Cutting Edge: Back to “One-Way” Germinal Centers
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The present status of germinal center (GC) research is revisited using in silico simulations based on recent lymphocyte motility data in mice. The generally adopted view of several rounds of somatic hypermutations and positive selection is analyzed with special emphasis on the spatial organization of the GC reaction. We claim that the development of dark zones is not necessary for successful GC reactions to develop. We find that a recirculation of positively selected centrocytes to the dark zone is rather unlikely. Instead we propose a scenario that combines a multiple-step mutation and selection concept with a “one-way” GC in the sense of cell migration.
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An acute infectious disease can be self-limiting and involve an innate immune response of 2 to 3 days; the subsequent phase of the adaptive immune response can last approximately 3 to 4 weeks.
“An acute infectious disease can be self-limiting and involve an innate immune response of 2 to 3 days; the subsequent phase of the adaptive immune response can last approximately 3 to 4 weeks.”
From Evolutionary medicine and chronic inflammatory state—known and new concepts in pathophysiology (2012) · cites this paper as [22]
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Evolutionary medicine and chronic inflammatory state—known and new concepts in pathophysiology
Straub, R. H. (2012) · Journal of Molecular Medicine · doi:10.1007/s00109-012-0861-8 · Cited by 105 · see citing works
- Authors
- Meyer-Hermann, M. E., & Maini, P. K.
- Affiliations
- Centre for Mathematical Biology, Mathematical Institute , Oxford ,
- University of Oxford (GB)
- ORCID
- Maini, Philip K
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2005-03-01
- Volume
- 174
- Issue
- 5
- Pages
- 2489-2493
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2137783233
- Cited by
- 50
- References
- 45
- Citations by year
- 2024: 2 · 2020: 1 · 2019: 4 · 2018: 2 · 2017: 2 · 2016: 3 · 2015: 2 · 2014: 1 · 2012: 4
- FWCI
- 2.25
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Immunology (publishedVersion)
- PubMed (publishedVersion)
- Oxford University Research Archive (ORA) (University of Oxford) (acceptedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Physical Sciences › Engineering › Biomedical Engineering › Artificial Immune Systems Applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › vaccines and immunoinformatics approaches
- Keywords
- germinal center, somatic hypermutation, positive selection, centrocytes, lymphocyte motility, dark zone, computer simulation, cell migration, B cell tolerance
- MeSH terms
- Animals, Cell Communication, Cell Cycle, Cell Differentiation, Clone Cells, Lymphocyte Activation, B-Lymphocyte Subsets, T-Lymphocyte Subsets, Models, Immunological, Germinal Center, Computational Biology, Dendritic Cells, Follicular, Cell Proliferation, Mice, Rats
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