Multilayered specification of the T-cell lineage fate.
Open accessAbstract
Summary: T‐cell development from stem cells has provided a highly accessible and detailed view of the regulatory processes that can go into the choice of a cell fate in a postembryonic, stem cell‐based system. But it has been a view from the outside. The problems in understanding the regulatory basis for this lineage choice begin with the fact that too many transcription factors are needed to provide crucial input: without any one of them, T‐cell development fails. Furthermore, almost all the factors known to provide crucial functions during the climax of T‐lineage commitment itself are also vital for earlier functions that establish the pool of multilineage precursors that would normally feed into the T‐cell specification process. When the regulatory genes that encode them are mutated, the confounding effects on earlier stages make it difficult to dissect T‐cell specification genetically. Yet both the positive and the negative regulatory events involved in the choice of a T‐cell fate are actually a mosaic of distinct functions. New evidence has emerged recently that finally provides a way to separate the major components that fit together to drive this process. Here, we review insights into T‐cell specification and commitment that emerge from a combination of molecular, cellular, and systems biology approaches. The results reveal the regulatory structure underlying this lineage decision.
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The transition at commitment includes general downregulation of phase 1 genes and major reorganization of active chromatin and chromatin interactions genome-wide.
“This is part of a general downregulation of stem/progenitor associated regulatory genes (“phase 1 genes”) (34, 43) and a major reorganization of active chromatin and chromatin interactions, genome-wide, that occurs during this transition (44).”
From Mechanisms of Action of Hematopoietic Transcription Factor PU.1 in Initiation of T-Cell Development (2019) · cites this paper as [43]
Citation (44) is attached to the claim of genome-wide reorganization of active chromatin and chromatin interactions. Our copy discusses downregulation of stem/progenitor-associated genes in “Unleashing the expression of T-cell identity by negative regulation?” and local chromatin opening at TCR loci in “Emergence of T-cell identity,” but neither establishes the cited genome-wide reorganization. Searches for chromatin reorganization and chromatin interactions found no passage addressing it; page numbers were unavailable. (LLM, conf=0.77)
Experimental — accuracy not yet measuredlck-driven Cre expression is most robust starting at the DN2 stage of development.
“This may have occurred because expression of lck used to drive Cre expression is most robust starting at the DN2 stage of development, 2”
From Fibroblast growth factor-7 partially reverses murine thymocyte progenitor aging by repression of Ink4a (2012) · cites this paper as [2]
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Cites
The Immunological Genome Project: networks of gene expression in immune cells
The Immunological Genome Project Consortium, Heng, T. S. P., Painter, M. W., Elpek, K., Lukacs-Kornek, V., Mauermann, N., Turley, S. J., Koller, D., Kim, F. S., Wagers, A. J., et al. (2008) · Nature Immunology · doi:10.1038/ni1008-1091 · Cited by 1,864 · see citing works
Pax5: the guardian of B cell identity and function
Cobaleda, C., Schebesta, A., Delogu, A., & Busslinger, M. (2007) · Nature Immunology · doi:10.1038/ni1454 · Cited by 697 · see citing works
Pandolfi, P. P., Roth, M. E., Karis, A., Leonard, M. W., Dzierzak, E. A., Grosveld, F. G., Engel, J. D., & Lindenbaum, M. (1995) · Nature Genetics · doi:10.1038/ng0995-40 · Cited by 625 · see citing works
Transcription factor GATA-3 is required for development of the T-cell lineage
Ting, C.-N., Olson, M. C., Barton, K., & Leiden, J. M. (1996) · Nature · doi:10.1038/384474a0 · Cited by 607 · see citing works
Transcriptional regulation of erythropoiesis: an affair involving multiple partners
Cantor, A. B., & Orkin, S. H. (2002) · Oncogene · doi:10.1038/sj.onc.1205326 · Cited by 584 · see citing works
Chang, H.-C., Sehra, S., Goswami, R., Yao, W., Yu, Q., Stritesky, G. L., Jabeen, R., McKinley, C., Ahyi, A.-N., Han, L., et al. (2010) · Nature Immunology · doi:10.1038/ni.1867 · Cited by 577 · see citing works
Bifurcation dynamics in lineage-commitment in bipotent progenitor cells
Huang, S., Guo, Y.-P., May, G., & Enver, T. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2007.02.036 · Cited by 560 · see citing works
Doulatov, S. R., Notta, F., Eppert, K., Nguyen, L. T., Ohashi, P. S., & Dick, J. E. (2010) · Nature Immunology · doi:10.1038/ni.1889 · Cited by 510 · see citing works
Kirstetter, P., Anderson, K., Porse, B., Jacobsen, S., & Nerlov, C. (2006) · Nature Immunology · doi:10.1038/ni1381 · Cited by 504 · see citing works
Launching the T-cell-lineage developmental programme
Rothenberg, E. V., Moore, J. E., & Yui, M. A. (2007) · Nature reviews. Immunology · doi:10.1038/nri2232 · Cited by 475 · see citing works
Self-citationDevelopmental pathways that generate natural-killer-cell diversity in mice and humans
Huntington, N. D., Vosshenrich, C. A. J., & Santo, J. P. D. (2007) · Nature reviews. Immunology · doi:10.1038/nri2154 · Cited by 461 · see citing works
The earliest thymic progenitors for T cells possess myeloid lineage potential
Bell, J. J., & Bhandoola, A. (2008) · Nature · doi:10.1038/nature06840 · Cited by 460 · see citing works
Wnt Signaling Regulates B Lymphocyte Proliferation through a LEF-1 Dependent Mechanism
Reya, T., O'Riordan, M., Okamura, R., Devaney, E., Willert, K., Nusse, R., & Grosschedl, R. (2000) · Immunity · doi:10.1016/s1074-7613(00)00004-2 · Cited by 450 · see citing works
GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation
Ho, I., Tai, T.-S., & Pai, S. (2009) · Nature reviews. Immunology · doi:10.1038/nri2476 · Cited by 425 · see citing works
Global regulation of erythroid gene expression by transcription factor GATA-1
Welch, J. J. (2004) · Blood · doi:10.1182/blood-2004-04-1603 · Cited by 408 · see citing works
An Early T Cell Lineage Commitment Checkpoint Dependent on the Transcription Factor Bcl11b
Li, L., Leid, M. E., & Rothenberg, E. V. (2010) · Science · doi:10.1126/science.1188989 · Cited by 396 · see citing works
Self-citationHematopoietic stem cell and multilineage defects generated by constitutive β-catenin activation
Scheller, M., Huelsken, J., Rosenbauer, F., Taketo, M. M., Birchmeier, W., Tenen, D. G., & Leutz, A. (2006) · Nature Immunology · doi:10.1038/ni1387 · Cited by 394 · see citing works
Boos, M. D., Yokota, Y., Eberl, G., & Kee, B. L. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20061959 · Cited by 389 · see citing works
Global regulatory logic for specification of an embryonic cell lineage
Oliveri, P., Tu, Q., & Davidson, E. H. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0711220105 · Cited by 381 · see citing works
Reprogramming of T Cells to Natural Killer–Like Cells upon <i>Bcl11b</i> Deletion
