Gut microbiota, inflammation and colorectal cancer

Sun, Jun; Kato, Ikuko

doi:10.1016/j.gendis.2016.03.004

Cited by 257Gut microbiota and healthOral microbiology and periodontitis researchClostridium difficile and Clostridium perfringens research

Gut microbiota, inflammation and colorectal cancer

Open access

Sun, Jun, Kato, Ikuko·2016·Genes & Diseases

DOI 10.1016/j.gendis.2016.03.004PMC PMC5221561

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Abstract

Although genes contribute to colorectal cancer, the gut microbiota are an important player. Accumulating evidence suggests that chronic infection and the ensuing inflammation contributes to tumor initiation and tumor progression. A variety of bacterial species and tumor-promoting virulence mechanisms have been investigated. Significant advances have been made in understanding the composition and functional capabilities of the gut microbiota and its roles in cancer. In the current review, we discuss the novel roles of microbiota in the progression of colon cancer. Although microbiota technically include organisms other than bacteria e.g., viruses and fungi, this review will primarily focus on bacteria. We summarize epidemiological studies of human microbiome and colon cancer. We discuss the progress in the scientific understanding of the interplay between the gut microbiota, barrier function, and host responses in experimental models. Further, we discuss the potential application in prevention, diagnosis, and therapy of colon cancer by targeting microbiota. We discuss the challenges lie ahead and the future direction in studying gut microbiome in colon cancer to close the gap between the basic sciences and clinical application.

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Strategies to detect specific bacteria or bacterial DNA sequences might be used in screening for early-stage colorectal adenomas or carcinomas.
“Strategies to detect specific bacteria or bacterial DNA sequences might be used in screening for early-stage colorectal adenomas or carcinomas.60, 61”
From Influence of the Gut Microbiome, Diet, and Environment on Risk of Colorectal Cancer (2020) · cites this paper as [60]

