The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Human Thymic Stromal Lymphopoietin Preferentially Stimulates Myeloid Cells
Open accessAbstract
The sequence of a novel hemopoietic cytokine was discovered in a computational screen of genomic databases, and its homology to mouse thymic stromal lymphopoietin (TSLP) suggests that it is the human orthologue. Human TSLP is proposed to signal through a heterodimeric receptor complex that consists of a new member of the hemopoietin family termed human TSLP receptor and the IL-7R α-chain. Cells transfected with both receptor subunits proliferated in response to purified, recombinant human TSLP, with induced phosphorylation of Stat3 and Stat5. Human TSLPR and IL-7Rα are principally coexpressed on monocytes and dendritic cell populations and to a much lesser extent on various lymphoid cells. In accord, we find that human TSLP functions mainly on myeloid cells; it induces the release of T cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c+ dendritic cells, as evidenced by the strong induction of the costimulatory molecules CD40 and CD80 and the enhanced capacity to elicit proliferation of naive T cells.
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Metadata
- Authors
- Reche, P. A., Soumelis, V., Gorman, D. M., Clifford, T., Liu, M.-R., Travis, M., Zurawski, S. M., Johnston, J., Liu, Y.-J., Spits, H., de Waal Malefyt, R., Kastelein, R. A., & Bazan, J. F.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2001-07-01
- Volume
- 167
- Issue
- 1
- Pages
- 336-343
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2137465231
- Cited by
- 403
- References
- 33
- FWCI
- 2.04
- Type
- journal article
- Language
- en
- Open access
- bronze
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