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Cited by 280

The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.

CD8− Dendritic Cell Activation Status Plays an Integral Role in Influencing Th2 Response Development

MacDonald, Andrew S, Straw, Amy D, Bauman, Beverley, Pearce, Edward J·2001·The Journal of Immunology
DOI 10.4049/jimmunol.167.4.1982
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Abstract

Whether dendritic cells (DC) play a passive or active role in Th2 response induction is poorly understood. In this study, we show that CD8− DC pulsed with Th2-polarizing Ag (soluble egg Ag (SEA)) from Schistosoma mansoni potently stimulate Th2 responses in vivo and in vitro while failing to undergo a conventional maturation process. Thus, in contrast to DC pulsed with the Th1 response inducing Ag Propionebacterium acnes, SEA-exposed DC exhibit a phenotype that is most similar to that of immature DC, failing to up-regulate expression of CD40, CD54, CD80, CD86, or OX40L; producing no detectable IL-4, IL-10, or IL-12; and displaying only a minor increase in MHC class II expression. Importantly, in vitro derived DC exposed to SEA were phenotypically similar to CD8− DC isolated from active S. mansoni infection. By discriminating between different types of pathogen and responding appropriately, CD8− DC play a major role in the decision process to mount either a Th1 or Th2 response.

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Crossref · 10.4049/jimmunol.167.4.1982

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Metadata

Authors
MacDonald, A. S., Straw, A. D., Bauman, B., & Pearce, E. J.
Venue
The Journal of Immunology
Publisher
Oxford University Press (OUP)
Published
2001-08
Volume
167
Issue
4
Pages
1982-1988
ISSN
  • 0022-1767 (ISSN-L)
  • 1550-6606
DOI
10.4049/jimmunol.167.4.1982
OpenAlex
W1881253097
Cited by
280
References
48
FWCI
5.92
Type
journal article
Language
en
Open access
closed

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.