The DOI matches its Crossref record; 64 of the 64 references it cites were found in a registry or an index.
Altered Innate Immune Functioning of Dendritic Cells in Elderly Humans: A Role of Phosphoinositide 3-Kinase-Signaling Pathway
Abstract
Aging represents a state of paradox where chronic inflammation is associated with declining immune responses. Dendritic cells (DCs) are the major APCs responsible for initiating an immune response. However, DC functions in aging have not been studied in detail. In this study, we have compared the innate immune functions of monocyte-derived myeloid DCs from elderly subjects with DCs from young individuals. We show that although phenotypically comparable, DCs from the aging are functionally different from DCs from the young. In contrast to DCs from the young, DCs from elderly individuals display 1) significantly reduced capacity to phagocytose Ags via macropinocytosis and endocytosis as determined by flow cytometry; 2) impaired capacity to migrate in vitro in response to the chemokines MIP-3β and stromal cell-derived factor-1; and 3) significantly increased LPS and ssRNA-induced secretion of TNF-α and IL-6, as determined by ELISA. Investigations of intracellular signaling revealed reduced phosphorylation of AKT in DCs from the aging, indirectly suggesting decreased activation of the PI3K pathway. Because the PI3K-signaling pathway plays a positive regulatory role in phagocytosis and migration, and also functions as a negative regulator of TLR signaling by inducing activation of p38 MAPK, this may explain the aberrant innate immune functioning of DCs from elderly subjects. Results from real-time PCR and protein expression by flow cytometry demonstrated an increased expression of phosphatase and tensin homolog, a negative regulator of the PI3K-signaling pathway, in DCs from the aging. Increased phosphatase and tensin homolog may thus be responsible for the defect in AKT phosphorylation and, therefore, the altered innate immune response of DCs from elderly humans.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Circulating numbers of myeloid and plasmacytoid DCs, their phenotypes, and their ability to express costimulatory molecules appear to be intact in older individuals”
From Successful and Maladaptive T Cell Aging (2017) · cites this paper as Agrawal et al., 2007
In the citing paper
“In humans, a reduced mobilization of LCs from the skin to lymphoid organs upon TNF-alpha stimulation have been shown in aged subjects [56], while an age-associated increase in TLR4- and TLR8-dependent cytokine production has been observed in human MDDCs [59].”
From Aging of the immune system: Focus on inflammation and vaccination (2016) · cites this paper as [59]
In the citing paper
“In addition, aged DCs maintain the ability to upregulate chemokines and chemokine receptors but exhibit decreased migratory capacity in response to stimuli (114).”
From Aging and Lung Disease (2020) · cites this paper as [114]
In the citing paper
“Altered PRR expression and/or changes in downstream signaling cascades may underlie dysregulated DC responses in older persons (114, 116).”
From Aging and Lung Disease (2020) · cites this paper as [114]
In the citing paper
“Despite comparable cell numbers, differentiation, and morphology in the young and aged, DCs from older persons exhibit impaired phagocytosis of antigen (113, 114).”