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Method
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Result
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Background
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Enhanced Escherichia coli adherence and invasion in Crohn’s disease and colon cancer 1 1The authors thank Professor T. K. Korhonen (Division of General Microbiology, University of Helsinki, Finland), who kindly donated Escherichia coli IH11165; Professor J.-F. Colombel (Laboratoire de Recherche sur les Maladies Inflammatoire de l’Intestine, Centre Hospitalier Universitaire, Lille, France) and Professor A. Darfeuille-Michaud (Faculte de Pharmacie, Clermont-Ferrand, France), who kindly donated the Crohn’s disease ileal isolates LF10 and LF82; and Dr. Keith Leiper (Gastroenterology Unit, Royal Liverpool & Broadgreen University Hospitals Trust, Liverpool, UK) for his cooperation in obtaining colorectal tissue specimens.As a consequence of the work described herein, a patent application has been filed by the University of Liverpool regarding the use of soluble plantain fiber in Crohn’s disease.
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Background
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Background
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Result
High Prevalence of Mucosa-Associated E. coli Producing Cyclomodulin and Genotoxin in Colon Cancer
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Background
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Method
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Bacterial genotoxin colibactin promotes colon tumour growth by inducing a senescence-associated secretory phenotype
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Background
Gut microbial metabolism drives transformation of MSH2-deficient colon epithelial cells
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Method
A possible role of Bacteroides fragilis enterotoxin in the aetiology of colorectal cancer
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“The potential association of this bacterium with colorectal cancer may be further corroborated by several other metagenomic studies that observed the overrepresentation of genus Porphyromonas or Porphyromonadaceae family in colorectal cancer specimens than control specimens.(10,13,92) Overall, the information availabl…”
BackgroundResult
Increased Short- and Long-Term Risk of Inflammatory Bowel Disease After Salmonella or Campylobacter Gastroenteritis
Gradel, K. O., Nielsen, H. L., Schønheyder, H. C., Ejlertsen, T., Kristensen, B., & Nielsen, H. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.04.001 · Cited by 424 · cited 1× · see citing works
“These chronic infections increase the risk of several gastrointestinal(138) diseases, including chronic cholecystitis and gallbladder cancer.(139,140) Recently, Kato et al reported that antibody against Salmonella flagellin was higher in colorectal cancer and pre-cancer cases than controls in two distinct populations…”
Background
Enterotoxigenic Bacteroides fragilis : a Rogue among Symbiotes
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“fragilis.(78) BFT binds to a specific colonic epithelial receptor activating Wnt and NF-kB signaling pathways with increased cell proliferation, epithelial release of proinflammatory mediators, and induction of DNA damage(78,79) and ETBF promotes tumor formation in experimental animals.”
Background
Smoking Cessation Induces Profound Changes in the Composition of the Intestinal Microbiota in Humans
Biedermann, L., Zeitz, J., Mwinyi, J., Sutter-Minder, E., Rehman, A., Ott, S. J., Steurer-Stey, C. A., Frei, A. L., Frei, P., Scharl, M. M., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0059260 · Cited by 411 · see citing works
Gastric precancerous process in a high risk population: cohort follow-up.
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Is overexpression of HER-2 a predictor of prognosis in colorectal cancer?
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Co-occurrence of anaerobic bacteria in colorectal carcinomas
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Increased Short- and Long-Term Risk of Inflammatory Bowel Disease After Salmonella or Campylobacter Gastroenteritis
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Real‐time polymerase chain reaction quantification of specific butyrate‐producing bacteria, Desulfovibrio and Enterococcus faecalis in the feces of patients with colorectal cancer
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“These include Desulfovibrio, Enterococcus faecalis due to hydrogen sulfide and superoxide respectively,(100) Faecalibacterium prausnitzii and Bifidobacteria due to butyrate and lactate, respectively.(101,102) The presence or density/quantity of these bacteria in feces or mucosa has been primarily studied by qPCR.”
Background
Association between intraepithelial Escherichia coli and colorectal cancer
Swidsinski, A. V., Khilkin, M., Kerjaschki, D., Schreiber, S., Ortner, M., Weber, J., & Lochs, H. (1998) · Gastroenterology · doi:10.1016/s0016-5085(98)70194-5 · Cited by 302 · see citing works
Association of Fusobacterium nucleatum with clinical and molecular features in colorectal serrated pathway: F. Nucleatum and molecular features of serrated lesions
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Cutting Edge: Salmonella AvrA Effector Inhibits the Key Proinflammatory, Anti-Apoptotic NF-κB Pathway
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Gastrin and colorectal cancer: A prospective study
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Microbial mucosal colonic shifts associated with the development of colorectal cancer reveal the presence of different bacterial and archaeal biomarkers
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“But it is now clear that bacterial populations in feces and mucosa are distinct.(6,7) As summarized in Table 1, the majority of these studies have demonstrated beta diversity by principal coordinate or component analysis illustrating structural difference of gut microbiome, where samples belonging to different disease…”
Background
Coordination of tolerogenic immune responses by the commensal microbiota
Round, J. L., O’Connell, R. M., & Mazmanian, S. K. (2009) · Journal of Autoimmunity · doi:10.1016/j.jaut.2009.11.007 · Cited by 260 · cited 1× · see citing works
“Polysaccharide A, produced by a commensal bacteria, increases local interleukin 10 by inducing Foxp3þ regulatory T-cell and this effect is mediated by Toll like receptor 2 signaling.(156,157) Although recent studies provide insights into the roles of the bacterial products, the molecular mechanisms of the beneficial e…”
Background
Commensal Bacteria, Redox Stress, and Colorectal Cancer: Mechanisms and Models
Huycke, M. M., & Gaskins, H. R. (2004) · Experimental Biology and Medicine · doi:10.1177/153537020422900702 · Cited by 244 · see citing works
The Microbe-Derived Short Chain Fatty Acid Butyrate Targets miRNA-Dependent p21 Gene Expression in Human Colon Cancer
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Over-expression of COX-2 mRNA in colorectal cancer
Roelofs, H. M. J., Morsche, R. H. T., van Heumen, B. W. H., Nagengast, F. M., & Peters, W. H. M. (2014) · BMC Gastroenterology · doi:10.1186/1471-230x-14-1 · Cited by 225 · see citing works
The Microbiome and Inflammatory Bowel Disease: Is There a Therapeutic Role for Fecal Microbiota Transplantation?
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“Bacterial metabolic products Firmicutes and Bacteroidetes predominate the gut microbiota, followed by Proteobacteria and Actinobacteria, with minor contributors including Verrucomicrobia and Fusobacteria.123 Bacteroides and Ruminococcus are consistent with enriched intake of animal sources, while a plant-based diet fa…”
Background
Strict vegetarian diet improves the risk factors associated with metabolic diseases by modulating gut microbiota and reducing intestinal inflammation
Kim, M., Hwang, S., Park, E., & Bae, J. (2013) · Environmental Microbiology Reports · doi:10.1111/1758-2229.12079 · Cited by 220 · cited 1× · see citing works
“Although meat intake itself has been rarely studied, removal of animal products (vegan diet) was recently tested in a few clinical trials, showing changes in the Firmicutes/Bacteroidetes ratio and abundance of bacteria capable of triggering inflammation.(112,113) Moreover, as discussed above, meats are one of the susp…”
Background
Streptococcus bovis Septicemia and Carcinoma of the Colon
Klein, R. S., CATALANO, M. T., EDBERG, S. C., CASEY, J. I., & STEIGBIGEL, N. H. (1979) · Annals of Internal Medicine · doi:10.7326/0003-4819-91-4-560 · Cited by 214 · see citing works
Salmonella Effector AvrA Regulation of Colonic Epithelial Cell Inflammation by Deubiquitination
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A secreted Salmonella protein with homology to an avirulence determinant of plant pathogenic bacteria
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Microbiome, demystifying the role of microbial communities in the biosphere
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Enteric bacterial protein AvrA promotes colonic tumorigenesis and activates colonic beta-catenin signaling pathway
Lu, R., Wu, S., Zhang, Y.-G., Xia, Y., Liu, X., Zheng, Y., Chen, H., Schaefer, K. L., Zhou, Z., Bissonnette, M., et al. (2014) · Oncogenesis · doi:10.1038/oncsis.2014.20 · Cited by 206 · cited 2× · see citing works
“Uninfected mice treated with AOM/DSS developed tumors in the distal colon.(150) In contrast, in mice infected with AvrAexpressing bacteria, tumors were found more in the proximal colon.”
BackgroundSelf-citation
The gastrointestinal microbiota and colorectal cancer
Keku, T. O., Dulal, S., Deveaux, A. E., Jovov, B., & Han, X. (2014) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00360.2012 · Cited by 205 · cited 1× · see citing works
“Transplanting feces from mice with CRC into germ-free mice leads to increased tumorigenesis.(153) While emerging evidence suggests a link between the gut microbiota and colon cancer, it is hard to say that certain bacteria strain(s) play a causal role in CRC.”
Background
Association of Streptococcus bovis Bacteremia With Colonic Neoplasia and Extracolonic Malignancy
Gold, J. S. (2004) · Archives of Surgery · doi:10.1001/archsurg.139.7.760 · Cited by 202 · see citing works
Identification and quantitation of mucosal and faecal desulfovibrios using real time polymerase chain reaction
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“However, there have been only sporadic studies reporting a significant association with colorectal cancer itself,(101,102) while others found higher prevalence or density of these bacteria in IBD than in controls, which was further correlated with disease activity.(4,103,104) In addition to F.”
Result
Bacteremia with Streptococcus bovis and Streptococcus salivarius: clinical correlates of more accurate identification of isolates
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Role of colonic microbiota in colorectal carcinogenesis: A systematic review
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“It is clear that bacteria metabolites amino acids are increased and butyrate is decreased throughout colonic carcinogenesis.(121) Identification of components of the microbiota and elucidation of the molecular mechanisms of their action in inducing pathological changes or exerting beneficial activities could aid in ou…”
Background
Disease tolerance mediated by microbiome E. coli involves inflammasome and IGF-1 signaling
Schieber, A. M. P., Lee, Y. M., Chang, M. W., Leblanc, M., Collins, B., Downes, M., Evans, R. M., & Ayres, J. S. (2015) · Science · doi:10.1126/science.aac6468 · Cited by 189 · cited 2× · see citing works
“This effect was dependent on engagement of the NLRC4 inflammasome.(161) Therefore, commensal bacteria in gut promote tolerance to diverse diseases.”
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Short- and Long-term Effects of Bacterial Gastrointestinal Infections
Ternhag, A., Törner, A., Svensson, Å., Ekdahl, K., & Giesecke, J. (2008) · Emerging infectious diseases · doi:10.3201/eid1401.070524 · Cited by 185 · cited 1× · see citing works
“Two studies from Scandinavian countries have found that the probability of new IBD diagnosis significantly (2e3 fold) increases compared with general population following an episode of non-typhoid salmonella infection, particularly within the first 10 years.(97,98) Although data directly linking to colorectal cancer a…”
Background
Smoking Cessation Alters Intestinal Microbiota: Insights from Quantitative Investigations on Human Fecal Samples Using FISH
