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Cited by 991

The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.

Distinct dendritic cell subsets differentially regulate the class of immune response invivo

Open access
Pulendran, B., Smith, J. L., Caspary, G., Brasel, K., Pettit, D., Maraskovsky, E., Maliszewski, C. R.·1999·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.96.3.1036
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Abstract

Dendritic cells (DCs) are unique in their ability to stimulate T cells and initiate adaptive immunity. Injection of mice with the cytokine Flt3-ligand (FL) dramatically expands mature lymphoid and myeloid-related DC subsets. In contrast, injection of a polyethylene glycol-modified form of granulocyte/macrophage colony-stimulating factor (GM-CSF) into mice only expands the myeloid-related DC subset. These DC subsets differ in the cytokine profiles they induce in T cells in vivo. The lymphoid-related subset induces high levels of the Th1 cytokines interferon γ and interleukin (IL)-2 but little or no Th2 cytokines. In contrast, the myeloid-related subset induces large amounts of the Th2 cytokines IL-4 and IL-10, in addition to interferon γ and IL-2. FL- or GM-CSF-treated mice injected with soluble ovalbumin display dramatic increases in antigen-specific antibody titers, but the isotype profiles seem critically dependent on the cytokine used. Although FL treatment induces up to a 10,000-fold increase in ovalbumin-specific IgG2a and a more modest increase in IgG1 titers, GM-CSF treatment favors a predominantly IgG1 response with little increase in IgG2a levels. These data suggest that distinct DC subsets have strikingly different influences on the type of immune response generated in vivo and may thus be targets for pharmacological intervention.

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Metadata

Authors
Pulendran, B., Smith, J. L., Caspary, G., Brasel, K., Pettit, D., Maraskovsky, E., & Maliszewski, C. R.
Venue
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences
Published
1999-02-02
Volume
96
Issue
3
Pages
1036-1041
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.96.3.1036
OpenAlex
W2035572849
Cited by
991
References
37
FWCI
29.80
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Distinct dendritic cell subsets differentially regulate the class of immune response invivo. https://app.cochat.ai/papers/10.1073/pnas.96.3.1036
The paper
Pulendran, B., Smith, J. L., Caspary, G., Brasel, K., Pettit, D., Maraskovsky, E., & Maliszewski, C. R. (1999). Distinct dendritic cell subsets differentially regulate the class of immune response invivo. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.96.3.1036

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.