The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Mouse Strain Differences in Plasmacytoid Dendritic Cell Frequency and Function Revealed by a Novel Monoclonal Antibody
Abstract
We report in this study the generation of a novel rat mAb that recognizes mouse plasmacytoid dendritic cells (pDC). This Ab, named 120G8, stains a small subset of CD11clow spleen cell with high specificity. This population produces high amounts of IFN-α upon in vitro viral stimulation. Both ex vivo- and in vitro-derived 120G8+ cells display a phenotype identical with that of the previously described mouse pDC (B220highLy6ChighGr1lowCD11b−CD11clow). Mice treated with 120G8 mAb are depleted of B220highLy6ChighCD11clow cells and have a much-reduced ability to produce IFN-α in response to in vivo CpG stimulation. The mAb 120G8 stains all and only B220highLy6ChighCD11clow pDC in all lymphoid organs. Immunohistochemical studies performed with this mAb indicate that pDC are located in the T cell area of spleen, lymph nodes, and Peyer’s patches. Although the Ag recognized by 120G8 is not yet known, we show that its expression is up-regulated by type I IFN on B cells and DC. Using this mAb in immunofluorescence studies demonstrates strain- and organ-specific differences in the frequency of pDC and other DC subsets. 129Sv mice have a much higher frequency of pDC, together with a lower frequency of conventional CD8α+CD11chigh DC, compared with C57BL/6 mice, both in spleen and blood. The higher ability of 129Sv mice to produce IFN-α in vivo is related to a higher number of pDC, but also to a higher ability of pDC from 129Sv mice to produce IFN-α in vitro in response to viral stimulation.
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Cites
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The Nature of the Principal Type 1 Interferon-Producing Cells in Human Blood
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The Induction of Tolerance by Dendritic Cells That Have Captured Apoptotic Cells
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Mouse type I IFN-producing cells are immature APCs with plasmacytoid morphology
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Cited by
IPC: Professional Type 1 Interferon-Producing Cells and Plasmacytoid Dendritic Cell Precursors
Liu, Y.-J. (2005) · Annual Review of Immunology · doi:10.1146/annurev.immunol.23.021704.115633 · Cited by 1,625
Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA
Judge, A. D., Sood, V., Shaw, J. R., Fang, D., McClintock, K., & MacLachlan, I. (2005) · Nature Biotechnology · doi:10.1038/nbt1081 · Cited by 1,250
Spatiotemporal regulation of MyD88–IRF-7 signalling for robust type-I interferon induction
Honda, K., Ohba, Y., Yanai, H., Negishi, H., Mizutani, T., Takaoka, A., Taya, C., & Taniguchi, T. (2005) · Nature · doi:10.1038/nature03547 · Cited by 912
Dendritic cells in intestinal immune regulation
Coombes, J. L., & Powrie, F. (2008) · Nature Reviews Immunology · doi:10.1038/nri2335 · Cited by 788
de Heer, H. J., Hammad, H., Soullié, T., Hijdra, D., Vos, N., Willart, M. A. M., Hoogsteden, H. C., & Lambrecht, B. N. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20040035 · Cited by 785
Metadata
- Authors
- Asselin-Paturel, C., Brizard, G., Pin, J.-J., Brière, F., & Trinchieri, G.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2003-12
- Volume
- 171
- Issue
- 12
- Pages
- 6466-6477
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1925863651
- Cited by
- 360
- References
- 45
- FWCI
- 8.53
- Type
- journal article
- Language
- en
- Open access
- closed
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- Asselin-Paturel, C., Brizard, G., Pin, J.-J., Brière, F., & Trinchieri, G. (2003). Mouse Strain Differences in Plasmacytoid Dendritic Cell Frequency and Function Revealed by a Novel Monoclonal Antibody. The Journal of Immunology. https://doi.org/10.4049/jimmunol.171.12.6466
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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