Li, P., Burke, S., Wang, J., Chen, X., Ortiz, M., Lee, S.-C., Lu, D., Campos, L., Goulding, D., Ng, B. L., et al. (2010) · Science · doi:10.1126/science.1188063 · Cited by 374 · see citing works
Adult T-cell progenitors retain myeloid potential
Wada, H., Masuda, K., Satoh, R., Kakugawa, K., Ikawa, T., Katsura, Y., & Kawamoto, H. (2008) · Nature · doi:10.1038/nature06839 · Cited by 368 · see citing works
Notch signaling controls the generation and differentiation of early T lineage progenitors
Sambandam, A., Maillard, I. P., Zediak, V. P., Xu, L., Gerstein, R. M., Aster, J. C., Pear, W. S., & Bhandoola, A. (2005) · Nature Immunology · doi:10.1038/ni1216 · Cited by 364 · see citing works
Bcl11b is required for differentiation and survival of αβ T lymphocytes
Wakabayashi, Y., Watanabe, H., Inoue, J., Takeda, N., Sakata, J., Mishima, Y., Hitomi, J., Yamamoto, T., Utsuyama, M., Niwa, O., et al. (2003) · Nature Immunology · doi:10.1038/ni927 · Cited by 356 · see citing works
Laiosa, C. V., Stadtfeld, M., Xie, H., de Andres-Aguayo, L., & Graf, T. (2006) · Immunity · doi:10.1016/j.immuni.2006.09.011 · Cited by 351 · see citing works
Bcl11a is essential for normal lymphoid development
Liu, P., Keller, J. R., Ortiz, M., Tessarollo, L., Rachel, R. A., Nakamura, T., Jenkins, N. A., & Copeland, N. G. (2003) · Nature Immunology · doi:10.1038/ni925 · Cited by 351 · see citing works
Dik, W. A., Pike‐Overzet, K., Weerkamp, F., de Ridder, D., de Haas, E. F. E., Baert, M. R. M., van der Spek, P. J., Koster, E. E. L., Reinders, M. J. T., van Dongen, J. J. M., et al. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20042524 · Cited by 334 · see citing works
Okamura, R. M., Sigvardsson, M., Galcerán, J., Verbeek, S. J., Clevers, H. C., & Grosschedl, R. (1998) · Immunity · doi:10.1016/s1074-7613(00)80454-9 · Cited by 333 · see citing works
Schmitt, T. M., Ciofani, M., Petrie, H. T., & Zúñiga‐Pflücker, J. C. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20040394 · Cited by 328 · see citing works
An Essential Developmental Checkpoint for Production of the T Cell Lineage
Ikawa, T., Hirose, S., Masuda, K., Kakugawa, K., Satoh, R., Shibano-Satoh, A., Kominami, R., Katsura, Y., & Kawamoto, H. (2010) · Science · doi:10.1126/science.1188995 · Cited by 327 · see citing works
Fate Mapping Reveals Separate Origins of T Cells and Myeloid Lineages in the Thymus
Schlenner, S., Madan, V., Busch, K., Tietz, A., Läufle, C., Costa, C., Blum, C., Fehling, H. J., & Rodewald, H.-R. (2010) · Immunity · doi:10.1016/j.immuni.2010.03.005 · Cited by 322 · see citing works
Hematopoietic Fingerprints: An Expression Database of Stem Cells and Their Progeny
Chambers, S. M., Boles, N. C., Lin, K. K., Tierney, M., Bowman, T. V., Bradfute, S. B., Chen, A. J., Merchant, A. A., Sirin, O., Weksberg, D. C., et al. (2007) · Cell stem cell · doi:10.1016/j.stem.2007.10.003 · Cited by 318 · see citing works
Yu, M., Riva, L., Xie, H., Schindler, Y. L., Moran, T. B., Cheng, Y., Yu, D., Hardison, R. C., Weiss, M. J., Orkin, S. H., et al. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.11.002 · Cited by 308 · see citing works
Meis1 is an essential and rate-limiting regulator of MLL leukemia stem cell potential.Preprint
Wong, P., Iwasaki, M., Somervaille, T., So, C., & Cleary, M. (2007) · Genes & Development · doi:10.1101/gad.1602107 · Cited by 297 · see citing works
PU.1 regulates the commitment of adult hematopoietic progenitors and restricts granulopoiesis
Dakic, A., Metcalf, D., Di Rago, L., Mifsud, S., Wu, L., & Nutt, S. L. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20050075 · Cited by 297 · see citing works
The In Vivo Pattern of Binding of RAG1 and RAG2 to Antigen Receptor Loci
Ji, Y., Resch, W., Corbett, E., Yamane, A., Casellas, R. C., & Schatz, D. G. (2010) · Cell · doi:10.1016/j.cell.2010.03.010 · Cited by 296 · see citing works
Bhandoola, A., von Boehmer, H., Petrie, H. T., & Zúñiga‐Pflücker, J. C. (2007) · Immunity · doi:10.1016/j.immuni.2007.05.009 · Cited by 272 · see citing works
Loughran, S. J., Kruse, E., Hacking, D. F., de Graaf, C. A., Hyland, C. D., Willson, T. A., Henley, K. J., Ellis, S. L., Voss, A. K., Metcalf, D., et al. (2008) · Nature Immunology · doi:10.1038/ni.1617 · Cited by 265 · see citing works
PU.1 is a major downstream target of AML1 (RUNX1) in adult mouse hematopoiesis.
Huang, G., Zhang, P., Hirai, H., Elf, S., Yan, X., Chen, Z., Koschmieder, S., Okuno, Y., Dayaram, T., Growney, J. D., et al. (2008) · Nature Genetics · doi:10.1038/ng.2007.7 · Cited by 259 · see citing works
MOLECULAR GENETICS OF T CELL DEVELOPMENT
Rothenberg, E. V., & Taghon, T. (2004) · Annual Review of Immunology · doi:10.1146/annurev.immunol.23.021704.115737 · Cited by 256 · see citing works
Self-citationGATA-3 Expression Is Controlled by TCR Signals and Regulates CD4/CD8 Differentiation
Hernández‐Hoyos, G., Anderson, M. K., Wang, C., Rothenberg, E. V., & Alberola‐Ila, J. (2003) · Immunity · doi:10.1016/s1074-7613(03)00176-6 · Cited by 254 · see citing works
Self-citationThe β-catenin–TCF-1 pathway ensures CD4+CD8+ thymocyte survival
Ioannidis, V., Beermann, F., Clevers, H. C., & Held, W. (2001) · Nature Immunology · doi:10.1038/90623 · Cited by 246 · see citing works
Ng, S. Y., Yoshida, T., Zhang, J., & Georgopoulos, K. (2009) · Immunity · doi:10.1016/j.immuni.2009.01.014 · Cited by 245 · see citing works
Self-citationJeannet, G., Scheller, M., Scarpellino, L., Duboux, S., Gardiol, N., Back, J., Kuttler, F., Malanchi, I., Birchmeier, W., Leutz, A., et al. (2008) · Blood · doi:10.1182/blood-2007-07-102558 · Cited by 241 · see citing works
Azcoitia, V., Aracil, M., Martínez‐A, C., & Torres, M. (2005) · Developmental Biology · doi:10.1016/j.ydbio.2005.01.004 · Cited by 239 · see citing works
Rosenbauer, F., Owens, B. M., Yu, L., Tumang, J. R., Steidl, U., Kutok, J. L., Clayton, L. K., Wagner, K., Scheller, M., Iwasaki, H., et al. (2006) · Nature Genetics · doi:10.1038/ng1679 · Cited by 237 · see citing works
Critical Involvement of Tcf-1 in Expansion of Thymocytes
Schilham, M. W., Wilson, A., Moerer, P., Benaissa-Trouw, B. J., Cumano, A., & Clevers, H. C. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.8.3984 · Cited by 237 · see citing works
The Lmo2 Oncogene Initiates Leukemia in Mice by Inducing Thymocyte Self-Renewal
McCormack, M. P., Young, L. F., Vasudevan, S., de Graaf, C. A., Codrington, R., Rabbitts, T. H., Jane, S. M., & Curtis, D. J. (2010) · Science · doi:10.1126/science.1182378 · Cited by 231 · see citing works
E2A Proteins Promote Development of Lymphoid-Primed Multipotent Progenitors
Dias, S., Månsson, R., Gurbuxani, S. K., Sigvardsson, M., & Kee, B. L. (2008) · Immunity · doi:10.1016/j.immuni.2008.05.015 · Cited by 226 · see citing works
Larson, R. C., Lavenir, I., Larson, T., Baer, R. J., Warren, A. J., Wadman, I., Nottage, K., & Rabbitts, T. H. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00439.x · Cited by 219 · see citing works
Herblot, S., Steff, A., Hugo, P., Aplan, P. D., & Hoang, T. (2000) · Nature Immunology · doi:10.1038/77819 · Cited by 214 · see citing works
GATA-1 converts lymphoid and myelomonocytic progenitors into the megakaryocyte/erythrocyte lineages.