From Aging and Lung Disease (2020) · cites this paper as [114]
Citations
Cites
Dendritic cells and the control of immunity
Banchereau, J., & Steinman, R. M. (1998) · Nature · doi:10.1038/32588 · Cited by 14,486
Immunobiology of Dendritic Cells
Banchereau, J., Brière, F., Caux, C., Davoust, J. M., Lebecque, S., Liu, Y., Pulendran, B., & Palucka, K. (2000) · Annual Review of Immunology · doi:10.1146/annurev.immunol.18.1.767 · Cited by 6,755
The Dendritic Cell System and its Role in Immunogenicity
Steinman, R. M. (1991) · Annual Review of Immunology · doi:10.1146/annurev.iy.09.040191.001415 · Cited by 4,659
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism
Engelman, J. A., Luo, J., & Cantley, L. C. (2006) · Nature Reviews Genetics · doi:10.1038/nrg1879 · Cited by 3,330
Fadok, V. A., Bratton, D. L., Konowal, A., Freed, P. W., Westcott, J. Y., & Henson, P. M. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1112 · Cited by 3,166
Maehama, T., & Dixon, J. E. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.22.13375 · Cited by 3,104
Sallusto, F., Cella, M., Danieli, C., & Lanzavecchia, A. (1995) · The Journal of Experimental Medicine · doi:10.1084/jem.182.2.389 · Cited by 2,501
Cantley, L. C., & Neel, B. G. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.8.4240 · Cited by 2,018
Toll-like receptors control activation of adaptive immune responses
Schnare, M., Barton, G. M., Czopik, A. K., Takeda, K., Akira, S., & Medzhitov, R. M. (2001) · Nature Immunology · doi:10.1038/ni712 · Cited by 1,364
Sauter, B., Albert, M. L., Francisco, L. M., Larsson, M., Somersan, S., & Bhardwaj, N. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.191.3.423 · Cited by 1,357
Flagged first, then by citations
Research works printed but not linked: 63
- 2003, Microbes Infect., 1279
- 1997, Exp. Gerontol., 401
- 1998, Mech. Ageing Dev., 11
- 2004, J. Immunol., 3437
- 2001, Curr. Opin. Hematol., 131
- 2004, Ann. NY Acad. Sci., 104
- 1999, Acta. Neurol. Scand., 34
- 1992, Life Sci., 1953
- 1998, Front. Biosci., d59
- 2004, Nat. Immunol., 133
- 1996, J. Exp. Med., 1891
- 2003, Proc. Natl. Acad. Sci. USA, 15053
- 1997, Immunol. Rev., 79
- 1999, Exp. Gerontol., 7
- 1992, Mech. Ageing Dev., 57
- 2004, Exp. Gerontol., 545
- 2003, Biochem. Soc. Trans., 447
- 2002, Semin. Immunol., 267
- 1991, Annu. Rev. Immunol., 271
- 1998, Nature, 245
- 2000, Annu. Rev. Immunol., 767
- 2001, Nat. Immunol., 947
- 2001, Science, 253
- 1997, Eur. J. Immunol., 3135
- 2003, J. Immunol., 4984
- 2002, J. Biol. Chem., 32124
- 2003, Trends Immunol., 358
- 2002, Nat. Immunol., 875
- 2003, Blood, 3560
- 1995, J. Exp. Med., 389
- 1995, FEBS Lett., 272
- 1996, J. Cell Biol., 1249
- 2003, Semin. Immunol., 271
- 2005, Nat. Rev. Immunol., 617
- 1999, J. Immunol., 3859
- 2004, EMBO J., 3505
- 2000, Immunol. Rev., 217
- 2002, Immunology, 125
- 1999, Proc. Natl. Acad. Sci. USA, 4240
- 2001, Exp. Cell Res., 29
- 2000, Cell, 87
- 1999, Trends Cell Biol., 125
- 1998, J. Biol. Chem., 13375
- 1996, Genes Dev., 1084
- 2000, Vaccine, 1606
- 1996, Clin. Exp. Immunol., 544
- 1987, Mech. Ageing Dev., 69
- 1990, J. Invest. Dermatol., 247
- 2002, Scand. J. Immunol., 518
- 1995, Eur. J. Immunol., 1319
- 2000, Exp. Gerontol., 213
- 1993, Eur. J. Immunol., 2375
- 2006, J. Gerontol. A Biol. Sci. Med. Sci., 1039
- 2002, J. Immunol., 4697
- 1998, J. Clin. Invest., 890
- 2000, J. Exp. Med., 423
- 2002, Immunology, 466
- 2005, Immunol. Rev., 207
- 2006, Nat. Rev. Genet., 606
- 2006, Immunol. Res., 33
- 2003, J. Immunol., 717
- 1999, Proc. Natl. Acad. Sci. USA, 6199
- 2003, Trends Cell Biol., 478
Cited by
Sorted by citations
Items 301–400 of 439
