2000) · Blood · doi:10.1182/blood.v95.7.2284 · Cited by 440 · see citing works

Fate tracing of mature hepatocytes in mouse liver homeostasis and regeneration

Malato, Y., Naqvi, S., Schürmann, N., Ng, R., Wang, B., Zape, J., Kay, M. A., Grimm, D., & Willenbring, H. (2011) · Journal of Clinical Investigation · doi:10.1172/jci59261 · Cited by 434 · see citing works

Adult Hepatocytes Are Generated by Self-Duplication Rather than Stem Cell Differentiation

Yanger, K., Knigin, D., Zong, Y., Maggs, L., Gu, G., Akiyama, H., Pikarsky, E., & Stanger, B. Z. (2014) · Cell Stem Cell · doi:10.1016/j.stem.2014.06.003 · Cited by 426 · see citing works

Single-cell transcriptomics uncovers zonation of function in the mesenchyme during liver fibrosis

Dobie, R., Wilson-Kanamori, J. R., Henderson, B. E. P., Smith, J. R., Matchett, K. P., Portman, J. R., Wallenborg, K., Picelli, S., Zagorska, A., Pendem, S. V., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.10.024 · Cited by 420 · see citing works

Efficient endoderm induction from human pluripotent stem cells by logically directing signals controlling lineage bifurcations

Loh, K. M., Ang, L. T., Zhang, J., Kumar, V., Ang, J., Auyeong, J. Q., Lee, K. L., Choo, S. H., Lim, C. Y. Y., Nichane, M., et al. (2014) · Cell Stem Cell · doi:10.1016/j.stem.2013.12.007 · Cited by 418 · see citing works

Two distinct endothelial lineages in ontogeny, one of them related to hemopoiesis

Pardanaud, L., Luton, D., Prigent, M., Bourcheix, L.-M., Catala, M., & Dieterlen‐Lièvre, F. (1996) · Development · doi:10.1242/dev.122.5.1363 · Cited by 417 · see citing works

ISSCR Guidelines for Stem Cell Research and Clinical Translation: The 2021 update

Lovell-Badge, R. H., Anthony, E., Barker, R. A., Bubela, T. M., Brivanlou, A. H., Carpenter, M., Charo, R. A., Clark, A. T., Clayton, E. W., Cong, Y., et al. (2021) · Stem Cell Reports · doi:10.1016/j.stemcr.2021.05.012 · Cited by 411 · see citing works

Massive and Reproducible Production of Liver Buds Entirely from Human Pluripotent Stem Cells

Takebe, T., Sekine, K., Kimura, M., Yoshizawa, E., Ayano, S., Koido, M., Funayama, S., Nakanishi, N., Hisai, T., Kobayashi, T., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.11.005 · Cited by 405 · see citing works

The Endoderm of the Mouse Embryo Arises by Dynamic Widespread Intercalation of Embryonic and Extraembryonic Lineages

Kwon, G. S., Viotti, M., & Hadjantonakis, A.-K. (2008) · Developmental Cell · doi:10.1016/j.devcel.2008.07.017 · Cited by 402 · see citing works

The role of TGFβ1 in initiating hepatic stellate cell activation in vivo

Hellerbrand, C., Stefanovic, B., Giordano, F., Burchardt, E. R., & Brenner, D. A. (1999) · Journal of Hepatology · doi:10.1016/s0168-8278(99)80010-5 · Cited by 393 · see citing works

The Pioneer Transcription Factor FoxA Maintains an Accessible Nucleosome Configuration at Enhancers for Tissue-Specific Gene Activation

Iwafuchi-Doi, M., Donahue, G., Kakumanu, A., Watts, J. A., Mahony, S., Pugh, B. F., Lee, D., Kaestner, K. H., & Zaret, K. S. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.03.001 · Cited by 390 · see citing works

The emergent landscape of the mouse gut endoderm at single-cell resolution

Nowotschin, S., Setty, M., Kuo, Y.-Y., Liu, V., Garg, V., Sharma, R., Simon, C. S., Saiz, N., Gardner, R., Boutet, S. C., et al. (2019) · Nature · doi:10.1038/s41586-019-1127-1 · Cited by 383 · see citing works

Hepatocyte migration during liver development requires Prox1

Sosa-Pineda, B., Wigle, J. T., & Oliver, G. (2000) · Nature Genetics · doi:10.1038/76996 · Cited by 381 · see citing works

Orchestrating liver development

Gordillo, M., Evans, T., & Gouon-Evans, V. (2015) · Development · doi:10.1242/dev.114215 · Cited by 375 · see citing works

Long-Term Hematopoietic Stem Cells Require Stromal Cell-Derived Factor-1 for Colonizing Bone Marrow during Ontogeny

Ara, T., Tokoyoda, K., Sugiyama, T., Egawa, T., Kawabata, K., & Nagasawa, T. (2003) · Immunity · doi:10.1016/s1074-7613(03)00201-2 · Cited by 369 · see citing works

Paired-cell sequencing enables spatial gene expression mapping of liver endothelial cells

Halpern, K. B., Shenhav, R., Massalha, H., Toth, B., Egozi, A., Massasa, E. E., Medgalia, C., David, E., Giladi, A., Moor, A. E., et al. (2018) · Nature Biotechnology · doi:10.1038/nbt.4231 · Cited by 368 · see citing works

The onecut transcription factor HNF6 is required for normal development of the biliary tract

Clotman, F., Lannoy, V. J., Reber, M., Cereghini, S., Cassiman, D. M., Jacquemin, P., Roskams, T., Rousseau, G. G., & Lemaigre, F. P. (2002) · Development · doi:10.1242/dev.129.8.1819 · Cited by 368 · see citing works

Control of liver cell fate decision by a gradient of TGFβ signaling modulated by Onecut transcription factorsPreprint

Clotman, F., Jacquemin, P., Plumb–Rudewiez, N., Pierreux, C. E., Smissen, P. V. D., Dietz, H. C., Courtoy, P. J., Rousseau, G. G., & Lemaigre, F. P. (2005) · Genes & Development · doi:10.1101/gad.340305 · Cited by 363 · see citing works

Intrahepatic Bile Ducts Develop According to a New Mode of Tubulogenesis Regulated by the Transcription Factor SOX9