Iwasaki, H., Mizuno, S., Wells, R., Cantor, A., Watanabe, S., & Akashi, K. (2003) · Immunity · doi:10.1016/s1074-7613(03)00242-5 · Cited by 214 · see citing works
Maillard, I. P., Tu, L., Sambandam, A., Yashiro–Ohtani, Y., Millholland, J. M., Keeshan, K., Shestova, O. E., Xu, L., Bhandoola, A., & Pear, W. S. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20061020 · Cited by 200 · see citing works
E proteins and Notch signaling cooperate to promote T cell lineage specification and commitment
Ikawa, T., Kawamoto, H., Goldrath, A. W., & Murre, C. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20060268 · Cited by 197 · see citing works
Taghon, T., Yui, M. A., & Rothenberg, E. V. (2007) · Nature Immunology · doi:10.1038/ni1486 · Cited by 195 · see citing works
Self-citationTAL1/SCL induces leukemia by inhibiting the transcriptional activity of E47/HEB
O’Neil, J., Shank, J., Cusson, N., Murre, C., & Kelliher, M. A. (2004) · Cancer Cell · doi:10.1016/j.ccr.2004.05.023 · Cited by 194 · see citing works
Requirement for Notch1 signals at sequential early stages of intrathymic T cell development
Tan, J. B. L., Visan, I., Yuan, J. S., & Guidos, C. J. (2005) · Nature Immunology · doi:10.1038/ni1217 · Cited by 191 · see citing works
Anderson, M. K., Weiss, A. H., Hernandez-Hoyos, G., Dionne, C. J., & Rothenberg, E. V. (2002) · Immunity · doi:10.1016/s1074-7613(02)00277-7 · Cited by 182 · cited 3× · see citing works
“1 has no lasting inhibitory effects on T-cell development provided that it is transient (37,73).”
BackgroundSelf-citationHierarchy of Notch–Delta interactions promoting T cell lineage commitment and maturation
Besseyrias, V., Fiorini, E., Strobl, L. J., Zimber‐Strobl, U., Dumortier, A., Koch, U., Arcangeli, M.-L., Ezine, S., MacDonald, H. R., & Radtke, F. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20061442 · Cited by 181 · see citing works
Feyerabend, T. B., Terszowski, G., Tietz, A., Blum, C., Luche, H., Gossler, A., Gale, N. W., Radtke, F., Fehling, H. J., & Rodewald, H.-R. (2008) · Immunity · doi:10.1016/j.immuni.2008.10.016 · Cited by 177 · see citing works
Mohtashami, M., Shah, D., Nakase, H., Kianizad, K., Petrie, H. T., & Zúñiga‐Pflücker, J. C. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1000782 · Cited by 176 · see citing works
BCL11B functionally associates with the NuRD complex in T lymphocytes to repress targeted promoter
Cismasiu, V. B., Adamo, K., Gecewicz, J., Duque, J., Lin, Q., & Avram, D. (2005) · Oncogene · doi:10.1038/sj.onc.1208904 · Cited by 175 · see citing works
Gounari, F., Aifantis, I., Khazaie, K., Hoeflinger, S., Harada, N., Taketo, M. M., & von Boehmer, H. (2001) · Nature Immunology · doi:10.1038/ni0901-863 · Cited by 167 · see citing works
Porritt, H. E., Gordon, K., & Petrie, H. T. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030837 · Cited by 167 · see citing works
Chen, D., & Rothenberg, E. V. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.179.3.931 · Cited by 163 · see citing works
Self-citationAccessibility Control of V(D)J Recombination
Cobb, R. M., Oestreich, K. J., Osipovich, O. A., & Oltz, E. M. (2006) · Advances in immunology · doi:10.1016/s0065-2776(06)91002-5 · Cited by 161 · see citing works
Balciunaite, G., Ceredig, R., & Rolink, A. G. (2005) · Blood · doi:10.1182/blood-2004-08-3087 · Cited by 158 · see citing works
From the cradle to the grave: activities of GATA‐3 throughout T‐cell development and differentiation
Hosoya, T., Maillard, I. P., & Engel, J. D. (2010) · Immunological Reviews · doi:10.1111/j.1600-065x.2010.00954.x · Cited by 157 · see citing works
GATA-3 is required for early T lineage progenitor development
Hosoya, T., Kuroha, T., Moriguchi, T., Cummings, D. R., Maillard, I. P., Lim, K.-C., & Engel, J. D. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20090934 · Cited by 154 · see citing works
Delayed, asynchronous, and reversible T-lineage specification induced by Notch/Delta signalingPreprint
Taghon, T., David‐Fung, E., Zúñiga‐Pflücker, J. C., & Rothenberg, E. V. (2005) · Genes & Development · doi:10.1101/gad.1298305 · Cited by 154 · see citing works
Self-citationFine-Scale Staging of T Cell Lineage Commitment in Adult Mouse Thymus
Yui, M. A., Feng, N., & Rothenberg, E. V. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1000679 · Cited by 152 · see citing works
Self-citationLong-Term Cultured E2A-Deficient Hematopoietic Progenitor Cells Are Pluripotent
Ikawa, T., Kawamoto, H., Wright, L. Y. T., & Murre, C. (2004) · Immunity · doi:10.1016/s1074-7613(04)00049-4 · Cited by 151 · see citing works
Avram, D., Fields, A. J., Senawong, T., Topark‐Ngarm, A., & Leid, M. E. (2002) · Biochemical Journal · doi:10.1042/bj20020496 · Cited by 146 · see citing works
Senawong, T., Peterson, V. J., Avram, D., Shepherd, D. M., Frye, R. A., Minucci, S., & Leid, M. E. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m307477200 · Cited by 145 · see citing works
Schwartz, R., Engel, I., Fallahi‐Sichani, M., Petrie, H. T., & Murre, C. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0603728103 · Cited by 144 · see citing works
Hattori, N., Kawamoto, H., Fujimoto, S., Kuno, K., & Katsura, Y. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.184.3.1137 · Cited by 142 · see citing works
Serwold, T. F., Ehrlich, L. I. R., & Weissman, I. L. (2008) · Blood · doi:10.1182/blood-2008-08-173682 · Cited by 139 · see citing works
Garrity, P., Chen, D. S., Rothenberg, E. V., & Wold, B. J. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.3.2159-2169.1994 · Cited by 139 · see citing works
Self-citationAdult Hematopoietic Stem and Progenitor Cells Require Either Lyl1 or Scl for Survival
Souroullas, G. P., Salmon, J. M., Sablitzky, F., Curtis, D. J., & Goodell, M. A. (2009) · Cell stem cell · doi:10.1016/j.stem.2009.01.001 · Cited by 137 · see citing works
Ontogeny and Regulation of IL-7-Expressing Thymic Epithelial Cells
Zamisch, M., Moore‐Scott, B. A., Su, D., Lucas, P. J., Manley, N. R., & Richie, E. R. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.1.60 · Cited by 134 · see citing works
BCL11B is required for positive selection and survival of double-positive thymocytes