Jirru, E., Lee, S. F., Harris, R. M., Yang, J., Cho, S. J., & Stout-Delgado, H. W. (2020) · Vaccines · doi:10.3390/vaccines8020298 · Cited by 6
Bufan, B., Djikić, J., Nacka-Aleksić, M., Stojić-Vukanić, Z., Dimitrijevic, M., & Leposavić, G. (2014) · Genetika · doi:10.2298/gensr1401287b · Cited by 6
Caro, V. D., D’Anneo, A., Phillips, B. E., Engman, C., Harnaha, J., Trucco, M., & Giannoukakis, N. (2011) · Immunologic Research · doi:10.1007/s12026-011-8206-1 · Cited by 6
An oncologist perspective on COVID 19: A mysterious cryptic virus
Shetty, S. S., Rao, V. U. S., Kudpaje, A., Mithra, S., Merchant, Y. P., & Shabadi, N. (2020) · Oral Oncology · doi:10.1016/j.oraloncology.2020.104694 · Cited by 6
Hoffman, R. A., Huang, S., Chalasani, G., & Vallejo, A. N. (2021) · Aging and Disease · doi:10.14336/ad.2021.0119 · Cited by 6
Yang, J., Kim, J., Kwak, C., & Poo, H. (2022) · Immunity & Ageing · doi:10.1186/s12979-022-00282-z · Cited by 5
The Role of Inflammation in Alzheimer’s Disease
Müller, N., Krause, D., Schwarz, M., Weidinger, E., & Reinisch, V. M. (2015) · Current topics in neurotoxicity · doi:10.1007/978-3-319-13602-8_15 · Cited by 5
Rožman, P. J. (2019) · Rejuvenation Research · doi:10.1089/rej.2018.2164 · Cited by 5
The immune system during ageing
Müller, L., Pawelec, G., & Derhovanessian, E. (2013) · Elsevier eBooks · doi:10.1533/9780857095749.4.631 · Cited by 5
Phenotypic and Functional Changes of Circulating Monocytes in Elderly
Ginaldi, L., & Martinis, M. D. (2009) · Springer eBooks · doi:10.1007/978-1-4020-9063-9_26 · Cited by 5
Nutraceuticals in immunosenescence
Magrone, T., & Jirillo, E. (2015) · Anti‐ageing nutrients · doi:10.1002/9781118823408.ch5 · Cited by 4
Urdy, S., Hanke, M., Marrero, A. I. T., Ratto, N., Jacob, E., Peyronnet, E., Gourlet, J.-B., Chaves, S. S., Thommes, E. W., Coudeville, L., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-72716-1 · Cited by 5
Age and sex determine CD4+ T cell stimulatory and polarizing capacity of rat splenic dendritic cells
Stojić-Vukanić, Z., Pilipović, I., Bufan, B., Stojanović, M., & Leposavić, G. (2019) · Biogerontology · doi:10.1007/s10522-019-09845-y · Cited by 4
Sirtuins and the prevention of immunosenescence
Lasigliè, D. (2021) · Vitamins and hormones · doi:10.1016/bs.vh.2020.12.011 · Cited by 5
Immunseneszenz. Bestandsaufnahme und molekulare Grundlagen
Peters, T. (2011) · Der Hautarzt · Cited by 4
Effect of Anti-influenza Vaccination on Immune System in the Elderly
Trzonkowski, P. (2009) · Springer eBooks · doi:10.1007/978-1-4020-9063-9_70 · Cited by 4
Vieillissement des muqueuses buccales : aspects fondamentaux et cliniques
Séguier, S., Bodineau, A., & Folliguet, M. (2010) · NPG. Neurologie, psychiatrie, gériatrie/NPG · doi:10.1016/j.npg.2010.10.003 · Cited by 4
Espia, M., Sebastián, C., Mulero, M., Giralt, M., Mallol, J., Celada, A., & Lloberas, J. (2008) · The Journals of Gerontology Series A · doi:10.1093/gerona/63.11.1161 · Cited by 4
Hearps, A. C., Schafer, K. R., High, K. P., & LANDAY, A. L. (2015) · Springer eBooks · doi:10.1007/978-3-319-23246-1_17 · Cited by 5
Somatische Veränderungen im Alter
Langsenlehner, U., Muchar, H., & Schippinger, W. (2013) · Springer eBooks · doi:10.1007/978-3-7091-1581-7_4 · Cited by 4
Accuracy of interleukin-27 in diagnosing tuberculous pleural effusion: Age should be considered
Zhu, H.-Z., Niu, Y., Wen, J.-X., Cheng, Y., Cha, S., Gao, Y., Hao, X.-L., Hou, W., Yan, L., Jiang, T., et al. (2024) · Cytokine · doi:10.1016/j.cyto.2024.156844 · Cited by 3
Effects of Aging on Human Toll-Like Receptor Function
Shaw, A. C. (2019) · Springer eBooks · doi:10.1007/978-3-319-99375-1_98 · Cited by 2
Does Dysregulation of Redox State Underpin the Decline of Innate Immunity with Aging?
