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Altered Innate Immune Functioning of Dendritic Cells in Elderly Humans: A Role of Phosphoinositide 3-Kinase-Signaling Pathway
Abstract
Aging represents a state of paradox where chronic inflammation is associated with declining immune responses. Dendritic cells (DCs) are the major APCs responsible for initiating an immune response. However, DC functions in aging have not been studied in detail. In this study, we have compared the innate immune functions of monocyte-derived myeloid DCs from elderly subjects with DCs from young individuals. We show that although phenotypically comparable, DCs from the aging are functionally different from DCs from the young. In contrast to DCs from the young, DCs from elderly individuals display 1) significantly reduced capacity to phagocytose Ags via macropinocytosis and endocytosis as determined by flow cytometry; 2) impaired capacity to migrate in vitro in response to the chemokines MIP-3β and stromal cell-derived factor-1; and 3) significantly increased LPS and ssRNA-induced secretion of TNF-α and IL-6, as determined by ELISA. Investigations of intracellular signaling revealed reduced phosphorylation of AKT in DCs from the aging, indirectly suggesting decreased activation of the PI3K pathway. Because the PI3K-signaling pathway plays a positive regulatory role in phagocytosis and migration, and also functions as a negative regulator of TLR signaling by inducing activation of p38 MAPK, this may explain the aberrant innate immune functioning of DCs from elderly subjects. Results from real-time PCR and protein expression by flow cytometry demonstrated an increased expression of phosphatase and tensin homolog, a negative regulator of the PI3K-signaling pathway, in DCs from the aging. Increased phosphatase and tensin homolog may thus be responsible for the defect in AKT phosphorylation and, therefore, the altered innate immune response of DCs from elderly humans.
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In the citing paper
“Circulating numbers of myeloid and plasmacytoid DCs, their phenotypes, and their ability to express costimulatory molecules appear to be intact in older individuals”
From Successful and Maladaptive T Cell Aging (2017) · cites this paper as Agrawal et al., 2007
In the citing paper
“In humans, a reduced mobilization of LCs from the skin to lymphoid organs upon TNF-alpha stimulation have been shown in aged subjects [56], while an age-associated increase in TLR4- and TLR8-dependent cytokine production has been observed in human MDDCs [59].”
From Aging of the immune system: Focus on inflammation and vaccination (2016) · cites this paper as [59]
In the citing paper
“In addition, aged DCs maintain the ability to upregulate chemokines and chemokine receptors but exhibit decreased migratory capacity in response to stimuli (114).”
From Aging and Lung Disease (2020) · cites this paper as [114]
In the citing paper
“Altered PRR expression and/or changes in downstream signaling cascades may underlie dysregulated DC responses in older persons (114, 116).”
From Aging and Lung Disease (2020) · cites this paper as [114]
In the citing paper
“Despite comparable cell numbers, differentiation, and morphology in the young and aged, DCs from older persons exhibit impaired phagocytosis of antigen (113, 114).”
From Aging and Lung Disease (2020) · cites this paper as [114]
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Metadata
- Authors
- Agrawal, A., Agrawal, S., Cao, J.-N., Su, H., Osann, K., & Gupta, S.
- Affiliations
- University of California, Irvine (US)
- Division of Basic and Clinical Immunology, University of California , Irvine, CA 92697
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-06-01
- Volume
- 178
- Issue
- 11
- Pages
- 6912-6922
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1508177354
- Cited by
- 435
- References
- 64
- Citations by year
- 2026: 10 · 2025: 20 · 2024: 20 · 2023: 18 · 2022: 20 · 2021: 20 · 2020: 33 · 2019: 28 · 2018: 29 · 2017: 26 · 2016: 22 · 2015: 22 · 2014: 28 · 2013: 34 · 2012: 21
- FWCI
- 8.05
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of California, Irvine
- National Institute on Aging (AG-027512, R21AG027512)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Keywords
- dendritic cells, aging, innate immunity, phosphoinositide 3-kinase signaling, Akt phosphorylation, phagocytosis, dendritic cell migration, chemokines, CCL19, CXCL12, TNF-α, interleukin-6, lipopolysaccharide, phosphatase and tensin homolog, chronic inflammation, p38 MAPK, Toll-like receptor signaling
- MeSH terms
- Phosphoinositide-3 Kinase Inhibitors, Adult, Aged, Aged, 80 and over, Aging, Cell Count, Cell Differentiation, Cells, Cultured, Dendritic Cells, Humans, Immunity, Innate, Monocytes, Signal Transduction, Up-Regulation, Cytokines, Inflammation Mediators, Jurkat Cells, Phosphatidylinositol 3-Kinases, PTEN Phosphohydrolase
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