Albu, D. I., Feng, D., Bhattacharya, D., Jenkins, N. A., Copeland, N. G., Liu, P., & Avram, D. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070863 · Cited by 134 · see citing works
Wakabayashi, Y., Inoue, J., Takahashi, Y., Matsuki, A., Kosugi-Okano, H., Shinbo, T., Mishima, Y., Niwa, O., & Kominami, R. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)03069-3 · Cited by 128 · see citing works
E2A and HEB Are Required to Block Thymocyte Proliferation Prior to Pre-TCR Expression
Wojciechowski, J., Lai, A. Y., Kondo, M., & Zhuang, Y. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.9.5717 · Cited by 126 · see citing works
Transcription control of early B cell differentiation
Mandel, E. M., & Grosschedl, R. (2010) · Current Opinion in Immunology · doi:10.1016/j.coi.2010.01.010 · Cited by 125 · see citing works
Hoogenkamp, M., Lichtinger, M., Krysinska, H., Lancrin, C., Clarke, D., Williamson, A., Mazzarella, L., Ingram, R., Jorgensen, H., Fisher, A., et al. (2009) · Blood · doi:10.1182/blood-2008-11-191890 · Cited by 121 · see citing works
Weerkamp, F., Baert, M. R. M., Naber, B. A. E., Koster, E. E. L., de Haas, E. F. E., Atkuri, K. R., van Dongen, J. J. M., Herzenberg, L. A., & Staal, F. J. T. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0511299103 · Cited by 119 · see citing works
Critical roles of Bcl11b in T‐cell development and maintenance of T‐cell identity
Liu, P., Li, P., & Burke, S. (2010) · Immunological Reviews · doi:10.1111/j.1600-065x.2010.00953.x · Cited by 118 · see citing works
Yang, Q., Bell, J. J., & Bhandoola, A. (2010) · Immunological Reviews · doi:10.1111/j.1600-065x.2010.00956.x · Cited by 116 · see citing works
Staal, F. J. T., Weerkamp, F., Baert, M. R. M., van den Burg, C. M. M., van Noort, M., de Haas, E. F. E., & van Dongen, J. J. M. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.2.1099 · Cited by 116 · see citing works
King, A. G., Kondo, M., Scherer, D. C., & Weissman, I. L. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.072087899 · Cited by 115 · see citing works
From hematopoietic progenitors to B cells: mechanisms of lineage restriction and commitment
Ramírez, J. A., Lukin, K., & Hagman, J. R. (2010) · Current Opinion in Immunology · doi:10.1016/j.coi.2010.02.003 · Cited by 114 · see citing works
Notch/Delta signaling constrains reengineering of pro-T cells by PU.1
Franco, C. B., Scripture-Adams, D. D., Proekt, I., Taghon, T., Weiss, A. H., Yui, M. A., Adams, S. L., Diamond, R. A., & Rothenberg, E. V. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601188103 · Cited by 109 · see citing works
Self-citationChickarmane, V. S., Enver, T., & Peterson, C. (2009) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1000268 · Cited by 105 · see citing works
T Cell Development in PU.1-Deficient Mice
Spain, L. M., Guerriero, A., Kunjibettu, S., & Scott, E. W. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.5.2681 · Cited by 101 · see citing works
Molecular Dissection of Prethymic Progenitor Entry into the T Lymphocyte Developmental Pathway
Tydell, C. C., David-Fung, E.-S., Moore, J. E., Rowen, L., Taghon, T., & Rothenberg, E. V. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.1.421 · Cited by 99 · see citing works
Self-citationHeinzel, K., Benz, C., Martins, V. C., Haidl, I. D., & Bleul, C. C. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.2.858 · Cited by 99 · see citing works
Bcl11b represses a mature T‐cell gene expression program in immature CD4+CD8+ thymocytes
Kastner, P., Chan, S. H., Vogel, W., Zhang, L., Topark‐Ngarm, A., Golonzhka, O., Jost, B., Gras, S. L., Gross, M. K., & Leid, M. E. (2010) · European Journal of Immunology · doi:10.1002/eji.200940258 · Cited by 98 · see citing works
The role of Notch and IL‐7 signaling in early thymocyte proliferation and differentiation
Balc̆iūnaite, G., Ceredig, R. H., Fehling, H. J., Zúñiga‐Pflücker, J. C., & Rolink, A. G. (2005) · European Journal of Immunology · doi:10.1002/eji.200425822 · Cited by 98 · see citing works
Baba, Y., Garrett, K. P., & Kincade, P. W. (2005) · Immunity · doi:10.1016/j.immuni.2005.10.009 · Cited by 96 · see citing works
A gene regulatory network armature for T lymphocyte specification
Georgescu, C., Longabaugh, W. J. R., Scripture-Adams, D. D., David‐Fung, E., Yui, M. A., Zarnegar, M. A., Bolouri, H., & Rothenberg, E. V. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0806501105 · Cited by 95 · see citing works
Self-citationT‐cell development, doing it in a dish
Schmitt, T. M., & Zúñiga‐Pflücker, J. C. (2006) · Immunological Reviews · doi:10.1111/j.0105-2896.2006.00353.x · Cited by 92 · see citing works
Dontje, W., Schotte, R., Cupedo, T., Nagasawa, M., Scheeren, F. A., Gimeno, R., Spits, H., & Blom, B. (2005) · Blood · doi:10.1182/blood-2005-05-2090 · Cited by 92 · see citing works
Kawamoto, H., Ikawa, T., Masuda, K., Wada, H., & Katsura, Y. (2010) · Immunological Reviews · doi:10.1111/j.1600-065x.2010.00959.x · Cited by 89 · see citing works
Modularity and design principles in the sea urchin embryo gene regulatory network
Peter, I. S., & Davidson, E. H. (2009) · FEBS Letters · doi:10.1016/j.febslet.2009.11.060 · Cited by 89 · see citing works
Capron, C., Lécluse, Y., Kaushik, A. L., Foudi, A., Lacout, C., Sekkaı̈, D., Godin, I., Albagli, O., Poullion, I., Svinartchouk, F., et al. (2006) · Blood · doi:10.1182/blood-2005-08-3145 · Cited by 86 · see citing works
Anderson, M. K., Hernández‐Hoyos, G., Dionne, C. J., Arias, A. M., Chen, D., & Rothenberg, E. V. (2002) · Developmental Biology · doi:10.1006/dbio.2002.0674 · Cited by 85 · see citing works
Self-citationThe homeoprotein Hex is required for hemangioblast differentiation
Guo, Y., Chan, R. J., Ramsey, H. E., Li, W., Xie, X., Shelley, W. C., Martı́nez-Barberá, J. P., Bort, B., Zaret, K. S., Yöder, M. C., et al. (2003) · Blood · doi:10.1182/blood-2003-02-0634 · Cited by 83 · see citing works
T/B lineage choice occurs prior to intrathymic Notch signaling
Harman, B. C., Jenkinson, W. E., Parnell, S. M., Rossi, S. W., Jenkinson, E. J., & Anderson, G. (2005) · Blood · doi:10.1182/blood-2004-12-4881 · Cited by 80 · see citing works
