Immune and neuroendocrine mechanisms of stress vulnerability and resilience
Open accessAbstract
Diagnostic criteria for mood disorders including major depressive disorder (MDD) largely ignore biological factors in favor of behavioral symptoms. Compounding this paucity of psychiatric biomarkers is a need for therapeutics to adequately treat the 30-50% of MDD patients who are unresponsive to traditional antidepressant medications. Interestingly, MDD is highly prevalent in patients suffering from chronic inflammatory conditions, and MDD patients exhibit higher levels of circulating pro-inflammatory cytokines. Together, these clinical findings suggest a role for the immune system in vulnerability to stress-related psychiatric illness. A growing body of literature also implicates the immune system in stress resilience and coping. In this review, we discuss the mechanisms by which peripheral and central immune cells act on the brain to affect stress-related neurobiological and neuroendocrine responses. We specifically focus on the roles of pro-inflammatory cytokine signaling, peripheral monocyte infiltration, microglial activation, and hypothalamic-pituitary-adrenal axis hyperactivity in stress vulnerability. We also highlight recent evidence suggesting that adaptive immune responses and treatment with immune modulators (exogenous glucocorticoids, humanized antibodies against cytokines) may decrease depressive symptoms and thus represent an attractive alternative to the current antidepressant treatments.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Growing evidence implicates the immune system in stress resilience and coping through peripheral and central immune mechanisms of action, affecting the brain and all stress-related neurobiological and neuroendocrine responses.
“Growing evidence, accordingly, implicates the immune system in stress resilience and coping through peripheral and central immune mechanisms of action, affecting the brain and all stress-related neurobiological and neuroendocrine responses (160).”
From Developmental Trajectories of Early Life Stress and Trauma: A Narrative Review on Neurobiological Aspects Beyond Stress System Dysregulation (2019) · cites this paper as [160]
The Introduction (page unavailable) identifies a role for the immune system in stress vulnerability and resilience, and the section on chronic psychological stress describes relevant peripheral and central inflammation. The section on neuroendocrine mechanisms says immune, autonomic, and HPA-axis processes interact, but it does not support the claim that immune mechanisms affect *all* stress-related neurobiological and neuroendocrine responses. (LLM, conf=0.86)
Experimental — accuracy not yet measuredWhen exposed to stressful events, only a subgroup of individuals develops major depression.
“When exposed to stressful events, only a subgroup of individuals develops major depression.192–195”
From Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential (2023) · cites this paper as [194]
Clinical studies report higher levels of circulating pro-inflammatory cytokines in MDD patients, a pattern replicated in preclinical animal models of depression.
“clinical studies report higher levels of circulating pro-inflammatory cytokines in MDD patients, a pattern that has been replicated in preclinical animal models of depression1, 7–10.”
From Social stress induces neurovascular pathology promoting depression (2017) · cites this paper as [1]
Heightened peripheral inflammation contributes to the pathogenesis of major depressive disorder.
“Studies suggest that heightened peripheral inflammation contributes to the pathogenesis of major depressive disorder.”
From Social stress induces neurovascular pathology promoting depression (2017) · cites this paper as [1]
Hippocampal IL4 levels vary inversely with stress vulnerability.
“Our results, together with evidence from the literature (26, 27), suggest that levels of hippocampal IL4 vary inversely with stress vulnerability.”
From IL4-driven microglia modulate stress resilience through BDNF-dependent neurogenesis (2021) · cites this paper as [26]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Kessler, R. C. (1994) · Archives of General Psychiatry · doi:10.1001/archpsyc.1994.03950010008002 · Cited by 12,370 · see citing works
Kessler, R. C., Chiu, W. T., Demler, O., & Walters, E. E. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.6.617 · Cited by 12,052 · see citing works
Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies
Lang, U. E., & Borgwardt, S. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350094 · Cited by 8,501 · see citing works
Ordinary magic: Resilience processes in development.
Masten, A. S. (2001) · American Psychologist · doi:10.1037/0003-066x.56.3.227 · Cited by 8,497 · see citing works
From inflammation to sickness and depression: when the immune system subjugates the brain
Dantzer, R., O'Connor, J. C., Freund, G. G., Johnson, R. W., & Kelley, K. W. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2297 · Cited by 7,395 · see citing works
Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo
Nimmerjahn, A., Kirchhoff, F., & Helmchen, F. (2005) · Science · doi:10.1126/science.1110647 · Cited by 5,827 · see citing works
Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages
Ginhoux, F., Greter, M., Leboeuf, M., Nandi, S., See, P., Gokhan, S., Mehler, M. F., Conway, S. J., Ng, L. G., Stanley, E. R., et al. (2010) · Science · doi:10.1126/science.1194637 · Cited by 5,175 · see citing works
Korn, T., Bettelli, E., Oukka, M., & Kuchroo, V. K. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132710 · Cited by 4,873 · see citing works
Higgins, S. M. F., Macken, A. P., Cullen, W., Saunders, J., Dunne, C. P., & O’Gorman, C. S. (2013) · PubMed · doi:10.34961/9953 · Cited by 4,806 · see citing works
A Meta-Analysis of Cytokines in Major Depression
Dowlati, Y., Herrmann, N., Swardfager, W., Liu, H., Sham, L., Reim, E. K., & Lanctôt, K. L. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.09.033 · Cited by 4,729 · see citing works
Structural and functional features of central nervous system lymphatic vessels
Louveau, A., Smirnov, I., Keyes, T. J., Eccles, J. D., Rouhani, S. J., Peske, J. D., Derecki, N. C., Castle, D., Mandell, J. W., Lee, K. S., et al. (2015) · Nature · doi:10.1038/nature14432 · Cited by 4,413 · see citing works
Overweight, Obesity, and Depression: A Systematic Review and Meta-analysis of Longitudinal Studies
Luppino, F. S., de Wit, L. M., Bouvy, P. F., Stijnen, T., Cuijpers, P., Penninx, B. W. J. H., & Zitman, F. G. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.2 · Cited by 4,322 · see citing works
Synaptic Pruning by Microglia Is Necessary for Normal Brain Development
