CoChat
Sign Up
Cited by 109Neuroinflammation and Neurodegeneration MechanismsImmune cells in cancerNeurogenesis and neuroplasticity mechanisms

The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.

Granulocyte-Macrophage Colony-Stimulating Factor Induces an Expression Program in Neonatal Microglia That Primes Them for Antigen Presentation

Open access
Re, Fabio, Belyanskaya, Svetlana L, Riese, Richiard J, Cipriani, Barbara, Fischer, Falko R, Granucci, Francesca, Ricciardi-Castagnoli, Paola, Brosnan, Celia, Stern, Lawrence J, Strominger, Jack L, Santambrogio, Laura·2002·The Journal of Immunology
DOI 10.4049/jimmunol.169.5.2264
Open this paper in CoChat — free accountOpen PDF

Abstract

Neonatal microglial cells respond to GM-CSF and M-CSF by acquiring different morphologies and phenotypes. To investigate the extent and consequences of this process, a global gene expression analysis was performed, with significant changes in transcript levels confirmed by biochemical analyses. Primary murine microglial cells underwent substantial expression reprogramming after treatment with GM-CSF or M-CSF with many differentially expressed transcripts important in innate and adaptive immunity. In particular, many gene products involved in Ag presentation were induced by GM-CSF, but not M-CSF, thus potentially priming relatively quiescent microglia cells for Ag presentation. This function of GM-CSF is distinct from its primary function in cell proliferation and survival.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.4049/jimmunol.169.5.2264

Cites

56 of 56 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Flagged first, then by citations

Research works printed but not linked: 56

  1. 1993, Glia, 9
  2. 1994, J. Leukocyte Biol., 732
  3. 1996, Res. Virol., 79
  4. 1988, Science, 290
  5. 2001, Glia, 156
  6. 1996, Exp. Neurol., 367
  7. 1996, Eur. J. Neurosci., 2582
  8. 1998, Proc. Natl. Acad. Sci. USA, 5779
  9. 1999, Glia, 344
  10. 1999, J. Neuroimmunol., 127
  11. 1993, J. Neuroimmunol., 193
  12. 1990, J. Neuroimmunol., 111
  13. 2001, Proc. Natl. Acad. Sci. USA, 6295
  14. 2001, J. Immunol., 2717
  15. 1998, J. Biol. Chem., 20967
  16. 1996, J. Leukocyte Biol., 502
  17. 1993, J. Neuroimmunol., 87
  18. 1999, Eur. J. Immunol., 3063
  19. 2000, J. Immunol., 1705
  20. 1990, J. Immunol., 3816
  21. 1999, Pediatr. Res., 358
  22. 1989, Cell Immunol., 445
  23. 2001, Immunity, 547
  24. 1994, Glia, 309
  25. 1999, Proc. Natl. Acad. Sci. USA, 15050
  26. 2000, Prog. Brain Res., 23
  27. 1995, Curr. Opin. Neurobiol., 625
  28. 2000, J. Neuroimmunol., 78
  29. 2001, Annu. Rev. Neurosci., 1217
  30. 1992, Brain Res., 202
  31. 1994, J. Neurochem., 2387
  32. 1993, Brain Res., 49
  33. 2000, J. Neurochem., 1498
  34. 1992, J. Exp. Med., 437
  35. 2000, J. Clin. Invest., 1227
  36. 1998, J. Neurochem., 2574
  37. 1999, J. Immunol., 5989
  38. 2002, Immunology, 73
  39. 2001, Brain Res. Brain Res. Rev., 249
  40. 2002, Arch. Neurol., 391
  41. 1995, Nature, 603
  42. 1999, Proc. Natl. Acad. Sci. USA, 12691
  43. 2001, Science, 870
  44. 1995, J. Neurosci. Res., 535
  45. 1993, J. Cell Sci., 1021
  46. 2001, Immunity, 557
  47. 1992, Proc. Natl. Acad. Sci. USA, 4295
  48. 1991, Proc. Natl. Acad. Sci. USA, 5082
  49. 1998, J. Biol. Chem., 19411
  50. 1998, J. Immunol., 5320
  51. 1992, J. Cell Biol., 1245
  52. 1997, J. Exp. Med., 251
  53. 1998, Science, 450
  54. 1999, Immunity, 197
  55. 2000, J. Exp. Med., 1177
  56. 1999, Mol. Med., 334

Cited by

Sorted by citations

See all 109

Related

See all

Metadata

Authors
Re, F., Belyanskaya, S. L., Riese, R. J., Cipriani, B., Fischer, F. R., Granucci, F., Ricciardi-Castagnoli, P., Brosnan, C., Stern, L. J., Strominger, J. L., & Santambrogio, L.
Affiliations
  • Dana-Farber Cancer Institute (US)
  • Brigham and Women's Hospital (US)
  • Albert Einstein College of Medicine (US)
  • Justus-Liebig-Universität Gießen (DE)
  • University of Milano-Bicocca (IT)
  • Department of Biotechnology and Bioscience, University of Milano-Bicocca , Milan ,
  • Massachusetts Institute of Technology (US)
Corresponding author
  • Re, Fabio
  • Santambrogio, Laura
ORCID
Venue
The Journal of Immunology
Publisher
Oxford University Press (OUP)
Published
2002-09-01
Volume
169
Issue
5
Pages
2264-2273
ISSN
  • 0022-1767 (ISSN-L)
  • 1550-6606
DOI
10.4049/jimmunol.169.5.2264
OpenAlex
W2116369972
Cited by
109
References
56
Citations by year
2025: 3 · 2024: 1 · 2023: 4 · 2022: 1 · 2021: 3 · 2020: 4 · 2019: 2 · 2018: 4 · 2015: 4 · 2014: 2 · 2013: 10 · 2012: 4
FWCI
6.24
Type
journal article
Language
en
Open access
Licence
academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations
  • The Journal of Immunology (publishedVersion)
  • PubMed (publishedVersion)
  • INFM-OAR (INFN Catania) (submittedVersion, other-oa)
  • Zenodo (CERN European Organization for Nuclear Research) (other-oa)
Funders
  • National Institutes of Health (5r35ca047554-13, AI48833)
  • National Cancer Institute (R35CA47554)
  • National Institute of Allergy and Infectious Diseases (R01-AI-48832, R01-AI48833, R01AI048833, R01AI048832)
Topics
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords
GM-CSF, microglia, macrophage colony-stimulating factor, gene expression reprogramming, antigen presentation, microglial activation, innate immunity, adaptive immunity
MeSH terms
Animals, Animals, Newborn, Cathepsins, Cells, Cultured, Dendritic Cells, Macrophages, Mice, Inbred Strains, Phagocytosis, Receptors, Immunologic, Biomarkers, Macrophage Colony-Stimulating Factor, Granulocyte-Macrophage Colony-Stimulating Factor, Cytokines, Microglia, Antigen Presentation, Receptors, Cytokine, Chemokines, Receptors, Chemokine, Oligonucleotide Array Sequence Analysis, Matrix Metalloproteinases, Gene Expression Profiling, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review