Lu, M., Tayu, R., Ikawa, T., Masuda, K., Matsumoto, I., Mugishima, H., Kawamoto, H., & Katsura, Y. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.9.5848 · Cited by 79 · see citing works
T Cell Lineage Determination Precedes the Initiation of <i>TCR</i> β Gene Rearrangement
Masuda, K., Kakugawa, K., Nakayama, T., Minato, N., Katsura, Y., & Kawamoto, H. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.6.3699 · Cited by 77 · see citing works
E proteins and the regulation of early lymphocyte development
de Pooter, R. F., & Kee, B. L. (2010) · Immunological Reviews · doi:10.1111/j.1600-065x.2010.00957.x · Cited by 77 · see citing works
Guo, Y., Maillard, I. P., Chakraborti, S., Rothenberg, E. V., & Speck, N. A. (2008) · Blood · doi:10.1182/blood-2007-10-120261 · Cited by 74 · see citing works
Self-citationEarly decisions in lymphoid development
Ye, M., & Graf, T. (2007) · Current Opinion in Immunology · doi:10.1016/j.coi.2007.02.007 · Cited by 74 · see citing works
Tcf/Lef transcription factors during T-cell development: unique and overlapping functions
Staal, F. J. T., & Clevers, H. C. (2000) · The Hematology Journal · doi:10.1038/sj.thj.6200001 · Cited by 72 · see citing works
Thymic Anlage Is Colonized by Progenitors Restricted to T, NK, and Dendritic Cell Lineages
Masuda, K., Itoi, M., Amagai, T., Minato, N., Katsura, Y., & Kawamoto, H. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.5.2525 · Cited by 68 · see citing works
Transcription factor expression dynamics of early T-lymphocyte specification and commitment
David‐Fung, E., Butler, R. R., Buzi, G., Yui, M. A., Diamond, R. A., Anderson, M. K., Rowen, L., & Rothenberg, E. V. (2008) · Developmental Biology · doi:10.1016/j.ydbio.2008.10.021 · Cited by 68 · see citing works
Self-citationPU.1 regulates TCR expression by modulating GATA-3 activity
Chang, H.-C., Han, L., Jabeen, R., Carotta, S., Nutt, S. L., & Kaplan, M. H. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0900363 · Cited by 66 · see citing works
Desplats, P., Lambert, J. R., & Thomas, E. A. (2008) · Neurobiology of Disease · doi:10.1016/j.nbd.2008.05.005 · Cited by 64 · see citing works
T/NK Bipotent Progenitors in the Thymus Retain the Potential to Generate Dendritic Cells
Shen, H. Q., Lu, M. M., Ikawa, T., Masuda, K., Ohmura, K., Minato, N., Katsura, Y., & Kawamoto, H. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.7.3401 · Cited by 63 · see citing works
Cooperating pre–T-cell receptor and TCF-1–dependent signals ensure thymocyte survival
Goux, D., Coudert, J. D., Maurice, D., Scarpellino, L., Jeannet, G., Piccolo, S., Weston, K., Huelsken, J., & Held, W. (2005) · Blood · doi:10.1182/blood-2005-01-0337 · Cited by 62 · see citing works
Enforced Expression of Spi-B Reverses T Lineage Commitment and Blocks β-Selection
Lefebvre, J. M., Haks, M. C., Carleton, M. O., Rhodes, M., Sinnathamby, G., Simon, M. C., Eisenlohr, L. C., Garrett-Sinha, L. A., & Wiest, D. L. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.10.6184 · Cited by 60 · see citing works
Zhang, S., Rozell, M., Verma, R. K., Albu, D. I., Califano, D., VanValkenburgh, J., Merchant, A., Rangel‐Moreno, J., Randall, T. D., Jenkins, N. A., et al. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20092136 · Cited by 58 · see citing works
Tabrizifard, S., Olaru, A., Plotkin, J., Fallahi‐Sichani, M., Livák, F., & Petrie, H. T. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.2.1094 · Cited by 58 · see citing works
Distinct roles of IL-7 and stem cell factor in the OP9-DL1 T-cell differentiation culture system
Wang, H., Pierce, L., & Spangrude, G. J. (2006) · Experimental Hematology · doi:10.1016/j.exphem.2006.08.001 · Cited by 54 · see citing works
Zarnegar, M. A., Chen, J., & Rothenberg, E. V. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.00354-10 · Cited by 52 · see citing works
Self-citationGrowth factor independent 1B (Gfi1b) is an E2A target gene that modulates Gata3 in T-cell lymphomas
Xu, W., & Kee, B. L. (2007) · Blood · doi:10.1182/blood-2006-08-043331 · Cited by 51 · see citing works
Inoue, J., Kanefuji, T., Okazuka, K., Watanabe, H., Mishima, Y., & Kominami, R. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.10.5871 · Cited by 49 · see citing works
Overexpression of a transcription factor LYL1 induces T- and B-cell lymphoma in mice
田中, 義., Jiang, L., Hiai, H., Toyokuni, S., & Yamada, Y. (2007) · Oncogene · doi:10.1038/sj.onc.1210494 · Cited by 48 · see citing works
Pongracz, J. E., Parnell, S. M., Jones, T., Anderson, G., & Jenkinson, E. J. (2006) · European Journal of Immunology · doi:10.1002/eji.200535721 · Cited by 48 · see citing works
Huang, J., Garrett, K. P., Pelayo, R., Zúñiga‐Pflücker, J. C., Petrie, H. T., & Kincade, P. W. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.8.4858 · Cited by 48 · see citing works
George, A., Morse, H. C., & Justice, M. J. (2003) · Oncogene · doi:10.1038/sj.onc.1206822 · Cited by 47 · see citing works
Kawamoto, H., Ohmura, K., Fujimoto, S., Lu, M. M., Ikawa, T., & Katsura, Y. (2003) · European Journal of Immunology · doi:10.1002/eji.200323461 · Cited by 44 · see citing works
Competition and collaboration: GATA-3, PU.1, and Notch signaling in early T-cell fate determination
Rothenberg, E. V., & Scripture-Adams, D. D. (2008) · Seminars in Immunology · doi:10.1016/j.smim.2008.07.006 · Cited by 43 · see citing works
Self-citationUntangling the T branch of the hematopoiesis tree
Chi, A. W., Bell, J. J., Zlotoff, D. A., & Bhandoola, A. (2009) · Current Opinion in Immunology · doi:10.1016/j.coi.2009.01.012 · Cited by 37 · see citing works
Cismasiu, V. B., Duque, J., Paskaleva, E. E., Califano, D., Ghanta, S., Young, H. A., & Avram, D. (2008) · Biochemical Journal · doi:10.1042/bj20080925 · Cited by 35 · see citing works
The intrathymic crossroads of T and NK cell differentiation
Wolterink, R. G. J. K., García‐Ojeda, M. E., Vosshenrich, C. A. J., Hendriks, R. W., & Santo, J. P. D. (2010) · Immunological Reviews · doi:10.1111/j.1600-065x.2010.00960.x · Cited by 34 · see citing works
Down‐regulation of the myeloid homeobox protein Hex is essential for normal T‐cell development