Paolicelli, R. C., Bolasco, G., Pagani, F., Maggi, L., Scianni, M., Panzanelli, P., Giustetto, M., Ferreira, T. A., Guiducci, E., Dumas, L., et al. (2011) · Science · doi:10.1126/science.1202529 · Cited by 4,244 · see citing works
Depression, chronic diseases, and decrements in health: results from the World Health Surveys
Moussavi, S., Chatterji, S., Verdes, E., Tandon, A., Patel, V., & Ustun, B. (2007) · The Lancet · doi:10.1016/s0140-6736(07)61415-9 · Cited by 4,070 · see citing works
The role of inflammation in depression: from evolutionary imperative to modern treatment target
Miller, A. H., & Raison, C. L. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2015.5 · Cited by 3,942 · see citing works
The Prevalence of Comorbid Depression in Adults With Diabetes
Anderson, R. J., Freedland, K. E., Clouse, R. E., & Lustman, P. J. (2001) · Diabetes Care · doi:10.2337/diacare.24.6.1069 · Cited by 3,926 · see citing works
Neural regulation of endocrine and autonomic stress responses
Ulrich-Lai, Y. M., & Herman, J. P. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2647 · Cited by 3,318 · see citing works
The Classical Complement Cascade Mediates CNS Synapse Elimination
Stevens, B., Allen, N. J., Vazquez, L. E., Howell, G. R., Christopherson, K. S., Nouri, N., Micheva, K. D., Mehalow, A. K., Huberman, A. D., Stafford, B., et al. (2007) · Cell · doi:10.1016/j.cell.2007.10.036 · Cited by 3,313 · see citing works
Synaptic Activity and the Construction of Cortical Circuits
Katz, L. C., & Shatz, C. J. (1996) · Science · doi:10.1126/science.274.5290.1133 · Cited by 3,048 · see citing works
Monocyte recruitment during infection and inflammation
Shi, C., & Pamer, E. G. (2011) · Nature Reviews Immunology · doi:10.1038/nri3070 · Cited by 3,015 · see citing works
The molecular neurobiology of depression
Krishnan, V., & Nestler, E. J. (2008) · Nature · doi:10.1038/nature07455 · Cited by 2,889 · see citing works
Molecular dissection of reactive astrogliosis and glial scar formation
Sofroniew, M. V. (2009) · Trends in Neurosciences · doi:10.1016/j.tins.2009.08.002 · Cited by 2,594 · see citing works
Krishnan, V., Han, M.-H., Graham, D. L., Berton, O., Renthal, W., Russo, S. J., LaPlant, Q., Graham, A., Lutter, M., Lagace, D. C., et al. (2007) · Cell · doi:10.1016/j.cell.2007.09.018 · Cited by 2,307 · see citing works
Self-citationKessler, R. (1993) · Journal of Affective Disorders · doi:10.1016/0165-0327(93)90026-g · Cited by 2,207 · see citing works
Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress
Berton, O., McClung, C. A., DiLeone, R. J., Krishnan, V., Renthal, W., Russo, S. J., Graham, D., Tsankova, N. M., Bolanos, C. A., Rios, M., et al. (2006) · Science · doi:10.1126/science.1120972 · Cited by 2,129 · see citing works
Self-citationThe brain reward circuitry in mood disorders
Russo, S. J., & Nestler, E. J. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3381 · Cited by 1,870 · see citing works
Self-citationMonocytes and macrophages: developmental pathways and tissue homeostasis
Ginhoux, F., & Jung, S. (2014) · Nature Reviews Immunology · doi:10.1038/nri3671 · Cited by 1,840 · see citing works
Reactive astrocytes: cellular and molecular cues to biological function
Ridet, J., Privat, A., Malhotra, S. K., & Gage, F. H. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(97)01139-9 · Cited by 1,766 · see citing works
Plotsky, P. M., & Meaney, M. J. (1993) · Molecular Brain Research · doi:10.1016/0169-328x(93)90189-v · Cited by 1,638 · see citing works
Raison, C. L., Rutherford, R. E., Woolwine, B. J., Shuo, C., Schettler, P., Drake, D. F., Haroon, E., & Miller, A. H. (2013) · JAMA Psychiatry · doi:10.1001/2013.jamapsychiatry.4 · Cited by 1,617 · see citing works
The global burden of disease, 1990–2020
López, A. D., & Murray, C. C. J. L. (1998) · Nature Medicine · doi:10.1038/3218 · Cited by 1,613 · see citing works
Charney, D. S. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.2.195 · Cited by 1,605 · see citing works
A standardized protocol for repeated social defeat stress in mice
Golden, S. A., Covington, H. E., Berton, O., & Russo, S. J. (2011) · Nature Protocols · doi:10.1038/nprot.2011.361 · Cited by 1,581 · see citing works
Self-citationMicroglial interactions with synapses are modulated by visual experience
Tremblay, M.-È., Lowery, R. L., & Majewska, A. K. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000527 · Cited by 1,542 · see citing works
Chronic stress, glucocorticoid receptor resistance, inflammation, and disease risk
Cohen, S., Janicki-Deverts, D., Doyle, W. J., Miller, G. E., Frank, E., Rabin, B. S., & Turner, R. B. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1118355109 · Cited by 1,419 · see citing works
Ali, S., Stone, M. A., Peters, J., Davies, M. J., & Khunti, K. K. (2006) · Diabetic Medicine · doi:10.1111/j.1464-5491.2006.01943.x · Cited by 1,281 · see citing works
Daynes, R. A., Araneo, B. A., Ershler, W. B., Maloney, C., Li, G. Z., & Ryu, S. Y. (1993) · The Journal of Immunology · doi:10.4049/jimmunol.150.12.5219 · Cited by 1,264 · see citing works
Evidence for a morphological sex difference within the medial preoptic area of the rat brain
Gorski, R. A., Gordon, J. H., Shryne, J. E., & Southam, A. M. (1978) · Brain Research · doi:10.1016/0006-8993(78)90723-0 · Cited by 1,230 · see citing works
Russo, S. J., Murrough, J. W., Han, M.-H., Charney, D. S., & Nestler, E. J. (2012) · Nature Neuroscience · doi:10.1038/nn.3234 · Cited by 1,206 · see citing works
Self-citationMurrough, J. W., Iosifescu, D. V., Chang, L. C., Al Jurdi, R. K., Green, C. E., Perez, A. M., Iqbal, S., Pillemer, S., Foulkes, A., Shah, A., et al. (2013) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2013.13030392 · Cited by 1,205 · see citing works
Harrison, J. K., Jiang, Y., Chen, S., Xia, Y., Maciejewski, D., McNamara, R. K., Streit, W. J., Salafranca, M. N., Adhikari, S., Thompson, D. A., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.18.10896 · Cited by 1,176 · see citing works
Stetler, C., & Miller, G. E. (2011) · Psychosomatic Medicine · doi:10.1097/psy.0b013e31820ad12b · Cited by 1,123 · see citing works
Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool
Ajami, B., Bennett, J. L., Krieger, C., McNagny, K. M., & Rossi, F. M. V. (2011) · Nature Neuroscience · doi:10.1038/nn.2887 · Cited by 1,061 · see citing works
Innate immunity in the central nervous system
Ransohoff, R. M., & Brown, M. A. (2012) · Journal of Clinical Investigation · doi:10.1172/jci58644 · Cited by 1,034 · see citing works
Tissue-resident memory T cells: local specialists in immune defence
Mueller, S. N., & Mackay, L. K. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2015.3 · Cited by 1,006 · see citing works
Evidence for an immune response in major depression: A review and hypothesis
Maes, M. (1995) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/0278-5846(94)00101-m · Cited by 1,003 · see citing works
The Role of Microglia in the Healthy Brain: Figure 1.
