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Cited by 219Heat shock proteins researchImmune Response and InflammationImmunotherapy and Immune Responses

The DOI matches its Crossref record; 107 of the 107 references it cites were found in a registry or an index.

Heat Shock Proteins as Endogenous Adjuvants in Sterile and Septic Inflammation

Quintana, Francisco J, Cohen, Irun R·2005·The Journal of Immunology
DOI 10.4049/jimmunol.175.5.2777
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Abstract

Heat shock proteins (HSPs) have been reported to stimulate the immune system via innate receptors. However, the role of HSPs as endogenous adjuvants has been challenged by reports claiming that pure HSPs are not innate ligands; it is only the bacterial molecules trapped by the HSPs that can signal the innate immune system. In this review, we discuss data suggesting that both views, in essence, are correct; pure HSPs are indeed innate immunostimulators, but HSPs can also function as transducers of pathogen signals. In other words, HSPs perform diverse functions in two alternative modes of inflammation: sterile inflammation, which results from endogenous stimuli and is necessary for body maintenance, and septic inflammation, which protects us from environmental pathogens. Endogenous HSPs are key players in the modulation of these two modes of inflammation, and as such, they are potential targets for new and more efficient therapies for cancer, infections, and autoimmunity.

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Crossref · 10.4049/jimmunol.175.5.2777

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Metadata

Authors
Quintana, F. J., & Cohen, I. R.
Affiliations
Weizmann Institute of Science (IL)
ORCID
Venue
The Journal of Immunology
Publisher
Oxford University Press (OUP)
Published
2005-09-01
Volume
175
Issue
5
Pages
2777-2782
ISSN
  • 0022-1767 (ISSN-L)
  • 1550-6606
DOI
10.4049/jimmunol.175.5.2777
OpenAlex
W2140403277
Cited by
219
References
106
Citations by year
2026: 1 · 2025: 4 · 2024: 6 · 2023: 7 · 2022: 6 · 2021: 8 · 2020: 9 · 2019: 11 · 2018: 10 · 2017: 14 · 2016: 10 · 2015: 6 · 2014: 12 · 2013: 18 · 2012: 13
FWCI
1.43
Type
journal article
Language
en
Open access
closed
Licence
academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations
  • The Journal of Immunology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heat shock proteins research
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Keywords
heat shock proteins, sterile inflammation, septic inflammation, innate immunity, inflammation modulation, cancer immunotherapy, infection immunity, autoimmunity
MeSH terms
Animals, Heat-Shock Proteins, Humans, Immunity, Innate, Inflammation, T-Lymphocytes, Sepsis

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