Mack, D. L., Leibowitz, D. S., Cooper, S. H., Ramsey, H. E., Broxmeyer, H. E., & Hromas, R. (2002) · Immunology · doi:10.1046/j.1365-2567.2002.01523.x · Cited by 32 · see citing works
Henderson, A. J., McDougall, S., Leiden, J. M., & Calame, K. L. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.6.4286-4294.1994 · Cited by 30 · see citing works
Transcriptional regulation of lymphocyte development
Dias, S., Xu, W., McGregor, S. M., & Kee, B. L. (2008) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2008.07.015 · Cited by 30 · see citing works
Pre-TCR-Induced β-Catenin Facilitates Traversal through β-Selection
Xu, M., Sharma, A., Wiest, D. L., & Sen, J. M. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.182.2.751 · Cited by 28 · see citing works
Kawazu, M., Yamamoto, G., Yoshimi, M., Yamamoto, K. Z., Asai, T., Ichikawa, M., Seo, S., Nakagawa, M. M., Chiba, S., Kurokawa, M., et al. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.8.5335 · Cited by 26 · see citing works
Balmelle, N., Zamarreño, N., Krangel, M. S., & Hernández-Munaín, C. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.8.5054 · Cited by 23 · see citing works
Promoter activity 5′ of Dβ2 is coordinated by E47, Runx1, and GATA-3
McMillan, R. E., & Sikes, M. L. (2009) · Molecular Immunology · doi:10.1016/j.molimm.2009.06.013 · Cited by 22 · see citing works
Xu, M., Sharma, A., Hossain, M. Z., Wiest, D. L., & Sen, J. M. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.182.2.759 · Cited by 19 · see citing works
Regulatory factors for initial T lymphocyte lineage specification
Rothenberg, E. V. (2007) · Current Opinion in Hematology · doi:10.1097/moh.0b013e3281de72a8 · Cited by 16 · see citing works
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A critical role for TCF-1 in T-lineage specification and differentiation
Weber, B., Chi, A. W. S., Chavez, A., Yashiro–Ohtani, Y., Yang, Q., Shestova, O. E., & Bhandoola, A. (2011) · Nature · doi:10.1038/nature10279 · Cited by 420 · see citing works
Developmental gene networks: a triathlon on the course to T cell identity
Yui, M. A., & Rothenberg, E. V. (2014) · Nature Reviews Immunology · doi:10.1038/nri3702 · Cited by 342 · see citing works
Self-citationThe transcriptional landscape of αβ T cell differentiation
Mingueneau, M., Kreslavsky, T., Gray, D. H. D., Heng, T. S. P., Cruse, R., Ericson, J., Bendall, S. C., Spitzer, M. H., Nolan, G. P., Kobayashi, K. S., et al. (2013) · Nature Immunology · doi:10.1038/ni.2590 · Cited by 267 · see citing works
Transcriptional Control of Early T and B Cell Developmental Choices
Rothenberg, E. V. (2014) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032712-100024 · Cited by 232 · see citing works
Self-citationBcl11a is essential for lymphoid development and negatively regulates p53
Yu, Y., Wang, J., Khaled, W. T., Burke, S., Li, P., Chen, X., Yang, W., Jenkins, N. A., Copeland, N. G., Zhang, S., et al. (2012) · The Journal of Experimental Medicine · doi:10.1084/jem.20121846 · Cited by 223 · see citing works
Wolterink, R. G. J. K., Serafini, N., van Nimwegen, M., Vosshenrich, C. A. J., de Bruijn, M. J. W., Fonseca‐Pereira, D., Veiga‐Fernandes, H., Hendriks, R. W., & Santo, J. P. D. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1217158110 · Cited by 226 · see citing works
The genetic network controlling plasma cell differentiation
Nutt, S. L., Taubenheim, N., Hasbold, J., Corcoran, L. M., & Hodgkin, P. D. (2011) · Seminars in Immunology · doi:10.1016/j.smim.2011.08.010 · Cited by 224 · see citing works
T-cell factor 1 is a gatekeeper for T-cell specification in response to Notch signaling
Germar, K., Dose, M., Konstantinou, T., Zhang, J., Wang, H., Lobry, C., Arnett, K. L., Blacklow, S. C., Aifantis, I., Aster, J. C., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1110230108 · Cited by 219 · see citing works
Self-citationIntrathymic programming of effector fates in three molecularly distinct γδ T cell subtypes
Narayan, K., Sylvia, K., Malhotra, N., Yin, C., Martens, G. W., Vallerskog, T., Kornfeld, H., Xiong, N., Cohen, N. R., Brenner, M. B., et al. (2012) · Nature Immunology · doi:10.1038/ni.2247 · Cited by 199 · see citing works
Specific bone cells produce DLL4 to generate thymus-seeding progenitors from bone marrow
Yu, V. W. C., Sáez, B., Cook, C., Lotinun, S., Pardo–Saganta, A., Wang, Y., Lymperi, S., Ferraro, F., Raaijmakers, M. H. G. P., Wu, J. Y., et al. (2015) · The Journal of Experimental Medicine · doi:10.1084/jem.20141843 · Cited by 163 · see citing works
Ettersperger, J., Montcuquet, N., Malamut, G., Guégan, N., Lopez‐Lastra, S., Gayraud, S., Reimann, C., Vidal, E., Cagnard, N., Villarèse, P., et al. (2016) · Immunity · doi:10.1016/j.immuni.2016.07.018 · Cited by 166 · see citing works
Transcriptional Regulation of Innate and Adaptive Lymphocyte Lineages
Obaldia, M. E. D., & Bhandoola, A. (2015) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032414-112032 · Cited by 163 · see citing works
Design principles of adaptive immune systems
Boehm, T. L. J. (2011) · Nature reviews. Immunology · doi:10.1038/nri2944 · Cited by 155 · see citing works
Origin and Evolution of Adaptive Immunity
Boehm, T. L. J., & Swann, J. B. (2013) · Annual Review of Animal Biosciences · doi:10.1146/annurev-animal-022513-114201 · Cited by 144 · see citing works
GATA-3 promotes T-cell specification by repressing B-cell potential in pro–T cells in mice
García‐Ojeda, M. E., Wolterink, R. G. J. K., Lemaı̂tre, F., Goff, O. R.-L., Hasan, M., Hendriks, R. W., Cumano, A., & Santo, J. P. D. (2013) · Blood · doi:10.1182/blood-2012-06-440065 · Cited by 105 · see citing works
Mechanisms of Action of Hematopoietic Transcription Factor PU.1 in Initiation of T-Cell Development
Rothenberg, E. V., Hosokawa, H., & Ungerbäck, J. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00228 · Cited by 99 · see citing works
“This is part of a general downregulation of stem/progenitor associated regulatory genes (“phase 1 genes”) (34, 43) and a major reorganization of active chromatin and chromatin interactions, genome-wide, that occurs during this transition (44).”
