The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Microbial Compounds Selectively Induce Th1 Cell-Promoting or Th2 Cell-Promoting Dendritic Cells In Vitro with Diverse Th Cell-Polarizing Signals
Open accessAbstract
Upon microbial infection, specific Th1 or Th2 responses develop depending on the type of microbe. Here, we demonstrate that different microbial compounds polarize the maturation of human myeloid dendritic cells (DCs) into stably committed Th1 cell-promoting (DC1) or Th2 cell-promoting (DC2) effector DCs that polarize Th cells via different mechanisms. Protein extract derived from the helminth Schistosoma mansoni induced the development of DC2s that promote the development of Th2 cells via the enhanced expression of OX40 ligand. Likewise, toxin from the extracellular bacterium Vibrio cholerae induced development of DC2s as well, however, via an OX40 ligand-independent, still unknown mechanism. In contrast, toxin from the intracellular bacterium Bordetella pertussis induced the development of DC1s with enhanced IL-12 production, which promotes a Th1 cell development. Poly(I:C) (dsRNA, mimic for virus) induced the development of extremely potent Th1-inducing DC1, surprisingly, without an enhanced IL-12 production. The obtained DC1s and DC2s are genuine effector cells that stably express Th cell-polarizing factors and are unresponsive to further modulation. The data suggest that the molecular basis of Th1/Th2 polarization via DCs is unexpectedly diverse and is adapted to the nature of the microbial compounds.
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Cites
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Self-citationNatural Interferon α/β–Producing Cells Link Innate and Adaptive Immunity
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Cited by
Allergy, Parasites, and the Hygiene Hypothesis
Yazdanbakhsh, M., Kremsner, P. G., & van Ree, R. (2002) · Science · doi:10.1126/science.296.5567.490 · Cited by 1,526
Self-citationA Novel Host-Parasite Lipid Cross-talk
van der Kleij, D., Latz, E., Brouwers, J. F. H. M., Kruize, Y. C. M., Schmitz, M., Kurt-Jones, E. A., Espevik, T., de Jong, E. C., Kapsenberg, M. L., Golenbock, D. T., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m206941200 · Cited by 587
Self-citationα-Type-1 Polarized Dendritic Cells
Mailliard, R. B., Wankowicz-Kalinska, A., Cai, Q., Wesa, A., Hilkens, C. M., Kapsenberg, M. L., Kirkwood, J. M., Storkus, W. J., & Kalinski, P. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-1261 · Cited by 470
Self-citationSanin, D. E., & Mountford, A. P. (2015) · Parasites & Vectors · doi:10.1186/s13071-014-0608-1 · Cited by 441
Steinfelder, S., Andersen, J. F., Cannons, J. L., Feng, C. G., Joshi, M., Dwyer, D., Caspar, P., Schwartzberg, P. L., Sher, A., & Jankovic, D. (2009) · Journal of Experimental Medicine · doi:10.1084/jem.20082462 · Cited by 294
Metadata
- Authors
- de Jong, E. C., Vieira, P. L., Kalinski, P., Schuitemaker, J. H. N., Tanaka, Y., Wierenga, E. A., Yazdanbakhsh, M., & Kapsenberg, M. L.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2002-02
- Volume
- 168
- Issue
- 4
- Pages
- 1704-1709
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2160655212
- Cited by
- 503
- References
- 32
- FWCI
- 18.15
- Type
- journal article
- Language
- en
- Open access
- bronze
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- de Jong, E. C., Vieira, P. L., Kalinski, P., Schuitemaker, J. H. N., Tanaka, Y., Wierenga, E. A., Yazdanbakhsh, M., & Kapsenberg, M. L. (2002). Microbial Compounds Selectively Induce Th1 Cell-Promoting or Th2 Cell-Promoting Dendritic Cells In Vitro with Diverse Th Cell-Polarizing Signals. The Journal of Immunology. https://doi.org/10.4049/jimmunol.168.4.1704
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
