The DOI matches its Crossref record; 180 of the 180 references it cites were found in a registry or an index.
Central Nervous System Damage, Monocytes and Macrophages, and Neurological Disorders in AIDS
Abstract
▪ Abstract This review focuses on the role of the extended macrophage/monocyte family in the central nervous system during HIV or SIV infection. The accumulated data, buttressed by recent experimental results, suggest that these cells play a central, pathogenic role in retroviral-associated CNS disease. While the immune system is able to combat the underlying retroviral infection, the accumulation and widespread activation of macrophages, microglia, and perivascular cells in the CNS are held in check. However, with the collapse of the immune system and the disappearance of the CD4+T cell population, productive infection reemerges, especially in CNS macrophages. These cells, as well as noninfected macrophages, are stimulated to high levels of activation. When members of this cell group become highly activated, they elaborate a wide spectrum of deleterious substances into the neural parenchyma. In the final phases of HIV or SIV infection, this chronic, widespread, and dramatic level of macrophage/monocyte/microglial activation constitutes a self-sustaining state of macrophage dysregulation, which results in pathological alterations and the emergence of various neurological problems.
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Cites
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Cited by
Role of Microglia in Central Nervous System Infections
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Breaking down the barrier: The effects of HIV-1 on the blood–brain barrier
Strazza, M., Pirrone, V., Wigdahl, B., & Nonnemacher, M. R. (2011) · Brain Research · doi:10.1016/j.brainres.2011.05.015 · Cited by 218
Metadata
- Authors
- Williams, K. C., & Hickey, W. F.
- Venue
- Annual Review of Neuroscience
- Publisher
- Annual Reviews
- Published
- 2002-03
- Volume
- 25
- Issue
- 1
- Pages
- 537-562
- ISSN
- 0147-006X (ISSN-L)
- 1545-4126
- OpenAlex
- W2103348038
- Cited by
- 309
- References
- 180
- FWCI
- 1.49
- Type
- journal article
- Language
- en
- Open access
- closed
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- Williams, K. C., & Hickey, W. F. (2002). Central Nervous System Damage, Monocytes and Macrophages, and Neurological Disorders in AIDS. Annual Review of Neuroscience. https://doi.org/10.1146/annurev.neuro.25.112701.142822
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