BackgroundSelf-citationTreanor, L. M., Zhou, S., Janke, L. J., Churchman, M. L., Ma, Z., Lu, T., Chen, S.-C., Mullighan, C. G., & Sorrentino, B. P. (2014) · The Journal of Experimental Medicine · doi:10.1084/jem.20122727 · Cited by 98 · see citing works
T Cell Lineage Commitment: Identity and Renunciation
Rothenberg, E. V. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1003703 · Cited by 90 · see citing works
Self-citationTranscriptional drivers of the T-cell lineage program
Rothenberg, E. V. (2012) · Current Opinion in Immunology · doi:10.1016/j.coi.2011.12.012 · Cited by 80 · see citing works
Self-citationChamphekar, A., Damle, S. S., Freedman, G., Carotta, S., Nutt, S. L., & Rothenberg, E. V. (2015) · Genes & Development · doi:10.1101/gad.259879.115 · Cited by 74 · see citing works
Self-citationRole of the transcription factor Bcl11b in development and lymphomagenesis
Kominami, R. (2012) · Proceedings of the Japan Academy Series B · doi:10.2183/pjab.88.72 · Cited by 71 · see citing works
The T-ALL related gene BCL11B regulates the initial stages of human T-cell differentiation
Ha, V. L., Luong, A., Li, F., Casero, D., Malvar, J., Kim, Y. M., Bhatia, R., Crooks, G. M., & Parekh, C. (2017) · Leukemia · doi:10.1038/leu.2017.70 · Cited by 70 · see citing works
From inception to output, Tcf1 and Lef1 safeguard development of T cells and innate immune cells
Steinke, F. C., & Xue, H. (2014) · Immunologic Research · doi:10.1007/s12026-014-8545-9 · Cited by 69 · see citing works
Runx3-mediated Transcriptional Program in Cytotoxic Lymphocytes
Lotem, J., Levanon, D., Negreanu, V., Leshkowitz, D., Friedlander, G., & Groner, Y. (2013) · PLoS ONE · doi:10.1371/journal.pone.0080467 · Cited by 73 · see citing works
Zohren, F., Souroullas, G. P., Luo, M., Gerdemann, U., Imperato, M. R., Wilson, N. K., Göttgens, B., Lukov, G. L., & Goodell, M. A. (2012) · Nature Immunology · doi:10.1038/ni.2365 · Cited by 63 · see citing works
T cell immunity as a tool for studying epigenetic regulation of cellular differentiation
Russ, B. E., Prier, J. E., Rao, S., & Turner, S. J. (2013) · Frontiers in Genetics · doi:10.3389/fgene.2013.00218 · Cited by 62 · see citing works
Berent-Maoz, B., Montecino-Rodriguez, E., Signer, R. A. J., & Dorshkind, K. (2012) · Blood · doi:10.1182/blood-2011-12-400002 · Cited by 46 · see citing works
A crucial role for the homeodomain transcription factor Hhex in lymphopoiesis
Jackson, J. T., Nasa, C., Shi, W., Huntington, N. D., Bogue, C. W., Alexander, W. S., & McCormack, M. P. (2014) · Blood · doi:10.1182/blood-2014-06-579813 · Cited by 44 · see citing works
Regulatory gene network circuits underlying T cell development from multipotent progenitors
Kueh, H. Y., & Rothenberg, E. V. (2011) · WIREs Systems Biology and Medicine · doi:10.1002/wsbm.162 · Cited by 41 · see citing works
Self-citationMalleshaiah, M. K., Padi, M., Rué, P., Quackenbush, J. F., Martínez-Arias, A., & Gunawardena, J. (2016) · Cell Reports · doi:10.1016/j.celrep.2015.12.101 · Cited by 38 · see citing works
Hidalgo, L., Martínez, V. G., Valencia, J., Hernández‐López, C., Vázquez, M., Nuñez, J. R., Zapata, A. G., Sacedón, R., Varas, A., & Vicente, Á. (2011) · Blood · doi:10.1182/blood-2011-07-370650 · Cited by 30 · see citing works
Regulation of Memory T Cells by Interleukin-23
Li, Y.-C., Wang, H.-B., Lu, H., & Hua, S. (2016) · International Archives of Allergy and Immunology · doi:10.1159/000445834 · Cited by 28 · see citing works
Mangel, M., & Bonsall, M. B. (2013) · Theoretical Biology and Medical Modelling · doi:10.1186/1742-4682-10-5 · Cited by 28 · see citing works
miR-146a and miR-150 promote the differentiation of CD133+ cells into T-lymphoid lineage
Fallah, P., Arefian, E., Naderi, M., Aghaee‐Bakhtiari, S. H., Atashi, A., Ahmadi, K., Shafiee, A., & Soleimani, M. (2013) · Molecular Biology Reports · doi:10.1007/s11033-013-2567-6 · Cited by 27 · see citing works
The roles of miR-146a in the differentiation of Jurkat T-lymphoblasts
Saki, N., Abroun, S., Soleimani, M., Mortazavi, Y., Kaviani, S., & Arefian, E. (2013) · Hematology · doi:10.1179/1607845413y.0000000105 · Cited by 26 · see citing works
Phelan, J. D., Saba, I., Zeng, H., Kosan, C., Wynn, M. S., Olsson, H. A., Fraszczak, J., Hildeman, D. A., Aronow, B. J., Möröy, T., et al. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003713 · Cited by 25 · see citing works
Genetic regulation of thymocyte progenitor aging
Berent-Maoz, B., Montecino‐Rodriguez, E., & Dorshkind, K. A. (2012) · Seminars in Immunology · doi:10.1016/j.smim.2012.04.006 · Cited by 24 · see citing works
Belyaev, N. N., Biró, J., Athanasakis, D., Fernandez-Reyes, D., & Potocnik, A. J. (2012) · Immunogenetics · doi:10.1007/s00251-012-0620-6 · Cited by 24 · see citing works
Liu, F., Li, J., Lin, I. Y. C., Yang, X., Ma, J., Chen, Y., Lv, N., Shi, Y., Gao, G. F., & Zhu, B. (2020) · ImmunoHorizons · doi:10.4049/immunohorizons.1900095 · Cited by 23 · see citing works
Simons, L., Cavazzana, M., & André‐Schmutz, I. (2019) · Stem Cells Translational Medicine · doi:10.1002/sctm.18-0248 · Cited by 21 · see citing works
Luche, H., Rao, T. N., Kumar, S., Tasdogan, A., Beckel, F., Blum, C., Martins, V. C., Rodewald, H.-R., & Fehling, H. J. (2013) · The Journal of Experimental Medicine · doi:10.1084/jem.20122609 · Cited by 21 · see citing works
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Rothenberg, E. V., & Zhang, J. A. (2011) · Current topics in microbiology and immunology · doi:10.1007/82_2011_168 · Cited by 17 · see citing works
Self-citationInteraction between γδTCR signaling and the E protein‐Id axis in γδ T cell development
Anderson, M. K., & Selvaratnam, J. S. (2020) · Immunological Reviews · doi:10.1111/imr.12924 · Cited by 15 · see citing works
Nielsen, H. (2010) · Methods in molecular biology · doi:10.1007/978-1-59745-248-9_1 · Cited by 17 · see citing works
Rothenberg, E. V., Champhekar, A. S., Damle, S. S., Real, M. M. D., Kueh, H. Y., Li, L., & Yui, M. A. (2013) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2013.78.020271 · Cited by 13 · see citing works
Self-citationEstablishment and Maintenance of B Cell IdentityPreprint
Grosschedl, R. (2013) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2013.78.020057 · Cited by 13 · see citing works
Smeets, M. F. M. A., Wiest, D. L., & Izon, D. J. (2014) · European Journal of Immunology · doi:10.1002/eji.201444442 · Cited by 13 · see citing works