Biedermann, L., Brülisauer, K., Zeitz, J., Frei, P., Scharl, M., Vavricka, S. R., Fried, M., Loessner, M. J., Rogler, G., & Schuppler, M. (2014) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000129 · Cited by 178 · see citing works
Human gut microbiota: Does diet matter?
Maukonen, J., & Saarela, M. (2015) · Proceedings of The Nutrition Society · doi:10.1017/s0029665114000688 · Cited by 177 · cited 1× · see citing works
“Dietary fiber and resistant starch are well known to stimulate gut bacterial fermentation to generate short chain fatty acids (SCFA) as well as lactate and to increase relative abundance of bacterial groups with the relevant metabolic activities.(111) Although meat intake itself has been rarely studied, removal of ani…”
Background
Systematic review with meta‐analysis: the relationship between chronic S almonella typhi carrier status and gall‐bladder cancer
Nagaraja, V., & Eslick, G. D. (2014) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.12655 · Cited by 161 · cited 1× · see citing works
“Salmonellosis has also been implicated in the development of various chronic sequelae, including reactive arthritis, irritable bowel syndrome, IBD(95) and even cancer.(96) Two studies from Scandinavian countries have found that the probability of new IBD diagnosis significantly (2e3 fold) increases compared with gener…”
Background
Salmonellosis and the gastrointestinal tract: More than just peanut butter
Crum-Cianflone, N. F. (2008) · Current Gastroenterology Reports · doi:10.1007/s11894-008-0079-7 · Cited by 157 · see citing works
Infectious Agents and Colorectal Cancer: A Review ofHelicobacter pylori, Streptococcus bovis, JC Virus, and Human Papillomavirus
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“In addition, there may be indirect consequences from gastric pathology, such as hypergastrinemia, which is common in patients with Helicobacter infection and has been hypothesized to stimulate colorectal tumor growth.(70)”
Background
Enteric Salmonella or Campylobacter infections and the risk of inflammatory bowel disease
Jess, T., Simonsen, J., Nielsen, N. M., Jørgensen, K. T., Bager, P., Ethelberg, S., & Frisch, M. (2010) · Gut · doi:10.1136/gut.2010.223396 · Cited by 154 · cited 1× · see citing works
“Two studies from Scandinavian countries have found that the probability of new IBD diagnosis significantly (2e3 fold) increases compared with general population following an episode of non-typhoid salmonella infection, particularly within the first 10 years.(97,98) Although data directly linking to colorectal cancer a…”
Background
Endocarditis due to group D streptococci
Moellering, R. C., Watson, B. K., & Kunz, L. J. (1974) · The American Journal of Medicine · doi:10.1016/0002-9343(74)90448-3 · Cited by 153 · see citing works
Helicobacter pylori infection in gastric cancerogenesis.
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Attaching and Effacing Escherichia coli Downregulate DNA Mismatch Repair Protein In Vitro and Are Associated with Colorectal Adenocarcinomas in Humans
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Protective activity of butyrate on hydrogen peroxide-induced DNA damage in isolated human colonocytes and HT29 tumour cells
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“SCFA promotes and maintains colonic epithelial health through maintaining barrier function,(129) suppressing colonic cancer, inhibiting intestinal inflammation (Wu et al 2014), modulating immune response,(133) regulating DNA methylation for proliferation,(132) and diminishing oxidative DNA damage.(134) The balance bet…”
Background
Fusobacterium nucleatum
Allen‐Vercoe, E., Strauss, J., & Chadee, K. (2011) · Gut Microbes · doi:10.4161/gmic.2.5.18603 · Cited by 145 · see citing works
Streptococcus bovis endocarditis, a silent sign for colonic tumour
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Changes in gut bacterial populations and their translocation into liver and ascites in alcoholic liver cirrhotics
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Streptococcus bovis Bacteremia and Underlying Gastrointestinal Disease
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Non Digestible Oligosaccharides Modulate the Gut Microbiota to Control the Development of Leukemia and Associated Cachexia in Mice
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Prevalence of antibiotic resistance in lactic acid bacteria isolated from the faeces of broiler chicken in Malaysia
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Fusobacterium and Enterobacteriaceae: Important players for CRC?
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The Triad of Streptococcus Bovis Bacteremia, Colonic Pathology, and Liver Disease
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Salmonella regulation of intestinal stem cells through the Wnt/β‐catenin pathway
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Artisanal and experimental Pecorino Siciliano cheese: Microbial dynamics during manufacture assessed by culturing and PCR–DGGE analyses
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Diversified pattern of the human colorectal cancer microbiome
Geng, J., Fan, H., Tang, X., Zhai, H., & Zhang, Z. (2013) · Gut Pathogens · doi:10.1186/1757-4749-5-2 · Cited by 126 · cited 1× · see citing works
“On the contrary a richness index was higher in rectal mucosa of colorectal cancer patients than in that of control subjects(7) or in cancer tissues than paired normal tissue.(11) Others did not find differences in these alpha diversity indices.”
Background
Culture-independent analysis of desulfovibrios in the human distal colon of healthy, colorectal cancer and polypectomized individuals
Scanlan, P. D., Shanahan, F., & Marchesi, J. R. (2009) · FEMS Microbiology Ecology · doi:10.1111/j.1574-6941.2009.00709.x · Cited by 124 · cited 1× · see citing works
“coli, hydrogen sulfide (H2S)-, and bile salt-producing bacteria was associated with increased risk of colon cancer.(5,136) Cancer is associated with reduced abundances of Clostridium, Roseburia, Eubacteria spp.”
Background
Qualitative and quantitative analyses of the bifidobacterial microbiota in the colonic mucosa of patients with colorectal cancer, diverticulitis and inflammatory bowel disease
Gueimonde, M. (2007) · World Journal of Gastroenterology · doi:10.3748/wjg.v13.i29.3985 · Cited by 124 · cited 1× · see citing works
“These include Desulfovibrio, Enterococcus faecalis due to hydrogen sulfide and superoxide respectively,(100) Faecalibacterium prausnitzii and Bifidobacteria due to butyrate and lactate, respectively.(101,102) The presence or density/quantity of these bacteria in feces or mucosa has been primarily studied by qPCR.”
Background
Comprehensive Study of Strains Previously DesignatedStreptococcus bovisConsecutively Isolated from Human Blood Cultures and Emended Description ofStreptococcus gallolyticusandStreptococcus infantariussubsp.coli
Beck, M., Frodl, R., & Funke, G. (2008) · Journal of Clinical Microbiology · doi:10.1128/jcm.00078-08 · Cited by 122 · see citing works
Salmonella Type III Effector AvrA Stabilizes Cell Tight Junctions to Inhibit Inflammation in Intestinal Epithelial Cells
Liao, A. P., Petrof, E. O., Kuppireddi, S., Zhao, Y., Xia, Y., Claud, E. C., & Sun, J. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002369 · Cited by 121 · see citing works
Infection as a risk factor for gallbladder cancer
Kumar, S., Kumar, S., & Kumar, S. (2006) · Journal of Surgical Oncology · doi:10.1002/jso.20530 · Cited by 119 · cited 1× · see citing works
“These chronic infections increase the risk of several gastrointestinal(138) diseases, including chronic cholecystitis and gallbladder cancer.(139,140) Recently, Kato et al reported that antibody against Salmonella flagellin was higher in colorectal cancer and pre-cancer cases than controls in two distinct populations…”
Background
Metagenomic profile of gut microbiota in children during cholera and recovery
Monira, S., Nakamura, S., Gotoh, K., Izutsu, K., Watanabe, H., Alam, N., Nakaya, T., Horii, T., Ali, S. I., Iida, T., et al. (2013) · Gut Pathogens · doi:10.1186/1757-4749-5-1 · Cited by 119 · see citing works
Association Between Bacteremia Due to Streptococcus gallolyticus subsp. gallolyticus (Streptococcus bovis I) and Colorectal Neoplasia: A Case-Control Study
Corredoira, J., Garcı́a-Garrote, F., Rey, R. R., López-Rosés, L., García-Pais, M. J., Gracián-Castro, E., González-Soler, R., Coira, A., Pita, J., Lopez-Alvarez, M. J., et al. (2012) · Clinical Infectious Diseases · doi:10.1093/cid/cis434 · Cited by 116 · see citing works
Clinical characteristics and significance of Streptococcus salivarius bacteremia and Streptococcus bovis bacteremia: a prospective 16-year study
Corredoira, J., Alonso, M. P., García, J. F., Casariego, E., Coira, A., Rodríguez, A., Pita, J., Louzao, C., Pombo, B., López, M. J., et al. (2005) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-005-1314-x · Cited by 112 · see citing works
Probiotics for the Treatment of Inflammatory Bowel Disease
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Longitudinal Analyses of Gut Mucosal Microbiotas in Ulcerative Colitis in Relation to Patient Age and Disease Severity and Duration
Fite, A., Macfarlane, S., Furrie, E., Bahrami, B., Cummings, J. H., Steinke, D. T., & Macfarlane, G. T. (2012) · Journal of Clinical Microbiology · doi:10.1128/jcm.02574-12 · Cited by 110 · cited 1× · see citing works
“However, there have been only sporadic studies reporting a significant association with colorectal cancer itself,(101,102) while others found higher prevalence or density of these bacteria in IBD than in controls, which was further correlated with disease activity.(4,103,104) In addition to F.”
Result
Streptococcus infantarius sp. nov., Streptococcus infantarius subsp. infantarius subsp. nov. and Streptococcus infantarius subsp. coli subsp. nov., isolated from humans and food.
Schlegel, L., Grimont, F., COLLINS, M. D., Regnault, B., Grimont, P. A. D., & Bouvet, A. (2000) · INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY · doi:10.1099/00207713-50-4-1425 · Cited by 110 · cited 3× · see citing works
“Approximately 10% of healthy individuals have been estimated to carry this bacterium asymptomatically in their digestive tract.(20) While fecaleoral or oraleoral is a possible transmission route between humans, it may be acquired through dietary intake of ruminant-derived foods, such as unpasteurized dairy products,(2…”
Background
Bacterial activation of β-catenin signaling in human epithelia
Sun, J., Hobert, M. E., Rao, A. S., Neish, A. S., & Madara, J. (2004) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00498.2003 · Cited by 105 · see citing works
Selective Inhibition of Type III Secretion Activated Signaling by the Salmonella Effector AvrA
Du, F., & Galán, J. E. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000595 · Cited by 104 · see citing works
Association between H elicobacter pylori infection and the risk of colorectal neoplasia: a systematic review and meta‐analysis
Wu, Q., Yang, Z., Xu, P., Gao, L., & Fan, D. (2013) · Colorectal Disease · doi:10.1111/codi.12284 · Cited by 102 · see citing works
Investigation into the controversial association of Streptococcus gallolyticus with colorectal cancer and adenoma
Abdulamir, A. S., Hafidh, R. R., Mahdi, L. K., Al-jeboori, T., & Abubaker, F. (2009) · BMC Cancer · doi:10.1186/1471-2407-9-403 · Cited by 100 · see citing works
Profiling the humoral immune response in colon cancer patients: Diagnostic antigens from Streptococcus bovis
Tjalsma, H., Schöller‐Guinard, M., Lasonder, E., Ruers, T. J. M., Willems, H. L., & Swinkels, D. W. (2006) · International Journal of Cancer · doi:10.1002/ijc.22116 · Cited by 97 · see citing works
Characteristics of Streptococcus bovis endocarditis and its differences with Streptococcus viridans endocarditis
Corredoira, J., Alonso, M. P., Coira, A., Casariego, E., Arias, C. A., Alonso, D., Pita, J., Rodríguez, A., López, M. J., & Varela, J. (2008) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-007-0441-y · Cited by 89 · see citing works
Co-occurrence of driver and passenger bacteria in human colorectal cancer
Geng, J., Song, Q., Tang, X., Xiao, L., Fan, H., Peng, H., Guo, Q., & Zhang, Z. (2014) · Gut Pathogens · doi:10.1186/1757-4749-6-26 · Cited by 89 · see citing works
Rates of production and utilization of lactate by microbial communities from the human colon
Belenguer, Á., Holtrop, G., Duncan, S. H., Anderson, S. E., Calder, A. G., Flint, H. J., & Lobley, G. E. (2011) · FEMS Microbiology Ecology · doi:10.1111/j.1574-6941.2011.01086.x · Cited by 85 · see citing works