Tremblay, M.-È., Stevens, B., Sierra, A., Wake, H., Bessis, A., & Nimmerjahn, A. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.4158-11.2011 · Cited by 992 · see citing works
Sex-Specific Programming of Offspring Emotionality after Stress Early in Pregnancy
Mueller, B. R., & Bale, T. L. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.1424-08.2008 · Cited by 988 · see citing works
Glucocorticoid resistance in inflammatory diseases
Barnes, P. J., & Adcock, I. M. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60326-3 · Cited by 983 · see citing works
Köhler, O., Benros, M. E., Nordentoft, M., Farkouh, M. E., Iyengar, R. L., Mors, O., & Krogh, J. (2014) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2014.1611 · Cited by 941 · see citing works
The macrophage theory of depression
Smith, R. S. (1991) · Medical Hypotheses · doi:10.1016/0306-9877(91)90272-z · Cited by 931 · see citing works
The prevalence of depression in rheumatoid arthritis: a systematic review and meta-analysis
Matcham, F., Rayner, L., Steer, S., & Hotopf, M. (2013) · Rheumatology · doi:10.1093/rheumatology/ket169 · Cited by 928 · see citing works
Zhao, Q.-F., Tan, L., Wang, H.-F., Jiang, T., Tan, M.-S., Tan, L., Xu, W., Li, J.-Q., Wang, J., Lai, T.-J., et al. (2016) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.09.069 · Cited by 916 · see citing works
Weaver, I. C. G., Champagne, F. A., Brown, S. E., Dymov, S., Sharma, S., Meaney, M. J., & Szyf, M. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.3652-05.2005 · Cited by 905 · see citing works
De Bosscher, K., Vanden Berghe, W., & Haegeman, G. (2003) · Endocrine Reviews · doi:10.1210/er.2002-0006 · Cited by 898 · see citing works
IL-1β is an essential mediator of the antineurogenic and anhedonic effects of stress
Koo, J. W., & Duman, R. S. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0708092105 · Cited by 862 · see citing works
Differential roles of microglia and monocytes in the inflamed central nervous system
Yamasaki, R., Lu, H., Butovsky, O., Ohno, N., Rietsch, A. M., Cialic, R., Wu, P. M., Doykan, C. E., Lin, J., Cotleur, A. C., et al. (2014) · Journal of Experimental Medicine · doi:10.1084/jem.20132477 · Cited by 855 · see citing works
Stunkard, A. J., Faith, M. S., & Allison, K. C. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00608-5 · Cited by 820 · see citing works
Chronic variable stress activates hematopoietic stem cells
Heidt, T., Sager, H. B., Courties, G., Dutta, P., Iwamoto, Y., Zaltsman, A., von zur Muhlen, C., Bode, C., Fricchione, G. L., Denninger, J., et al. (2014) · Nature Medicine · doi:10.1038/nm.3589 · Cited by 803 · see citing works
Murrough, J. W., Perez, A. M., Pillemer, S., Stern, J., Parides, M. K., aan het Rot, M., Collins, K. A., Mathew, S. J., Charney, D. S., & Iosifescu, D. V. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.06.022 · Cited by 786 · see citing works
Passage of cytokines across the blood–brain barrier
Banks, W. A., Kastin, A. J., & Broadwell, R. D. (1996) · Neuroimmunomodulation · doi:10.1159/000097202 · Cited by 778 · see citing works
Passos, I. C., Vasconcelos-Moreno, M. P., Costa, L. G., Kunz, M., Brietzke, E., Quevedo, J., Salum, G., Magalhães, P. V., Kapczinski, F., & Kauer-Sant'Anna, M. (2015) · The Lancet Psychiatry · doi:10.1016/s2215-0366(15)00309-0 · Cited by 743 · see citing works
Cytokine Production and Treatment Response in Major Depressive Disorder
Lanquillon, S. (2000) · Neuropsychopharmacology · doi:10.1016/s0893-133x(99)00134-7 · Cited by 735 · see citing works
Maes, M., Bosmans, E., De Jongh, R., Kenis, G., Vandoolaeghe, E., & Neels, H. (1997) · Cytokine · doi:10.1006/cyto.1997.0238 · Cited by 728 · see citing works
Anxiety and Depression in COPD
Maurer, J., Rebbapragada, V., Borson, S., Goldstein, R., Kunik, M. E., Yohannes, A. M., & Hanania, N. A. (2008) · Chest · doi:10.1378/chest.08-0342 · Cited by 720 · see citing works
Depression in multiple sclerosis: a review
Siegert, R. J. (2005) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.2004.054635 · Cited by 718 · see citing works
Hodes, G. E., Pfau, M. L., Leboeuf, M., Golden, S. A., Christoffel, D. J., Bregman, D., Rebusi, N., Heshmati, M., Aleyasin, H., Warren, B. L., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1415191111 · Cited by 692 · see citing works
Self-citationMartin, L. A., Neighbors, H. W., & Griffith, D. M. (2013) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2013.1985 · Cited by 674 · see citing works
Sex differences in microglial colonization of the developing rat brain
Schwarz, J. M., Sholar, P. W., & Bilbo, S. D. (2012) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07630.x · Cited by 672 · see citing works
Kirschbaum, C., Prussner, J. C., Stone, A. A., Federenko, I., Gaab, J., Lintz, D., Schommer, N., & Hellhammer, D. H. (1995) · Psychosomatic Medicine · doi:10.1097/00006842-199509000-00009 · Cited by 666 · see citing works
Kreisel, T., Frank, M. G., Licht, T., Reshef, R., Ben-Menachem-Zidon, O., Baratta, M. V., Maier, S. F., & Yirmiya, R. (2014) · Molecular Psychiatry · doi:10.1038/mp.2013.155 · Cited by 663 · see citing works
Wohleb, E. S., Hanke, M. L., Corona, A. W., Powell, N. D., Stiner, L. M., Bailey, M. T., Nelson, R. J., Godbout, J. P., & Sheridan, J. F. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.0450-11.2011 · Cited by 638 · see citing works
Depression in Rheumatoid Arthritis: A Systematic Review of the Literature With Meta-Analysis
Dickens, C. M., McGowan, L., Clark-Carter, D. D., & Creed, F. H. (2002) · Psychosomatic Medicine · doi:10.1097/00006842-200201000-00008 · Cited by 635 · see citing works
CX3CR1 deficiency leads to impairment of hippocampal cognitive function and synaptic plasticity
Rogers, J. T., Morganti, J. M., Bachstetter, A. D., Hudson, C. E., Peters, M. M., Grimmig, B. A., Weeber, E. J., Bickford, P. C., & Gemma, C. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.3667-11.2011 · Cited by 624 · see citing works
Maes, M., Meltzer, H. Y., Bosmans, E., Bergmans, R., Vandoolaeghe, E., Ranjan, R., & Desnyder, R. (1995) · Journal of Affective Disorders · doi:10.1016/0165-0327(95)00028-l · Cited by 622 · see citing works
Felger, J. C., Li, Z., Haroon, E., Woolwine, B. J., Jung, M. Y., Hu, X., & Miller, A. H. (2016) · Molecular Psychiatry · doi:10.1038/mp.2015.168 · Cited by 620 · see citing works
Inflamed moods: A review of the interactions between inflammation and mood disorders
Rosenblat, J. D., Cha, D. S., Mansur, R. B., & McIntyre, R. S. (2014) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2014.01.013 · Cited by 609 · see citing works
Pathogenesis of depression: Insights from human and rodent studies
Ménard, C., Hodes, G. E., & Russo, S. J. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2015.05.053 · Cited by 593 · see citing works
Self-citationPowell, N. D., Sloan, E. K., Bailey, M. T., Arevalo, J. M. G., Miller, G. E., Chen, E., Kobor, M. S., Reader, B. F., Sheridan, J. F., & Cole, S. W. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1310655110 · Cited by 588 · see citing works
Neuroimmune mechanisms of depression
Hodes, G. E., Kana, V., Menard, C., Merad, M., & Russo, S. J. (2015) · Nature Neuroscience · doi:10.1038/nn.4113 · Cited by 585 · see citing works
Self-citationThe inflammasome: Pathways linking psychological stress, depression, and systemic illnesses
Iwata, M., Ota, K. T., & Duman, R. S. (2013) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2012.12.008 · Cited by 580 · see citing works
Association of depression with medical illness: Does cortisol play a role?
