Cited by 219Heat shock proteins researchImmune Response and InflammationImmunotherapy and Immune Responses

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Heat Shock Proteins as Endogenous Adjuvants in Sterile and Septic Inflammation

Quintana, Francisco J, Cohen, Irun R·2005·The Journal of Immunology

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Abstract

Heat shock proteins (HSPs) have been reported to stimulate the immune system via innate receptors. However, the role of HSPs as endogenous adjuvants has been challenged by reports claiming that pure HSPs are not innate ligands; it is only the bacterial molecules trapped by the HSPs that can signal the innate immune system. In this review, we discuss data suggesting that both views, in essence, are correct; pure HSPs are indeed innate immunostimulators, but HSPs can also function as transducers of pathogen signals. In other words, HSPs perform diverse functions in two alternative modes of inflammation: sterile inflammation, which results from endogenous stimuli and is necessary for body maintenance, and septic inflammation, which protects us from environmental pathogens. Endogenous HSPs are key players in the modulation of these two modes of inflammation, and as such, they are potential targets for new and more efficient therapies for cancer, infections, and autoimmunity.

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Crossref · 10.4049/jimmunol.175.5.2777

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Authors: Quintana, F. J., & Cohen, I. R.
Affiliations: Weizmann Institute of Science (IL)
ORCID: Quintana, Francisco J
Cohen, Irun R
Venue: The Journal of Immunology
Publisher: Oxford University Press (OUP)
Published: 2005-09-01
Volume: 175
Issue: 5
Pages: 2777-2782
ISSN: 0022-1767 (ISSN-L)
1550-6606
DOI: 10.4049/jimmunol.175.5.2777
OpenAlex: W2140403277
Cited by: 219
References: 106
Citations by year: 2026: 1 · 2025: 4 · 2024: 6 · 2023: 7 · 2022: 6 · 2021: 8 · 2020: 9 · 2019: 11 · 2018: 10 · 2017: 14 · 2016: 10 · 2015: 6 · 2014: 12 · 2013: 18 · 2012: 13
FWCI: 1.43
Type: journal article
Language: en
Open access: closed
Licence: academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: The Journal of Immunology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heat shock proteins research
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Keywords: heat shock proteins, sterile inflammation, septic inflammation, innate immunity, inflammation modulation, cancer immunotherapy, infection immunity, autoimmunity
MeSH terms: Animals, Heat-Shock Proteins, Humans, Immunity, Innate, Inflammation, T-Lymphocytes, Sepsis

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Heat Shock Proteins as Endogenous Adjuvants in Sterile and Septic Inflammation

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