Antoniou, A., Raynaud, P., Cordi, S., Zong, Y., Tronche, F., Stanger, B. Z., Jacquemin, P., Pierreux, C. E., Clotman, F., & Lemaigre, F. P. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.02.051 · Cited by 362 · see citing works

Liver Progenitor Cells Yield Functional Hepatocytes in Response to Chronic Liver Injury in Mice

Español–Suñer, R., Carpentier, R., Van Hul, N., Legry, V., Achouri, Y., Cordi, S., Jacquemin, P., Lemaigre, F., & Leclercq, I. A. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.08.024 · Cited by 356 · see citing works

Bile system morphogenesis defects and liver dysfunction upon targeted deletion of HNF1β

Coffinier, C., Gresh, L., Fiette, L., Tronche, F., Schütz, G., Babinet, C., Pontoglio, M., Yaniv, M., & Barra, J. (2002) · Development · doi:10.1242/dev.129.8.1829 · Cited by 354 · see citing works

The Human Liver Contains Multiple Populations of NK Cells, T Cells, and CD3+CD56+ Natural T Cells with Distinct Cytotoxic Activities and Th1, Th2, and Th0 Cytokine Secretion Patterns

Doherty, D. G., Norris, S., Madrigal-Estebas, L., McEntee, G., Traynor, O., Hegarty, J. E., & O’Farrelly, C. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.4.2314 · Cited by 350 · see citing works

Intrahepatic cholangiocarcinoma can arise from Notch-mediated conversion of hepatocytes

Sekiya, S., & Suzuki, A. (2012) · Journal of Clinical Investigation · doi:10.1172/jci63065 · Cited by 348 · see citing works

Hepatocytes Do Not Undergo Epithelial-Mesenchymal Transition in Liver Fibrosis in Mice

Taura, K., Miura, K., Iwaisako, K., Österreicher, C. H., Kodama, Y., Penz-Österreicher, M., & Brenner, D. A. (2010) · Hepatology · doi:10.1002/hep.23368 · Cited by 336 · see citing works

Impaired migration but not differentiation of haematopoietic stem cells in the absence of β1 integrins

Hirsch, E., Iglesias, A. H., Potocnik, A. J., Hartmann, U., & Fässler, R. (1996) · Nature · doi:10.1038/380171a0 · Cited by 332 · see citing works

Modelling human hepato-biliary-pancreatic organogenesis from the foregut–midgut boundary

Koike, H., Iwasawa, K., Ouchi, R., Maezawa, M., Giesbrecht, K., Saiki, N., Ferguson, A., Kimura, M., Thompson, W. L., Wells, J. M., et al. (2019) · Nature · doi:10.1038/s41586-019-1598-0 · Cited by 325 · see citing works

Transdifferentiation of rat hepatocytes into biliary cells after bile duct ligation and toxic biliary injury†

Michalopoulos, G. K., Barua, L., & Bowen, W. C. (2005) · Hepatology · doi:10.1002/hep.20600 · Cited by 319 · see citing works

Human Hepatic Stem Cell and Maturational Liver Lineage Biology Δ

Turner, R., Lozoya, O. A., Wang, Y., Cardinale, V., Gaudio, E., Alpini, G. D., Mendel, G., Wauthier, E., Barbier, C., Alvaro, D., et al. (2011) · Hepatology · doi:10.1002/hep.24157 · Cited by 316 · see citing works

Building consensus on definition and nomenclature of hepatic, pancreatic, and biliary organoids

Marsee, A., Roos, F. J. M., Verstegen, M. M. A., Marsee, A., Roos, F., Verstegen, M., Clevers, H., Vallier, L., Takebe, T., Huch, M., et al. (2021) · Cell Stem Cell · doi:10.1016/j.stem.2021.04.005 · Cited by 310 · see citing works

Septum Transversum-Derived Mesothelium Gives Rise to Hepatic Stellate Cells and Perivascular Mesenchymal Cells in Developing Mouse Liver §Δ

Asahina, K., Zhou, B., Pu, W. T., & Tsukamoto, H. (2010) · Hepatology · doi:10.1002/hep.24119 · Cited by 308 · see citing works

Single‐Cell, Single‐Nucleus, and Spatial RNA Sequencing of the Human Liver Identifies Cholangiocyte and Mesenchymal Heterogeneity

Andrews, T. S., Atif, J., Liu, J. C., Perciani, C. T., Ma, X., Thoeni, C., Slyper, M., Eraslan, G., Segerstolpe, A., Manuel, J., et al. (2022) · Hepatology Communications · doi:10.1002/hep4.1854 · Cited by 307 · see citing works

Fast and efficient generation of knock-in human organoids using homology-independent CRISPR–Cas9 precision genome editing

Artegiani, B., Hendriks, D. F. G., Beumer, J., Kok, R. N. U., Zheng, X., Joore, I. P., Lopes, S. M. C. D. S., van Zon, J. S., Tans, S. J., & Clevers, H. C. (2020) · Nature Cell Biology · doi:10.1038/s41556-020-0472-5 · Cited by 302 · see citing works

An ultrastructural characterization of the endothelial cell in the rat liver sinusoid under normal and various experimental conditions, as a contribution to the distinction between endothelial and Kupffer cells

Wisse, E. (1972) · Journal of Ultrastructure Research · doi:10.1016/0022-5320(72)90089-5 · Cited by 300 · see citing works

Distinct populations of endoderm cells converge to generate the embryonic liver bud and ventral foregut tissues

Tremblay, K. D., & Zaret, K. S. (2005) · Developmental Biology · doi:10.1016/j.ydbio.2005.01.003 · Cited by 299 · see citing works

Chronic Liver Injury Induces Conversion of Biliary Epithelial Cells into Hepatocytes

Deng, X., Zhang, X., Li, W., Feng, R.-X., Li, L., Yi, G.-R., Zhang, X.-N., Yin, C., Yu, H.-Y., Zhang, J.-P., et al. (2018) · Cell Stem Cell · doi:10.1016/j.stem.2018.05.022 · Cited by 289 · see citing works

Hex homeobox gene controls the transition of the endoderm to a pseudostratified, cell emergent epithelium for liver bud development