Helicobacter pylori in colorectal neoplasms: is there an aetiological relationship?
Jones, M., Helliwell, P., Pritchard, C. W., Tharakan, J., & Mathew, J. (2007) · World Journal of Surgical Oncology · doi:10.1186/1477-7819-5-51 · Cited by 85 · see citing works
The association of Streptococcus bovis fecal carriage and colon neoplasia: possible relationship with polyps and their premalignant potential.
Burns, C., McCaughey, R. S., & Lauter, C. B. (1985) · PubMed · Cited by 82 · see citing works
Association of Streptococcus bovis Bacteremia with Bowel Disease
Reynolds, J. G., da Silva, E. T. G., & McCormack, W. M. (1983) · Journal of Clinical Microbiology · doi:10.1128/jcm.17.4.696-697.1983 · Cited by 82 · see citing works
Interplay of host microbiota, genetic perturbations, and inflammation promotes local development of intestinal neoplasms in mice
Bongers, G., Pacer, M. E., Geraldino, T. H., Chen, L., He, Z., Hashimoto, D., Furtado, G. C., Ochando, J., Kelley, K. A., Clemente, J. C., et al. (2014) · The Journal of Experimental Medicine · doi:10.1084/jem.20131587 · Cited by 78 · cited 1× · see citing works
“This study indicates that the same genetic mutation in different individuals may have a different outcome.(152) One environmental factor e a diet low in fiber e may impact the intestinal microbiota in a way that affects host cell physiology, cellular homeostasis, energy regulation, and/or metabolism of xenobiotics.”
Background
Salmonella Promoters Preferentially Activated Inside Tumors
Arrach, N., Zhao, M. D., Porwollik, S., Hoffman, R. M., & McClelland, M. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-0552 · Cited by 78 · cited 1× · see citing works
“In animal models, Salmonella and its derivatives have been observed invading transformed tissue more efficiently than normal tissue.(141,142) Salmonella AvrA is a multifunctional protein that influences eukaryotic cell pathways by altering ubiquitination and acetylation of target proteins.”
Background
Association between Streptococcus infantarius (Formerly S. bovis II/1) Bacteremia and Noncolonic Cancer
Corredoira, J., Alonso, M. P., Coira, A., & Varela, J. (2008) · Journal of Clinical Microbiology · doi:10.1128/jcm.00129-08 · Cited by 74 · cited 1× · see citing works
“infantarius to non-colonic cancers, primarily in the pancreas and biliary tract.(19) Although SB is a member of normal gastrointestinal flora in ruminants, e.”
Background
Inhibition by Resistant Starch of Red Meat–Induced Promutagenic Adducts in Mouse Colon
Winter, J. M., Nyskohus, L. S., Young, G. P., Hu, Y. C., Conlon, M. A., Bird, A. R., Topping, D. L., & Leu, R. K. L. (2011) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-11-0176 · Cited by 74 · see citing works
Helicobacter pylori seropositivity and colorectal cancer risk: a prospective study of male smokers.
Limburg, P. J., Stolzenberg‐Solomon, R. Z., Colbert, L. H., Perez-Perez, G. I., Blaser, M. J., Taylor, P. R., Virtamo, J. R. K., & Albanes, D. (2002) · PubMed · Cited by 74 · see citing works
Association between Streptococcus bovis and Colon Cancer
Boleij, A., Schaeps, R. M. J., & Tjalsma, H. (2009) · Journal of Clinical Microbiology · doi:10.1128/jcm.01755-08 · Cited by 71 · cited 1× · see citing works
“These variations may also be due to the heterogeneous definition of the cases, as adenomas have been defined as diseased in some studies but not in the others.(46) A more recent study found that 52% of SB bacteremia patients had advanced adenoma/cancer, which was approximately 2.”
Result
Geographical difference of disease association in Streptococcus bovis bacteraemia
Lee, R. A., Woo, P. C. Y., To, A. P. C., Lau, S. K. P., Wong, S. S. Y., & Yuen, K. (2003) · Journal of Medical Microbiology · doi:10.1099/jmm.0.05199-0 · Cited by 69 · see citing works
Prevalence of Liver Disease in Patients with Streptococcus bovis Bacteraemia
Gonzlez-Quintela, A., Martínez-Rey, C., Castroagudı́n, J. F., Rajo-Iglesias, M. C., & Domínguez‐Santalla, M. J. (2001) · Journal of Infection · doi:10.1053/jinf.2001.0799 · Cited by 65 · see citing works
A prospective study of plasma inflammatory markers and risk of colorectal cancer in men
Song, M., Wu, K., Ogino, S., Fuchs, C. S., Giovannucci, E. L., & Chan, A. T. (2013) · British Journal of Cancer · doi:10.1038/bjc.2013.172 · Cited by 63 · see citing works
The Association of Streptococcus bovis Bacteremia and Gastrointestinal Diseases: A Retrospective Analysis
Alazmi, W. M., Bustamante, M., O’Loughlin, C. J., González, J. D., & Raskin, J. B. (2006) · Digestive Diseases and Sciences · doi:10.1007/s10620-006-3199-7 · Cited by 59 · see citing works
A prospective controlled study of the association of Streptococcus bovis with colorectal carcinoma.
Potter, M. A., Cunliffe, N. A., Smith, M. H., Miles, R., Flapan, A. D., & Dunlop, M. G. (1998) · Journal of Clinical Pathology · doi:10.1136/jcp.51.6.473 · Cited by 59 · see citing works
Characteristics and regional variations of group D streptococcal endocarditis in France
Giannitsioti, E., Chirouze, C., Bouvet, A., Béguinot, I., Delahaye, F., Mainardi, J., Célard, M., Mihaïla-Amrouche, L., Moing, V. L., & Hoen, B. (2007) · Clinical Microbiology and Infection · doi:10.1111/j.1469-0691.2007.01753.x · Cited by 58 · see citing works
16S Ribosomal DNA Sequence Analysis Distinguishes Biotypes of Streptococcus bovis : Streptococcus bovis Biotype II/2 Is a Separate Genospecies and the Predominant Clinical Isolate in Adult Males
Clarridge, J. E., Attorri, S., Zhang, Q., & Bartell, J. G. (2001) · Journal of Clinical Microbiology · doi:10.1128/jcm.39.4.1549-1552.2001 · Cited by 58 · see citing works
Increased exposure to bacterial antigen RpL7/L12 in early stage colorectal cancer patients
Boleij, A., Roelofs, R., Schaeps, R. M. J., Schülin, T., Glaser, P., Swinkels, D. W., Kato, I., & Tjalsma, H. (2010) · Cancer · doi:10.1002/cncr.25212 · Cited by 54 · see citing works
Serological investigation into the association between Streptococcus bovis and colonic cancer.
Darjee, R., & Gibb, A. P. (1993) · Journal of Clinical Pathology · doi:10.1136/jcp.46.12.1116 · Cited by 51 · see citing works
Association of S treptococcus gallolyticus subspecies gallolyticus with colorectal cancer: Serological evidence
Butt, J., Romero‐Hernández, B., Pérez‐Gómez, B., Willhauck‐Fleckenstein, M., Holzinger, D., Martín, V., Moreno, V. R., Linares, C., Dierssen‐Sotos, T., Barricarte, A., et al. (2015) · International Journal of Cancer · doi:10.1002/ijc.29914 · Cited by 51 · see citing works
Systematic review and meta-analysis of the proportion of non-typhoidal Salmonella cases that develop chronic sequelae
Keithlin, J., Sargeant, J. M., Thomas, M. K., & Fazil, A. (2014) · Epidemiology and Infection · doi:10.1017/s0950268814002829 · Cited by 48 · see citing works
Fecal carriage of Streptococcus bovis and colorectal adenomas
Dubrow, R., Edberg, S. C., Wikfors, E., Callan, D. A., Troncale, F. J., Vender, R. J., Brand, M., & Yapp, R. G. (1991) · Gastroenterology · doi:10.1016/0016-5085(91)90531-o · Cited by 46 · see citing works
Partial associations of dietary iron, smoking and intestinal bacteria with colorectal cancer risk
Kato, I., Boleij, A., Kortman, G. A. M., Roelofs, R., Djuric, Z., Severson, R. K., & Tjalsma, H. (2013) · Nutrition and Cancer · doi:10.1080/01635581.2013.748922 · Cited by 46 · see citing works
Bacteremic Streptococcus bovis infections at a university hospital, 1992-2001.
Jean, S., Teng, L., Hsueh, P., Ho, S. W., & Luh, K. T. (2004) · PubMed · Cited by 43 · see citing works
Unusual Bacterial Infections and Colorectal Carcinoma— Streptococcus bovis and Clostridium septicum : Report of Three Cases
Wentling, G. K., Metzger, P. P., Dozois, E. J., Chua, H. K., & Krishna, M. (2006) · Diseases of the Colon & Rectum · doi:10.1007/s10350-006-0576-4 · Cited by 43 · see citing works
Selective Antibody Response to Streptococcus gallolyticus Pilus Proteins in Colorectal Cancer Patients
Boleij, A., Roelofs, R., Danne, C., Bellais, S., Dramsi, S., Kato, I., & Tjalsma, H. (2011) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-11-0321 · Cited by 38 · see citing works
Association of S treptococcus bovis endocarditis and advanced colorectal neoplasia: A case–control study
Sharara, A. I., Hamdan, T. A., Malli, A. H., El-Halabi, M. M., Hashash, J. G., Ghaith, O. A., & Kanj, S. S. (2013) · Journal of Digestive Diseases · doi:10.1111/1751-2980.12059 · Cited by 28 · cited 2× · see citing works
“Similar prevalence (60%) of advanced adenoma/ cancer was reported in SB endocarditis patients by Sharara et al.(48) The second set of evidence is derived from studies comparing SB prevalence among various patient groups with or without colonic diseases.”
Background
DNA Methylation in the Rectal Mucosa Is Associated with Crypt Proliferation and Fecal Short-Chain Fatty Acids
Worthley, D. L., Whitehall, V., Leu, R. K. L., Irahara, N., Buttenshaw, R. L., Mallitt, K., Greco, S. A., Ramsnes, I., Winter, J. M., Hu, Y. C., et al. (2010) · Digestive Diseases and Sciences · doi:10.1007/s10620-010-1312-4 · Cited by 28 · see citing works
Inflammatory Bowel Disease and Streptococcus bovis
Teitelbaum, J. E., & Triantafyllopoulou, M. (2006) · Digestive Diseases and Sciences · doi:10.1007/s10620-005-9053-5 · Cited by 24 · see citing works
Cancer Therapies Use a Little Help From Microbial Friends
Pennisi, E. (2013) · Science · doi:10.1126/science.342.6161.921 · Cited by 22 · see citing works
Streptococcus bovis septicaemia associated with uncomplicated colonic carcinoma
McMahon, A. J., Auld, C. D., Dale, B. A. S., Walls, A. D. F., & McCormick, J. S. (1991) · British journal of surgery · doi:10.1002/bjs.1800780734 · Cited by 22 · see citing works
Gentamicin-thallous-carbonate medium for isolation of fecal streptococci from foods
Thian, T. S., & Hartman, P. A. (1981) · Applied and Environmental Microbiology · doi:10.1128/aem.41.3.724-728.1981 · Cited by 20 · cited 1× · see citing works
“In fact SB is a frequently detected contaminant in commercially available meat.(23,24) The correlation between SB and colonic disease has long been recognized.”
Background
Streptococcs bovis Bacteremia and Digestive System Neoplasms
Pigrau, C., Lorente, A., Pahissa, A., & Martinez-Vazquez, J. M. (1988) · Scandinavian Journal of Infectious Diseases · doi:10.3109/00365548809032490 · Cited by 20 · see citing works
Smoking and other personal characteristics as potential predictors for fecal bacteria populations in humans.
Kato, I., Nechvatal, J. M., Dzinic, S. H., Basson, M. D., Majumdar, A. P. N., & Ram, J. L. (2010) · PubMed · Cited by 19 · see citing works
Efficient tumor targeting by anaerobic butyrate-producing bacteria
Tirandaz, H., & Mohammadi, E. (2013) · Medical Hypotheses · doi:10.1016/j.mehy.2013.01.024 · Cited by 17 · see citing works
A Case ofStreptococcus gallolyticussubsp.gallolyticusInfective Endocarditis with Colon Cancer: Identification by 16S Ribosomal DNA Sequencing
Kim, S. Y., Joo, S.-I., Yi, J., & Kim, E. C. (2010) · Annals of Laboratory Medicine · doi:10.3343/kjlm.2010.30.2.160 · Cited by 16 · see citing works
Comparison of fluorescent gentamicin-thallous-carbonate and KF streptococcal agars to enumerate enterococci and fecal streptococci in meats
Knudtson, L. M., & Hartman, P. A. (1993) · Applied and Environmental Microbiology · doi:10.1128/aem.59.3.936-938.1993 · Cited by 14 · see citing works
Streptococcus bovis bacteremia related to colon adenoma in a chronic hemodialysis patient
Kahveci, A., Arı, E., Arikan, I. H., Koç, M., Tuğlular, S., & Ozener, C. I. (2009) · Hemodialysis International · doi:10.1111/j.1542-4758.2009.00400.x · Cited by 8 · see citing works
The influence of endoscopic procedures upon the contamination of Helicobacter pylori cultures
Ribeiro, M. L., Godoy, A. P. O., Benvengo, Y. H. B., Ecclissato, C., Mendonça, S., & Pedrazzoli, J. (2004) · Arquivos de Gastroenterologia · doi:10.1590/s0004-28032004000200006 · Cited by 6 · cited 1× · see citing works
“, cattle, sheep, horses, pigs, camels and deers, it is also found in human feces as well as gastric biopsy materials.(20,21) Approximately 10% of healthy individuals have been estimated to carry this bacterium asymptomatically in their digestive tract.”
Background
The Presence of Helicobacter pylori in Colorectal Polyps Detected by Immunohistochemical Methods in Children
Cheng, H., Zhang, T., Gu, W., Shu, X., Zhang, Y., Zhang, X., Wu, X., Chen, J., & Jiang, M. (2011) · The Pediatric Infectious Disease Journal · doi:10.1097/inf.0b013e3182467538 · Cited by 6 · see citing works
[Molecular-biological methods of diagnosing colon-related Streptococcus bovis endocarditis].
Nielsen, S. D., Christensen, J. J., Laerkeborg, A., Haunsø, S., & Knudsen, J. D. (2007) · PubMed · Cited by 5 · see citing works