Brown, E. S., Varghese, F. P., & McEwen, B. S. (2004) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00473-6 · Cited by 578 · see citing works
Frank, M. G., Baratta, M. V., Sprunger, D. B., Watkins, L. R., & Maier, S. F. (2007) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2006.03.005 · Cited by 578 · see citing works
Wohleb, E. S., Powell, N. D., Godbout, J. P., & Sheridan, J. F. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.1671-13.2013 · Cited by 563 · see citing works
Miller, G. E., Chen, E., Sze, J., Marin, T., Arevalo, J. M. G., Doll, R., Ma, R., & Cole, S. W. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.03.017 · Cited by 552 · see citing works
Epidemiology of comorbid coronary artery disease and depression
Rudisch, B. E., & Nemeroff, C. B. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00587-0 · Cited by 549 · see citing works
Torres-Platas, S. G., Cruceanu, C., Chen, G. G., Turecki, G., & Mechawar, N. (2014) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2014.05.007 · Cited by 545 · see citing works
Galea, L. A. M., McEwen, B. S., Tanapat, P., Deak, T., Spencer, R. L., & Dhabhar, F. S. (1997) · Neuroscience · doi:10.1016/s0306-4522(97)00233-9 · Cited by 540 · see citing works
Tynan, R. J., Naicker, S., Hinwood, M., Nalivaiko, E., Buller, K. M., Pow, D. V., Day, T. A., & Walker, F. R. (2010) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2010.02.001 · Cited by 531 · see citing works
Microglia Are Essential to Masculinization of Brain and Behavior
Lenz, K. M., Nugent, B. M., Haliyur, R., & McCarthy, M. M. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.1268-12.2013 · Cited by 526 · see citing works
The incidence and prevalence of psychiatric disorders in multiple sclerosis: A systematic review
Marrie, R. A., Reingold, S., Cohen, J., Stuve, O., Trojano, M., Sorensen, P. S., Cutter, G., & Reider, N. (2015) · Multiple Sclerosis Journal · doi:10.1177/1352458514564487 · Cited by 519 · see citing works
Lower CSF oxytocin concentrations in women with a history of childhood abuse
Heim, C., Young, L. J., Newport, D. J., Mletzko, T., Miller, A. H., & Nemeroff, C. B. (2009) · Molecular Psychiatry · doi:10.1038/mp.2008.112 · Cited by 518 · see citing works
Depression in HIV Infected Patients: a Review
Nanni, M. G., Caruso, R., Mitchell, A. J., Meggiolaro, E., & Grassi, L. (2015) · Current Psychiatry Reports · doi:10.1007/s11920-014-0530-4 · Cited by 511 · see citing works
Inflammation and the Phenomenology, Pathophysiology, Comorbidity, and Treatment of Bipolar Disorder
Goldstein, B. I., Kemp, D. E., Soczynska, J. K., & McIntyre, R. S. (2009) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.08r04505 · Cited by 510 · see citing works
Layé, S., Parnet, P., Goujon, E., & Dantzer, R. (1994) · Molecular Brain Research · doi:10.1016/0169-328x(94)90197-x · Cited by 500 · see citing works
Penetration of interleukin-6 across the murine blood-brain barrier
Banks, W. A., Kastin, A. J., & Gutierrez, E. G. (1994) · Neuroscience Letters · doi:10.1016/0304-3940(94)90933-4 · Cited by 485 · see citing works
The prevalence of neuropsychiatric syndromes in systemic lupus erythematosus
Ainiala, H., Loukkola, J., Peltola, J., Korpela, M. M., & Hietaharju, A. (2001) · Neurology · doi:10.1212/wnl.57.3.496 · Cited by 485 · see citing works
Neural activity and the dynamics of central nervous system development
Hua, J. Y., & Smith, S. J. (2004) · Nature Neuroscience · doi:10.1038/nn1218 · Cited by 450 · see citing works
Psychiatric Complications of Long-term Interferon Alfa Therapy
Renault, P. F. (1987) · Archives of Internal Medicine · doi:10.1001/archinte.1987.00370090055011 · Cited by 413 · see citing works
Vulnerability research and the issue of primary prevention.
Garmezy, N. (1971) · American Journal of Orthopsychiatry · doi:10.1111/j.1939-0025.1971.tb01111.x · Cited by 410 · see citing works
Shechter, R., London, A., & Schwartz, M. (2013) · Nature reviews. Immunology · doi:10.1038/nri3391 · Cited by 399 · see citing works
Hodes, G. E., Pfau, M. L., Purushothaman, I., Ahn, H. F., Golden, S. A., Christoffel, D. J., Magida, J., Brancato, A., Takahashi, A., Flanigan, M. E., et al. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.1392-15.2015 · Cited by 395 · see citing works
Self-citationIwata, M., Ota, K. T., Li, X.-Y., Sakaue, F., Li, N., Dutheil, S., Banasr, M., Duric, V., Yamanashi, T., Kaneko, K., et al. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.11.026 · Cited by 387 · see citing works
Indicators of immune activation in major depression
Sluzewska, A., RYBAKOWSKI, J. K., Bosmans, E., Sobieska, M., Berghmans, R., Maes, M. H. J., & Wiktorowicz, K. (1996) · Psychiatry Research · doi:10.1016/s0165-1781(96)02783-7 · Cited by 384 · see citing works
Tynan, R. J., Weidenhofer, J., Hinwood, M., Cairns, M. J., Day, T. A., & Walker, F. R. (2012) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2011.12.011 · Cited by 382 · see citing works
Hanamsagar, R., & Bilbo, S. D. (2015) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2015.09.039 · Cited by 378 · see citing works
Allostasis, Homeostats, and the Nature of Stress
Goldstein, D. S., & McEwen, B. S. (2002) · Stress · doi:10.1080/102538902900012345 · Cited by 373 · see citing works
Black, C., & Miller, B. J. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.10.014 · Cited by 366 · see citing works
Interleukin-1 beta: a putative mediator of HPA axis hyperactivity in major depression?
(1993) · American Journal of Psychiatry · doi:10.1176/ajp.150.8.1189 · Cited by 364 · see citing works
Straub, R. H., Konecná, L., Hrach, S., Rothe, G., Kreutz, M. P., Schölmerich, J., Falk, W., & Lang, B. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.6.4876 · Cited by 352 · see citing works
Sica, A., Wang, J. M., Colotta, F., Dejana, E., Mantovani, A., Oppenheim, J. J., Larsen, C. G., Zachariae, C. O. C., & Matsushima, K. (1990) · The Journal of Immunology · doi:10.4049/jimmunol.144.8.3034 · Cited by 343 · see citing works
Induction of PGE2 by estradiol mediates developmental masculinization of sex behavior
Amateau, S. K., & McCarthy, M. M. (2004) · Nature Neuroscience · doi:10.1038/nn1254 · Cited by 340 · see citing works
Depression and immunity: A role for T cells?