Bort, R., Signore, M., Tremblay, K. D., Martı́nez-Barberá, J. P., & Zaret, K. S. (2005) · Developmental Biology · doi:10.1016/j.ydbio.2005.11.006 · Cited by 285 · see citing works

Human Pluripotent Stem Cell-Derived Organoids as Models of Liver Disease

Ramli, M. N. B., Lim, Y. S., Koe, C. T., Demircioglu, D., Tng, W., Gonzales, K. A. U., Tan, C. P., Szczerbinska, I., Liang, H., Soe, E. L., et al. (2020) · Gastroenterology · doi:10.1053/j.gastro.2020.06.010 · Cited by 278 · see citing works

Role of stem cell migration in initiation of mouse foetal liver haemopoiesis

Johnson, G. R., & Moore, M. A. S. (1975) · Nature · doi:10.1038/258726a0 · Cited by 273 · see citing works

Embryonic Ductal Plate Cells Give Rise to Cholangiocytes, Periportal Hepatocytes, and Adult Liver Progenitor Cells

Carpentier, R., Español‐Suñer, R., Hul, N. V., Kopp, J. L., Beaudry, J., Cordi, S., Antoniou, A., Raynaud, P., Lepreux, S., Jacquemin, P., et al. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.06.049 · Cited by 271 · see citing works

Single-Cell Analysis of the Liver Epithelium Reveals Dynamic Heterogeneity and an Essential Role for YAP in Homeostasis and Regeneration

Pepe-Mooney, B. J., Dill, M. T., Alemany, A., Ordovas-Montanes, J., Matsushita, Y., Rao, A., Sen, A., Miyazaki, M., Anakk, S., Dawson, P. A., et al. (2019) · Cell Stem Cell · doi:10.1016/j.stem.2019.04.004 · Cited by 266 · see citing works

Epigenetic Priming of Enhancers Predicts Developmental Competence of hESC-Derived Endodermal Lineage Intermediates

Wang, A., Yue, F., Li, Y., Xie, R., Harper, T. C., Patel, N. A., Muth, K., Palmer, J., Qiu, Y., Wang, J., et al. (2015) · Cell stem cell · doi:10.1016/j.stem.2015.02.013 · Cited by 263 · see citing works

Evidence against a Stem Cell Origin of New Hepatocytes in a Common Mouse Model of Chronic Liver Injury

Schaub, J. R., Malato, Y., Gormond, C., & Willenbring, H. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.07.003 · Cited by 254 · see citing works

Ex utero mouse embryogenesis from pre-gastrulation to late organogenesis

Aguilera-Castrejon, A., Oldak, B., Shani, T., Ghanem, N., Itzkovich, C., Slomovich, S., Tarazi, S., Bayerl, J., Chugaeva, V., Ayyash, M., et al. (2021) · Nature · doi:10.1038/s41586-021-03416-3 · Cited by 251 · see citing works

Jagged1 in the portal vein mesenchyme regulates intrahepatic bile duct development: insights into Alagille syndrome

Hofmann, J. J., Zovein, A. C., Koh, H., Radtke, F., Weinmaster, G., & Iruela‐Arispe, M. L. (2010) · Development · doi:10.1242/dev.052118 · Cited by 247 · see citing works

Human hepatic organoids for the analysis of human genetic diseases

Guan, Y., Xu, D., Garfin, P. M., Ehmer, U., Hurwitz, M., Enns, G., Michie, S., Wu, M., Zheng, M., Nishimura, T., et al. (2017) · JCI Insight · doi:10.1172/jci.insight.94954 · Cited by 243 · see citing works

Fetal liver hematopoietic stem cell niches associate with portal vessels

Khan, J. A., Mendelson, A., Kunisaki, Y., Birbrair, A., Kou, Y., Estape, A. A., Pinho, S., Ciero, P., Nakahara, F., Ma’ayan, A., et al. (2015) · Science · doi:10.1126/science.aad0084 · Cited by 242 · see citing works

Hepatocyte Nuclear Factor 4α Suppresses the Development of Hepatocellular Carcinoma

Ning, B., Ding, J., Yin, C., Zhong, W. H., Wu, K., Zeng, X. Y., Yang, W. K., Chen, Y.-X., Zhang, J., Zhang, X., et al. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-0824 · Cited by 241 · see citing works

Zf9, a Kruppel-like transcription factor up-regulated in vivo during early hepatic fibrosis

Ratziu, V., Lalazar, A., Wong, L., Dang, Q., Collins, C. C., Shaulian, E., Jensen, S., & Friedman, S. L. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.16.9500 · Cited by 240 · see citing works

The role of notch signaling in the development of intrahepatic bile ducts

Kodama, Y., Hijikata, M., Kageyama, R., Shimotohno, K., & Chiba, T. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.09.004 · Cited by 240 · see citing works

Regeneration of Liver After Extreme Hepatocyte Loss Occurs Mainly via Biliary Transdifferentiation in Zebrafish

He, J., Lu, H., Zou, Q., & Luo, L. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.11.045 · Cited by 240 · see citing works

Extensive Conversion of Hepatic Biliary Epithelial Cells to Hepatocytes After Near Total Loss of Hepatocytes in Zebrafish

Choi, T., Ninov, N., Stainier, D. Y. R., & Shin, D. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.10.019 · Cited by 238 · see citing works

Mesenchymal origin of hepatic stellate cells, submesothelial cells, and perivascular mesenchymal cells during mouse liver development

Asahina, K., Tsai, S. Y., Li, P., Ishii, M., Maxson, R. E., Sucov, H. M., & Tsukamoto, H. (2009) · Hepatology · doi:10.1002/hep.22721 · Cited by 238 · see citing works

Single-cell RNA sequencing reveals the heterogeneity of liver-resident immune cells in human

Zhao, J., Zhang, S., Liu, Y., He, X., Qu, M., Xu, G., Wang, H., Huang, M., Pan, J., Liu, Z., et al. (2020) · Cell Discovery · doi:10.1038/s41421-020-0157-z · Cited by 237 · see citing works

Genetic Labeling Does Not Detect Epithelial-to-Mesenchymal Transition of Cholangiocytes in Liver Fibrosis in Mice

Scholten, D., Österreicher, C. H., Scholten, A., Iwaisako, K., Gu, G., Brenner, D. A., & Kisseleva, T. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.05.005 · Cited by 225 · see citing works

