The Earliest Thymic Progenitors in Adults Are Restricted to T, NK, and Dendritic Cell Lineage and Have a Potential to Form More Diverse TCRβ Chains than Fetal Progenitors
Abstract
T cell progenitors in the adult thymus (AT) are not well characterized. In the present study, we show that the earliest progenitors in the murine AT are, like those in fetal thymus (FT), unable to generate B or myeloid cells, but still retain the ability to generate NK cells and dendritic cells. However, AT progenitors are distinct from those in FT or fetal liver, in that they are able to produce ∼100 times larger numbers of T cells than progenitors in fetuses. Such a capability to generate a large number of T cells was mainly attributed to their potential to extensively proliferate before the TCRβ chain gene rearrangement. We propose that the AT is colonized by T/NK/dendritic cell tripotential progenitors with much higher potential to form diversity in TCRβ chains than FT progenitors.
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Population dynamic models imply that the stages when PU.1 is expressed occupy a minimum of 7-10 intrathymic cell divisions of pro-T cells.
“Population dynamic models imply that the stages when PU.1 is expressed occupy a minimum of 7–10 intrathymic cell divisions of pro-T cells (39, 66, 67).”
From Mechanisms of Action of Hematopoietic Transcription Factor PU.1 in Initiation of T-Cell Development (2019) · cites this paper as [66]
Cites
Ikuta, K., Kina, T., MacNeil, I., Uchida, N., Peault, B., Chien, Y.-H., & Weissman, I. L. (1990) · Cell · doi:10.1016/0092-8674(90)90262-d · Cited by 583 · see citing works
Thymopoiesis independent of common lymphoid progenitors.
Allman, D., Sambandam, A., Kim, S., Miller, J. P., Pagan, A., Well, D., Meraz, A., & Bhandoola, A. (2003) · Nature Immunology · doi:10.1038/ni878 · Cited by 544 · see citing works
Balciunaite, G., Ceredig, R., & Rolink, A. G. (2005) · Blood · doi:10.1182/blood-2004-08-3087 · Cited by 158 · see citing works
T/B lineage choice occurs prior to intrathymic Notch signaling
Harman, B. C., Jenkinson, W. E., Parnell, S. M., Rossi, S. W., Jenkinson, E. J., & Anderson, G. (2005) · Blood · doi:10.1182/blood-2004-12-4881 · Cited by 80 · see citing works
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Adult T-cell progenitors retain myeloid potential
Wada, H., Masuda, K., Satoh, R., Kakugawa, K., Ikawa, T., Katsura, Y., & Kawamoto, H. (2008) · Nature · doi:10.1038/nature06839 · Cited by 368 · see citing works
Self-citationMechanisms of Action of Hematopoietic Transcription Factor PU.1 in Initiation of T-Cell Development
Rothenberg, E. V., Hosokawa, H., & Ungerbäck, J. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00228 · Cited by 99 · see citing works
“1 is expressed occupy a minimum of 7–10 intrathymic cell divisions of pro-T cells (39, 66, 67).”
BackgroundMultilayered specification of the T-cell lineage fate.
Rothenberg, E. V., Zhang, J., & Li, L. (2010) · Immunological Reviews · doi:10.1111/j.1600-065x.2010.00964.x · Cited by 81 · see citing works
T Cell Lineage Determination Precedes the Initiation of <i>TCR</i> β Gene Rearrangement
Masuda, K., Kakugawa, K., Nakayama, T., Minato, N., Katsura, Y., & Kawamoto, H. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.6.3699 · Cited by 77 · see citing works
Self-citation
- Authors
- Lu, M., Tayu, R., Ikawa, T., Masuda, K., Matsumoto, I., Mugishima, H., Kawamoto, H., & Katsura, Y.
- Affiliations
- Nihon University (JP)
- Kyoto University (JP)
- RIKEN (JP)
- Ochanomizu University (JP)
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2005-11-01
- Volume
- 175
- Issue
- 9
- Pages
- 5848-5856
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1507372361
- Cited by
- 79
- References
- 4
- Citations by year
- 2025: 1 · 2024: 5 · 2023: 2 · 2022: 1 · 2021: 4 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 3 · 2016: 5 · 2015: 3 · 2014: 5 · 2013: 5 · 2012: 2
- FWCI
- 2.47
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Immunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- adult thymus, T cell development, natural killer cells, dendritic cells, T-cell receptor gene rearrangement, progenitor cell proliferation, fetal thymus
- MeSH terms
- Animals, B-Lymphocytes, Cell Differentiation, Dendritic Cells, Fetus, Hematopoietic Stem Cells, Killer Cells, Natural, Mice, Inbred C57BL, T-Lymphocytes, Thymus Gland, Gene Rearrangement, beta-Chain T-Cell Antigen Receptor, Cell Lineage, Mice
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