Flagged first, then by citations

1 of the 170 references couldn’t be matched to a known paper.

Research works printed but not linked: 2

[45]Beck M. Frodl R. Funke G. Comprehensive study of strains previously designated Streptococcus bovis consecutively isolated from human blood cultures and emended description of Streptococcus gallolyticus and Streptococcus infantarius subsp. coli J Clin Microbiol 46 2008 2966 2972 18614655 PMC2546750
[72]Martin H.M. Campbell B.J. Hart C.A. Enhanced Escherichia coli adherence and invasion in Crohn's disease and colon cancer Gastroenterology 127 2004 80 93 15236175

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NF-κB, inflammation, immunity and cancer: coming of age
Taniguchi, K., & Karin, M. (2018) · Nature Reviews Immunology · doi:10.1038/nri.2017.142 · Cited by 2,679 · see citing works
Influence of the Gut Microbiome, Diet, and Environment on Risk of Colorectal Cancer
Song, M., Chan, A. T., & Sun, J. (2020) · Gastroenterology · doi:10.1053/j.gastro.2019.06.048 · Cited by 752 · see citing works
The Gut Microbiota and Inflammation: An Overview
Bander, Z. A., Nitert, M. D., Mousa, A., & Naderpoor, N. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17207618 · Cited by 783 · see citing works
Tumor biomarkers for diagnosis, prognosis and targeted therapy
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Dysbiosis of Gram‑negative gut microbiota and the associated serum lipopolysaccharide exacerbates inflammation in type�2 diabetic patients with chronic kidney disease
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“The present study identified five previously reported genera in the phylum Bacteroidetes, including Porphyromonas , Prevotella , Paraprevotella and Flavobacterium (38,39).”
The Mechanism of Bacteroides fragilis Toxin Contributes to Colon Cancer Formation
Cheng, W. T., Kantilal, H. K., & Davamani, F. A. (2020) · Malaysian Journal of Medical Sciences · doi:10.21315/mjms2020.27.4.2 · Cited by 244 · see citing works
Oral–Gut Microbiome Axis in Gastrointestinal Disease and Cancer
Park, S.-Y., Hwang, B.-O., Lim, M., Ok, S.-H., Lee, S., Chun, K., Park, K.-K., Hu, Y., Chung, W., & Song, N. (2021) · Cancers · doi:10.3390/cancers13092124 · Cited by 237 · see citing works
Mucosa-associated microbiota dysbiosis in colitis associated cancer
Richard, M. L., Liguori, G., Lamas, B., Brandi, G., Costa, G. D., Hoffmann, T. W., Simone, M. P. D., Calabrese, C., Poggioli, G., Langella, P., et al. (2017) · Gut Microbes · doi:10.1080/19490976.2017.1379637 · Cited by 214 · see citing works
“Colorectal cancer (CRC) is the third commonest cancer type worldwide with, every year, 1,360,000 new cases and 600,000 deaths.(1,2) Its incidence rate is rapidly rising in less developed regions, with a poorer prognosis compared to western countries where routine diagnosis have been efficient in reducing the incidence…”
Background
Fecal Clostridium symbiosum for Noninvasive Detection of Early and Advanced Colorectal Cancer: Test and Validation Studies
Xie, Y., Gao, Q., Cai, G. X., Sun, X. M., Zou, T.-H., Chen, H. M., Yu, S.-Y., Qiu, Y.-W., Gu, W.-Q., Chen, X. Y., et al. (2017) · EBioMedicine · doi:10.1016/j.ebiom.2017.10.005 · Cited by 192 · see citing works
“…or her genetic status, feeding pattern, age, gender, dietary habit, health situation, drug intake and wealth level, making gut microbiota a highly potential biomarker (Ding and Schloss, 2014, Costello et al., 2009, Quigley, 2017, Sun and Kato, 2016, Peters et al., 2016, Yatsunenko et al., 2012).”
Background
Microbiota’s role in health and diseases
El-Sayed, A., Aleya, L., & Kamel, M. S. (2021) · Environmental Science and Pollution Research · doi:10.1007/s11356-021-14593-z · Cited by 195 · see citing works
“This is attributed to the higher microbial population in the large intestine, especially the gut virome and bacteriophages (Dahiya and Renuka 2017; Sun and Kato 2016).”
Background
Understanding the role of the gut microbiome in gastrointestinal cancer: A review
Ağagündüz, D., Cocozza, E., Cemali, Ö., Bayazıt, A. D., Nanì, M. F., Cerqua, I., Morgillo, F., Saygılı, S. K., Berni Canani, R., Amero, P., et al. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1130562 · Cited by 189 · see citing works
“Cancer prevention is the main target, and it is reported that a better understanding of the interactions between gut microbiota, barrier function, and inflammatory responses is significant in identifying new targets in cancer therapy (Bultman, 2016; Sun and Kato, 2016).”
Background
Gastro-Intestinal and Oral Microbiome Signatures Associated with Healthy Aging
Singh, H., Torralba, M. G., Moncera, K. J., DiLello, L., Petrini, J., Nelson, K. E., & Pieper, R. (2019) · GeroScience · doi:10.1007/s11357-019-00098-8 · Cited by 158 · see citing works
Macrophage depletion using clodronate liposomes decreases tumorigenesis and alters gut microbiota in the AOM/DSS mouse model of colon cancer
Bader, J. E., Enos, R. T., Velázquez, K. T., Carson, M. S., Nagarkatti, M., Nagarkatti, P. S., Chatzistamou, I., Davis, J. M., Carson, J. A., Robinson, C. M., et al. (2017) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00229.2017 · Cited by 170 · see citing works
Neutrophils Restrict Tumor-Associated Microbiota to Reduce Growth and Invasion of Colon Tumors in Mice
Triner, D. A., Devenport, S. N., Ramakrishnan, S. K., Ma, X., Frieler, R. A., Greenson, J. K., Inohara, N., Núñez, G., Colacino, J. A., Mortensen, R. M., et al. (2018) · Gastroenterology · doi:10.1053/j.gastro.2018.12.003 · Cited by 167 · see citing works
Gut Microbiota Dysbiosis Drives the Development of Colorectal Cancer
Fan, X., Jin, Y., Chen, G., Ma, X., & Zhang, L. (2020) · Digestion · doi:10.1159/000508328 · Cited by 169 · see citing works
Gut Microbiota in Colorectal Cancer: Biological Role and Therapeutic Opportunities
Pandey, H., Tang, D. W. T., Wong, S. H., & Lal, D. (2023) · Cancers · doi:10.3390/cancers15030866 · Cited by 165 · see citing works
“The Firmicutes/Bacteroidetes ratio (Bacillota/Bacteroidota) has been used as a critical parameter for gut health [53] and is critical for CRC progression [54].”
Method
Linking Obesity with Colorectal Cancer: Epidemiology and Mechanistic Insights
Ye, P., Xi, Y., Huang, Z., & Xu, P. (2020) · Cancers · doi:10.3390/cancers12061408 · Cited by 160 · see citing works
“for gastrointestinal health to maintain intestinal barrier function [136].”
Background
Polyphenols: Immunomodulatory and Therapeutic Implication in Colorectal Cancer
Mileo, A. M., Nisticò, P., & Miccadei, S. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00729 · Cited by 152 · see citing works
Linking Gut Microbiota to Colorectal Cancer
Raskov, H., Burcharth, J., & Pommergaard, H. (2017) · Journal of Cancer · doi:10.7150/jca.20497 · Cited by 151 · see citing works
Cervical Cancer, Different Treatments and Importance of Bile Acids as Therapeutic Agents in This Disease
Šarenac, T., & Mikov, M. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00484 · Cited by 143 · see citing works
Green Tea Liquid Consumption Alters the Human Intestinal and Oral Microbiome
Yuan, X., Long, Y., Ji, Z., Gao, J., Fu, T., Yan, M., Zhang, L., Su, H., Zhang, W., Wen, X., et al. (2018) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201800178 · Cited by 142 · see citing works
Fusobacterium nucleatum Facilitates M2 Macrophage Polarization and Colorectal Carcinoma Progression by Activating TLR4/NF-κB/S100A9 Cascade
Hu, L., Liu, Y., Kong, X., Wu, R., Peng, Q., Zhang, Y., Zhou, L., & Duan, L. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.658681 · Cited by 141 · see citing works
“Recently, accumulating evidence by metagenome-wide association studies indicated an association between gut microbiota dysbiosis and CRC, and enteropathogenic microorganism plays a role in shaping the inflammatory environment and promoting tumor initiation and progression (4, 5).”
Background
Fusobacterium nucleatum in the Colorectum and Its Association with Cancer Risk and Survival: A Systematic Review and Meta-analysis
Gethings-Behncke, C., Coleman, H. G., Jordão, H. W. T., Longley, D. B., Crawford, N., Murray, L., & Kunzmann, A. T. (2020) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-18-1295 · Cited by 137 · see citing works
“A number of bacterial species have been implicated with colorectal cancer onset, including Helicobacter pylori, Escherichia coli, Bacteroides fragilis, Salmonella enterica, and Fusobacterium nucleatum (3).”
BackgroundInfluential
Efficient inter-species conjugative transfer of a CRISPR nuclease for targeted bacterial killing
Hamilton, T. A., Pellegrino, G. M., Therrien, J. A., Ham, D. T., Bartlett, P. C., Karas, B. J., Gloor, G. B., & Edgell, D. R. (2019) · Nature Communications · doi:10.1038/s41467-019-12448-3 · Cited by 134 · see citing works
Gut microbes as future therapeutics in treating inflammatory and infectious diseases: Lessons from recent findings
Mukherjee, S., Joardar, N., Sengupta, S., & Babu, S. P. S. (2018) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2018.07.010 · Cited by 127 · see citing works
“Several current studies that assessed beta diversity through 16S rRNA sequencing have illustrated structural differences amongst the gut microbiota, where samples belonging to different disease status (cancer, adenoma, or control/normal adjacent tissue) cluster in different two-dimensional spaces indicating the presen…”
Background
Microbiome or Infections: Amyloid-Containing Biofilms as a Trigger for Complex Human Diseases
Miller, A. L., Bessho, S., Grando, K. C. M., & Tükel, Ç. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.638867 · Cited by 131 · see citing works
“Specific changes within the intestinal microbial community are observed in CRC patients, such as increased abundance of Fusobacteria, Alistipes, Porphyromonadaceae, Coriobacteridae, Staphylococcaceae, Akkermansia, and Methanobacteriales, while representation of Bifidobacterium, Lactobacillus, Ruminococcus, Faecalibact…”
Background
Blueprint for cancer research: Critical gaps and opportunities
Elmore, L. W., Greer, S. F., Daniels, E. C., Saxe, C. C., Melner, M. H., Krawiec, G. M., Cance, W. G., & Phelps, W. C. (2020) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.21652 · Cited by 121 · see citing works
Gut microbiota-derived metabolites in CRC progression and causation
Dalal, N., Jalandra, R., Bayal, N., Yadav, A. K., Harshulika, Sharma, M., Makharia, G. K., Kumar, P., Singh, R. K., Solanki, P. R., et al. (2021) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-021-03729-w · Cited by 102 · see citing works
“P. anaerobius is normally harmless but it may be harmful in immunocompromised conditions (Sun and Kato 2016).”
Background
The Effect of the Gut Microbiota on Systemic and Anti-Tumor Immunity and Response to Systemic Therapy against Cancer
Aghamajidi, A., & Vareki, S. M. (2022) · Cancers · doi:10.3390/cancers14153563 · Cited by 102 · see citing works
“In addition, the immune dysregulation caused by other commensal microbial species such as Streptococcus gallolyticus, Enterococcus faecalis, Bacteroides fragilis, and Fusobacterium nucleatum also contribute to CRC development [65].”
Background
Vitamin D Receptor Influences Intestinal Barriers in Health and Disease
Sun, J., & Zhang, Y. (2022) · Cells · doi:10.3390/cells11071129 · Cited by 100 · see citing works
Gut Microbiome in Colorectal Cancer: Clinical Diagnosis and Treatment
Liu, Y., Lau, H. C.-H., Cheng, W. Y., & Yu, J. Q. (2022) · Genomics Proteomics & Bioinformatics · doi:10.1016/j.gpb.2022.07.002 · Cited by 98 · see citing works
“Bacteria-derived signals identified by PRRs can activate downstream inflammatory signaling pathways, including nuclear factor kappa-lightchain-enhancer of activated B cells (NF-jB), mitogenactivated protein kinase (MAPK), and signal transducer and activator of transcription 3 (STAT3) which are all important pathways t…”
Background
Alterations in the gut bacterial microbiome in fungal Keratitis patients