The spatiotemporal program of zonal liver regeneration following acute injury

Ben-Moshe, S., Veg, T., Manco, R., Dan, S., Papinutti, D., Lifshitz, A., Kolodziejczyk, A. A., Bahar Halpern, K., Elinav, E., & Itzkovitz, S. (2022) · Cell Stem Cell · doi:10.1016/j.stem.2022.04.008 · Cited by 224 · see citing works

Biliary tree stem/progenitor cells in glands of extrahepatic and intraheptic bile ducts: an anatomical in situ study yielding evidence of maturational lineages

Carpino, G., Cardinale, V., Onori, P., Franchitto, A., Berloco, P. B., Rossi, M., Wang, Y., Semeraro, R., Anceschi, M. M., Brunelli, R., et al. (2011) · Journal of Anatomy · doi:10.1111/j.1469-7580.2011.01462.x · Cited by 224 · see citing works

A Roadmap for Human Liver Differentiation from Pluripotent Stem Cells

Ang, L. T., Tan, A. K. Y., Autio, M. I., Goh, S. H., Choo, S. H., Lee, K. L., Tan, J., Pan, B., Lee, J. J. H., Lum, J. J., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.01.087 · Cited by 220 · see citing works

Clonal Tracing of Sox9+ Liver Progenitors in Mouse Oval Cell Injury

Tarlow, B., Finegold, M. J., & Grompe, M. (2014) · Hepatology · doi:10.1002/hep.27084 · Cited by 220 · see citing works

HNF4A is essential for specification of hepatic progenitors from human pluripotent stem cells

DeLaForest, A., Nagaoka, M., Si-Tayeb, K., Noto, F. K., Konopka, G., Battle, M. A., & Duncan, S. A. (2011) · Development · doi:10.1242/dev.062547 · Cited by 219 · see citing works

Toll‐like receptor‐induced innate immune responses in non‐parenchymal liver cells are cell type‐specific

Wu, J., Meng, Z., Jiang, M., Zhang, E., Trippler, M., Broering, R., Bucchi, A., Krux, F., Dittmer, U., Yang, D., et al. (2009) · Immunology · doi:10.1111/j.1365-2567.2009.03179.x · Cited by 213 · see citing works

Mesothelial cells give rise to hepatic stellate cells and myofibroblasts via mesothelial–mesenchymal transition in liver injury

Li, Y., Wang, J., & Asahina, K. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1214136110 · Cited by 211 · see citing works

Differentiation of the mouse hepatic primordium. I. An analysis of tissue interactions in hepatocyte differentiation

Houssaint, E. (1980) · Cell Differentiation · doi:10.1016/0045-6039(80)90026-3 · Cited by 209 · see citing works

Lineage tracing demonstrates no evidence of cholangiocyte epithelial-to-mesenchymal transition in murine models of hepatic fibrosis

Chu, A. S., Díaz, R., Hui, J., Yanger, K., Zong, Y., Alpini, G. D., Stanger, B. Z., & Wells, R. G. (2011) · Hepatology · doi:10.1002/hep.24206 · Cited by 207 · see citing works

Small-Molecule-Driven Hepatocyte Differentiation of Human Pluripotent Stem Cells

Siller, R., Greenhough, S., Naumovska, E., & Sullivan, G. J. (2015) · Stem Cell Reports · doi:10.1016/j.stemcr.2015.04.001 · Cited by 203 · see citing works

Spatial Transcriptomics to define transcriptional patterns of zonation and structural components in the mouse liver

Hildebrandt, F., Andersson, A., Saarenpää, S., Larsson, L., Hul, N. V., Kanatani, S., Masek, J., Ellis, E. C. S., Barragán, A., Mollbrink, A., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-27354-w · Cited by 195 · see citing works

Liver sinusoidal endothelial cell progenitor cells promote liver regeneration in rats

Wang, L., Wang, X., Xie, G., Wang, L., Hill, C. K., & DeLeve, L. D. (2012) · Journal of Clinical Investigation · doi:10.1172/jci58789 · Cited by 194 · see citing works

Lymph Circulation in the Liver

Ohtani, O., & Ohtani, Y. (2008) · The Anatomical Record · doi:10.1002/ar.20681 · Cited by 193 · see citing works

The biliary epithelium gives rise to liver progenitor cells

Rodrigo-Torres, D., Affò, S., Coll, M., Morales-Ibanez, O., Millán, C., Blaya, D., Alvarez-Guaita, A., Rentero, C., José Lozano, J., Maestro, M. A., et al. (2014) · Hepatology · doi:10.1002/hep.27078 · Cited by 189 · see citing works

Single-cell RNA-seq analysis unveils a prevalent epithelial/mesenchymal hybrid state during mouse organogenesis

Dong, J., Hu, Y., Fan, X., Wu, X., Mao, Y., Hu, B., Guo, H., Wen, L., & Tang, F. (2018) · Genome Biology · doi:10.1186/s13059-018-1416-2 · Cited by 187 · see citing works

A CK19CreERT knockin mouse line allows for conditional DNA recombination in epithelial cells in multiple endodermal organs

Means, A. L., Xu, Y., Zhao, A., Ray, K. C., & Gu, G. (2008) · genesis · doi:10.1002/dvg.20397 · Cited by 183 · see citing works

Single cell transcriptomics identifies a signaling network coordinating endoderm and mesoderm diversification during foregut organogenesis

Han, L., Chaturvedi, P., Kishimoto, K., Koike, H., Nasr, T., Iwasawa, K., Giesbrecht, K., Witcher, P. C., Eicher, A. K., Haines, L. E., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-17968-x · Cited by 178 · see citing works

Efficient temporally controlled targeted somatic mutagenesis in hepatocytes of the mouse

Schuler, M. J., Dierich, A., Chambon, P., & METZGER, D. (2004) · genesis · doi:10.1002/gene.20039 · Cited by 175 · see citing works

Common Lymphatic Endothelial and Vascular Endothelial Receptor-1 Mediates the Transmigration of Regulatory T Cells across Human Hepatic Sinusoidal Endothelium

Shetty, S., Weston, C. J., Oo, Y. H., Westerlund, N., Stamataki, Z., Youster, J., Hübscher, S. G., Salmi, M., Jalkanen, S., Lalor, P. F., et al. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1002961 · Cited by 174 · see citing works

