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Cited by 259

The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.

Heat Shock Proteins gp96 and hsp70 Activate the Release of Nitric Oxide by APCs

Panjwani, Naveed N, Popova, Lana, Srivastava, Pramod K·2002·The Journal of Immunology
DOI 10.4049/jimmunol.168.6.2997
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Abstract

NO is a cytotoxic and immunomodulatory cytokine produced by macrophages and dendritic cells. We show that stimulation of murine and human macrophages with the heat shock proteins gp96 and hsp70 results in induction of inducible NO synthase and the production of NO. The release of NO by monocytes exposed to hsp60 has been documented previously. Immature, but not mature, dendritic cells respond in the same manner. The activity of heat shock proteins is relatively unaffected by an antagonist of LPS, and is abrogated by heat denaturation. Macrophages have been shown previously to produce NO in response to stimulation with IFN-γ; stimulation of macrophages with mixtures of IFN-γ and gp96 or hsp70 leads to a synergistic production of NO. The present observations extend the roles of these heat shock proteins in innate immune responses to another potent and highly conserved function of APC.

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Metadata

Authors
Panjwani, N. N., Popova, L., & Srivastava, P. K.
Venue
The Journal of Immunology
Publisher
Oxford University Press (OUP)
Published
2002-03
Volume
168
Issue
6
Pages
2997-3003
ISSN
  • 0022-1767 (ISSN-L)
  • 1550-6606
DOI
10.4049/jimmunol.168.6.2997
OpenAlex
W1555650656
Cited by
259
References
48
FWCI
5.94
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Heat Shock Proteins gp96 and hsp70 Activate the Release of Nitric Oxide by APCs. https://app.cochat.ai/papers/10.4049/jimmunol.168.6.2997
The paper
Panjwani, N. N., Popova, L., & Srivastava, P. K. (2002). Heat Shock Proteins gp96 and hsp70 Activate the Release of Nitric Oxide by APCs. The Journal of Immunology. https://doi.org/10.4049/jimmunol.168.6.2997

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.