Griffiths, H. R., Rooney, M. C. O., & Perrie, Y. (2020) · Antioxidants and Redox Signaling · doi:10.1089/ars.2020.8021 · Cited by 3
Aging Immunity and the Impact of Physical Exercise
Bigley, A. B., Baker, F. L., Spielmann, G., & Simpson, R. J. (2019) · Springer eBooks · doi:10.1007/978-3-319-99375-1_165 · Cited by 3
SARS Coronavirus Pathogenesis and Therapeutic Treatment Design
Sheahan, T. P., & Baric, R. S. (2009) · Springer eBooks · doi:10.1007/978-3-642-03683-5_13 · Cited by 4
Aging Immunity and the Impact of Physical Exercise
Spielmann, G., Bigley, A. B., LaVoy, E. C. P., & Simpson, R. J. (2013) · Springer eBooks · doi:10.1007/978-3-642-39495-9_26 · Cited by 4
Innate Immune System Modulation During Aging: Contributions of Macrophages and Dendritic Cells
Maletto, B. A., Morón, G., & Pistoresi-Palencia, M. C. (2010) · Current Immunology Reviews · doi:10.2174/1573395511006040329 · Cited by 3
Lifestyle Interventions to Improve Immunesenescence
Bartlett, D. B., & Huffman, K. M. (2016) · Springer eBooks · doi:10.1007/978-3-319-43365-3_10 · Cited by 3
Role of Dendritic Cells in Aging
Agrawal, A., Agrawal, S., & Gupta, S. (2009) · Springer eBooks · doi:10.1007/978-1-4020-9063-9_25 · Cited by 3
Self-citationDevelopment of therapeutic cancer vaccines based on cancer immunity cycle
Zhang, J., Zheng, Y., Xu, L., Gao, J., Ou, Z., Zhu, M., & Wang, W. (2025) · Frontiers of Medicine · doi:10.1007/s11684-025-1134-6 · Cited by 2
Dai, H., Sun, R., Xie, B., Xu, F., Yu, X., Weng, C., Yao, C., Wang, H., Wu, B., Xu, J., et al. (2026) · Nature Aging · doi:10.1038/s43587-026-01068-4 · Cited by 5
Skin aging: Mechanistic insights and targeted therapeutic strategies
Beaziz, J., Avallone, G., Langer, K., DUCA, E. D., Navrazhina, K., He, H., & Guttman‐Yassky, E. (2026) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2026.05.015 · Cited by 3
Immune aging biomarkers for clinical trials
Cipriano, A., Justice, J. N., Poganik, J. R., Moqri, M., Abudayyeh, O. O., Gootenberg, J. S., Haynes, L., Levin, Y., Martin-Herranz, D. E., Akbar, A. N., et al. (2026) · Nature Medicine · doi:10.1038/s41591-026-04493-5 · Cited by 3
Ghoneum, M. H., Tolentino, L., & Seto, Y. (2009) · PubMed · Cited by 2
Agrawal, A. (2010) · Methods in molecular biology · doi:10.1007/978-1-60761-063-2_12 · Cited by 2
Self-citationCancer Vaccination at Older Age
Gravekamp, C. (2013) · Interdisciplinary topics in gerontology and geriatrics · doi:10.1159/000343596 · Cited by 2
Innate Immunosenescence and Its Impact on Health in Old Age
Tariq, M. A., Hazeldine, J., & Lord, J. M. (2016) · Springer eBooks · doi:10.1007/978-3-319-43365-3_1 · Cited by 2
Tummala, M. K., Taub, D. D., & Ershler, W. B. (2010) · Elsevier eBooks · doi:10.1016/b978-1-4160-6231-8.10013-3 · Cited by 2
Kahn, J., Pregartner, G., Avian, A., Kniepeiss, D., Müller, H., & Schemmer, P. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01584 · Cited by 2
Effects of Aging on Human Toll-Like Receptor Function
Shaw, A. C. (2018) · Springer eBooks · doi:10.1007/978-3-319-64597-1_98-1 · Cited by 3
Phenotypic and Functional Changes of Circulating Monocytes in Elderly
Ginaldi, L., & Martinis, M. D. (2019) · Springer eBooks · doi:10.1007/978-3-319-99375-1_26 · Cited by 2
Frailty in Old Age Is Associated with Altered Cytokine Production in Response to TLR Ligation
Compté, N., Pepersack, T., & Goriely, S. (2019) · Springer eBooks · doi:10.1007/978-3-319-99375-1_152 · Cited by 2
Conway, J., Rees, N. P., & Duggal, N. A. (2023) · Healthy ageing and longevity · doi:10.1007/978-3-031-14023-5_3 · Cited by 2
When wrinkles appear on the immune system can it be reversed?