Mechanosensing by β1 integrin induces angiocrine signals for liver growth and survival

Lorenz, L., Axnick, J., Buschmann, T., Henning, C., Urner, S., Fang, S., Nurmi, H., Eichhorst, N., Holtmeier, R., Bódis, K., et al. (2018) · Nature · doi:10.1038/s41586-018-0522-3 · Cited by 171 · see citing works

Endothelial GATA4 controls liver fibrosis and regeneration by preventing a pathogenic switch in angiocrine signaling

Winkler, M., Staniczek, T., Kürschner, S. W., Schmid, C. D., Schönhaber, H., Cordero, J., Kessler, L., Mathes, A., Sticht, C., Neßling, M., et al. (2020) · Journal of Hepatology · doi:10.1016/j.jhep.2020.08.033 · Cited by 170 · see citing works

AFP promotes HCC progression by suppressing the HuR-mediated Fas/FADD apoptotic pathway

Chen, T., Dai, X., Dai, J., Ding, C., Zhang, Z., Lin, Z., Hu, J., Lu, M., Wang, Z., Qi, Y., et al. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-03030-7 · Cited by 168 · see citing works

GATA4-dependent organ-specific endothelial differentiation controls liver development and embryonic hematopoiesis

Géraud, C., Reiners-Koch, P.-S., Zierow, J., Klapproth, K., Busch, K., Olsavszky, V., Leibing, T., Demory, A., Ulbrich, F., Diett, M., et al. (2017) · Journal of Clinical Investigation · doi:10.1172/jci90086 · Cited by 164 · see citing works

Bioprinting of Multiscaled Hepatic Lobules within a Highly Vascularized Construct

Kang, D., Hong, G., An, S., Jang, I., Yun, W., Shim, J., & Jin, S. (2020) · Small · doi:10.1002/smll.201905505 · Cited by 164 · see citing works

A single‐cell transcriptomic analysis reveals precise pathways and regulatory mechanisms underlying hepatoblast differentiation

Yang, L. C., Wang, W., Qiu, W., Guo, Z., Bi, E., & Xu, C. (2017) · Hepatology · doi:10.1002/hep.29353 · Cited by 162 · see citing works

Single-cell RNA sequencing of human liver reveals hepatic stellate cell heterogeneity

Payen, V. L., Lavergne, A., Alevra Sarika, N., Colonval, M., Karim, L., Deckers, M., Najimi, M., Coppieters, W., Charloteaux, B., Sokal, E. M., et al. (2021) · JHEP Reports · doi:10.1016/j.jhepr.2021.100278 · Cited by 160 · see citing works

Establishment of human fetal hepatocyte organoids and CRISPR–Cas9-based gene knockin and knockout in organoid cultures from human liver

Hendriks, D. F. G., Artegiani, B., Hu, H., Lopes, S. M. C. D. S., & Clevers, H. C. (2020) · Nature Protocols · doi:10.1038/s41596-020-00411-2 · Cited by 159 · see citing works

Passive and Active Mechanisms Trap Activated CD8+ T Cells in the Liver

John, B., & Crispe, I. N. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.9.5222 · Cited by 157 · see citing works

Regrowth of the rat biliary tree after 70% partial hepatectomy is coupled to increased secretin-induced ductal secretion

LeSage, G., Glaser, S., Gubba, S., Robertson, W., Phinizy, J. L., Lasater, J., Rodgers, R., & Alpini, G. D. (1996) · Gastroenterology · doi:10.1016/s0016-5085(96)70027-6 · Cited by 152 · see citing works

Single-cell atlas of human liver development reveals pathways directing hepatic cell fates

Wesley, B. T., Ross, A. D. B., Muraro, D., Miao, Z., Saxton, S., Tomaz, R. A., Morell, C. M., Ridley, K., Zacharis, E. D., Petrus-Reurer, S., et al. (2022) · Nature Cell Biology · doi:10.1038/s41556-022-00989-7 · Cited by 146 · see citing works

Increased Activities of Glycogenolytic Enzymes in Liver after Splanchnic-Nerve Stimulation

Shimazu, T., & Fukuda, A. (1965) · Science · doi:10.1126/science.150.3703.1607 · Cited by 144 · see citing works

Origin and development of the epicardium in the mouse embryo

Komiyama, M., Ito, K., & Shimada, Y. (1987) · Anatomy and Embryology · doi:10.1007/bf00310051 · Cited by 144 · see citing works

Role and mechanisms of action of acetylcholine in the regulation of rat cholangiocyte secretory functions.

Alvaro, D., Alpini, G. D., Jezequel, A. M., Bassotti, C., Francia, C., FRAIOLI, F., Roméo, R., Marucci, L., LeSage, G., Glaser, S. S., et al. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119655 · Cited by 137 · see citing works

MMP2 activation by collagen I and concanavalin A in cultured human hepatic stellate cells

Théret, N., Lehti, K., Musso, O. C., & Clément, B. (1999) · Hepatology · doi:10.1002/hep.510300236 · Cited by 137 · see citing works

The Glycoprotein IIb Molecule Is Expressed on Early Murine Hematopoietic Progenitors and Regulates Their Numbers in Sites of Hematopoiesis

Emambokus, N. R., & Frampton, J. (2003) · Immunity · doi:10.1016/s1074-7613(03)00173-0 · Cited by 135 · see citing works

Developments and Opportunities for 3D Bioprinted Organoids

Ya, R., Yang, X., Ma, Z., Sun, X., Zhang, Y., Li, W., Yang, H. S., Qiang, L., Yang, Z., Liu, Y., et al. (2021) · International Journal of Bioprinting · doi:10.18063/ijb.v7i3.364 · Cited by 129 · see citing works

Comparative analysis of cell lineage differentiation during hepatogenesis in humans and mice at the single-cell transcriptome level

Wang, X., Yang, L. C., Wang, Y., Xu, Z., Ye, F., Zhang, J., Wang, Y., & Xu, C. (2020) · Cell Research · doi:10.1038/s41422-020-0378-6 · Cited by 127 · see citing works

Single cell analysis of human foetal liver captures the transcriptional profile of hepatobiliary hybrid progenitors

