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Cited by 287

The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.

Latent Murine γ-Herpesvirus Infection Is Established in Activated B Cells, Dendritic Cells, and Macrophages

Flaño, Emilio, Husain, S Mazher, Sample, Jeffery T, Woodland, David L, Blackman, Marcia A·2000·The Journal of Immunology
DOI 10.4049/jimmunol.165.2.1074
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Abstract

Intranasal infection of mice with the murine γ-herpesvirus MHV-68 results in an acute lytic infection in the lung, followed by the establishment of lifelong latency. Development of an infectious mononucleosis-like syndrome correlates with the establishment of latency and is characterized by splenomegaly and the appearance of activated CD8+ T cells in the peripheral blood. Interestingly, a large population of activated CD8+ T cells in the peripheral blood expresses the Vβ4+ element in their TCR. In this report we show that MHV-68 latency in the spleen after intranasal infection is harbored in three APC types: B cells, macrophages, and dendritic cells. Surprisingly, since latency has not previously been described in dendritic cells, these cells harbored the highest frequency of latent virus. Among B cells, latency was preferentially associated with activated B cells expressing the phenotype of germinal center B cells, thus formally linking the previously reported association of latency gene expression and germinal centers to germinal center B cells. Germinal center formation, however, was not required for the establishment of latency. Significantly, although three cell types were latently infected, the ability to stimulate Vβ4+CD8+ T cell hybridomas was limited to latently infected, activated B cells.

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Metadata

Authors
Flaño, E., Husain, S. M., Sample, J. T., Woodland, D. L., & Blackman, M. A.
Venue
The Journal of Immunology
Publisher
Oxford University Press (OUP)
Published
2000-07
Volume
165
Issue
2
Pages
1074-1081
ISSN
  • 0022-1767 (ISSN-L)
  • 1550-6606
DOI
10.4049/jimmunol.165.2.1074
OpenAlex
W2111368862
Cited by
287
References
35
FWCI
7.16
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Latent Murine γ-Herpesvirus Infection Is Established in Activated B Cells, Dendritic Cells, and Macrophages. https://app.cochat.ai/papers/10.4049/jimmunol.165.2.1074
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Flaño, E., Husain, S. M., Sample, J. T., Woodland, D. L., & Blackman, M. A. (2000). Latent Murine γ-Herpesvirus Infection Is Established in Activated B Cells, Dendritic Cells, and Macrophages. The Journal of Immunology. https://doi.org/10.4049/jimmunol.165.2.1074

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.