Miller, A. H. (2009) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2009.09.009 · Cited by 340 · see citing works
Chen, E., Miller, G. E., Kobor, M. S., & Cole, S. W. (2011) · Molecular Psychiatry · doi:10.1038/mp.2010.53 · Cited by 340 · see citing works
Structural and synaptic plasticity in stress-related disorders
Christoffel, D. J., Golden, S. A., & Russo, S. J. (2011) · Reviews in the Neurosciences · doi:10.1515/rns.2011.044 · Cited by 334 · see citing works
Self-citationvan Dam, A.-M., Brouns, M., Louisse, S., & Berkenbosch, F. (1992) · Brain Research · doi:10.1016/0006-8993(92)91588-6 · Cited by 333 · see citing works
Multiple Roles for Astrocytes as Effectors of Cytokines and Inflammatory Mediators
Sofroniew, M. V. (2014) · The Neuroscientist · doi:10.1177/1073858413504466 · Cited by 333 · see citing works
Hinwood, M., Tynan, R. J., Charnley, J. L., Beynon, S. B., Day, T. A., & Walker, F. R. (2012) · Cerebral Cortex · doi:10.1093/cercor/bhs151 · Cited by 325 · see citing works
Plasma oxytocin levels and anxiety in patients with major depression
Scantamburlo, G., Hansenne, M., Fuchs, S., Pitchot, W., Maréchal, P., Péqueux, C., Ansseau, M., & Legros, J. J. (2007) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2007.01.009 · Cited by 325 · see citing works
Vogelzangs, N., Duivis, H. E., Beekman, A. T. F., Kluft, C., Neuteboom, J., Hoogendijk, W., Smit, J. H., de Jonge, P., & Penninx, B. W. J. H. (2012) · Translational Psychiatry · doi:10.1038/tp.2012.8 · Cited by 323 · see citing works
Social stress induces glucocorticoid resistance in subordinate animals
Avitsur, R., Stark, J. L., & Sheridan, J. F. (2001) · Hormones and Behavior · doi:10.1006/hbeh.2001.1653 · Cited by 321 · see citing works
Pro- and Anti-Inflammatory Cytokine Balance in Major Depression: Effect of Sertraline Therapy
Sutcigil, L., Oktenli, C., Musabak, U., Bozkurt, A., Cansever, A., Uzun, O., Sanisoglu, S. Y., Yesilova, Z., Ozmenler, N., Ozsahin, A., et al. (2007) · Clinical and Developmental Immunology · doi:10.1155/2007/76396 · Cited by 315 · see citing works
EARLY INTERVENTIONS FOR PTSD: A REVIEW: Review: Early Intervention
Kearns, M. C., Ressler, K. J., Zatzick, D., & Rothbaum, B. O. (2012) · Depression and Anxiety · doi:10.1002/da.21997 · Cited by 310 · see citing works
Interleukin‐6 Serum Levels in Depressed Patients before and after Treatment with Fluoxetine
Sluzewska, A., RYBAKOWSKI, J. K., Łaciak, M., Mackiewicz, A., Sobieska, M., & WIKTOROWICV, K. (1995) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1995.tb32372.x · Cited by 306 · see citing works
Maes, M. H. J., Kubera, M., Obuchowiczwa, E., Goehler, L. E., & Brzeszcz, J. (2011) · PubMed · Cited by 303 · see citing works
Mikovа, O. E., Yakimova, R., Bosmans, E., Kenis, G., & Maes, M. H. J. (2001) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(01)00081-5 · Cited by 299 · see citing works
Social stress induces glucocorticoid resistance in macrophages
Stark, J. L., Avitsur, R., Padgett, D. A., Campbell, K. A., Beck, F. M., & Sheridan, J. F. (2001) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2001.280.6.r1799 · Cited by 295 · see citing works
Astrogliosis in CNS Pathologies: Is There A Role for Microglia?
Zhang, D., Hu, X., Li, Q., O'Callaghan, J. P., & Hong, J. (2010) · Molecular Neurobiology · doi:10.1007/s12035-010-8098-4 · Cited by 295 · see citing works
Warner-Schmidt, J. L., Vanover, K. E., Chen, E. Y., Marshall, J. J., & Greengard, P. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1104836108 · Cited by 291 · see citing works
Pro-inflammatory cytokines and treatment response to escitaloprsam in major depressive disorder
Eller, T., Vasar, V., Shlik, J., & Maron, E. (2008) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2007.09.015 · Cited by 290 · see citing works
A detailed examination of cytokine abnormalities in Major Depressive Disorder
Simon, N. M., McNamara, K., Chow, C. W., Maser, R. S., Papakostas, G. I., Pollack, M. H., Nierenberg, A. A., Fava, M., & Wong, K. K. (2008) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2007.06.004 · Cited by 286 · see citing works
A Starring Role for Microglia in Brain Sex Differences
Lenz, K. M., & McCarthy, M. M. (2015) · The Neuroscientist · doi:10.1177/1073858414536468 · Cited by 281 · see citing works
Moieni, M., Irwin, M. R., Jevtic, I., Olmstead, R., Breen, E. C., & Eisenberger, N. I. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.17 · Cited by 273 · see citing works
Release of cytokines by brain endothelial cells: A polarized response to lipopolysaccharide
Verma, S., Nakaoke, R., Dohgu, S., & Banks, W. A. (2005) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2005.10.005 · Cited by 267 · see citing works
IκB Kinase Regulates Social Defeat Stress-Induced Synaptic and Behavioral Plasticity
Christoffel, D. J., Golden, S. A., Dumitriu, D., Robison, A. J., Janssen, W. G., Ahn, H. F., Krishnan, V., Reyes, C. M., Han, M.-H., Ables, J. L., et al. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.4763-10.2011 · Cited by 267 · see citing works
Self-citationWeiss, J. M., Nath, A., Major, E. O., & Berman, J. W. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.5.2953 · Cited by 265 · see citing works
Clinical depression and regulation of the inflammatory response during acute stress
Miller, G. E., Rohleder, N., Stetler, C., & Kirschbaum, C. (2005) · Psychosomatic Medicine · doi:10.1097/01.psy.0000174172.82428.ce · Cited by 253 · see citing works
McEwen, B. S., Gray, J. D., & Nasca, C. (2015) · Journal of Endocrinology · doi:10.1530/joe-15-0121 · Cited by 253 · see citing works
Hellwig, S., Brioschi, S., Dieni, S., Frings, L., Masuch, A., Blank, T., & Biber, K. (2016) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2015.11.008 · Cited by 252 · see citing works
Quan, N., Stern, E. L., Whiteside, M. B., & Herkenham, M. (1999) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(98)00193-3 · Cited by 251 · see citing works
Grippo, A. J., Trahanas, D. M., Zimmerman, R. R., Porges, S. W., & Carter, C. S. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.05.017 · Cited by 240 · see citing works
Low cortisol, high DHEA, and high levels of stimulated TNF‐α, and IL‐6 in women with PTSD
Gill, J., Vythilingam, M., & Page, G. G. (2008) · Journal of Traumatic Stress · doi:10.1002/jts.20372 · Cited by 240 · see citing works
Plasma and Cerebrospinal Fluid Interleukin-6 Concentrations in Posttraumatic Stress Disorder
Baker, D. G., Ekhator, N. N., Kasckow, J. W., Hill, K. K., Zoumakis, E., Dashevsky, B. A., Chrousos, G. P., & Geracioti Jr., T. D. (2001) · Neuroimmunomodulation · doi:10.1159/000049028 · Cited by 238 · see citing works
Frank, M. G., Weber, M. D., Watkins, L. R., & Maier, S. F. (2015) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2015.03.010 · Cited by 237 · see citing works
Peripheral biomarkers and illness activity in bipolar disorder
Kapczinski, F. P., Dal‐Pizzol, F., Teixeira, A. L., Magalhães, P. V. D. S., Kauer‐Sant’Anna, M., Klamt, F., Moreira, J. C. F., Pasquali, M. A. D. B., Fries, G. R., Quevedo, J., et al. (2010) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2010.05.015 · Cited by 236 · see citing works