Segal, J. M., Kent, D., Wesche, D. J., Ng, S. S., Serra, M. P., Oulès, B., Kar, G., Emerton, G., Blackford, S. J. I., Darmanis, S., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-11266-x · Cited by 126 · see citing works

Transcription factors SOX4 and SOX9 cooperatively control development of bile ducts

Poncy, A., Antoniou, A., Cordi, S., Pierreux, C. E., Jacquemin, P., & Lemaigre, F. P. (2015) · Developmental Biology · doi:10.1016/j.ydbio.2015.05.012 · Cited by 125 · see citing works

ER71 directs mesodermal fate decisions during embryogenesis

Rasmussen, T. L., Kweon, J., Diekmann, M. A., Belema-Bedada, F., Song, Q., Bowlin, K., Shi, X., Ferdous, A., Li, T., Kyba, M., et al. (2011) · Development · doi:10.1242/dev.070912 · Cited by 123 · see citing works

Endocardial cells are a distinct endothelial lineage derived from Flk1+ multipotent cardiovascular progenitors

Misfeldt, A. M., Boyle, S. C., Tompkins, K. L., Bautch, V. L., Labosky, P. A., & Baldwin, H. S. (2009) · Developmental Biology · doi:10.1016/j.ydbio.2009.06.033 · Cited by 123 · see citing works

Models of haematopoiesis: seeing the wood for the trees

Ceredig, R. H., Rolink, A. G., & Brown, G. (2009) · Nature reviews. Immunology · doi:10.1038/nri2525 · Cited by 123 · see citing works

CHARACTERIZATION OF INTERSTITIAL DENDRITIC CELLS IN HUMAN LIVER

Prickett, T. C. R., McKenzie, J. L., & Hart, D. N. J. (1988) · Transplantation · doi:10.1097/00007890-198811000-00024 · Cited by 119 · see citing works

Assembly and Function of a Bioengineered Human Liver for Transplantation Generated Solely from Induced Pluripotent Stem Cells

Takeishi, K., Collin de l’Hortet, A., Wang, Y., Handa, K., Guzman-Lepe, J., Matsubara, K., Morita, K., Jang, S., Haep, N., Florentino, R. M., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107711 · Cited by 118 · see citing works

Hepatic Stellate Cell Regulation of Liver Regeneration and Repair

Kitto, L. J., & Henderson, N. C. (2020) · Hepatology Communications · doi:10.1002/hep4.1628 · Cited by 117 · see citing works

Tbx3 promotes liver bud expansion during mouse development by suppression of cholangiocyte differentiation†

Lüdtke, T. H. ‐., Christoffels, V. M., Petry, M., & Kispert, A. (2009) · Hepatology · doi:10.1002/hep.22700 · Cited by 117 · see citing works

Temporal analyses of postnatal liver development and maturation by single-cell transcriptomics

Liang, Y., Kaneko, K., Xin, B., Lee, J., Sun, X., Zhang, K., & Feng, G.-S. (2022) · Developmental Cell · doi:10.1016/j.devcel.2022.01.004 · Cited by 116 · see citing works

Hippo Signaling Influences HNF4A and FOXA2 Enhancer Switching during Hepatocyte Differentiation

Alder, O., Cullum, R., Lee, S., Kan, A. C., Wei, W., Yi, Y., Garside, V. C., Bilenky, M., Griffith, M., Morrissy, A. S., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.08.046 · Cited by 113 · see citing works

Identification of HSC/MPP expansion units in fetal liver by single-cell spatiotemporal transcriptomics

Gao, S., Shi, Q., Zhang, Y., Liang, G., Kang, Z., Huang, B., Ma, D., Wang, L., Jiao, J., Fang, X., et al. (2021) · Cell Research · doi:10.1038/s41422-021-00540-7 · Cited by 112 · see citing works

Paraxial Mesoderm Is the Major Source of Lymphatic Endothelium

Stone, O. A., & Stainier, D. Y. R. (2019) · Developmental Cell · doi:10.1016/j.devcel.2019.04.034 · Cited by 112 · see citing works

Vagus-macrophage-hepatocyte link promotes post-injury liver regeneration and whole-body survival through hepatic FoxM1 activation

Izumi, T., Imai, J., Yamamoto, J., Kawana, Y., Endo, A., Sugawara, H., Kohata, M., Asai, Y., Takahashi, K., Kodama, S., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-07747-0 · Cited by 109 · see citing works

Genetic lineage tracing identifies endocardial origin of liver vasculature

Zhang, H., Pu, W., Tian, X., Huang, X., He, L., Liu, Q., Li, Y., Zhang, L., He, L., Liu, K., et al. (2016) · Nature Genetics · doi:10.1038/ng.3536 · Cited by 105 · see citing works

Relationship between vascular development and vascular differentiation during liver organogenesis in humans

Gouysse, G., Couvelard, A., Collardeau‐Frachon, S., Bouvier, R., Nejjari, M., Dauge, M., Feldmann, G., Hénin, D., & Scoazec, J. (2002) · Journal of Hepatology · doi:10.1016/s0168-8278(02)00282-9 · Cited by 104 · see citing works

Generation of Functional Liver Sinusoidal Endothelial Cells from Human Pluripotent Stem-Cell-Derived Venous Angioblasts

Gage, B. K., Liu, J. C., Innes, B. T., MacParland, S. A., McGilvray, I. D., Bader, G. D., & Keller, G. M. (2020) · Cell stem cell · doi:10.1016/j.stem.2020.06.007 · Cited by 104 · see citing works

Single-cell and bulk transcriptomics of the liver reveals potential targets of NASH with fibrosis

Wang, Z.-Y., Keogh, A., Waldt, A., Cuttat, R., Neri, M., Zhu, S., Schuierer, S., Ruchti, A., Crochemore, C., Knehr, J., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-98806-y · Cited by 103 · see citing works

Functional compensation precedes recovery of tissue mass following acute liver injury

Walesky, C. M., Kolb, K. E., Winston, C. L., Henderson, J., Kruft, B., Fleming, I., Ko, S., Monga, S. P., Mueller, F., Apte, U., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-19558-3 · Cited by 103 · see citing works

Fetal stem cell transplantation: Past, present, and future

Ishii, T. (2014) · World Journal of Stem Cells · doi:10.4252/wjsc.v6.i4.404 · Cited by 100 · see citing works