Sibaii, H., El-Zayat, S. R., & Khalil, M. (2020) · European Cytokine Network · doi:10.1684/ecn.2020.0441 · Cited by 4
Role of Dendritic Cells in Aging
Agrawal, A., Agrawal, S., & Gupta, S. (2017) · Springer eBooks · doi:10.1007/978-3-319-64597-1_25-1 · Cited by 2
Self-citationZeng, Y., Chen, H., Liu, X., Ye, R., Xie, E., Chen, Z., Lu, J., Li, J., Tian, Y., Ni, T., et al. (2017) · doi:10.4054/mpidr-wp-2017-004 · Cited by 2
Naik, S. (2013) · Iowa State University Digital Repository (Iowa State University) · doi:10.31274/etd-180810-3398 · Cited by 2
Rink, L., & Weßels, I. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-818731-9.00072-0 · Cited by 2
Zhivaki, D., Borriello, F., Kennedy, S. N., Evavold, C. L., Bahleda, K. M., Chapman, K. L., Zanoni, I., & Kagan, J. C. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.11.08.515695 · Cited by 2
Using Insects as Models of Immunosenescence
Leips, J. (2019) · Springer eBooks · doi:10.1007/978-3-319-99375-1_4 · Cited by 1
Cell-to-Cell Communication in Aging: Mechanisms, Impact and Therapeutic Prospects
Mas‐Bargues, C., Sanz‐Ros, J., Huete-Acevedo, J., & Borrás, C. (2024) · Springer eBooks · doi:10.1007/978-3-031-55022-5_8 · Cited by 1
Gasmi, M., Hejazi, M., Muscella, A., Marsigliante, S., & Sharma, A. (2025) · Physiological Reports · doi:10.14814/phy2.70364 · Cited by 1
Zúquete, S., Ferreira, M. D. S., Delgado, I. L. S., Rosa, M. T., Mendes, A. C., dos Santos, D. M. M. F., Nolasco, S., Graça, L., Leitão, A., & Basto, A. P. (2025) · Journal of Leukocyte Biology · doi:10.1093/jleuko/qiaf096 · Cited by 1
Immunosenescence and Cancer: Cellular Aging Programs That Reshape Antitumor Immunity
Oh, S.-H., Kim, Y. W., Kim, S. H., & Chang, S.-Y. (2026) · Immune Network · doi:10.4110/in.2026.26.e15 · Cited by 2
Liu, J., Zhang, Z., Zhang, J., & Nian, X. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1919049 · Cited by 1
Desai, A., & Yung, R. L. (2011) · Springer eBooks · doi:10.1007/978-1-4419-5792-4_1 · Cited by 1
The Role of T-regulatory Cells in Immune Senescence
Moss, P. A. H. (2009) · Springer eBooks · doi:10.1007/978-1-4020-9063-9_10 · Cited by 1
Glucocorticoids and DHEA: Do They Have a Role in Immunosenescence?
