Characterization of human lung tumor-associated fibroblasts and their ability to modulate the activation of tumor-associated T cells
Open accessAbstract
The tumor microenvironment of human non-small cell lung cancer (NSCLC) is composed largely of stromal cells, including fibroblasts, yet these cells have been the focus of few studies. In this study, we established stromal cell cultures from primary NSCLC through isolation of adherent cells. Characterization of these cells by flow cytometry demonstrated a population which expressed a human fibroblast-specific 112-kDa surface molecule, Thy1, α-smooth muscle actin, and fibroblast activation protein, but failed to express CD45 and CD11b, a phenotype consistent with that of an activated myofibroblast. A subset of the tumor-associated fibroblasts (TAF) was found to express B7H1 (PD-L1) and B7DC (PD-L2) constitutively, and this expression was up-regulated by IFN-γ. Production of cytokines and chemokines, including IFN-γ, monokine induced by IFN-γ, IFN-γ-inducible protein-10, RANTES, and TGF-β1 was also demonstrated in these cells. Together, these characteristics provide multiple opportunities for the TAF to influence cellular interactions within the tumor microenvironment. To evaluate the ability of TAF to modulate tumor-associated T cell (TAT) activation, we conducted coculture experiments between autologous TAF and TAT. In five of eight tumors, TAF elicited a contact-dependent enhancement of TAT activation, even in the presence of a TGF-β1-mediated suppressive effect. In the three other tumors, TAF had a net suppressive effect upon TAT activation, and, in one of these cases, blockade of B7H1 or B7DC was able to completely abrogate the TAF-mediated suppression. We conclude that TAF in human NSCLC are functionally and phenotypically heterogeneous and provide multiple complex regulatory signals that have the potential to enhance or suppress TAT function in the tumor microenvironment.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
There is evidence of antigen-specific, T cell-intrinsic dysfunction in the tumor microenvironment.
“There is evidence indicating antigen specific, T cell-intrinsic dysfunction in the tumor microenvironment [15,16].”
From T cell anergy, exhaustion, senescence, and stemness in the tumor microenvironment (2013) · cites this paper as [15]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Jemal, A., Murray, T., Ward, E., Samuels, A., Tiwari, R. C., Ghafoor, A., Feuer, E. J., & Thun, M. J. (2005) · CA A Cancer Journal for Clinicians · doi:10.3322/canjclin.55.1.10 · Cited by 5,433 · see citing works
Freeman, G. J., Long, A. J., Iwai, Y., Bourque, K., Chernova, T., Nishimura, H., Fitz, L. J., Malenkovich, N., Okazaki, T., Byrne, M. C., et al. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.7.1027 · Cited by 5,294 · see citing works
Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion
Dong, H., Strome, S. E., Salomao, D. R., Tamura, H., Hirano, F., Flies, D. B., Roche, P. C., Lu, J., Zhu, G., Tamada, K., et al. (2002) · Nature Medicine · doi:10.1038/nm730 · Cited by 5,025 · see citing works
PD-L2 is a second ligand for PD-1 and inhibits T cell activation
Latchman, Y., Wood, C. R., Chernova, T., Chaudhary, D., Borde, M., Chernova, I., Iwai, Y., Long, A. J., Brown, J. A., Nunes, R., et al. (2001) · Nature Immunology · doi:10.1038/85330 · Cited by 2,955 · see citing works
Dong, H., Zhu, G., Tamada, K., & Chen, L. (1999) · Nature Medicine · doi:10.1038/70932 · Cited by 2,496 · see citing works
Inflammation. Basic principles and clinical correlates
(1989) · Biomedicine & Pharmacotherapy · doi:10.1016/0753-3322(89)90156-x · Cited by 2,388 · see citing works
