The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
HIV-1 Tat Induces Monocyte Chemoattractant Protein-1-Mediated Monocyte Transmigration Across a Model of the Human Blood-Brain Barrier and Up-Regulates CCR5 Expression on Human Monocytes
Abstract
AIDS dementia is characterized by neuronal loss in association with synaptic damage. A central predictor for clinical onset of these symptoms is the infiltration of monocytes and macrophages into CNS parenchyma. Chronic HIV-1 infection of monocytes also allows these cells to serve as reservoirs for persistent viral infection. Using a coculture of endothelial cells and astrocytes that models several aspects of the human blood-brain barrier, we examined the mechanism whereby the HIV-derived factor Tat may facilitate monocyte transmigration. We demonstrate that treatment of cocultures on the astrocyte side with HIV-1 Tat induced significant monocyte chemoattractant protein (MCP)-1 protein. Astrocytes, but not endothelial cells, were the source of this MCP-1 expression. Supernatants from Tat-treated cocultures induced significant monocyte transmigration, which was detected by 2.5 h after the addition of PBMC. Pretreatment of the supernatants from Tat-stimulated cocultures with an Ab to MCP-1 completely blocked monocyte transmigration. Flow cytometric analysis of Tat-stimulated PBMC demonstrated that Tat up-regulated expression of the chemokine receptor, CCR5, on monocytes in a time-dependent manner. Taken together, our data indicate that HIV-1 Tat may facilitate the recruitment of monocytes into the CNS by inducing MCP-1 expression in astrocytes. These recruited monocytes may contribute to the pathogenesis of HIV-1-associated AIDS encephalitis and dementia.
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Eugenin, E. A., Osiecki, K., Lopez, L., Goldstein, H., Calderon, T. M., & Berman, J. W. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.3863-05.2006 · Cited by 392
Self-citationImmune and neuroendocrine mechanisms of stress vulnerability and resilience
Ménard, C., Pfau, M. L., Hodes, G. E., & Russo, S. J. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.90 · Cited by 374
Central Nervous System Damage, Monocytes and Macrophages, and Neurological Disorders in AIDS
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Metadata
- Authors
- Weiss, J. M., Nath, A., Major, E. O., & Berman, J. W.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1999-09-01
- Volume
- 163
- Issue
- 5
- Pages
- 2953-2959
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1530364137
- Cited by
- 265
- References
- 44
- FWCI
- 4.52
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: HIV-1 Tat Induces Monocyte Chemoattractant Protein-1-Mediated Monocyte Transmigration Across a Model of the Human Blood-Brain Barrier and Up-Regulates CCR5 Expression on Human Monocytes. https://app.cochat.ai/papers/10.4049/jimmunol.163.5.2953
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- Weiss, J. M., Nath, A., Major, E. O., & Berman, J. W. (1999). HIV-1 Tat Induces Monocyte Chemoattractant Protein-1-Mediated Monocyte Transmigration Across a Model of the Human Blood-Brain Barrier and Up-Regulates CCR5 Expression on Human Monocytes. The Journal of Immunology. https://doi.org/10.4049/jimmunol.163.5.2953
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