Panenka, W. J., Jijon, H. B., Herx, L., Armstrong, J. N., Feighan, D., Wei, T., Yong, V. W., Ransohoff, R. M., & MacVicar, B. A. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-18-07135.2001 · Cited by 233 · see citing works
The innate immune system, toll-like receptors and dermal wound healing: A review
Portou, M. J., Baker, D., Abraham, D., & Tsui, J. C. S. (2015) · Vascular Pharmacology · doi:10.1016/j.vph.2015.02.007 · Cited by 233 · see citing works
Neuroendocrine and cytokine profile of chronic mild stress-induced anhedonia
Grippo, A. J., Francis, J., Beltz, T. G., Felder, R. B., & Johnson, A. K. (2005) · Physiology & Behavior · doi:10.1016/j.physbeh.2005.02.011 · Cited by 233 · see citing works
Depression in Alzheimer’s disease: heterogeneity and related issues
Lee, H. B., & Lyketsos, C. G. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00543-2 · Cited by 230 · see citing works
Hamby, M. E., Coppola, G., Ao, Y., Geschwind, D. H., Khakh, B. S., & Sofroniew, M. V. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.1256-12.2012 · Cited by 228 · see citing works
Kim, Y.-K., Suh, I.-B., Kim, H., Han, C.-S., Lim, C.-S., Choi, S.-H., & Licinio, J. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001084 · Cited by 224 · see citing works
Ketamine and Peripheral Inflammation
Kock, M. D., Loix, S., & Lavand'homme, P. M. (2013) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12104 · Cited by 224 · see citing works
IL-6 levels decrease with SSRI treatment in patients with major depression
Başterzi, A. D., Aydemir, Ç., Kısa, C., Aksaray, S., Tüzer, V., Yazıcı, K., & Göka, E. (2005) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.717 · Cited by 219 · see citing works
Bollinger, J. L., Burns, C. M. B., & Wellman, C. L. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.10.003 · Cited by 216 · see citing works
Learned helplessness: Validity and reliability of depressive-like states in mice
Chourbaji, S., Zacher, C., Sanchis-Segura, C., Dormann, C., Vollmayr, B., & Gass, P. (2005) · Brain Research Protocols · doi:10.1016/j.brainresprot.2005.09.002 · Cited by 216 · see citing works
P2Y1 Receptor-evoked Glutamate Exocytosis from Astrocytes
Domercq, M., Brambilla, L., Pilati, E., Marchaland, J., Volterra, A., & Bezzi, P. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m606429200 · Cited by 215 · see citing works
Acute phase proteins in major depression
Berk, M., Wadee, A. A., Kuschke, R. H., & O’Neill-Kerr, A. (1997) · Journal of Psychosomatic Research · doi:10.1016/s0022-3999(97)00139-6 · Cited by 215 · see citing works
Transcriptional modulation of the developing immune system by early life social adversity
Cole, S. W., Conti, G., Arevalo, J. M. G., Ruggiero, A. M., Heckman, J. J., & Suomi, S. J. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1218253109 · Cited by 207 · see citing works
Oxytocin acts as an antidepressant in two animal models of depression
Arletti, R., & Bertolini, A. (1987) · Life Sciences · doi:10.1016/0024-3205(87)90600-x · Cited by 203 · see citing works
CNS-specific T cells shape brain function via the choroid plexus
Baruch, K., & Schwartz, M. (2013) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2013.04.002 · Cited by 195 · see citing works
Do chemokines mediate leukocyte recruitment in post-traumatic CNS inflammation?
Ransohoff, R. M., & Tani, M. (1998) · Trends in Neurosciences · doi:10.1016/s0166-2236(97)01198-3 · Cited by 193 · see citing works
Using patient self-reports to study heterogeneity of treatment effects in major depressive disorder
Kessler, R. C., van Loo, H. M., Wardenaar, K. J., Bossarte, R. M., Brenner, L. A., Ebert, D. D., de Jonge, P., Nierenberg, A. A., Rosellini, A. J., Sampson, N. A., et al. (2016) · Epidemiology and Psychiatric Sciences · doi:10.1017/s2045796016000020 · Cited by 193 · see citing works
Leukocytosis, monocytosis and neutrophilia: Hallmarks of severe depression
Maes, M., Van Der Planken, M., Stevens, W. J., Peeters, D., DeClerck, L. S., Bridts, C. H., Schotte, C., & Cosyns, P. (1992) · Journal of Psychiatric Research · doi:10.1016/0022-3956(92)90004-8 · Cited by 186 · see citing works
Meeuwsen, S., Persoon‐Deen, C., Bsibsi, M., Ravid, R., & Noort, J. M. V. (2003) · Glia · doi:10.1002/glia.10259 · Cited by 185 · see citing works
Depression and Cognition in the Elderly
Wang, S., & Blazer, D. G. (2015) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-032814-112828 · Cited by 181 · see citing works
Maier, S. F., & Watkins, L. R. (1995) · Brain Research · doi:10.1016/0006-8993(95)00930-o · Cited by 178 · see citing works
Oxytocin alleviates the neuroendocrine and cytokine response to bacterial endotoxin in healthy men
Clodi, M., Vila, G., Geyeregger, R., Riedl, M., Stulnig, T. M., Struck, J., Luger, T. A., & Luger, A. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90263.2008 · Cited by 176 · see citing works
Cohen, H., Ziv, Y., Cardon, M., Kaplan, Z., Matar, M. A., Gidron, Y., Schwartz, M., & Kipnis, J. (2006) · Journal of Neurobiology · doi:10.1002/neu.20249 · Cited by 173 · see citing works
Schelling, G., Roozendaal, B., Krauseneck, T., Schmoelz, M., de Quervain, D. J. ‐., & Briegel, J. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1364.005 · Cited by 173 · see citing works
Making room for oxytocin in understanding depression
McQuaid, R. J., McInnis, O. A., Abizaid, A. B., & Anisman, H. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.07.005 · Cited by 172 · see citing works
Peripheral and central mechanisms of stress resilience
Pfau, M. L., & Russo, S. J. (2015) · Neurobiology of Stress · doi:10.1016/j.ynstr.2014.09.004 · Cited by 170 · see citing works
Self-citationÖzsoy, S., Eşel, E., & Kula, M. (2009) · Psychiatry Research · doi:10.1016/j.psychres.2008.06.034 · Cited by 168 · see citing works
Amsterdam, A., Tajima, K., & Sasson, R. (2002) · Biochemical Pharmacology · doi:10.1016/s0006-2952(02)01147-4 · Cited by 167 · see citing works
Raised levels of plasma interleukin‐1β in major and postviral depression
Owen, B. M., ECCLESTON, D., Ferrier, I. N., & Young, H. (2001) · Acta Psychiatrica Scandinavica · doi:10.1034/j.1600-0447.2001.00162.x · Cited by 165 · see citing works
Preliminary evidence that plasma oxytocin levels are elevated in major depression
Parker, K. J., Kenna, H. A., Zeitzer, J. M., Keller, J., Blasey, C. M., Amico, J. A., & Schatzberg, A. F. (2010) · Psychiatry Research · doi:10.1016/j.psychres.2009.09.017 · Cited by 163 · see citing works
Prevalence and treatment of depression in Parkinson's disease
Veazey, C., Ozlem Erden Aki, S., Cook, K. F., Lai, E. C., & Kunik, M. E. (2005) · The Journal of Neuropsychiatry and Clinical Neurosciences · doi:10.1176/jnp.17.3.310 · Cited by 162 · see citing works
Stress-induced glucocorticoids as a neuroendocrine alarm signal of danger
Frank, M. G., Watkins, L. R., & Maier, S. F. (2013) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2013.02.004 · Cited by 160 · see citing works
Role of fear in mediating shuttle escape learning deficit produced by inescapable shock.