Immunosuppressive networks in the tumour environment and their therapeutic relevance
Zou, W. (2005) · Nature Reviews Cancer · doi:10.1038/nrc1586 · Cited by 2,057 · see citing works
Friends or foes — bipolar effects of the tumour stroma in cancer
Mueller, M. M., & Fusenig, N. E. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1477 · Cited by 1,757 · see citing works
Sharpe, A. H., & Freeman, G. J. (2002) · Nature reviews. Immunology · doi:10.1038/nri727 · Cited by 1,719 · see citing works
Carcinoma-associated fibroblasts stimulate tumor progression of initiated human epithelium
Olumi, A., Grossfeld, G., Hayward, S., Carroll, P., Cunha, G., Hein, P., & Tlsty, T. (2000) · Breast Cancer Research · doi:10.1186/bcr138 · Cited by 1,463 · see citing works
Blockade of B7-H1 improves myeloid dendritic cell-mediated antitumor immunity
Curiel, T. J., Wei, S., Dong, H., Alvarez, X., Cheng, P., Mottram, P., Krzysiek, R., Knutson, K. L., Daniel, B., Zimmermann, M. C., et al. (2003) · Nature Medicine · doi:10.1038/nm863 · Cited by 1,314 · see citing works
Co-inhibitory molecules of the B7–CD28 family in the control of T-cell immunity
Chen, L. (2004) · Nature reviews. Immunology · doi:10.1038/nri1349 · Cited by 1,257 · see citing works
Lymphocyte traffic control by chemokines
Moser, B., & Loetscher, P. (2001) · Nature Immunology · doi:10.1038/84219 · Cited by 1,235 · see citing works
Prostaglandins as modulators of immunity
Harris, S. G., Padilla, J., Koumas, L., Ray, D. M., & Phipps, R. P. (2002) · Trends in Immunology · doi:10.1016/s1471-4906(01)02154-8 · Cited by 1,168 · see citing works
Brown, J. A., Dorfman, D. M., Ma, F.-R., Sullivan, E. L., Munoz, O., Wood, C. R., Greenfield, E. A., & Freeman, G. J. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.3.1257 · Cited by 968 · see citing works
Expression of Programmed Death 1 Ligands by Murine T Cells and APC
Yamazaki, T., Akiba, H., Iwai, H., Matsuda, H., Aoki, M., Tanno, Y., Shin, T., Tsuchiya, H., Pardoll, D. M., Okumura, K., et al. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.10.5538 · Cited by 950 · see citing works
B7-Dc, a New Dendritic Cell Molecule with Potent Costimulatory Properties for T Cells
Tseng, S.-Y., Otsuji, M., Gorski, K. S., Huang, X., Slansky, J. E., Pai, S. I., Shalabi, A., Shin, T., Pardoll, D. M., & Tsuchiya, H. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.193.7.839 · Cited by 867 · see citing works
Rønnov‐Jessen, L., PETERSEN, O. W., & Bissell, M. J. (1996) · Physiological Reviews · doi:10.1152/physrev.1996.76.1.69 · Cited by 797 · see citing works
Fibroblasts regulate the switch from acute resolving to chronic persistent inflammation
Buckley, C. D., Pilling, D., Lord, J. M., Akbar, A. N., Scheel-Toellner, D., & Salmon, M. (2001) · Trends in Immunology · doi:10.1016/s1471-4906(01)01863-4 · Cited by 796 · see citing works
Konishi, J. S., Yamazaki, K., Azuma, M., Kinoshita, I., Dosaka‐Akita, H., & Nishimura, M. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-0428 · Cited by 678 · see citing works
Heterotypic Signaling between Epithelial Tumor Cells and Fibroblasts in Carcinoma Formation
Elenbaas, B., & Weinberg, R. A. (2001) · Experimental Cell Research · doi:10.1006/excr.2000.5133 · Cited by 557 · see citing works
Tumor-Specific Human CD4+ Regulatory T Cells and Their Ligands
Wang, H. Y., Lee, D. A., Peng, G., Guo, Z., Li, Y., Kiniwa, Y., Shevach, E. M., & Wang, R. (2004) · Immunity · doi:10.1016/s1074-7613(03)00359-5 · Cited by 515 · see citing works
Fibroblasts as sentinel cells. Synthesis of chemokines and regulation of inflammation.
(1997) · Europe PMC (PubMed Central) · Cited by 510 · see citing works
B7-H1 blockade augments adoptive T-cell immunotherapy for squamous cell carcinoma.