Chakravarthy, S. K., Jayasudha, R., Ranjith, K., Dutta, A., Pinna, N. K., Mande, S. S., Sharma, S., Garg, P., Murthy, S. I., & Shivaji, S. (2018) · PLoS ONE · doi:10.1371/journal.pone.0199640 · Cited by 88 · see citing works
Potential Role of Biofilm Formation in the Development of Digestive Tract Cancer With Special Reference to Helicobacter pylori Infection
Rizzato, C., Torres, J., Kasamatsu, E., Camorlinga‐Ponce, M., Bravo, M. M., Canzian, F., & Kato, I. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.00846 · Cited by 81 · see citing works
“infective endocarditis on cardiac valves (Boleij et al., 2010, 2012; Sun and Kato, 2016; Butt et al., 2018; Jans and Boleij, 2018).”
Background
Significant and Conflicting Correlation of IL-9 With Prevotella and Bacteroides in Human Colorectal Cancer
Niccolai, E., Russo, E., Baldi, S., Ricci, F., Nannini, G., Pedone, M., Stingo, F. C., Taddei, A., Ringressi, M. N., Bechi, P., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.573158 · Cited by 78 · see citing works
The gut microbiota and endometriosis: From pathogenesis to diagnosis and treatment
Qin, R., Tian, G., Liu, J., & Cao, L. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.1069557 · Cited by 77 · see citing works
“Studies have found that gut microbiota disorders can not only cause inflammatory bowel disease, irritable bowel syndrome, and colon cancer in the intestinal system, but can also induce diseases in the extraintestinal system, such as diabetes, mastitis, and polycystic ovary syndrome (Baothman et al., 2016; Sun and Kato…”
Background
Implication of Obesity and Gut Microbiome Dysbiosis in the Etiology of Colorectal Cancer
Singh, S., Sharma, P., Sarma, D. K., Kumawat, M., Tiwari, R. R., Verma, V., Nagpal, R., & Kumar, M. (2023) · Cancers · doi:10.3390/cancers15061913 · Cited by 80 · see citing works
Microbiota and Cancer: The Emerging Beneficial Role of Bifidobacteria in Cancer Immunotherapy
Longhi, G., van Sinderen, D., Ventura, M., & Turroni, F. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.575072 · Cited by 71 · see citing works
“(2020). The infant gut microbiome as a microbial organ influencing host well-being.”
Background
A Pilot Study: Changes of Gut Microbiota in Post-surgery Colorectal Cancer Patients
Cong, J., Zhu, H., Liu, D., Li, T., Zhang, C., Zhu, J., Lv, H., Liu, K., Hao, C., Tian, Z., et al. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.02777 · Cited by 69 · see citing works
“, 2011), and is influenced by heredity, diet, lifestyle, gut microbiota, and other factors (Berstad et al., 2015; Sun and Kato, 2016).”
Background
The Encapsulation Strategies for Targeted Delivery of Probiotics in Preventing and Treating Colorectal Cancer: A Review
Zhong, H., Jiang, J., Hussain, M., Zhang, H., Ling, C., & Guan, R. (2025) · Advanced Science · doi:10.1002/advs.202500304 · Cited by 66 · see citing works
Caffeine and its main targets of colorectal cancer
Cui, W., Wang, S.-T., Pan, D., Chang, B., & Sang, L.-X. (2020) · World Journal of Gastrointestinal Oncology · doi:10.4251/wjgo.v12.i2.149 · Cited by 66 · see citing works
Traditional Processed Meat Products Re-designed Towards Inulin-rich Functional Foods Reduce Polyps in Two Colorectal Cancer Animal Models
Fernández, J., Ledesma, E., Monte, J., Millán, E., Costa, P., de la Fuente, V. G., García, M. T. F., Martínez‐Camblor, P., Villar, C. J., & Lombó, F. (2019) · Scientific Reports · doi:10.1038/s41598-019-51437-w · Cited by 65 · see citing works
New insights into microbial bile salt hydrolases: from physiological roles to potential applications
Dong, Z., Yang, S., Tang, C., Li, D., Kan, Y., & Yao, L. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1513541 · Cited by 64 · see citing works
“…(Figure 1), which may promote colorectal cancer, cause DNA damage and reactive oxygen species-associated oxidative stress in epithelial intestinal cells, or lead to impaired colonic mucosal function that would cause diarrhea, inflammation, and some other GIT diseases (Sun and Kato, 2016).”
Vitamin D receptor upregulates tight junction protein claudin-5 against colitis-associated tumorigenesis
Zhang, Y., Garrett, S., Carroll, R. E., Xia, Y., & Sun, J. (2022) · Mucosal Immunology · doi:10.1038/s41385-022-00502-1 · Cited by 63 · see citing works
Oral and Gut Microbial Carbohydrate-Active Enzymes Landscape in Health and Disease
Onyango, S. O., Juma, J., Paepe, K. D., & de Wiele, T. V. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.653448 · Cited by 61 · see citing works
“Potentially, this reduces the generation of short-chain fatty acids such as butyrate which has also been reported to reduce the risk for cancer development (Sun and Kato, 2016).”
Background
Lactobacillus coryniformis MXJ32 administration ameliorates azoxymethane/dextran sulfate sodium-induced colitis-associated colorectal cancer via reshaping intestinal microenvironment and alleviating inflammatory response
Wang, T., Zhang, L., Wang, P., Liu, Y., Wang, G., Shan, Y., Yi, Y., Zhou, Y., Liu, B., Wang, X., et al. (2021) · European Journal of Nutrition · doi:10.1007/s00394-021-02627-8 · Cited by 61 · see citing works
“In addition, SCFAs, especially butyric acid, have been proved to have potential benefits for CA-CRC patients as they could promote and maintain colonic epithelial health [32], moderate cell growth and differentiation [45], inhibit histone deacetylases in colonocytes and immune cells [46] and exert anti-inflammatory ef…”
Background
Effect of industrial trans-fatty acids-enriched diet on gut microbiota of C57BL/6 mice
Ge, Y., Liu, W., Tao, H., Zhang, Y., Liu, L., Liu, Z., Qiu, B., & Xu, T. (2018) · European Journal of Nutrition · doi:10.1007/s00394-018-1810-2 · Cited by 63 · see citing works
Microbiota Effect on Trimethylamine N-Oxide Production: From Cancer to Fitness—A Practical Preventing Recommendation and Therapies
Tacconi, E., Palma, G., Biase, D. D., Luciano, A., Barbieri, M., de Nigris, F., & Bruzzese, F. (2023) · Nutrients · doi:10.3390/nu15030563 · Cited by 62 · see citing works
A Systematic Overview of Type II and III Toxin-Antitoxin Systems with a Focus on Druggability
Kang, S., Kim, D., Jin, C., & Lee, B. (2018) · Toxins · doi:10.3390/toxins10120515 · Cited by 60 · see citing works
tRNA Queuosine Modification Enzyme Modulates the Growth and Microbiome Recruitment to Breast Tumors
Zhang, J., Lu, R., Zhang, Y., Matuszek, Ż., Zhang, W., Xia, Y., Pan, T., & Sun, J. (2020) · Cancers · doi:10.3390/cancers12030628 · Cited by 60 · see citing works
“Tight junction proteins are the key players in the epithelial barrier function in inflammatory bowel disease [38-42].”
Background
Structure of the Mucosal and Stool Microbiome in Lynch Syndrome
Yan, Y., Drew, D. A., Markowitz, A. J., Lloyd‐Price, J., Abu-Ali, G., Nguyen, L. H., Tran, C., Chung, D. C., Gilpin, K. K., Meixell, D. A., et al. (2020) · Cell Host & Microbe · doi:10.1016/j.chom.2020.03.005 · Cited by 63 · see citing works
Immunometabolism in biofilm infection: lessons from cancer
Mirzaei, R., Sabokroo, N., Ahmadyousefi, Y., Motamedi, H., & Karampoor, S. (2022) · Molecular Medicine · doi:10.1186/s10020-022-00435-2 · Cited by 59 · see citing works
Molecular Aspects of Colorectal Adenomas: The Interplay among Microenvironment, Oxidative Stress, and Predisposition
Aceto, G. M., Catalano, T., & Curia, M. C. (2020) · BioMed Research International · doi:10.1155/2020/1726309 · Cited by 57 · see citing works
Gut microbiota modulation: a tool for the management of colorectal cancer
Wang, Y., & Li, H. (2022) · Journal of Translational Medicine · doi:10.1186/s12967-022-03378-8 · Cited by 57 · see citing works
“Mainly, three mechanisms have been identified for tumor-promoting activities of microbiota: pathogenic bacterial virulence factors/toxins, bacterial metabolic products, and immune modulation/reaction [18].”
Background
Commensal microbiota-derived metabolite agmatine triggers inflammation to promote colorectal tumorigenesis
Yu, L., Cui, A., & Zhang, X. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2348441 · Cited by 53 · see citing works
Multi-omics machine learning to study host-microbiome interactions in early-onset colorectal cancer
Jayakrishnan, T., Sangwan, N., Barot, S. V., Farha, N., Mariam, A., Shao, X., Aucejo, F., Conces, M. L., Nair, K. G., Krishnamurthi, S., et al. (2024) · npj Precision Oncology · doi:10.1038/s41698-024-00647-1 · Cited by 51 · see citing works
Heterogeneity of colon cancer: from bench to bedside
Merlano, M. C., Granetto, C., Fea, E., Ricci, V., & Garrone, O. (2017) · ESMO Open · doi:10.1136/esmoopen-2017-000218 · Cited by 51 · see citing works
Streptomyces, shared microbiome member of soil and gut, as ‘old friends’ against colon cancer
Bolourian, A., & Mojtahedi, Z. (2018) · FEMS Microbiology Ecology · doi:10.1093/femsec/fiy120 · Cited by 49 · see citing works
Akebia trifoliata pericarp extract ameliorates inflammation through NF-κB/MAPK signaling pathways and modifies gut microbiota
Wang, X., Yu, N., Wang, Z., Qiu, T., Jiang, L., Zhu, X., Sun, Y., & Xiong, H. (2020) · Food & Function · doi:10.1039/c9fo02917f · Cited by 49 · see citing works
The influence of blood on the human gut microbiome
Chénard, T., Malick, M., Dubé, J., & Massé, É. (2020) · BMC Microbiology · doi:10.1186/s12866-020-01724-8 · Cited by 48 · see citing works
Evaluation of the Cholesterol-Lowering Mechanism of Enterococcus faecium Strain 132 and Lactobacillus paracasei Strain 201 in Hypercholesterolemia Rats
Yang, L., Xie, X., Li, Y., Wu, L., Fan, C., Liang, T., Xi, Y., Yang, S., Li, H., Zhang, J., et al. (2021) · Nutrients · doi:10.3390/nu13061982 · Cited by 47 · see citing works
Colorectal Cancer Stage-Specific Fecal Bacterial Community Fingerprinting of the Taiwanese Population and Underpinning of Potential Taxonomic Biomarkers
Fang, C., Chen, J., Hsu, B., Hussain, B., Rathod, J., & Lee, K. (2021) · Microorganisms · doi:10.3390/microorganisms9081548 · Cited by 47 · see citing works
“Similarly, other common bacteria of the human gut, such as Streptococcus gallolyticus and Helicobacter pylori, are believed to be involved in colorectal cancer [26].”
Background
Role of Dietary Defatted Rice Bran in the Modulation of Gut Microbiota in AOM/DSS-Induced Colitis-Associated Colorectal Cancer Rat Model
Tajasuwan, L., Kettawan, A., Rungruang, T., Wunjuntuk, K., & Prombutara, P. (2023) · Nutrients · doi:10.3390/nu15061528 · Cited by 50 · see citing works
“The gut microbiota is vital in maintaining intestinal homeostasis [2].”
Background
Antioxidant and Anticancer Properties of Leaf and Fruit Extracts of the Wild Raspberry (Rubus idaeus L.)
Veljković, B. P., Djordjević, N. Z., Dolicanin, Z. C., Ličina, B., Topuzović, M. D., Stanković, M. S., Zlatić, N. M., & Stevanović, Z. D. (2018) · Notulae Botanicae Horti Agrobotanici Cluj-Napoca · doi:10.15835/nbha47111274 · Cited by 47 · see citing works
“There are some recent reports on linkage between gut microbiome and colorectal cancer (Sun and Kato, 2016), including the role of E.”
Background
Novel Regulatory Roles of Wnt1 in Infection-Associated Colorectal Cancer
Wang, J., Lu, R., Fu, X., Dan, Z., Zhang, Y., Chang, X., Liu, Q., Xia, Y., Liu, X., & Sun, J. (2018) · Neoplasia · doi:10.1016/j.neo.2018.03.001 · Cited by 45 · see citing works
“001 Introduction Growing interest and accumulating data on human microbiota indicate that host-microbe interplay has an important role in the development of colorectal cancer (CRC) [1], which suggests that chronic infection and inflammation contribute to tumor initiation and tumor progression [2].”
Background
Potential biomarkers associated with oxidative stress for risk assessment of colorectal cancer
Mandal, P. (2017) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-017-1352-9 · Cited by 43 · see citing works
“Cespedes Feliciano et al. (2016) reported that the effects of obesity and metabolic dysregulation on cancer survival are inconsistent with metabolic syndrome (MetSyn).”
Background
