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Cited by 352

The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.

Cutting Edge: Toll-Like Receptor (TLR)2- and TLR4-Mediated Pathogen Recognition in Resistance to Airborne Infection with Mycobacterium tuberculosis

Reiling, Norbert, Hölscher, Christoph, Fehrenbach, Alexandra, Kröger, Svenja, Kirschning, Carsten J, Goyert, Sanna, Ehlers, Stefan·2002·The Journal of Immunology
DOI 10.4049/jimmunol.169.7.3480
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Abstract

Innate resistance against Mycobacterium tuberculosis is thought to depend critically on engagement of pattern recognition receptors on macrophages. However, the relative contribution of these receptors for containing M. tuberculosis infection has remained unexplored in vivo. To address this issue, we infected mice defective in CD14, TLR2, or TLR4 with M. tuberculosis by aerosol. Following infection with 100 mycobacteria, either mutant strain was as resistant as congenic control mice. Granuloma formation, macrophage activation, and secretion of proinflammatory cytokines in response to low-dose aerosol infection were identical in mutant and control mice. However, high-dose aerosol challenge with 2000 CFU M. tuberculosis revealed TLR2-, but not TLR4-defective mice to be more susceptible than control mice. In conclusion, while TLR2 signaling contributes to innate resistance against M. tuberculosis in borderline situations, its function, and that of CD14 and TLR4, in initiating protective responses against naturally low-dose airborne infection is redundant.

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Cites

Research works printed but not linked: 30

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Metadata

Authors
Reiling, N., Hölscher, C., Fehrenbach, A., Kröger, S., Kirschning, C. J., Goyert, S., & Ehlers, S.
Affiliations
  • Division of Molecular Infection Biology, Research Center Borstel , Borstel ,
  • Institute of Medical Microbiology, Immunology, and Hygiene, Technical University of Munich , Munich ,
  • Division of Molecular Medicine, Cornell University Medical College , Manhasset, NY 11030
Venue
The Journal of Immunology
Publisher
Oxford University Press (OUP)
Published
2002-10-01
Volume
169
Issue
7
Pages
3480-3484
ISSN
  • 0022-1767
  • 1550-6606
DOI
10.4049/jimmunol.169.7.3480
Cited by
352
References
31
Language
en
Licence
academic.oup.com/pages/standard-publication-reuse-rights (vor)

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