Morphological and molecular left–right asymmetries in the development of the proepicardium: A comparative analysis on mouse and chick embryos

Schulte, I., Schlueter, J., Abu‐Issa, R., Brand, T., & Männer, J. (2007) · Developmental Dynamics · doi:10.1002/dvdy.21065 · Cited by 100 · see citing works

CFC1 Gene Involvement in Biliary Atresia With Polysplenia Syndrome

Spraul, A., Baussan, C., Hermeziu, B., et al. (2008) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/01.mpg.0000304465.60788.f4 · Cited by 99 · see citing works

Portal fibroblasts with mesenchymal stem cell features form a reservoir of proliferative myofibroblasts in liver fibrosis

Lei, L., Bruneau, A., El Mourabit, H., Guégan, J., Folseraas, T., Lemoinne, S., Karlsen, T. H., Hoareau, B., Morichon, R., Gonzalez‐Sanchez, E., et al. (2022) · Hepatology · doi:10.1002/hep.32456 · Cited by 94 · see citing works

System for tamoxifen‐inducible expression of cre‐recombinase from the Foxa2 locus in mice

Park, E. J., Sun, X., Nichol, P. F., Saijoh, Y., Martin, J. F., & Moon, A. (2007) · Developmental Dynamics · doi:10.1002/dvdy.21415 · Cited by 94 · see citing works

Human liver single nucleus and single cell RNA sequencing identify a hepatocellular carcinoma-associated cell-type affecting survival

Alvarez, M., Benhammou, J. N., Darci-Maher, N., French, S. W., Han, S. B., Sinsheimer, J. S., Agopian, V. G., Pisegna, J. R., & Pajukanta, P. (2022) · Genome Medicine · doi:10.1186/s13073-022-01055-5 · Cited by 90 · see citing works

PHENOTYPE AND HISTOLOGICAL DISTRIBUTION OF INTERSTITIAL DENDRITIC CELLS IN THE RAT PANCREAS, LIVER, HEART, AND KIDNEY

Steiniger, B. S., Klempnauer, J. L., & Wonigeit, K. (1984) · Transplantation · doi:10.1097/00007890-198408000-00016 · Cited by 90 · see citing works

Single-Cell Transcriptomics Reveals Early Emergence of Liver Parenchymal and Non-parenchymal Cell Lineages

Lotto, J., Drissler, S., Cullum, R., Wei, W., Setty, M., Bell, E. M., Boutet, S. C., Nowotschin, S., Kuo, Y.-Y., Garg, V., et al. (2020) · Cell · doi:10.1016/j.cell.2020.09.012 · Cited by 86 · see citing works

The developing human biliary system at the porta hepatis level between 29 days and 8 weeks of gestation: A way to understanding biliary atresia. Part 1

Tan, C. E. L., & Moscoso, G. J. (1994) · Pathology International · doi:10.1111/j.1440-1827.1994.tb01719.x · Cited by 84 · see citing works

Hepatic stellate cells do not derive from the neural crest

Cassiman, D. M., Barlow, A. J., Borght, S. V., Libbrecht, L. J., & Pachnis, V. (2005) · Journal of Hepatology · doi:10.1016/j.jhep.2005.09.023 · Cited by 83 · see citing works

Specification of fetal liver endothelial progenitors to functional zonated adult sinusoids requires c-Maf induction

Gómez-Salinero, J. M., Izzo, F., Lin, Y., Houghton, S., Itkin, T., Geng, F., Bram, Y., Adelson, R. P., Lu, T. M., Inghirami, G., et al. (2022) · Cell stem cell · doi:10.1016/j.stem.2022.03.002 · Cited by 81 · see citing works

Single-cell RNA-Seq analysis reveals dynamic trajectories during mouse liver development

Su, X., Shi, Y. Y., Zou, X., Lu, Z., Xie, G., Yang, J. Y. H., Wu, C.-C., Cui, X., He, K., Luo, Q., et al. (2017) · BMC Genomics · doi:10.1186/s12864-017-4342-x · Cited by 81 · see citing works

LYVE1 Marks the Divergence of Yolk Sac Definitive Hemogenic Endothelium from the Primitive Erythroid Lineage

Lee, L. K., Ghorbanian, Y., Wang, W., Wang, Y., Kim, Y. J., Weissman, I. L., Inlay, M. A., & Mikkola, H. K. A. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.10.080 · Cited by 79 · see citing works

Composition and functionality of the intrahepatic innate lymphoid cell‐compartment in human nonfibrotic and fibrotic livers

Forkel, M., Berglin, L., Kekäläinen, E., Carlsson, A., Svedin, E., Michaëlsson, J., Nagasawa, M., Erjefalt, J. S., Mori, M., Flodström‐Tullberg, M., et al. (2017) · European Journal of Immunology · doi:10.1002/eji.201646890 · Cited by 79 · see citing works

A tamoxifen-inducible chimeric Cre recombinase specifically effective in the fetal and adult mouse liver

Tannour‐Louet, M., Porteu, A., Vaulont, S., Kahn, A., & Vasseur-Cognet, M. (2002) · Hepatology · doi:10.1053/jhep.2002.33164 · Cited by 78 · see citing works

Lgr5+ stem and progenitor cells reside at the apex of a heterogeneous embryonic hepatoblast pool

Prior, N., Hindley, C. J., Rost, F., Esteban, E. M., Lau, W. W. Y., Göttgens, B., Rulands, S., Simons, B. D., & Huch, M. (2019) · Development · doi:10.1242/dev.174557 · Cited by 76 · see citing works

Hepatocyte Nuclear Factor 4‐Alpha Is Essential for the Active Epigenetic State at Enhancers in Mouse Liver

Thakur, A., Wong, J. C. H., Wang, E. Y., Lotto, J., Kim, D., Cheng, J., Mingay, M., Cullum, R., Moudgil, V., Ahmed, N., et al. (2019) · Hepatology · doi:10.1002/hep.30631 · Cited by 75 · see citing works

Dynamic cell contacts between periportal mesenchyme and ductal epithelium act as a rheostat for liver cell proliferation

