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Development of the Thymus Requires Signaling Through the Fibroblast Growth Factor Receptor R2-IIIb
Abstract
Mice deficient for fibroblast growth factor (Fgf)R2-IIIb show a block in thymic growth after embryonic day 12.5, a stage that just precedes its detection in thymic epithelial cells. Fgf7 and Fgf10, the main ligands for FgfR2-IIIb, are expressed in the mesenchyme surrounding the thymic epithelial primordium, and Fgf10-deficient mice also exhibit impaired thymic growth. Hence, Fgf signaling is essential for thymic epithelial proliferation. In addition to the proliferative block, most thymic epithelial cells fail to progress from an immature cytokeratin 5-positive to a cytokeratin 5-negative phenotype. Nevertheless, sufficient epithelial cell differentiation occurs in the severely hypoplastic thymus to allow the development of CD4/CD8-double-positive thymocytes and a very small number of single-positive thymocytes expressing TCRs.
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Cites
Gu, H., Zou, Y.-R., & Rajewsky, K. (1993) · Cell · doi:10.1016/0092-8674(93)90644-6 · Cited by 989
Cited by
Fon Tacer, K., Bookout, A. L., Ding, X., Kurosu, H., John, G. B., Wang, L., Goetz, R., Mohammadi, M., Kuro-o, M., Mangelsdorf, D. J., et al. (2010) · Molecular Endocrinology · doi:10.1210/me.2010-0142 · Cited by 700
Thyroid Development and Its Disorders: Genetics and Molecular Mechanisms
De Felice, M., & Di Lauro, R. (2004) · Endocrine Reviews · doi:10.1210/er.2003-0028 · Cited by 659
Mechanisms of thymus organogenesis and morphogenesis
Gordon, J., & Manley, N. R. (2011) · Development · doi:10.1242/dev.059998 · Cited by 293
Changes in primary lymphoid organs with aging
Chinn, I. K., Blackburn, C. C., Manley, N. R., & Sempowski, G. D. (2012) · Seminars in Immunology · doi:10.1016/j.smim.2012.04.005 · Cited by 282
Sharp, L. L., Jameson, J. M., Cauvi, G., & Havran, W. L. (2005) · Nature Immunology · doi:10.1038/ni1152 · Cited by 273
Metadata
- Authors
- Revest, J.-M., Suniara, R. K., Kerr, K., Owen, J. J. T., & Dickson, C.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2001-08
- Volume
- 167
- Issue
- 4
- Pages
- 1954-1961
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1511607328
- Cited by
- 241
- References
- 1
- FWCI
- 3.41
- Type
- journal article
- Language
- en
- Open access
- closed
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- The paper
- Revest, J.-M., Suniara, R. K., Kerr, K., Owen, J. J. T., & Dickson, C. (2001). Development of the Thymus Requires Signaling Through the Fibroblast Growth Factor Receptor R2-IIIb. The Journal of Immunology. https://doi.org/10.4049/jimmunol.167.4.1954
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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