The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Cutting Edge: Mitochondrial Assembly of the NLRP3 Inflammasome Complex Is Initiated at Priming
Abstract
The NLRP3 inflammasome is activated in response to microbial and danger signals, resulting in caspase-1–dependent secretion of the proinflammatory cytokines IL-1β and IL-18. Canonical NLRP3 inflammasome activation is a two-step process requiring both priming and activation signals. During inflammasome activation, NLRP3 associates with mitochondria; however, the role for this interaction is unclear. In this article, we show that mouse NLRP3 and caspase-1 independently interact with the mitochondrial lipid cardiolipin, which is externalized to the outer mitochondrial membrane at priming in response to reactive oxygen species. An NLRP3 activation signal is then required for the calcium-dependent association of the adaptor molecule ASC with NLRP3 on the mitochondrial surface, resulting in inflammasome complex assembly and activation. These findings demonstrate a novel lipid interaction for caspase-1 and identify a role for mitochondria as supramolecular organizing centers in the assembly and activation of the NLRP3 inflammasome.
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“For example, the MAMs have been shown to play key roles in autophagosome and inflammasome assembly [4, 5, 11].”
From The Mitochondria-Associated ER Membranes Are Novel Subcellular Locations Enriched for Inflammatory-Responsive MicroRNAs (2020) · cites this paper as [11]
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Cites
A role for mitochondria in nlrp3 inflammasome activation
Zhou, R., Yazdi, A. S., Menu, P., & Tschopp, J. (2011) · Nature · doi:10.1038/nature09663 · Cited by 5,602
Inflammatory caspases are innate immune receptors for intracellular LPS
Shi, J., Zhao, Y., Wang, Y., Gao, W., Ding, J., Li, P., Hu, L., & Shao, F. (2014) · Nature · doi:10.1038/nature13683 · Cited by 2,285
Tlr signalling augments macrophage bactericidal activity through mitochondrial ros
West, A. P., Brodsky, I. E., Rahner, C., Woo, D. K., Erdjument-Bromage, H., Tempst, P., Walsh, M. C., Choi, Y., Shadel, G. S., & Ghosh, S. (2011) · Nature · doi:10.1038/nature09973 · Cited by 1,659
Chu, C. T., Ji, J., Dagda, R. K., Jiang, J. F., Tyurina, Y. Y., Kapralov, A. A., Tyurin, V. A., Yanamala, N., Shrivastava, I. H., Mohammadyani, D., et al. (2013) · Nature Cell Biology · doi:10.1038/ncb2837 · Cited by 1,083
Sutterwala, F. S., Ogura, Y., Szczepanik, M., Lara-Tejero, M., Lichtenberger, G. S., Grant, E. P., Bertin, J., Coyle, A. J., Galán, J. E., Askenase, P. W., et al. (2006) · Immunity · doi:10.1016/j.immuni.2006.02.004 · Cited by 980
Initiation and perpetuation of NLRP 3 inflammasome activation and assembly
Elliott, E. I., & Sutterwala, F. S. (2015) · Immunological Reviews · doi:10.1111/imr.12286 · Cited by 821
Self-citationAn endogenous caspase-11 ligand elicits interleukin-1 release from living dendritic cells
Zanoni, I., Tan, Y., Di Gioia, M., Broggi, A., Ruan, J., Shi, J., Donado, C. A., Shao, F., Wu, H., Springstead, J. R., et al. (2016) · Science · doi:10.1126/science.aaf3036 · Cited by 583
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Research works printed but not linked: 13
- Kagan, 2014, SMOCs: supramolecular organizing centres that control innate immunity, Nat. Rev. Immunol., 14, 821, 10.1038/nri3757 · DOI
- Iyer, 2013, Mitochondrial cardiolipin is required for Nlrp3 inflammasome activation, Immunity, 39, 311, 10.1016/j.immuni.2013.08.001 · DOI
- Kuida, 1995, Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme, Science, 267, 2000, 10.1126/science.7535475 · DOI
- Dowler, 2002, Protein lipid overlay assay, Sci. STKE, 2002, pl6, 10.1126/stke.2002.129.pl6 · DOI
- Nakahira, 2011, Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome, Nat. Immunol., 12, 222, 10.1038/ni.1980 · DOI · Paper page
- Shimada, 2012, Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis, Immunity, 36, 401, 10.1016/j.immuni.2012.01.009 · DOI · Paper page
- Misawa, 2013, Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome, Nat. Immunol., 14, 454, 10.1038/ni.2550 · DOI
- Lee, 2012, The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP, Nature, 492, 123, 10.1038/nature11588 · DOI
- Rossol, 2012, Extracellular Ca2+ is a danger signal activating the NLRP3 inflammasome through G protein-coupled calcium sensing receptors, Nat. Commun., 3, 1329, 10.1038/ncomms2339 · DOI
- Kagan, 2015, Cardiolipin signaling mechanisms: collapse of asymmetry and oxidation, Antioxid. Redox Signal., 22, 1667, 10.1089/ars.2014.6219 · DOI
- Gonzalvez, 2008, Cardiolipin provides an essential activating platform for caspase-8 on mitochondria, J. Cell Biol., 183, 681, 10.1083/jcb.200803129 · DOI
- Jalmar, 2013, Caspase-8 binding to cardiolipin in giant unilamellar vesicles provides a functional docking platform for bid, PLoS One, 8, e55250, 10.1371/journal.pone.0055250 · DOI
- Boatright, 2003, A unified model for apical caspase activation, Mol. Cell, 11, 529, 10.1016/S1097-2765(03)00051-0 · DOI
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The NLRP3 inflammasome: molecular activation and regulation to therapeutics
Swanson, K. V., Deng, M., & Ting, J. P.-Y. (2019) · Nature Reviews Immunology · doi:10.1038/s41577-019-0165-0 · Cited by 4,884
The NLRP3 Inflammasome: an overview of mechanisms of activation and regulation
Kelley, N., Jeltema, D., Duan, Y., & He, Y. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20133328 · Cited by 3,539
Mitochondria in innate immune signaling
Banoth, B., & Cassel, S. L. (2018) · Translational Research · doi:10.1016/j.trsl.2018.07.014 · Cited by 410
Self-citationBarrera, M.-J., Aguilera, S., Castro, I., Carvajal, P., Jara, D., Molina, C., González, S., & González, M.-J. (2021) · Autoimmunity Reviews · doi:10.1016/j.autrev.2021.102867 · Cited by 213
Chen, K., Feng, L., Hu, W., Chen, J., Wang, X., Wang, L., & He, Y. (2019) · The FASEB Journal · doi:10.1096/fj.201801749rrr · Cited by 85
Metadata
- Authors
- Elliott, E. I., Miller, A. N., Banoth, B., Iyer, S. S., Stotland, A., Weiss, J. P., Gottlieb, R. A., Sutterwala, F. S., & Cassel, S. L.
- Affiliations
- Interdisciplinary Graduate Program in Molecular Medicine, University of Iowa , Iowa City, IA 52242
- Department of Medicine, Cedars-Sinai Medical Center , Los Angeles, CA 90048
- The Inflammation Program, Department of Internal Medicine, University of Iowa , Iowa City, IA 52242
- Smidt Heart Institute, Cedars-Sinai Medical Center , Los Angeles, CA 90048
- ORCID
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2018-05-01
- Volume
- 200
- Issue
- 9
- Pages
- 3047-3052
- ISSN
- 0022-1767
- 1550-6606
- PMC
- PMC5916517
- Cited by
- 195
- References
- 7
- Language
- en
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