Strome, S. E., Dong, H., Tamura, H., Voss, S. G., Flies, D. B., Tamada, K., Salomão, D. R., Cheville, J. C., Hirano, F., Lin, W. Y., et al. (2003) · PubMed · Cited by 489 · see citing works
Fibroblast biology. Role of synovial fibroblasts in the pathogenesis of rheumatoid arthritis.
Pap, T., Müller-Ladner, U., Gay, R. E., & Gay, S. (2000) · Arthritis Research · doi:10.1186/ar113 · Cited by 467 · see citing works
Gleave, M. E., Hsieh, J., Gao, C. A., von Eschenbach, A. C., & Chung, L. W. K. (1991) · PubMed · Cited by 452 · see citing works
Fibroblast-mediated acceleration of human epithelial tumor growth in vivo.
Camps, J. L., Chang, S. M., Hsu, T., Freeman, M. R., Hong, S. J., Zhau, H. E., von Eschenbach, A. C., & Chung, L. W. K. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.1.75 · Cited by 416 · see citing works
Plasmacytoid Dendritic Cells Induce CD8+ Regulatory T Cells In Human Ovarian Carcinoma
Wei, S., Kryczek, I., Zou, L., Daniel, B., Cheng, P. J., Mottram, P. J., Curiel, T. J., Lange, A., & Zou, W. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-4043 · Cited by 379 · see citing works
Wintterle, Schreiner, Mitsdoerffer, Schneider, Chen, Meyermann, Weller, M., & Wiendl (2003) · 中国神经肿瘤杂志 · Cited by 366 · see citing works
Arenberg, D. A., Kunkel, S. L., Polverini, P. J., Morris, S. B., Burdick, M. D., Glass, M., Taub, D. D., Iannettoni, M. D., Whyte, R. I., & Strieter, R. M. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.184.3.981 · Cited by 354 · see citing works
Anderson, G., Jenkinson, E. J., Moore, N. C., & Owen, J. J. T. (1993) · Nature · doi:10.1038/362070a0 · Cited by 351 · see citing works
Malignant transformation in a nontumorigenic human prostatic epithelial cell line.
Hayward, S. W., Wang, Y. Z., Cao, M., Hom, Y. K., Zhang, B., Grossfeld, G. D., Sudilovsky, D., & Cunha, G. R. (2001) · PubMed · Cited by 344 · see citing works
Tumour-stroma interaction: cancer-associated fibroblasts as novel targets in anti-cancer therapy?
Micke, P., & tman, A. (2004) · Lung Cancer · doi:10.1016/j.lungcan.2004.07.977 · Cited by 344 · see citing works
Hartmann, E., Wollenberg, B., Rothenfußer, S., Wagner, M., Wellisch, D., Mack, B., Giese, T., Gires, O., Endres, S., & Hartmann, G. (2003) · PubMed · Cited by 335 · see citing works
B7-H1 Is Expressed by Human Endothelial Cells and Suppresses T Cell Cytokine Synthesis
Mazanet, M. M., & Hughes, C. C. W. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.7.3581 · Cited by 326 · see citing works
Ishida, M., Iwai, Y., Tanaka, Y., Okazaki, T., Freeman, G. J., Minato, N., & Honjo, T. (2002) · Immunology Letters · doi:10.1016/s0165-2478(02)00142-6 · Cited by 280 · see citing works
Thy-1 Expression in Human Fibroblast Subsets Defines Myofibroblastic or Lipofibroblastic Phenotypes
Koumas, L., Smith, T. J., Feldon, S. E., Blumberg, N., & Phipps, R. P. (2003) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63488-8 · Cited by 277 · see citing works
B7-H1 pathway and its role in the evasion of tumor immunity
Dong, H., & Chen, L. (2003) · Journal of Molecular Medicine · doi:10.1007/s00109-003-0430-2 · Cited by 276 · see citing works
Regulatory T cells in immune surveillance and treatment of cancer
Yamaguchi, T., & Sakaguchi, S. (2006) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2005.11.005 · Cited by 263 · see citing works