Cordero-Espinoza, L., Dowbaj, A. M., Kohler, T. N., Strauss, B., Sarlidou, O., Belenguer, G., Pacini, C., Martins, N. P., Dobie, R., Wilson-Kanamori, J. R., et al. (2021) · Cell Stem Cell · doi:10.1016/j.stem.2021.07.002 · Cited by 74 · see citing works

Epithelial expression of angiogenic growth factors modulate arterial vasculogenesis in human liver development

Fabris, L., Cadamuro, M., Libbrecht, L. J., Raynaud, P., Spirlı̀, C., Fiorotto, R., Okolicsànyi, L., Lemaigre, F. P., Strazzabosco, M., & Roskams, T. (2007) · Hepatology · doi:10.1002/hep.22015 · Cited by 71 · see citing works

GATA6 defines endoderm fate by controlling chromatin accessibility during differentiation of human-induced pluripotent stem cells

Heslop, J. A., Pournasr, B., Liu, J.-T., & Duncan, S. A. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109145 · Cited by 70 · see citing works

Genetic lineage tracing with multiple DNA recombinases: A user's guide for conducting more precise cell fate mapping studies

Liu, K., Jin, H., & Zhou, B. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.rev120.011631 · Cited by 69 · see citing works

Spatial transcriptome profiling by MERFISH reveals fetal liver hematopoietic stem cell niche architecture

Lu, Y., Liu, M., Yang, J., Weissman, S. M., Pan, X., Katz, S. G., & Wang, S. (2021) · Cell Discovery · doi:10.1038/s41421-021-00266-1 · Cited by 68 · see citing works

The Dynamics of Transcriptional Activation by Hepatic Reprogramming Factors

Horisawa, K., Udono, M., Ueno, K., Ohkawa, Y., Nagasaki, M., Sekiya, S., & Suzuki, A. (2020) · Molecular Cell · doi:10.1016/j.molcel.2020.07.012 · Cited by 68 · see citing works

Fenestration patterns in endothelial cells of rat liver sinusoids

Vidal‐Vanaclocha, F., & Barberá‐Guillem, E. (1985) · Journal of Ultrastructure Research · doi:10.1016/0889-1605(85)90102-8 · Cited by 67 · see citing works

Innervation of the liver: morphology and function

TINIAKOS, D. G., Lee, J. A., & Burt, A. D. (1996) · Liver International · doi:10.1111/j.1600-0676.1996.tb00721.x · Cited by 64 · see citing works

Innervation of the sinusoidal wall: Regulation of the sinusoidal diameter

Ueno, T., Bioulac‐Sage, P., Balabaud, C. P., & Rosenbaum, J. (2004) · The Anatomical Record Part A Discoveries in Molecular Cellular and Evolutionary Biology · doi:10.1002/ar.a.20092 · Cited by 64 · see citing works

Hepatic Endothelial Notch Activation Protects against Liver Metastasis by Regulating Endothelial-Tumor Cell Adhesion Independent of Angiocrine Signaling

Wohlfeil, S. A., Häfele, V., Dietsch, B., Schledzewski, K., Winkler, M., Zierow, J., Leibing, T., Mohammadi, M. M., Heineke, J., Sticht, C., et al. (2018) · Cancer Research · doi:10.1158/0008-5472.can-18-1752 · Cited by 62 · see citing works

GATA4 loss in the septum transversum mesenchyme promotes liver fibrosis in mice

Delgado‐Sainz, I., Carrasco, M., Cano, E., Carmona, R., García‐Carbonero, R., Gómez, L. M. M., Soria, B., Martín, F., Cano, D. A., Muñoz‐Chápuli, R., et al. (2014) · Hepatology · doi:10.1002/hep.27005 · Cited by 60 · see citing works

Collapse of the hepatic gene regulatory network in the absence of FoxA factors

Reizel, Y., Morgan, A., Gao, L., Lan, Y., Manduchi, E., Waite, E. L., Wang, A. W., Wells, A., & Kaestner, K. H. (2020) · Genes & Development · doi:10.1101/gad.337691.120 · Cited by 60 · see citing works

Sequence logic at enhancers governs a dual mechanism of endodermal organ fate induction by FOXA pioneer factors

Geusz, R. J., Wang, A., Lam, D. K., Vinckier, N. K., Alysandratos, K., Roberts, D. A., Wang, J., Kefalopoulou, S., Ramirez, A., Qiu, Y., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-26950-0 · Cited by 60 · see citing works

Endoderm generates endothelial cells during liver development

Goldman, O., Han, S., Hamou, W., Jodon de Villeroche, V., Uzan, G., Lickert, H., & Gouon-Evans, V. (2014) · Stem Cell Reports · doi:10.1016/j.stemcr.2014.08.009 · Cited by 56 · see citing works

TBX3 advances the developmental chromatin landscape toward the hepatic fate

Stephan, T. L., Cullum, R., Drissler, S., Thomas, A., Fuglerud, B. M., Clement-Ranney, M., Lotto, J., Krentz, N. A. J., Duncan, S. A., & Hoodless, P. A. (2025) · Developmental Cell · doi:10.1016/j.devcel.2025.05.014 · Cited by 1 · see citing works

Rapidly increasing liver progenitor cell numbers in human regenerating liver after portal vein ligation and liver partition.

Lin, K.-H., Hsu, H.-L., Teng, T. H., et al. (2017) · PubMed · Cited by 1 · see citing works

Human mammary progenitor cell fate decisions are products of interactions with combinatorial microenvironments

LaBarge, M. A., Nelson, C. M., Villadsen, R., Fridriksdottir, A. J., Ruth, J. R., Stampfer, M. R., PETERSEN, O. W., & Bissell, M. J. (2008) · Integrative Biology · doi:10.1039/b816472j · Cited by 177 · see citing works

Liver sinusoidal endothelial cell progenitor cells promote liver regeneration in rats

Wang, L., Wang, X., Xie, G., Wang, L., Hill, C. K., & DeLeve, L. D. (2012) · Journal of Clinical Investigation · doi:10.1172/jci58789 · Cited by 194 · see citing works

Liver Regeneration and Its Regulators

Xue-ha, W. (2010) · Zhongguo pu-wai jichu yu linchuang zazhi

The roles of signaling pathways in liver repair and regeneration

Valizadeh, A., Majidinia, M., Kafil, H. S., Yousefi, M., & Yousefi, B. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28336 · Cited by 63 · see citing works