The DOI matches its Crossref record; 63 of the 63 references it cites were found in a registry or an index.
Papillomavirus-Like Particles Induce Acute Activation of Dendritic Cells
Abstract
The role of viral structural proteins in the initiation of adaptive immune responses is poorly understood. To address this issue, we focused on the effect of noninfectious papillomavirus-like particles (VLPs) on dendritic cell (DC) activation. We found that murine bone marrow-derived dendritic cells (BMDCs) effectively bound and rapidly internalized bovine papillomavirus VLPs. Exposure to fully assembled VLPs of bovine papillomavirus, human papillomavirus (HPV)16 or HPV18, but not to predominately disordered HPV16 capsomers, induced acute phenotypic maturation of BMDCs. Structurally similar polyomavirus VLPs bound to the DC surface and were internalized, but failed to induce maturation. DCs that had incorporated HPV16 VLPs produced proinflammatory cytokines IL-6 and TNF-α; however, the release of these cytokines was delayed relative to LPS activation. Production of IL-12p70 by VLP-exposed DCs required the addition of syngeneic T cells or rIFN-γ. Finally, BMDCs pulsed with HPV16 VLPs induced Th1-dominated primary T cell responses in vitro. Our data provide evidence that DCs respond to intact papillomavirus capsids and that they play a central role in VLP-induced immunity. These results offer a mechanistic explanation for the striking ability of papillomavirus VLP-based vaccines to induce potent T and B cell responses even in the absence of adjuvant.
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Cites
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Cited by
Didierlaurent, A. M., Morel, S., Lockman, L., Giannini, S. L., Bisteau, M., Carlsen, H., Kielland, A., Vosters, O., Vanderheyde, N., Schiavetti, F., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0901474 · Cited by 758
Cancer Immunotherapy by Dendritic Cells
Melief, C. J. M. (2008) · Immunity · doi:10.1016/j.immuni.2008.08.004 · Cited by 508
Efficient Intracellular Assembly of Papillomaviral Vectors
Buck, C. B., Pastrana, D. V., Lowy, D. R., & Schiller, J. T. (2004) · Journal of Virology · doi:10.1128/jvi.78.2.751-757.2004 · Cited by 489
Self-citationTolstov, Y. L., Pastrana, D. V., Feng, H., Becker, J. C., Jenkins, F. J., Moschos, S., Chang, Y., Buck, C. B., & Moore, P. S. (2009) · International Journal of Cancer · doi:10.1002/ijc.24509 · Cited by 339
Current understanding of the mechanism of HPV infection
Schiller, J. T., Day, P. M., & Kines, R. C. (2010) · Gynecologic Oncology · doi:10.1016/j.ygyno.2010.04.004 · Cited by 332
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Metadata
- Authors
- Lenz, P., Day, P. M., Pang, Y.-Y. S., Frye, S. A., Jensen, P. N., Lowy, D. R., & Schiller, J. T.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2001-05-01
- Volume
- 166
- Issue
- 9
- Pages
- 5346-5355
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1518785179
- Cited by
- 252
- References
- 63
- FWCI
- 6.12
- Type
- journal article
- Language
- en
- Open access
- closed
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- Lenz, P., Day, P. M., Pang, Y.-Y. S., Frye, S. A., Jensen, P. N., Lowy, D. R., & Schiller, J. T. (2001). Papillomavirus-Like Particles Induce Acute Activation of Dendritic Cells. The Journal of Immunology. https://doi.org/10.4049/jimmunol.166.9.5346
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