Tada, T., Ohzeki, S., Utsumi, K., Takiuchi, H., Muramatsu, M., Li, X. F., Shimizu, J., Fujiwara, H., & Hamaoka, T. (1991) · The Journal of Immunology · doi:10.4049/jimmunol.146.3.1077 · Cited by 259 · see citing works
The fibroblast: Sentinel cell and local immune modulator in tumor tissue
Silzle, T., Randolph, G. J., Kreutz, M. P., & Kunz‐Schughart, L. A. (2003) · International Journal of Cancer · doi:10.1002/ijc.11542 · Cited by 185 · see citing works
Shin, T., Kennedy, G., Gorski, K. S., Tsuchiya, H., Koseki, H., Azuma, M., Yagita∥, H., Chen, L., Powell, J. D., Pardoll, D. M., et al. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030242 · Cited by 160 · see citing works
Phipps, R. P., Penney, D. P., Keng, P., Quill, H., Paxhia, A., Derdak, S., & Felch, M. (1989) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb/1.1.65 · Cited by 141 · see citing works
Addison, C. L., Arenberg, D. A., Morris, S. B., Xue, Y.-Y., Burdick, M. D., Mulligan, M. S., Iannettoni, M. D., & Strieter, R. M. (2000) · Human Gene Therapy · doi:10.1089/10430340050015996 · Cited by 136 · see citing works
Zhang, Y., Cao, H., Graf, B., Meekins, H., Smith, T. J., & Phipps, R. P. (1998) · PubMed · Cited by 135 · see citing works
Picard, O., Rolland, Y., & Poupon, M. (1986) · PubMed · Cited by 129 · see citing works
Breast Cancer: Induction of Differentiation by Embryonic Tissue
DeCosse, J. J., Gossens, C. L., Kuzma, J. F., & Unsworth, B. R. (1973) · Science · doi:10.1126/science.181.4104.1057 · Cited by 129 · see citing works
More Than Structural Cells, Fibroblasts Create and Orchestrate the Tumor Microenvironment
Baglole, C. J., Ray, D. M., Bernstein, S. H., Feldon, S. E., Smith, T. J., Sime, P. J., & Phipps, R. P. (2006) · Immunological Investigations · doi:10.1080/08820130600754960 · Cited by 118 · see citing works
Cooper, M., & Pinkus, H. (1977) · PubMed · Cited by 111 · see citing works
Zhang, Y., Cao, H., Graf, B. A., Meekins, H., Smith, T. J., & Phipps, R. P. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.160.3.1053 · Cited by 109 · see citing works
Agostini, C., Facco, M., Siviero, M., Carollo, D., GALVAN, S., Cattelan, A. M., Zambello, R., Trentin, L., & Semenzato, G. (2000) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.162.4.2003130 · Cited by 98 · see citing works
Koumas, L., King, A. E., Critchley, H., KELLY, R. W., & Phipps, R. P. (2001) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)61768-3 · Cited by 94 · see citing works
In vitromodels of T cell development
Hare, K. J., Jenkinson, E. J., & Anderson, G. (1999) · Seminars in Immunology · doi:10.1006/smim.1998.0151 · Cited by 73 · see citing works
Broderick, L., Yokota, S. J., Reineke, J., Mathiowitz, E., Stewart, C. C., Barcos, M. P., Kelleher, R. J., & Bankert, R. B. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.2.898 · Cited by 72 · see citing works
Self-citationHsieh, C.-L., Chen, D., & Hwang, L.-H. (2000) · Human Gene Therapy · doi:10.1089/10430340050015581 · Cited by 69 · see citing works
Hess, S. D., Egilmez, N. K., Bailey, N. A., Anderson, T. M., Mathiowitz, E., Bernstein, S. H., & Bankert, R. B. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.1.400 · Cited by 67 · see citing works
Self-citationIFN-γ-Inducible Chemokines Enhance Adaptive Immunity and Colitis
Singh, U. P., Singh, S., Iqbal, N., Weaver, C. T., McGhee, J. R., & Lillard, J. W. (2003) · Journal of Interferon & Cytokine Research · doi:10.1089/107999003322485099 · Cited by 61 · see citing works
