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Cutting Edge: Invariant Vα14 NKT Cells Are Required for Allergen-Induced Airway Inflammation and Hyperreactivity in an Experimental Asthma Model
Open accessAbstract
Airway hyperreactivity (AHR), eosinophilic inflammation with a Th2-type cytokine profile, and specific Th2-mediated IgE production characterize allergic asthma. In this paper, we show that OVA-immunized Jα18−/− mice, which are exclusively deficient in the invariant Vα14+ (iVα14), CD1d-restricted NKT cells, exhibit impaired AHR and airway eosinophilia, decreased IL-4 and IL-5 production in bronchoalveolar lavage fluid, and reduced OVA-specific IgE compared with wild-type (WT) littermates. Adoptive transfer of WT iVα14 NKT cells fully reconstitutes the capacity of Jα18−/− mice to develop allergic asthma. Also, specific tetramer staining shows that OVA-immunized WT mice have activated (CD69+) iVα14 NKT cells. Importantly, anti-CD1d mAb treatment blocked the ability of iVα14 T cells to amplify eosinophil recruitment to airways, and both Th2 cytokine and IgE production following OVA challenge. In conclusion, these findings clearly demonstrate that iVα14 NKT cells are required to participate in allergen-induced Th2 airway inflammation through a CD1d-dependent mechanism.
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Cited by
Kim, E. Y., Battaile, J. T., Patel, A. C., You, Y., Agapov, E., Grayson, M. H., Benoit, L. A., Byers, D. E., Alevy, Y., Tucker, J., et al. (2008) · Nature Medicine · doi:10.1038/nm1770 · Cited by 523
Tissue-specific functions of invariant natural killer T cells
Crosby, C. M., & Kronenberg, M. (2018) · Nature Reviews Immunology · doi:10.1038/s41577-018-0034-2 · Cited by 367
Self-citationThe differential expression of IL-4 and IL-13 and its impact on type-2 immunity
Bao, K., & Reinhardt, R. L. (2015) · Cytokine · doi:10.1016/j.cyto.2015.05.008 · Cited by 316
The Intraepithelial T Cell Response to NKG2D-Ligands Links Lymphoid Stress Surveillance to Atopy
Strid, J., Sobolev, O., Zafirova, B., Polic, B., & Hayday, A. (2011) · Science · doi:10.1126/science.1211250 · Cited by 155
Park, S. K., Cho, M. K., Park, H.-K., Lee, K. H., Lee, S. J., Choi, S. H., Ock, M. S., Jeong, H. J., Lee, M. H., & Yu, H. S. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803533 · Cited by 82
Metadata
- Authors
- Lisbonne, M., Diem, S., de Castro Keller, A., Lefort, J., Araujo, L. M., Hachem, P., Fourneau, J.-M., Sidobre, S., Kronenberg, M., Taniguchi, M., Van Endert, P., Dy, M., Askenase, P., Russo, M., Vargaftig, B. B., Herbelin, A., & Leite-de-Moraes, M. C.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2003-08
- Volume
- 171
- Issue
- 4
- Pages
- 1637-1641
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2143618112
- Cited by
- 314
- References
- 0
- FWCI
- 11.40
- Type
- journal article
- Language
- en
- Open access
- bronze
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- The paper
- Lisbonne, M., Diem, S., de Castro Keller, A., Lefort, J., Araujo, L. M., Hachem, P., Fourneau, J.-M., Sidobre, S., Kronenberg, M., Taniguchi, M., Van Endert, P., Dy, M., Askenase, P., Russo, M., Vargaftig, B. B., Herbelin, A., & Leite-de-Moraes, M. C. (2003). Cutting Edge: Invariant Vα14 NKT Cells Are Required for Allergen-Induced Airway Inflammation and Hyperreactivity in an Experimental Asthma Model. The Journal of Immunology. https://doi.org/10.4049/jimmunol.171.4.1637
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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