Michaels, Y. S., Major, M. C., Bonham-Carter, B., Zhang, J.-Q., Heydari, T., Edgar, J. M., Siu, M. M., Greenstreet, L., Vilarrasa‐Blasi, R., Kim, S., et al. (2024) · Cell Systems · doi:10.1016/j.cels.2024.11.001 · Cited by 11 · see citing works
Self-citationNikhat, S., Yadavalli, A. D., Prusty, A., Narayan, P. K., Palakodeti, D., Murre, C., & Pongubala, J. M. R. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2104297118 · Cited by 10 · see citing works
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Goldsmith, C., Donovan, T., Vlahovich, N., & Pyne, D. B. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.729366 · Cited by 9 · see citing works
Schiavinato, J. L. D. S., Oliveira, L. H. B., Araújo, A. G., Orellana, M. D., Palma, P. V. B., Covas, D. T., Zago, M. A., & Panepucci, R. A. (2016) · In Vitro Cellular & Developmental Biology - Animal · doi:10.1007/s11626-016-0055-8 · Cited by 10 · see citing works
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Kitajima, K., Kawaguchi, M., Miyashita, K., Nakajima, M., Kanokoda, M., & Hara, T. (2015) · Genes to Cells · doi:10.1111/gtc.12266 · Cited by 8 · see citing works
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Golzari-Sorkheh, M., Yoganathan, K., Chen, E. L. Y., Singh, J., & Zúñiga‐Pflücker, J. C. (2025) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-77921-3_4 · Cited by 6 · see citing works
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Yoganathan, K., Chen, E. L. Y., Singh, J., & Zúñiga‐Pflücker, J. C. (2019) · Springer eBooks · doi:10.1007/978-3-030-12040-5_4 · Cited by 6 · see citing works
Yui, M. A., Feng, N., Zhang, J. A., Liaw, C. Y., Rothenberg, E. V., & Longmate, J. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1202970 · Cited by 5 · see citing works
Self-citationGATA3 Abundance Is a Critical Determinant of T Cell Receptor β Allelic Exclusion
Ku, C.-J., Sekiguchi, J., Panwar, B., Guan, Y., Takahashi, S., Yoh, K., Maillard, I. P., Hosoya, T., & Engel, J. D. (2017) · Molecular and Cellular Biology · doi:10.1128/mcb.00052-17 · Cited by 4 · see citing works
Chapter 43 – Thymus and Parathyroid Organogenesis
O'Neill, K. E., Nowell, C. S., Richie, E., Manley, N., & Blackburn, C. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-398358-9.00043-4 · Cited by 5 · see citing works
Champagne, D., & Shockett, P. E. (2014) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2014.01.007 · Cited by 4 · see citing works
Barik, S., Cattin-Roy, A. N., Ukah, T., Miller, M. M., Teixeiro, E., & Zaghouani, H. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.2000614 · Cited by 4 · see citing works
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Shuyu, E., Vega, F., Khanlari, M., Fang, H., Xu, J., Li, S., Hu, S., Wang, S. A., Wei, Q., Wang, W. J., et al. (2025) · Pathology · doi:10.1016/j.pathol.2025.01.010 · Cited by 3 · see citing works
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Cavazzana, M., Paillet, J., Fandi, A., Moirangthem, R. D., Heimendinger, P., Magrin, E., Oster, S., Žuklys, S., Devillier, R., Huynh, A., et al. (2025) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2025.08.004 · Cited by 2 · see citing works
Fibrotic liver microenvironment promotes Dll4 and SDF-1-dependent T-cell lineage development
Gong, Z., Shang, B., Chu, Y., Chen, X., Li, Q., Liu, K., Chen, Y., Huang, Y., Han, Y., Shang, Q., et al. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-1630-1 · Cited by 2 · see citing works
Thymus and parathyroid organogenesis
Nowell, C. S., O’Neill, K. E., Rouse, P., Henderson, T., Richie, E. R., Manley, N. R., & Blackburn, C. C. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-818422-6.00038-1 · Cited by 1 · see citing works
Bailis, W., & Pear, W. S. (2014) · Epigenetics and human health · doi:10.1007/978-3-642-45198-0_11 · Cited by 1 · see citing works
SATB1: Key Regulator of T Cell Development and Differentiation
Kamalvishnu, P., Burute, M., & Galande, S. (2012) · InTech eBooks · doi:10.5772/36303 · Cited by 1 · see citing works
A Systems Approach to Blood Disorders
Qasba, P. (2014) · Advances in experimental medicine and biology · doi:10.1007/978-1-4939-2095-2_19 · Cited by 1 · see citing works
Michaels, Y. S., Major, M. C., Bonham-Carter, B., Zhang, J.-Q., Heydari, T., Edgar, J. M., Greenstreet, L., Vilarrasa‐Blasi, R., Kim, S., Castle, E. L., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.10.06.561277 · Cited by 1 · see citing works
Self-citationMOLECULAR MECHANISMS UNDERLYING THE TRANSCRIPTIONAL REGULATION OF T HELPER 17 AND REGULATORY T CELLS
Martínez, G. (2011) · Digital Commons-TMC (Texas Medical Center)
Real, D. (2013) · CaltechTHESIS (California Institute of Technology) · doi:10.7907/pews-km18
Bosselut, R. (2012) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.13434971.14857100
The influence of type II cytokines in central tolerance
Cattin-Roy, A. N. (2021) · doi:10.32469/10355/90006
Goher, M. N. E. H., Moghaieb, R. E. A., Elmenawey, M. A., & Stino, F. K. R. (2024) · Journal of World s Poultry Research · doi:10.36380/jwpr.2024.4
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Papamatheakis, D.-A., Tzerpos, P., Tsoukatou, D., Mores, E., Kapsetaki, M., Dezsö, B., Igarashi, K., & Spilianakis, C. G. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.11.25.690242
- Authors
- Rothenberg, E. V., Zhang, J., & Li, L.
- Affiliations
- California Institute of Technology (US)
- Corresponding author
- Rothenberg, Ellen V.
- Venue
- Immunological Reviews
- Publisher
- Wiley
- Published
- 2010-10-25
- Volume
- 238
- Issue
- 1
- Pages
- 150-168
- ISSN
- 0105-2896 (ISSN-L)
- 1600-065X
- PMC
- PMC2965335
- OpenAlex
- W1525824369
- Cited by
- 81
- References
- 145
- Citations by year
- 2025: 4 · 2024: 2 · 2023: 1 · 2021: 4 · 2020: 4 · 2019: 5 · 2017: 2 · 2016: 5 · 2015: 4 · 2014: 9 · 2013: 18 · 2012: 11
- FWCI
- 1.04
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Immunological Reviews (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- CaltechAUTHORS (California Institute of Technology) (submittedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R33HL089123)
- National Cancer Institute (R01CA90233, R01CA090233, RC2CA148278)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Keywords
- T cell development, lineage commitment, transcription factors, hematopoietic stem cells, transcriptional regulation, systems biology
- MeSH terms
- Animals, Cell Differentiation, Hematopoietic Stem Cells, Humans, Repressor Proteins, T-Lymphocytes, T-Lymphocyte Subsets, Gene Expression Regulation, Developmental, Cell Lineage, Tumor Suppressor Proteins, Gene Regulatory Networks
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