Bauer, M. E., Jeckel, C. M. M., Bonorino, C., Ribeiro, F., & Luz, C. (2009) · Springer eBooks · doi:10.1007/978-1-4020-9063-9_43 · Cited by 1
Cellular Senescence in Aging Mucosal Tissues Is Accentuated by Periodontitis
Ebersole, J. L., & González, O. A. (2020) · Springer eBooks · doi:10.1007/978-3-030-42990-4_8 · Cited by 1
Phenotypic and Functional Changes of Circulating Monocytes in Elderly
Ginaldi, L., & Martinis, M. D. (2018) · Springer eBooks · doi:10.1007/978-3-319-64597-1_26-1 · Cited by 1
Pattern Recognition Receptors and Aging
Shalaby, K. H. (2013) · Springer eBooks · doi:10.1007/978-3-642-39495-9_8 · Cited by 1
Bella, S. D. (2017) · Springer eBooks · doi:10.1007/978-3-319-64597-1_92-1 · Cited by 1
Sex and the Aging Immune System
Gibson, D. C., & Bupp, M. G. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-811353-0.00059-2 · Cited by 1
Pinti, M., Biasi, S. D., Gibellini, L., Tartaro, D. L., Gaetano, A. D., Mattioli, M., Fidanza, L., Nasi, M., & Cossarizza, A. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822569-1.00008-1 · Cited by 1
Bella, S. D. (2019) · Springer eBooks · doi:10.1007/978-3-319-99375-1_92 · Cited by 1
Greenwood, H. L. (2014) · University of Birmingham Institutional Research Archive (University of Birmingham) · Cited by 1
Human Cytomegalovirus as a driving force towards Immunosenescence
Zadražil, Z. (2018) · doi:10.32657/10356/73417 · Cited by 1
Combination nanoadjuvant-based vaccine against influenza virus for older adults
Senapati, S. (2020) · doi:10.31274/etd-20210114-134 · Cited by 1
Growing Old and Immunity to Bacteria
Turner, J. (2014) · ASM Press eBooks · doi:10.1128/9781555816872.ch33 · Cited by 1
Cancer Immunotherapy and Aging: Lessons From the Mouse
Gravekamp, C. (2009) · Springer eBooks · doi:10.1007/978-1-4020-9063-9_59 · Cited by 1
Fallah, M. P. (2011) · UKnowledge (University of Kentucky)
Mechanisms underlying innate immunesenescence
Hazeldine, J. (2013) · University of Birmingham Institutional Research Archive (University of Birmingham)
Japtok, L. (2012) · Universitätsbibliothek der FU Berlin Hochschulschriftenstelle u. Dokumentenserver · doi:10.17169/refubium-17290
The effects of sleep dysregulation and adiponectin on immunity in older adults
Rossi, A. (2014) · University of Birmingham Institutional Research Archive (University of Birmingham)
Dendritic Cells and Dysregulated Immunity in the Elderly
Agrawal, A., & Gupta, S. (2013) · Springer eBooks · doi:10.1007/978-3-642-39495-9_6
Self-citationPrise en charge buccodentaire de la personne âgée
Séguier, S., Nebot, D., Folliguet, M., Postaire, M., Radoï, L., & Veille-Finet, A. (2014)
Role of Dendritic Cells in Autoimmunity in Aged Humans
Gupta, S. (2014) · Immunome Research · doi:10.4172/1745-7580.1000067
Self-citationInnate Immune Responses in the Geriatric Population
Compt, N., & Goriely, S. (2012) · InTech eBooks · doi:10.5772/37878
Immunosenescence and the 3Rs: Restoration, Replacement and Reprogramming
Mitchell, W. A., Pink, R. C., Lapenna, A., & Aspinall, R. (2011) · Springer eBooks · doi:10.1007/978-3-0346-0219-8_9
Clinthorne, J. F. (2013) · Michigan State University Libraries · doi:10.25335/m5zq68
The role of MerTK and BAFF in dendritic cell-B cell interactions
Gohlke, P. R. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/2zf1-z813
Hanania, N. A., & Busse, P. J. (2015) · Springer eBooks · doi:10.1007/978-3-319-23246-1_14
Devi-Marulkar, P. (2015) · theses.fr (ABES) · doi:10.70675/1afef94czc6daz4936zb0d3z44f75d1762b1
Impacto da prática da atividade física moderada regular no retardo da imunossenescência de idosos
da Silva, L. C. R. (2016) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.5.2016.tde-20042016-155531
Sampangi, S. (2015) · QUT ePrints (Queensland University of Technology)
Heterochronic Parabiosis Studies of the Aging Immune System
Davies, J. (2016) · UA Campus Repository (The University of Arizona)
Human Longevity Aging of the Immune System as a Prognostic Factor for
Larbi, A., Franceschi, C., Mazzatti, D. J., Solana, R., & Wikby, A. (2016)
The Aging Immune System, Vaccine Efficacy, and the Lung
Bartley, J. M., & Haynes, L. (2015) · WORLD SCIENTIFIC eBooks · doi:10.1142/9789814635011_0009
Can Nutritional Intervention Counteract Immunosenescence in the Elderly?
