The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
A Subset of Human Dendritic Cells Expresses IgA Fc Receptor (CD89), Which Mediates Internalization and Activation Upon Cross-Linking by IgA Complexes
Abstract
Immature dendritic cells (DC) sample Ags within nonlymphoid tissues and acquire exogenous proteins/pathogens via scavenger receptors or Ig FcR such as FcγR and FcεR. IgA is present in a significant proportion among serum Ig and is the main isotype in mucosae, where DC are numerous. We found that a functional FcαR (CD89) was expressed in situ and in vitro on interstitial-type DC but not on Langerhans cell-type DC. Interstitial-type DC expressed CD89 as a 50- to 75-kDa glycoprotein with a 32-kDa protein core, which was down-regulated upon addition of TGF-β1. DC, FcαR specifically, bound IgA1 and IgA2. Cross-linking of CD89 on DC triggered endocytosis in time-dependent manner. In addition, internalization of polymeric IgA complexes induced the production of IL-10 and DC activation, as reflected by up-regulation of CD86 costimulatory molecules, class II MHC expression, and increased allostimulatory activity. Therefore, interstitial-type DC may use FcαR-mediated Ag sampling in the subepithelium to check tissue integrity while Langerhans cells inside epithelial layers may neglect IgA immune complexes.
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Cites
Bieber, T., de la Salle, H., Wollenberg, A., Hakimi, J., Chizzonite, R., Ring, J., Hanau, D., & de la Salle, C. (1992) · The Journal of experimental medicine · doi:10.1084/jem.175.5.1285 · Cited by 481
Cited by
Antigen Presentation and T Cell Stimulation by Dendritic Cells
Guermonprez, P., Valladeau, J., Zitvogel, L., Théry, C., & Amigorena, S. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.100301.064828 · Cited by 1,926
Monteiro, R. C., & van de Winkel, J. G. J. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141011 · Cited by 531
Self-citationDendritic Cells: Immune Regulators in Health and Disease
Lipscomb, M. F., & Masten, B. J. (2002) · Physiological Reviews · doi:10.1152/physrev.00023.2001 · Cited by 465
Moura, I. C., Centelles, M. N., Arcos-Fajardo, M., Malheiros, D. M., Collawn, J. F., Cooper, M. D., & Monteiro, R. C. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.4.417 · Cited by 293
Self-citationTorres, J., Hu, J., Seki, A., Eisele, C., Nair, N., Huang, R., Tarassishin, L., Jharap, B., Cote-Daigneault, J., Mao, Q., et al. (2020) · Gut · doi:10.1136/gutjnl-2018-317855 · Cited by 218
Metadata
- Authors
- Geissmann, F., Launay, P., Pasquier, B., Lepelletier, Y., Leborgne, M., Lehuen, A., Brousse, N., & Monteiro, R. C.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2001-01-01
- Volume
- 166
- Issue
- 1
- Pages
- 346-352
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1942311877
- Cited by
- 165
- References
- 1
- FWCI
- 4.22
- Type
- journal article
- Language
- en
- Open access
- closed
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- The paper
- Geissmann, F., Launay, P., Pasquier, B., Lepelletier, Y., Leborgne, M., Lehuen, A., Brousse, N., & Monteiro, R. C. (2001). A Subset of Human Dendritic Cells Expresses IgA Fc Receptor (CD89), Which Mediates Internalization and Activation Upon Cross-Linking by IgA Complexes. The Journal of Immunology. https://doi.org/10.4049/jimmunol.166.1.346
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