Maier, S. F. (1990) · Journal of Experimental Psychology Animal Behavior Processes · doi:10.1037/0097-7403.16.2.137 · Cited by 158 · see citing works
Kitraki, E., Kremmyda, O., Youlatos, D., Alexis, Μ. N., & Kittas, C. N. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2003.12.024 · Cited by 156 · see citing works
Clinical correlates of DHEA associated with post‐traumatic stress disorder
Yehuda, R., Brand, S. R., Golier, J. A., & Yang, R. ‐. (2006) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2006.00801.x · Cited by 155 · see citing works
Depressive symptoms enhance stress-induced inflammatory responses.
Fagundes, C. P., Glaser, R., Hwang, B. S., Malarkey, W. B., & Kiecolt-Glaser, J. K. (2013) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2012.05.006 · Cited by 151 · see citing works
The role of IL-12 and TGF-β1 in the pathophysiology of major depressive disorder
Lee, K.-M., & Kim, Y.-K. (2006) · International Immunopharmacology · doi:10.1016/j.intimp.2006.03.015 · Cited by 150 · see citing works
Increased serum interleukin-1-receptor-antagonist concentrations in major depression
Maes, M. H. J., Vandoolaeghe, E., Ranjan, R., Bosmans, E., Bergmans, R., & Desnyder, R. (1995) · Journal of Affective Disorders · doi:10.1016/0165-0327(95)00049-6 · Cited by 149 · see citing works
Comorbidity between depression and asthma via immune-inflammatory pathways: a meta-analysis
Jiang, M., Qin, P., & Yang, X. (2014) · Journal of Affective Disorders · doi:10.1016/j.jad.2014.04.027 · Cited by 146 · see citing works
Major depressive disorder and disease activity in systemic lupus erythematosus
Nery, F. G., Borba, E. F., Hatch, J. P., Soares, J. C., Bonfá, E., & Neto, F. L. (2006) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2006.04.002 · Cited by 146 · see citing works
The Neuroendocrinology of Posttraumatic Stress Disorder: New Directions
Rasmusson, A. M., Vythilingam, M., & Morgan, C. A. (2003) · CNS Spectrums · doi:10.1017/s1092852900008841 · Cited by 144 · see citing works
Tumor necrosis factor inhibitors: clinical utility in autoimmune diseases
Willrich, M. A. V., Murray, D. L., & Snyder, M. R. (2014) · Translational research · doi:10.1016/j.trsl.2014.09.006 · Cited by 143 · see citing works
Hernández, M. E., Mendieta, D., Martínez-Fong, D., Loría, F., Moreno, J., Estrada, I., Bojalil, R., & Pavón, L. (2008) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2008.08.001 · Cited by 140 · see citing works
Antidepressive treatments for Parkinson's disease: A systematic review and meta-analysis
Bomasang-Layno, E., Fadlon, I., Murray, A. N., & Himelhoch, S. S. (2015) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2015.04.018 · Cited by 139 · see citing works
The interface of depression and cardiovascular disease: therapeutic implications
Seligman, F., & Nemeroff, C. B. (2015) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12738 · Cited by 139 · see citing works
Lymphocytes from Chronically Stressed Mice Confer Antidepressant-Like Effects to Naive Mice
Brachman, R. A., Lehmann, M. L., Maric, D., & Herkenham, M. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.2278-14.2015 · Cited by 130 · see citing works
Mood disorders: cardiovascular and diabetes comorbidity
Fenton, W. S., & Stover, E. S. (2006) · Current Opinion in Psychiatry · doi:10.1097/01.yco.0000228765.33356.9f · Cited by 128 · see citing works
Stimulatory effect of antidepressants on the production of IL-6
Kubera, M., Kenis, G., Bosmans, E., Kajta, M., Basta-Kaim, A., Scharpe, S., Budziszewska, B., & Maes, M. (2004) · International Immunopharmacology · doi:10.1016/j.intimp.2003.11.006 · Cited by 126 · see citing works
Social stress and the regulation of tumor necrosis factor-α secretion
Avitsur, R., Kavelaars, A., Heijnen, C. J., & Sheridan, J. F. (2004) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2004.09.005 · Cited by 124 · see citing works
Development of microglia in the postnatal rat hippocampus
Dalmau, I., Finsen, B. R., Zimmer, J., Gonz�lez, B., & Castellano, B. (1998) · Hippocampus · doi:10.1002/(sici)1098-1063(1998)8:5 · Cited by 124 · see citing works
Opacka‐Juffry, J., & Mohiyeddini, C. (2011) · Stress · doi:10.3109/10253890.2011.560309 · Cited by 122 · see citing works
A critical review of the efficacy of non-steroidal anti-inflammatory drugs in depression
Eyre, H. A., Air, T., Proctor, S. J., Rositano, S., & Baune, B. T. (2014) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2014.10.003 · Cited by 121 · see citing works
Immunologic variables in acute mania of bipolar disorder
Liu, H., Yang, Y., Chou, Y.-M., Chen, K.-P., Shen, W. W., & Leu, S. (2004) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2004.01.006 · Cited by 118 · see citing works
Jazayeri, S., Keshavarz, S. A., Tehrani-Doost, M., Djalali, M., Hosseini, M., Amini, H., Chamari, M., & Djazayery, A. (2010) · Psychiatry Research · doi:10.1016/j.psychres.2009.04.013 · Cited by 116 · see citing works
Impact of antidepressants on cytokine production of depressed patients in Vitro
Munzer, A., Sack, U., Mergl, R., Schönherr, J., Petersein, C., Bartsch, S., Kirkby, K., Bauer, K., & Himmerich, H. (2013) · Toxins · doi:10.3390/toxins5112227 · Cited by 114 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Social stress induces neurovascular pathology promoting depression
Menard, C., Pfau, M. L., Hodes, G. E., Kana, V., Wang, V. X., Bouchard, S., Takahashi, A., Flanigan, M. E., Aleyasin, H., LeClair, K. B., et al. (2017) · Nature Neuroscience · doi:10.1038/s41593-017-0010-3 · Cited by 1,028 · see citing works
Self-citationAntoniuk, S., Bijata, M., Ponimaskin, E., & Wlodarczyk, J. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.12.002 · Cited by 750 · see citing works
Sex Differences in Vulnerability and Resilience to Stress Across the Life Span
Hodes, G. E., & Epperson, C. N. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.04.028 · Cited by 417 · see citing works
Self-citationAgorastos, A., Pervanidou, P., Chrousos, G. P., & Baker, D. G. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00118 · Cited by 385 · see citing works
“neurobiological and neuroendocrine responses (160).”