DeCosse, J. J., Gossens, C. L., Kuzma, J. F., & Unsworth, B. R. (1975) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/54.4.913 · Cited by 60 · see citing works
Halliday, G. M., & Le, S. (2001) · International Immunology · doi:10.1093/intimm/13.9.1147 · Cited by 60 · see citing works
Differential Thy-1 Expression by Splenic Fibroblasts Defines Functionally Distinct Subsets
Borrello, M. A., & Phipps, R. P. (1996) · Cellular Immunology · doi:10.1006/cimm.1996.0268 · Cited by 56 · see citing works
The desmoplastic response: Induction of collagen synthesis by melanoma cells in vitro
Fearns, C., & Dowdle, E. B. (1992) · International Journal of Cancer · doi:10.1002/ijc.2910500423 · Cited by 48 · see citing works
Thy1 (+) and (-) lung fibrosis subpopulations in LEW and F344 rats
McIntosh, J., Hagood, J. S., Richardson, T., & Simecka, J. W. (1994) · European Respiratory Journal · doi:10.1183/09031936.94.07122131 · Cited by 48 · see citing works
Penney, D. P., Keng, P. C., Derdak, S., & Phipps, R. P. (1992) · The Anatomical Record · doi:10.1002/ar.1092320312 · Cited by 47 · see citing works
IL-12 reverses anergy to T cell receptor triggering in human lung tumor-associated memory T cells
Broderick, L., Brooks, S. P., Takita, H., Baer, A. N., Bernstein, J. M., & Bankert, R. B. (2006) · Clinical Immunology · doi:10.1016/j.clim.2005.09.008 · Cited by 47 · see citing works
Self-citationIwanuma, Y., Chen, F.-A., Egilmez, N. K., Takita, H., & Bankert, R. B. (1997) · PubMed · Cited by 46 · see citing works
Self-citationHuman renal fibroblast contraction of collagen I lattices is an integrin‐mediated process
Kelynack, K. J., Hewitson, T. D., Nicholls, K., Darby, I. A., & Becker, G. J. (2000) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/15.11.1766 · Cited by 34 · see citing works
Broderick, L., & Bankert, R. B. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.5.3082 · Cited by 33 · see citing works
Self-citationKoumas, L., & Phipps, R. P. (2002) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00065.2002 · Cited by 24 · see citing works
Mouri, H., Sakaguchi, K., Sawayama, T., Senoh, T., Ohta, T., Nishimura, M., Fujiwara, A., Terao, M., Shiratori, Y., & Tsuji, T. (2002) · PubMed · doi:10.18926/amo/31688 · Cited by 23 · see citing works
Monoclonal Antibody 11-Fibrau: A Useful Marker to Characterize Chondrocyte Differentiation Stage
van Osch, G. J. V. M., van der Veen, S. W., Marijnissen, W. J. C. M., & Verhaar, J. A. N. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.4168 · Cited by 18 · see citing works
Purkerson, J. M., Smith, R. S., Pollock, S. J., & Phipps, R. P. (2005) · European Journal of Immunology · doi:10.1002/eji.200526219 · Cited by 12 · see citing works
INDUCTION OF INTERFERON γ IN HUMAN GINGIVAL FIBROBLASTS CHALLENGED WITH PHYTOHAEMAGGLUTININ
Mustafa, M., Wondimu, B., Bakhiet, M., & Modéer, T. (2000) · Cytokine · doi:10.1006/cyto.1999.0565 · Cited by 12 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
The biology and function of fibroblasts in cancer
Kalluri, R. (2016) · Nature Reviews Cancer · doi:10.1038/nrc.2016.73 · Cited by 4,366 · see citing works
Zou, W., Wolchok, J. D., & Chen, L. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aad7118 · Cited by 2,382 · see citing works
Mao, X., Xu, J., Wang, W., Liang, C., Hua, J., Liu, J., Zhang, B., Meng, Q., Yu, X., & Shi, S. (2021) · Molecular Cancer · doi:10.1186/s12943-021-01428-1 · Cited by 2,290 · see citing works
Inhibitory B7-family molecules in the tumour microenvironment
