The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Cross-Talk in the Innate Immune System: Neutrophils Instruct Recruitment and Activation of Dendritic Cells during Microbial Infection
Open accessAbstract
Type I inflammatory cytokines are essential for immunity to many microbial pathogens, including Toxoplasma gondii. Dendritic cells (DC) are key to initiating type 1 immunity, but neutrophils are also a source of chemokines and cytokines involved in Th1 response ignition. We found that T. gondii triggered neutrophil synthesis of CC chemokine ligand (CCL)3, CCL4, CCL5, and CCL20, chemokines that were strongly chemotactic for immature DC. Moreover, supernatants obtained from parasite-stimulated polymorphonuclear leukocytes induced DC IL-12(p40) and TNF-α production. Parasite-triggered neutrophils also released factors that induced DC CD40 and CD86 up-regulation, and this response was dependent upon parasite-triggered neutrophil TNF-α production. In vivo evidence that polymorphonuclear leukocytes exert an important influence on DC activation was obtained by examining splenic DC cytokine production following infection of neutrophil-depleted mice. These animals displayed severely curtailed splenic DC IL-12 and TNF-α production, as revealed by ex vivo flow cytometric analysis and in vitro culture assay. Our results reveal a previously unrecognized regulatory role for neutrophils in DC function during microbial infection, and suggest that cross-talk between these cell populations is an important component of the innate immune response to infection.
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Kiefer, F., Brumell, J., Al-Alawi, N., Latour, S., Cheng, A., Veillette, A., Grinstein, S., & Pawson, T. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.7.4209 · Cited by 376
An immunoregulatory role for neutrophils in CD4+ T helper subset selection in mice with candidiasis
Romani, L., Mencacci, A., Cenci, E., Del Sero, G., Bistoni, F., & Puccetti, P. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.158.5.2356 · Cited by 191
Cited by
Neutrophils and immunity: challenges and opportunities
Nathan, C. (2006) · Nature reviews. Immunology · doi:10.1038/nri1785 · Cited by 2,971
In vivo labeling with 2H2O reveals a human neutrophil lifespan of 5.4 days
Pillay, J., den Braber, I., Vrisekoop, N., Kwast, L. M., de Boer, R. J., Borghans, J. A. M., Tesselaar, K., & Koenderman, L. (2010) · Blood · doi:10.1182/blood-2010-01-259028 · Cited by 872
Neutrophil-derived cytokines: facts beyond expression
Tecchio, C., Micheletti, A., & Cassatella, M. A. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00508 · Cited by 699
Solana, R., Tarazona, R., Gayoso, I., Lesur, O., Dupuis, G., & Fulop, T. (2012) · Seminars in Immunology · doi:10.1016/j.smim.2012.04.008 · Cited by 567
Zhang, Y., Chandra, V., Riquelme Sanchez, E., Dutta, P., Quesada, P. R., Rakoski, A., Zoltan, M., Arora, N., Baydogan, S., Horne, W., et al. (2020) · Journal of Experimental Medicine · doi:10.1084/jem.20190354 · Cited by 448
Metadata
- Authors
- Bennouna, S., Bliss, S. K., Curiel, T. J., & Denkers, E. Y.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2003-12-01
- Volume
- 171
- Issue
- 11
- Pages
- 6052-6058
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1942966726
- Cited by
- 329
- References
- 2
- FWCI
- 4.06
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Bennouna, S., Bliss, S. K., Curiel, T. J., & Denkers, E. Y. (2003). Cross-Talk in the Innate Immune System: Neutrophils Instruct Recruitment and Activation of Dendritic Cells during Microbial Infection. The Journal of Immunology. https://doi.org/10.4049/jimmunol.171.11.6052
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