The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
Prevention of T Cell Anergy by Signaling Through the γ c Chain of the IL-2 Receptor
Abstract
When stimulated through their antigen receptor without requisite costimulation, T cells enter a state of antigen-specific unresponsiveness, termed anergy. In this study, signaling through the common γ chain of the interleukin-2 (IL-2), IL-4, and IL-7 receptors in the presence of antigen was found to be sufficient to prevent the induction of anergy. After culture with IL-2, IL-4, or IL-7, Jak3 kinase was tyrosine-phosphorylated, which correlated with the prevention of anergy. Therefore, a signal through the common γ chain may regulate the decision of T cells to either clonally expand or enter a state of anergy.
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Schwartz, R. H. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141110 · Cited by 1,487
Interleukin-2 at the Crossroads of Effector Responses, Tolerance, and Immunotherapy
Liao, W., Lin, J.-X., & Leonard, W. J. (2013) · Immunity · doi:10.1016/j.immuni.2013.01.004 · Cited by 1,075
Defective lymphoid development in mice lacking expression of the common cytokine receptor γ chain
Cao, X., Shores, E. W., Hu-Li, J., Anver, M. R., Kelsail, B. L., Russell, S. M., Drago, J., Noguchi, M., Grinberg, A., Bloom, E. T., et al. (1995) · Immunity · doi:10.1016/1074-7613(95)90047-0 · Cited by 1,038
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Metadata
- Authors
- Boussiotis, V. A., Barber, D. L., Nakarai, T., Freeman, G. J., Gribben, J. G., Bernstein, G. M., D'Andrea, A. D., Ritz, J., & Nadler, L. M.
- Venue
- Science
- Published
- 1994-11-11
- Volume
- 266
- Issue
- 5187
- Pages
- 1039-1042
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2009417025
- Cited by
- 307
- References
- 49
- FWCI
- 14.63
- Type
- journal article
- Language
- en
- Open access
- closed
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- Boussiotis, V. A., Barber, D. L., Nakarai, T., Freeman, G. J., Gribben, J. G., Bernstein, G. M., D'Andrea, A. D., Ritz, J., & Nadler, L. M. (1994). Prevention of T Cell Anergy by Signaling Through the γ c Chain of the IL-2 Receptor. Science. https://doi.org/10.1126/science.7973657
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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