NLRP3 inflammasome-driven pathways in depression: clinical and preclinical findings
Kaufmann, F. N., Costa, A. P., Ghisleni, G., Diaz, A. P., Rodrigues, A. L. S., Peluffo, H., & Kaster, M. P. (2017) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2017.03.002 · Cited by 370 · see citing works
Molecular adaptations of the blood–brain barrier promote stress resilience vs. depression
Dudek, K. A., Dion-Albert, L., Lebel, M., LeClair, K., Labrecque, S., Tuck, E., Ferrer Perez, C., Golden, S. A., Tamminga, C., Turecki, G., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1914655117 · Cited by 361 · see citing works
Self-citationBreath of Life: The Respiratory Vagal Stimulation Model of Contemplative Activity
Gerritsen, R. J. S., & Band, G. P. H. (2018) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2018.00397 · Cited by 342 · see citing works
IL4-driven microglia modulate stress resilience through BDNF-dependent neurogenesis
Zhang, J., Rong, P., Zhang, L., He, H., Zhou, T., Fan, Y., Mo, L., Zhao, Q., Han, Y., Li, S., et al. (2021) · Science Advances · doi:10.1126/sciadv.abb9888 · Cited by 287 · see citing works
Yuan, M., Yang, B., Rothschild, G., Mann, J. J., Sanford, L. D., Tang, X., Huang, C., Wang, C., & Zhang, W. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01519-z · Cited by 246 · see citing works
Molecular links between endocrine, nervous and immune system during chronic stress
Zefferino, R., Di Gioia, S., & Conese, M. (2021) · Brain and Behavior · doi:10.1002/brb3.1960 · Cited by 204 · see citing works
A meta-analysis of cytokine concentrations in eating disorders
Dalton, B., Bartholdy, S., Robinson, L., Solmi, M., Ibrahim, M. A. A., Breen, G., Schmidt, U., & Himmerich, H. (2018) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2018.06.002 · Cited by 197 · see citing works
Kraynak, T. E., Marsland, A. L., Wager, T. D., & Gianaros, P. J. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.07.013 · Cited by 165 · see citing works
Microglia: A Central Player in Depression
Deng, S.-L., Chen, J.-G., & Wang, F. (2020) · Current Medical Science · doi:10.1007/s11596-020-2193-1 · Cited by 119 · see citing works
Salami, M. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.613120 · Cited by 67 · see citing works
Zhang, K., Sakamoto, A., Chang, L., Qu, Y., Wang, S., Pu, Y., Tan, Y., Wang, X., Fujita, Y., Ishima, T., et al. (2021) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-019-01092-z · Cited by 63 · see citing works
The Molecular Basis of Resilience: A Narrative Review
Ryan, M., & Ryznar, R. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.856998 · Cited by 65 · see citing works
Verhaegen, A. A., & Van Gaal, L. F. (2021) · Current Obesity Reports · doi:10.1007/s13679-020-00419-5 · Cited by 53 · see citing works
He, M.-C., Shi, Z., Sha, N.-N., Chen, N., Peng, S.-Y., Liao, D.-F., Wong, M.-S., Dong, X.-L., Wang, Y.-J., Yuan, T.-F., et al. (2019) · Biochemical Pharmacology · doi:10.1016/j.bcp.2019.01.021 · Cited by 54 · see citing works
Inflamed brain: Targeting immune changes and inflammation for treatment of depression
Sakamoto, S., Zhu, X., Hasegawa, Y., Karma, S., Obayashi, M., Alway, E., & Kamiya, A. (2021) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.13286 · Cited by 51 · see citing works
Role of Monocyte-Derived MicroRNA106b∼25 in Resilience to Social Stress
Pfau, M. L., Menard, C., Cathomas, F., Desland, F., Kana, V., Chan, K. L., Shimo, Y., LeClair, K., Flanigan, M. E., Aleyasin, H., et al. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.02.023 · Cited by 46 · see citing works
Self-citationBeerse, M. E., Van Lith, T., Pickett, S. M., & Stanwood, G. D. (2020) · Experimental Biology and Medicine · doi:10.1177/1535370219883634 · Cited by 45 · see citing works
Feng, M., Crowley, N. A., Patel, A., Guo, Y., Bugni, S. E., & Luscher, B. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2019.03.003 · Cited by 20 · see citing works
Koureta, A., Asimakopoulos, L. O., Bozikas, V. P., & Agorastos, A. (2023) · Brain Sciences · doi:10.3390/brainsci13030448 · Cited by 12 · see citing works
Food addiction and its associations to trauma, severity of illness, and comorbidity
Brewerton, T. D. (2019) · Compulsive Eating Behavior and Food Addiction · doi:10.1016/b978-0-12-816207-1.00015-9 · Cited by 6 · see citing works
Hypothalamic–pituitary–adrenal axis and stress
(2020) · Handbook of Clinical Neurology · doi:10.1016/b978-0-444-64123-6.00004-7 · Cited by 279 · see citing works
- Authors
- Ménard, C., Pfau, M. L., Hodes, G. E., & Russo, S. J.
- Affiliations
- Icahn School of Medicine at Mount Sinai (US)
- Corresponding author
- Russo, Scott J
- Venue
- Neuropsychopharmacology
- Published
- 2016-06-13
- Volume
- 42
- Issue
- 1
- Pages
- 62-80
- ISSN
- 0893-133X (ISSN-L)
- 1740-634X
- PMC
- PMC5143517
- OpenAlex
- W2443768325
- Cited by
- 374
- References
- 249
- Citations by year
- 2026: 27 · 2025: 30 · 2024: 50 · 2023: 32 · 2022: 55 · 2021: 60 · 2020: 41 · 2019: 35 · 2018: 28 · 2017: 13 · 2016: 3
- FWCI
- 1.63
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Neuropsychopharmacology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Office of Dietary Supplements (AT008661-01, P50 AT008661-01)
- National Institutes of Health (P50-AT008661-01)
- National Institute of Mental Health (R01MH090264, P50MH096890, T32MH096678, R01MH104559, T32MH087004)
- National Center for Complementary and Integrative Health (P50AT008661, AT008661-01, AT008661)
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- major depressive disorder, stress vulnerability, stress resilience, neuroinflammation, inflammatory cytokines, microglial activation, monocyte infiltration, hypothalamic-pituitary-adrenal axis, glucocorticoids, anti-cytokine antibodies, immunomodulators, antidepressant resistance, psychiatric biomarkers, chronic inflammation
- MeSH terms
- Humans, Hypothalamo-Hypophyseal System, Inflammation, Monocytes, Pituitary-Adrenal System, Stress, Psychological, Cytokines, Microglia, Mood Disorders
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
