The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
In vivo labeling with 2H2O reveals a human neutrophil lifespan of 5.4 days
Abstract
Neutrophils are essential effector cells of the innate immune response and are indispensable for host defense. Apart from their antimicrobial functions, neutrophils inform and shape subsequent immunity. This immune modulatory functionality might however be considered limited because of their generally accepted short lifespan (< 1 day). In contrast to the previously reported short lifespans acquired by ex vivo labeling or manipulation, we show that in vivo labeling in humans with the use of 2H2O under homeostatic conditions showed an average circulatory neutrophil lifespan of 5.4 days. This lifespan is at least 10 times longer than previously reported and might lead to reappraisal of novel neutrophil functions in health and disease.
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Cites
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Cited by
Neutrophil recruitment and function in health and inflammation
Kolaczkowska, E., & Kubes, P. (2013) · Nature Reviews Immunology · doi:10.1038/nri3399 · Cited by 5,472
Regulation of apoptosis in health and disease: the balancing act of BCL-2 family proteins
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The multifaceted functions of neutrophils
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Resolution of inflammation: an integrated view
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Metadata
- Authors
- Pillay, J., den Braber, I., Vrisekoop, N., Kwast, L. M., de Boer, R. J., Borghans, J. A. M., Tesselaar, K., & Koenderman, L.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2010-07-29
- Volume
- 116
- Issue
- 4
- Pages
- 625-627
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2125894404
- Cited by
- 872
- References
- 17
- FWCI
- 12.76
- Type
- journal article
- Language
- en
- Open access
- closed
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- Pillay, J., den Braber, I., Vrisekoop, N., Kwast, L. M., de Boer, R. J., Borghans, J. A. M., Tesselaar, K., & Koenderman, L. (2010). In vivo labeling with 2H2O reveals a human neutrophil lifespan of 5.4 days. Blood. https://doi.org/10.1182/blood-2010-01-259028
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