Zou, W., & Chen, L. (2008) · Nature Reviews Immunology · doi:10.1038/nri2326 · Cited by 1,608 · see citing works
The lung microenvironment: an important regulator of tumour growth and metastasis
Altorki, N. K., Markowitz, G. J., Gao, D., Port, J. L., Saxena, A., Stiles, B. M., McGraw, T. E., & Mittal, V. (2018) · Nature reviews. Cancer · doi:10.1038/s41568-018-0081-9 · Cited by 1,147 · see citing works
Cancer-associated fibroblasts: an emerging target of anti-cancer immunotherapy
Liu, T., Han, C., Wang, S., Fang, P., Ma, Z., Xu, L., & Yin, R. (2019) · Journal of Hematology & Oncology · doi:10.1186/s13045-019-0770-1 · Cited by 860 · see citing works
T cell anergy, exhaustion, senescence, and stemness in the tumor microenvironment
Crespo, J., Sun, H., Welling, T. H., Tian, Z., & Zou, W. (2013) · Current Opinion in Immunology · doi:10.1016/j.coi.2012.12.003 · Cited by 752 · see citing works
The clinical role of the TME in solid cancer
Giraldo, N. A., Sánchez-Salas, R., Peske, J. D., Vano, Y. A., Becht, É., Petitprez, F., Validire, P., Ingels, A., Cathelineau, X., Fridman, W. H., et al. (2018) · British Journal of Cancer · doi:10.1038/s41416-018-0327-z · Cited by 738 · see citing works
Stromal myofibroblasts are drivers of invasive cancer growth
De Wever, O., Demetter, P., Mareel, M., & Bracke, M. (2008) · International Journal of Cancer · doi:10.1002/ijc.23925 · Cited by 722 · see citing works
Fibrosis and cancer: A strained relationship
Piersma, B., Hayward, M.-K., & Weaver, V. M. (2020) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2020.188356 · Cited by 686 · see citing works
Wang, L.-C. S., Lo, A., Scholler, J., Sun, J., Majumdar, R. S., Kapoor, V., Antzis, M., Cotner, C. E., Johnson, L. A., Durham, A. C., et al. (2014) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-13-0027 · Cited by 653 · see citing works
Combination Immunotherapy with CAR T Cells and Checkpoint Blockade for the Treatment of Solid Tumors
Grosser, R., Cherkassky, L., Chintala, N., & Adusumilli, P. S. (2019) · Cancer Cell · doi:10.1016/j.ccell.2019.09.006 · Cited by 603 · see citing works
Cancer-associated fibroblasts in gastrointestinal cancer
Kobayashi, H., Enomoto, A., Woods, S. L., Burt, A. D., Takahashi, M., & Worthley, D. L. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0115-0 · Cited by 596 · see citing works
Lakins, M. A., Ghorani, E., Munir, H., Martins, C. P., & Shields, J. D. (2018) · Nature Communications · doi:10.1038/s41467-018-03347-0 · Cited by 578 · see citing works
Moon, E. K., Wang, L.-C., Dolfi, D. V., Wilson, C. B., Ranganathan, R., Sun, J., Kapoor, V., Scholler, J., Puré, E., Milone, M. C., et al. (2014) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-13-2627 · Cited by 405 · see citing works
Mesenchymal Cells of the Intestinal Lamina Propria
Powell, D. W., Pinchuk, I. V., Saada, J. I., Chen, X., & Mifflin, R. C. (2011) · Annual Review of Physiology · doi:10.1146/annurev.physiol.70.113006.100646 · Cited by 388 · see citing works
Alteration of the Antitumor Immune Response by Cancer-Associated Fibroblasts
Ziani, L., Chouaı̈b, S., & Thiery, J. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00414 · Cited by 379 · see citing works
Cancer-associated fibroblasts and their influence on tumor immunity and immunotherapy
Barrett, R. L., & Puré, E. (2020) · eLife · doi:10.7554/elife.57243 · Cited by 351 · see citing works
