The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Cutting Edge: DC-SIGN; a Related Gene, DC-SIGNR; and CD23 Form a Cluster on 19p13
Abstract
DC-SIGN is a C-type lectin, expressed on a dendritic cell subset. It is able to bind ICAM3 and HIV gp120 in a calcium-dependent manner. Here we report the genomic organization of DC-SIGN and map it to chromosome 19p13 adjacent to the C-type lectin CD23 (FcεRII). We also report a novel, closely linked gene, DC-SIGNR, which shows 73% identity to DC-SIGN at the nucleic acid level and a similar genomic organization. Proteins encoded by both genes have tracts of repeats of 23 aa, predicted to form a coiled coil neck region. They also possess motifs that are known to bind mannose in a calcium-dependent fashion. We show concomitant expression of the two genes in endometrium, placenta, and stimulated KG1 cells (phenotypically similar to monocyte-derived dendritic cells). The existence of a DC-SIGN-related gene calls for reinterpretation of the HIV data to consider possible DC-SIGN/DC-SIGNR hetero-oligomerization.
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Cites
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Cited by
C-type lectin receptors on dendritic cells and langerhans cells
Figdor, C. G., van Kooyk, Y., & Adema, G. J. (2002) · Nature Reviews Immunology · doi:10.1038/nri723 · Cited by 842
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Structural Basis for Selective Recognition of Oligosaccharides by DC-SIGN and DC-SIGNR
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A Novel Mechanism of Carbohydrate Recognition by the C-type Lectins DC-SIGN and DC-SIGNR
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Bashirova, A. A., Geijtenbeek, T. B. H., van Duijnhoven, G. C. F., van Vliet, S. J., Eilering, J. B. G., Martin, M. P., Wu, L., Martin, T. D., Viebig, N., Knolle, P. A., et al. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.193.6.671 · Cited by 358
Metadata
- Authors
- Soilleux, E. J., Barten, R., & Trowsdale, J.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2000-09
- Volume
- 165
- Issue
- 6
- Pages
- 2937-2942
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1563926425
- Cited by
- 258
- References
- 27
- FWCI
- 7.31
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Cutting Edge: DC-SIGN; a Related Gene, DC-SIGNR; and CD23 Form a Cluster on 19p13. https://app.cochat.ai/papers/10.4049/jimmunol.165.6.2937
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- Soilleux, E. J., Barten, R., & Trowsdale, J. (2000). Cutting Edge: DC-SIGN; a Related Gene, DC-SIGNR; and CD23 Form a Cluster on 19p13. The Journal of Immunology. https://doi.org/10.4049/jimmunol.165.6.2937
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