The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Autophagy Is Induced in CD4+ T Cells and Important for the Growth Factor-Withdrawal Cell Death
Abstract
Autophagy is a tightly regulated catabolic mechanism that degrades proteins and organelles. Autophagy mediates programmed cell death under certain conditions. To determine the role of autophagy in T cells, we examined, in mouse CD4+ T cells, conditions under which autophagy is induced and alterations of the cell fate when autophagy is blocked. We have found that resting naive CD4+ T cells do not contain detectable autophagosomes. Autophagy can be observed in activated CD4+ T cells upon TCR stimulation, cytokine culturing, and prolonged serum starvation. Induction of autophagy in T cells requires JNK and the class III PI3K. Autophagy is inhibited by caspases and mammalian target of rapamycin in T cells. Interestingly, more Th2 cells than Th1 cells undergo autophagy. Th2 cells become more resistant to growth factor-withdrawal cell death when autophagy is blocked using either chemical inhibitors 3-methyladenine, or by RNA interference knockdown of beclin 1 and Atg7. Therefore, autophagy is an important mechanism that controls homeostasis of CD4+ T cells.
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LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing.
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Autophagy as a Regulated Pathway of Cellular Degradation
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Bcl-2 Antiapoptotic Proteins Inhibit Beclin 1-Dependent Autophagy
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Loss of autophagy in the central nervous system causes neurodegeneration in mice
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The role of autophagy during the early neonatal starvation period
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Developmental cell death: morphological diversity and multiple mechanisms
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Cited by
Autophagy in the Pathogenesis of Disease
Levine, B., & Kroemer, G. (2008) · Cell · doi:10.1016/j.cell.2007.12.018 · Cited by 7,069
JNK1-Mediated Phosphorylation of Bcl-2 Regulates Starvation-Induced Autophagy
Wei, Y., Pattingre, S., Sinha, S., Bassik, M., & Levine, B. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.06.001 · Cited by 1,329
Metabolic Regulation of T Lymphocytes
MacIver, N. J., Michalek, R. D., & Rathmell, J. C. (2013) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032712-095956 · Cited by 1,244
Autophagy in inflammation, infection, and immunometabolism
Deretic, V. (2021) · Immunity · doi:10.1016/j.immuni.2021.01.018 · Cited by 862
Toll‐like receptors control autophagy
Delgado, M. A., Elmaoued, R. A., Davis, A. S., Kyei, G., & Deretic, V. (2008) · The EMBO Journal · doi:10.1038/emboj.2008.31 · Cited by 744
Metadata
- Authors
- Li, C., Capan, E., Zhao, Y., Zhao, J., Stolz, D., Watkins, S. C., Jin, S., & Lu, B.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-10
- Volume
- 177
- Issue
- 8
- Pages
- 5163-5168
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1559838741
- Cited by
- 276
- References
- 38
- FWCI
- 10.40
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Autophagy Is Induced in CD4+ T Cells and Important for the Growth Factor-Withdrawal Cell Death. https://app.cochat.ai/papers/10.4049/jimmunol.177.8.5163
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- Li, C., Capan, E., Zhao, Y., Zhao, J., Stolz, D., Watkins, S. C., Jin, S., & Lu, B. (2006). Autophagy Is Induced in CD4+ T Cells and Important for the Growth Factor-Withdrawal Cell Death. The Journal of Immunology. https://doi.org/10.4049/jimmunol.177.8.5163
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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