The suitability of BV2 cells as alternative model system for primary microglia cultures or for animal experiments examining brain inflammation.
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BV-2 cells share numerous properties with macrophages with respect to antigen profile, phagocytic capacity and antimicrobial activity.
“These cells share numerous properties with macrophages with respect to the antigen profile, their phagocytic capacity and antimicrobial activity [25].”
From MicroRNA 146a (miR-146a) Is Over-Expressed during Prion Disease and Modulates the Innate Immune Response and the Microglial Activation State (2012) · cites this paper as [25]
BV-2 cells form spineous processes and express inwardly rectifying, but not outwardly rectifying K+ channels.
“Additionally, like microglial cells, they form spineous processes and express inwardly rectifying, but not outwardly rectifying K+ channels [25].”
From MicroRNA 146a (miR-146a) Is Over-Expressed during Prion Disease and Modulates the Innate Immune Response and the Microglial Activation State (2012) · cites this paper as [25]
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Cites
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“It is important to validate these responses in vivo, in carefully-isolated primary microglia and iPS-derived microglia to fully understand the role of quinone-derived compounds in neuroinflammatory regulation, especially when considering the deviance of immortalised microglia to that of primary cells [180].”
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- Authors
- Henn, A.
- Venue
- ALTEX
- Publisher
- ALTEX Edition
- Published
- 2009
- Pages
- 83-94
- ISSN
- 1868-596X
- Cited by
- 660
- References
- 2
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