The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Mediators of Innate Immunity That Target Immature, But Not Mature, Dendritic Cells Induce Antitumor Immunity When Genetically Fused with Nonimmunogenic Tumor Antigens
Abstract
Chemokine receptors are differentially expressed on immature and mature dendritic cells (DC). Herein, we demonstrate for the first time that murine antimicrobial peptides β-defensins 2 and 3 bind murine CCR6, similarly to inflammatory chemokine macrophage-inflammatory protein 3α, and they chemoattract bone marrow-derived immature, but not mature DC. Using various chemokines or defensins fused with nonimmunogenic tumor Ags, we studied their capacity to delivery Ags to subsets of immune cells to elicit antitumor immunity. We demonstrate that DNA immunizations with fusion constructs with β-defensin 2 or inflammatory chemokines that target immature DC, but not homeostatic chemokines secondary lymphoid tissue chemokine, CCL21, or stromal cell-derived factor 1, CXCL12, which chemoattract mature DC, elicit humoral, protective, and therapeutic immunity against two different syngeneic lymphomas.
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Cites
The Nature of the Principal Type 1 Interferon-Producing Cells in Human Blood
Siegal, F. P., Kadowaki, N., Shodell, M., Fitzgerald-Bocarsly, P. A., Shah, K., Ho, S., Antonenko, S., & Liu, Y.-J. (1999) · Science · doi:10.1126/science.284.5421.1835 · Cited by 2,293
β-Defensins: Linking Innate and Adaptive Immunity Through Dendritic and T Cell CCR6
Yang, D., Chertov, O., Bykovskaia, S. N., Chen, Q., Buffo, M. J., Shogan, J., Anderson, M., Schröder, J. M., Wang, J. M., Howard, O. M. Z., et al. (1999) · Science · doi:10.1126/science.286.5439.525 · Cited by 1,809
Self-citation
Cited by
Alarmins: chemotactic activators of immune responses
Oppenheim, J. J., & Yang, D. (2005) · Current Opinion in Immunology · doi:10.1016/j.coi.2005.06.002 · Cited by 786
Self-citationMammalian defensins in immunity: more than just microbicidal
Yang, D., Biragyn, A., Kwak, L. W., & Oppenheim, J. J. (2002) · Trends in Immunology · doi:10.1016/s1471-4906(02)02246-9 · Cited by 696
Self-citationYang, D., Biragyn, A., Hoover, D. M., Lubkowski, J., & Oppenheim, J. J. (2004) · Annual Review of Immunology · doi:10.1146/annurev.immunol.22.012703.104603 · Cited by 572
Self-citationMookherjee, N., & Hancock, R. E. W. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-6475-6 · Cited by 462
Lehrer, R. I. (2004) · Nature Reviews Microbiology · doi:10.1038/nrmicro976 · Cited by 448
Metadata
- Authors
- Biragyn, A., Surenhu, M., Yang, D., Ruffini, P. A., Haines, B. A., Klyushnenkova, E., Oppenheim, J. J., & Kwak, L. W.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2001-12-01
- Volume
- 167
- Issue
- 11
- Pages
- 6644-6653
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2156911913
- Cited by
- 286
- References
- 2
- FWCI
- 5.92
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Mediators of Innate Immunity That Target Immature, But Not Mature, Dendritic Cells Induce Antitumor Immunity When Genetically Fused with Nonimmunogenic Tumor Antigens. https://app.cochat.ai/papers/10.4049/jimmunol.167.11.6644
- The paper
- Biragyn, A., Surenhu, M., Yang, D., Ruffini, P. A., Haines, B. A., Klyushnenkova, E., Oppenheim, J. J., & Kwak, L. W. (2001). Mediators of Innate Immunity That Target Immature, But Not Mature, Dendritic Cells Induce Antitumor Immunity When Genetically Fused with Nonimmunogenic Tumor Antigens. The Journal of Immunology. https://doi.org/10.4049/jimmunol.167.11.6644
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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