Clements, S. J., & Carding, S. R. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-801816-3.00028-5 · Cited by 1
Breuillard, C., Moinard, C., & Farges, M. (2016) · Springer eBooks · doi:10.1007/978-3-319-26009-9_11
Transplantation rénale du sujet âgé
Snanoudj, R., Lazareth, H., Desbuissons, G., Delville, M., Rabant, M., Amrouche, L., Timsit, M., Legendre, C., & Martinez, F. (2016)
The aging immune system and nutritional interventions
van Beek, A. A. (2017) · doi:10.18174/392235
Influence of Aging on Antigen Uptake and Cytokine Production by Dendritic Cells
Pinke, K. H., de Lima, H. G., & Lara, V. S. (2017) · Springer eBooks · doi:10.1007/978-3-319-64597-1_93-1
Using Insects as Models of Immunosenescence
Leips, J. (2017) · Springer eBooks · doi:10.1007/978-3-319-64597-1_4-1
Ismail, M. M. (2017) · American Journal of Immunology · doi:10.3844/ajisp.2017.233.252
Frailty in Old Age is Associated with Altered Cytokine Production in Response to TLR Ligation
Compté, N., Pepersack, T., & Goriely, S. (2017) · Springer eBooks · doi:10.1007/978-3-319-64597-1_152-1
Immunsuppression beim nierentransplantierten Patienten über 65 Lebensjahre
Reshetnik, A. (2019) · Der Klinikarzt · doi:10.1055/a-1025-7946
Immune Modulation and Its Role in Antiaging
Sitar, M. E., Alaşehir, E. A., & İpek, B. Ö. (2018) · Springer eBooks · doi:10.1007/978-981-13-1699-9_8
Metadata
- Authors
- Agrawal, A., Agrawal, S., Cao, J.-N., Su, H., Osann, K., & Gupta, S.
- Affiliations
- University of California, Irvine (US)
- Division of Basic and Clinical Immunology, University of California , Irvine, CA 92697
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-06-01
- Volume
- 178
- Issue
- 11
- Pages
- 6912-6922
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1508177354
- Cited by
- 435
- References
- 64
- Citations by year
- 2026: 10 · 2025: 20 · 2024: 20 · 2023: 18 · 2022: 20 · 2021: 20 · 2020: 33 · 2019: 28 · 2018: 29 · 2017: 26 · 2016: 22 · 2015: 22 · 2014: 28 · 2013: 34 · 2012: 21
- FWCI
- 8.05
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of California, Irvine
- National Institute on Aging (AG-027512, R21AG027512)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Keywords
- dendritic cells, aging, innate immunity, phosphoinositide 3-kinase signaling, Akt phosphorylation, phagocytosis, dendritic cell migration, chemokines, CCL19, CXCL12, TNF-α, interleukin-6, lipopolysaccharide, phosphatase and tensin homolog, chronic inflammation, p38 MAPK, Toll-like receptor signaling
- MeSH terms
- Phosphoinositide-3 Kinase Inhibitors, Adult, Aged, Aged, 80 and over, Aging, Cell Count, Cell Differentiation, Cells, Cultured, Dendritic Cells, Humans, Immunity, Innate, Monocytes, Signal Transduction, Up-Regulation, Cytokines, Inflammation Mediators, Jurkat Cells, Phosphatidylinositol 3-Kinases, PTEN Phosphohydrolase
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
