The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Cutting Edge: Salmonella AvrA Effector Inhibits the Key Proinflammatory, Anti-Apoptotic NF-κB Pathway
Open accessAbstract
Secreted prokaryotic effector proteins have evolved to modulate the cellular functions of specific eukaryotic hosts. Generally, these proteins are considered virulence factors that facilitate parasitism. However, in certain plant and insect eukaryotic/prokaryotic relationships, effector proteins are involved in the establishment of commensal or symbiotic interactions. In this study, we report that the AvrA protein from Salmonella typhimurium, a common enteropathogen of humans, is an effector molecule that inhibits activation of the key proinflammatory NF-κB transcription factor and augments apoptosis in human epithelial cells. This activity is similar but mechanistically distinct from that described for YopJ, an AvrA homolog expressed by the bacterial pathogen Yersinia. We suggest that AvrA may limit virulence in vertebrates in a manner analogous to avirulence factors in plants, and as such, is the first bacterial effector from a mammalian pathogen that has been ascribed such a function.
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Cites
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Self-citationMolecular basis of symbiosis between Rhizobium and legumes
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Cited by
Salmonellae interplay with host cells
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Inhibiting NF-κB activation by small molecules as a therapeutic strategy
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Two Pseudomonas syringae Type III Effectors Inhibit RIN4-Regulated Basal Defense in Arabidopsis
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Gut microbiota, inflammation and colorectal cancer
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Metadata
- Authors
- Collier-Hyams, L. S., Zeng, H., Sun, J., Tomlinson, A. D., Bao, Z. Q., Chen, H., Madara, J. L., Orth, K., & Neish, A. S.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2002-09
- Volume
- 169
- Issue
- 6
- Pages
- 2846-2850
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1624615502
- Cited by
- 275
- References
- 22
- FWCI
- 24.45
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Cutting Edge: Salmonella AvrA Effector Inhibits the Key Proinflammatory, Anti-Apoptotic NF-κB Pathway. https://app.cochat.ai/papers/10.4049/jimmunol.169.6.2846
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- Collier-Hyams, L. S., Zeng, H., Sun, J., Tomlinson, A. D., Bao, Z. Q., Chen, H., Madara, J. L., Orth, K., & Neish, A. S. (2002). Cutting Edge: Salmonella AvrA Effector Inhibits the Key Proinflammatory, Anti-Apoptotic NF-κB Pathway. The Journal of Immunology. https://doi.org/10.4049/jimmunol.169.6.2846
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