Bile acids as carcinogens in the colon and at other sites in the gastrointestinal system
Bernstein, H., & Bernstein, C. (2022) · Experimental Biology and Medicine · doi:10.1177/15353702221131858 · Cited by 43 · see citing works
Grow With the Challenge – Microbial Effects on Epithelial Proliferation, Carcinogenesis, and Cancer Therapy
von Frieling, J., Fink, C., Hamm, J., Klischies, K., Förster, M., Bosch, T. C. G., Roeder, T., Rosenstiel, P. C., & Sommer, F. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.02020 · Cited by 44 · see citing works
“This topic is extensively covered by excellent recent publications to which we refer to for further reading (Shebl et al., 2012; Antonic et al., 2013; Cummins and Tangney, 2013; Sun and Kato, 2016; Pasquereau-Kotula et al., 2018).”
Background
Escherichia coli and Colorectal Cancer: Unfolding the Enigmatic Relationship
Rezaee, M. A., Nouri, R., Hasani, A., Shirazi, K. M., Alivand, M. R., Sepehri, B., Sotoodeh, S., & Hemmati, F. (2021) · Current Pharmaceutical Biotechnology · doi:10.2174/1389201022666210910094827 · Cited by 45 · see citing works
Microbiota and epigenetics: promising therapeutic approaches?
El-Sayed, A., Aleya, L., & Kamel, M. S. (2021) · Environmental Science and Pollution Research · doi:10.1007/s11356-021-15623-6 · Cited by 41 · see citing works
“In addition to breast cancer, a clear relationship between microbiota and other cancer types was described in the literature where the microbiome is involved directly/indirectly, completely/partially in the induction of different cancer types affecting the digestive tract (Borges-Canha et al. 2015; Dahiya and Renuka 2…”
Background
The Effect of Microbiota on Colon Carcinogenesis
Yoon, K., & Kim, N. (2018) · Journal of Cancer Prevention · doi:10.15430/jcp.2018.23.3.117 · Cited by 41 · see citing works
“Adapted from Sun and Kato.(15) COLORECTAL NEOPLASM”
Background
Influence of Iron on the Gut Microbiota in Colorectal Cancer
Phipps, O., Al-Hassi, H. O., Quraishi, M. N., Kumar, A., & Brookes, M. (2020) · Nutrients · doi:10.3390/nu12092512 · Cited by 41 · see citing works
“Cancer occurrence in the large intestines is approximately 12-fold higher than the small intestines [33].”
Background
Inhibitory effect of sodium butyrate on colorectal cancer cells and construction of the related molecular network
Xi, Y., Jing, Z., Wu, W., Zhang, C., Quan, Q., Zhou, Q., Jiamin, X., & Han, S. (2021) · BMC Cancer · doi:10.1186/s12885-021-07845-1 · Cited by 40 · see citing works
Industrially Produced Rice Protein Ameliorates Dextran Sulfate Sodium-Induced Colitis via Protecting the Intestinal Barrier, Mitigating Oxidative Stress, and Regulating Gut Microbiota
Huang, Z., Yang, W., Wang, X., Guo, F., Cheng, Y., Cao, L., Zhu, W., Sun, Y., & Xiong, H. (2022) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.2c00585 · Cited by 39 · see citing works
The science behind TCM and Gut microbiota interaction—their combinatorial approach holds promising therapeutic applications
Xia, W., Liu, B., Tang, S., Yasir, M., & Khan, I. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.875513 · Cited by 39 · see citing works
“A balanced GM is key to host health, and any dysbiosis in gut microbial composition could put the host at a risk for obesity, inflammatory bowel disease, diabetes, autism, rheumatoid arthritis, and colorectal cancer (CRC) (Musso et al., 2010; Stefka et al., 2014; Sun and Kato, 2016; Maeda and Takeda, 2017).”
Background
Colorectal cancer: The epigenetic role of microbiome
Sabit, H., Çevik, E., & Tombuloğlu, H. (2019) · World Journal of Clinical Cases · doi:10.12998/wjcc.v7.i22.3683 · Cited by 39 · see citing works
Oral–Gut Microbiome Axis in Gastrointestinal Disease and Cancer
Park, S.-Y., Hwang, B.-O., Lim, M., Ok, S. H., Lee, S., Chun, K., Park, K.-K., Hu, Y., Chung, W., & Song, N. (2021) · Cancers · doi:10.3390/cancers13071748 · Cited by 43 · see citing works
Molecular mechanistic pathway of colorectal carcinogenesis associated with intestinal microbiota
Mandal, P. (2017) · Anaerobe · doi:10.1016/j.anaerobe.2017.12.008 · Cited by 38 · see citing works
Influence of Gut Microbiota-Mediated Immune Regulation on Response to Chemotherapy
Deng, Y., Hou, X., Wang, H., Du, H., & Liu, Y. (2024) · Pharmaceuticals · doi:10.3390/ph17050604 · Cited by 37 · see citing works
“SCFAs also promote the differentiation of T-cells into effector T-cells (Th1 and Th17 cell) [94,104].”
Background
Chemoprevention of Colorectal Cancer by Anthocyanidins and Mitigation of Metabolic Shifts Induced by Dysbiosis of the Gut Microbiome
Mudd, A. M., Gu, T., Munagala, R., Jeyabalan, J., Egilmez, N. K., & Gupta, R. C. (2019) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-19-0362 · Cited by 37 · see citing works
“enterica), and enterotoxigenic Bacteriodes fragilis (ETBF) (9).”
The probiotic Companilactobacillus crustorum MN047 alleviates colitis-associated tumorigenesis via modulating the intestinal microenvironment
Wang, T., Wang, P., Ge, W., Shi, C., Xiao, G., Wang, X., & Lü, X. (2021) · Food & Function · doi:10.1039/d1fo01531a · Cited by 37 · see citing works
Mechanism of Bile Acid-Induced Programmed Cell Death and Drug Discovery against Cancer: A Review
Jang, J. Y., Im, E., Choi, Y. H., & Kim, N. D. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23137184 · Cited by 36 · see citing works
“UDCA is the most hydrophilic bile acid, while DCA and LCA are the least polar and most toxic bile acids that can contribute to the development of colorectal cancer [45].”
Background
Role of preoperative gut microbiota on colorectal anastomotic leakage: preliminary results
Palmisano, S., Campisciano, G., Iacuzzo, C., Bonadio, L., Zucca, A., Cosola, D., Comar, M., & de Manzini, N. (2020) · Updates in Surgery · doi:10.1007/s13304-020-00720-x · Cited by 37 · see citing works
“Finally, as in the literature several studies show that the colorectal microbiota of individuals affected by cancer presents a decreased level of biodiversity [3, 6, 33], we analyzed the α-diversity.”
Result
Regulation of tissue-resident memory T cells by the Microbiota
Overacre-Delgoffe, A. E., & Hand, T. W. (2022) · Mucosal Immunology · doi:10.1038/s41385-022-00491-1 · Cited by 37 · see citing works
Endogenous Propionibacterium acnes Promotes Ovarian Cancer Progression via Regulating Hedgehog Signalling Pathway
Huang, Q., Wei, X., Li, W., Ma, Y., Chen, G., Zhao, L., Jiang, Y., Xie, S., Chen, Q., & Chen, T. (2022) · Cancers · doi:10.3390/cancers14215178 · Cited by 35 · see citing works
“Accumulating evidence has shown that microbiota is viewed as an increasingly important factor in the initiation and progression of many diseases, including cancer [15–18].”
Background
Connect between gut microbiome and diseases of the human eye
Shivaji, S. (2019) · Journal of Biosciences · doi:10.1007/s12038-019-9931-1 · Cited by 35 · see citing works
Carbohydrate polymers-based surface modified nano delivery systems for enhanced target delivery to colon cancer - A review
Ibrahim, I. A. A., Alzahrani, A. R., Alanazi, I. M., Shahzad, N., Shahid, I., Falemban, A. H., Azlina, M. F. N., & Arulselvan, P. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.126581 · Cited by 34 · see citing works
Intestinal biofilms: pathophysiological relevance, host defense, and therapeutic opportunities
Jandl, B., Dighe, S. N., Gasché, C., Makristathis, A., & Muttenthaler, M. (2024) · Clinical Microbiology Reviews · doi:10.1128/cmr.00133-23 · Cited by 35 · see citing works
“Within the B. fragilis group, enterotoxigenic B. fragilis is of particular clinical relevance, representing the most common carcinogenic bacteria and a pivotal pathogen implicated in the initiation and progression of colorectal cancers (177–179).”
Agave salmiana fructans as gut health promoters: Prebiotic activity and inflammatory response in Wistar healthy rats
Andrade, A. I. C., Rivera-Bautista, C., Ruiz‐Cabrera, M. A., Guerra, R. E. S., Chávez, E. G., Ahumada, C. F., & Grajales‐Lagunes, A. (2019) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2019.06.045 · Cited by 34 · see citing works
Lactobacillus fermentum V3 ameliorates colitis-associated tumorigenesis by modulating the gut microbiome.
Chou, Y.-C., Ho, P.-Y., Chen, W.-J., Wu, S.-H., & Pan, M. (2020) · PubMed Central · Cited by 34 · see citing works
Lacticaseibacillus rhamnosus LS8 Ameliorates Azoxymethane/Dextran Sulfate Sodium-Induced Colitis-Associated Tumorigenesis in Mice via Regulating Gut Microbiota and Inhibiting Inflammation
Wang, T., Zheng, J., Dong, S., Ismael, M., Shan, Y., Wang, X., & Lü, X. (2022) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-022-09967-9 · Cited by 34 · see citing works
“As the typical beneficial metabolites of intestinal microbiota, SCFAs (especially butyric acid) played important roles in ameliorating CRC [30], including inhibiting inflammation and histone deacetylases [31, 32], maintaining colonic epithelial health [33], inhibiting microbial pathogens [34], and regulating cell grow…”
Background
The gastrointestinal microbiota in colorectal cancer cell migration and invasion
Henstra, C., van Praagh, J., Olinga, P., & Nagelkerke, A. (2021) · Clinical & Experimental Metastasis · doi:10.1007/s10585-021-10130-x · Cited by 32 · see citing works
“coli, as a commensal, coexists peacefully with its mammalian host, promoting healthy intestinal homeostasis and causing disease only rarely [112].”
Background
Impact of bacterial infection and intestinal microbiome on colorectal cancer development
Sun, J. (2022) · Chinese Medical Journal · doi:10.1097/cm9.0000000000001979 · Cited by 33 · see citing works
“Factors that affect the risk of CRC also affect the intestinal microbiome, including obesity; physical activity; and dietary intake of fiber, whole grains, and red and processed meat.([89,95]) These factors, including Salmonella infection,([96]) alter microbiome structure and function, along with the metabolic and imm…”
Background
Protection from chemotherapy- and antibiotic-mediated dysbiosis of the gut microbiota by a probiotic with digestive enzymes supplement
Ichim, T. E., Kesari, S., & Shafer, K. (2018) · Oncotarget · doi:10.18632/oncotarget.25778 · Cited by 33 · see citing works
Exploring the Relationship Between Diet, Lifestyle and Gut Microbiome in Colorectal Cancer Development: A Recent Update
Saha, B., Rithi, A. T., Adhikary, S., Banerjee, A., Radhakrishnan, A., Duttaroy, A. K., & Pathak, S. (2024) · Nutrition and Cancer · doi:10.1080/01635581.2024.2367266 · Cited by 37 · see citing works
The clinical application of fruquintinib on colorectal cancer
Chen, Z., & Jiang, L. (2019) · Expert Review of Clinical Pharmacology · doi:10.1080/17512433.2019.1630272 · Cited by 32 · see citing works
An age stratified analysis of the biomarkers in patients with colorectal cancer
Yao, H. Q., Li, C., & Tan, X. (2021) · Scientific Reports · doi:10.1038/s41598-021-01850-x · Cited by 32 · see citing works
Colon and gut microbiota greatly affect the absorption and utilization of astaxanthin derived from Haematococcus pluvialis
Li, C., Gao, Y., Huan, Y., Ren, P., Zhi, J., Wu, A., Xu, J., Wei, Z., Xue, C., & Tang, Q. (2022) · Food Research International · doi:10.1016/j.foodres.2022.111324 · Cited by 32 · see citing works
The chemopreventive effects of Huangqin-tea against AOM-induced preneoplastic colonic aberrant crypt foci in rats and omics analysis
Shen, J., Li, P., Liu, S., Liu, Q., Li, Y., Zhang, Z., Yang, C., Hu, M., Sun, Y., He, C., et al. (2020) · Food & Function · doi:10.1039/d0fo01731k · Cited by 31 · see citing works
Immunomodulatory Effect of Lactobacillus casei in a Murine Model of Colon Carcinogenesis
Casas‐Solís, J., Huizar-López, M. D. R., Irecta-Nájera, C. A., Pita‐López, M. L., & Santerre, A. (2019) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-019-09611-z · Cited by 31 · see citing works
Microbial factors in inflammatory diseases and cancers
Ong, H. S., & Yim, H. C. H. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-981-10-5987-2_7 · Cited by 29 · see citing works

Microbiome, inflammation and colorectal cancer
Chen, J., Pitmon, E., & Wang, K. (2017) · Seminars in Immunology · doi:10.1016/j.smim.2017.09.006 · Cited by 267 · see citing works
Microbiome and colorectal cancer: Roles in carcinogenesis and clinical potential
Saus, E., Iraola‐Guzmán, S., Willis, J. R., Brunet‐Vega, A., & Gabaldón, T. (2019) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2019.05.001 · Cited by 348 · see citing works
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Can we change our microbiome to prevent colorectal cancer development?
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Authors: Sun, J., & Kato, I.
Affiliations: University of Illinois Chicago (US)
Wayne State University (US)
Corresponding author: Sun, Jun
ORCID: Sun, Jun
Kato, Ikuko
Venue: Genes & Diseases
Publisher: Elsevier BV
Published: 2016-06
Volume: 3
Issue: 2
Pages: 130-143
ISSN: 2352-3042 (ISSN-L)
DOI: 10.1016/j.gendis.2016.03.004
PMC: PMC5221561
OpenAlex: W2338446464
Cited by: 257
References: 170
Citations by year: 2026: 14 · 2025: 19 · 2024: 25 · 2023: 27 · 2022: 34 · 2021: 29 · 2020: 39 · 2019: 29 · 2018: 27 · 2017: 14
FWCI: 12.06
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by-nc-nd/4.0/ (vor)
Locations: Genes & Diseases (publishedVersion, cc-by-nc-nd)
PubMed Central (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
Funders: National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK105118)
Cancer Center, University of Illinois at Chicago
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
Health Sciences › Medicine › Infectious Diseases › Clostridium difficile and Clostridium perfringens research
Keywords: gut microbiota, colorectal cancer, inflammation, tumor progression, chronic infection, bacterial virulence factors, host-microbe interactions, intestinal barrier function, cancer prevention, cancer diagnosis

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Gut microbiota, inflammation and colorectal cancer

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