Melanoma-associated fibroblasts modulate NK cell phenotype and antitumor cytotoxicity
Balsamo, M., Scordamaglia, F., Pietra, G., Manzini, C., Cantoni, C., Boitano, M., Queirolo, P., Vermi, W., Facchetti, F., Moretta, A., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0906481106 · Cited by 327 · see citing works
Hepatocellular carcinoma-associated fibroblasts trigger NK cell dysfunction via PGE2 and IDO
Li, T., Yang, Y., Hua, X., Wang, G., Liu, W., Jia, C., Tai, Y., Zhang, Q., & Chen, G. (2011) · Cancer Letters · doi:10.1016/j.canlet.2011.12.020 · Cited by 329 · see citing works
Programmed Death Ligand 2 in Cancer-Induced Immune Suppression
Rozali, E. N., Hato, S. V., Robinson, B. W. S., Lake, R., & Lesterhuis, W. J. (2012) · Clinical and Developmental Immunology · doi:10.1155/2012/656340 · Cited by 326 · see citing works
Khalili, J. S., Liu, S., Rodríguez-Cruz, T., Whittington, M., Wardell, S., Liu, C., Zhang, M., Cooper, Z. A., Frederick, D. T., Li, Y., et al. (2012) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-12-1632 · Cited by 302 · see citing works
O’Hayre, M., Salanga, C. L., Handel, T. M., & Allen, S. J. (2008) · Biochemical Journal · doi:10.1042/bj20071493 · Cited by 297 · see citing works
Nanomaterials for cancer immunotherapy
Song, W., Musetti, S., & Huang, L. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.09.017 · Cited by 284 · see citing works
Fahy, N., Melle, M. L. D. V., Lehmann, J., Wei, W., Grotenhuis, N., Farrell, E., van der Kraan, P. M., Murphy, M. J., Bastiaansen-Jenniskens, Y. M., & van Osch, G. J. V. M. (2014) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2014.05.021 · Cited by 270 · see citing works
Regulation of the anti-tumour immune response by cancer-associated fibroblasts
Harper, J. A., & Sainson, R. C. A. (2014) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2013.12.005 · Cited by 269 · see citing works
Cheng, J.-T., Deng, Y.-N., Yi, H.-M., Wang, G.-S., Fu, B.-S., Chen, W., Liu, W., Tai, Y., Peng, Y.-W., & Zhang, Q. (2016) · Oncogenesis · doi:10.1038/oncsis.2016.7 · Cited by 268 · see citing works
Fibroblast heterogeneity in tumor micro-environment: Role in immunosuppression and new therapies
Mhaidly, R., & Mechta‐Grigoriou, F. (2020) · Seminars in Immunology · doi:10.1016/j.smim.2020.101417 · Cited by 258 · see citing works
Takahashi, H., Sakakura, K., Kudo, T., Toyoda, M., Kaira, K., Oyama, T., & Chikamatsu, K. (2016) · Oncotarget · doi:10.18632/oncotarget.14374 · Cited by 260 · see citing works
Mhaidly, R., & Mechta‐Grigoriou, F. (2021) · Immunological Reviews · doi:10.1111/imr.12978 · Cited by 231 · see citing works
Cho, Y., Yoon, H., Lee, J., Hong, S., & Hong, S. (2011) · Oral Oncology · doi:10.1016/j.oraloncology.2011.08.007 · Cited by 243 · see citing works
Cancer-Associated Fibroblasts Induce a Collagen Cross-link Switch in Tumor Stroma
Paňková, D., Chen, Y., Terajima, M., Schliekelman, M. J., Baird, B. N., Fahrenholtz, M. M., Sun, L., Gill, B. J., Vadakkan, T. J., Kim, M. P., et al. (2015) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-15-0307 · Cited by 233 · see citing works
Cancer Vaccines: Toward the Next Breakthrough in Cancer Immunotherapy
Igarashi, Y., & Sasada, T. (2020) · Journal of Immunology Research · doi:10.1155/2020/5825401 · Cited by 223 · see citing works
Liu, J., Li, P., Wang, L., Li, M., Ge, Z., Noordam, L., Lieshout, R., Verstegen, M. M. A., Ma, B., Su, J., et al. (2020) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2020.09.003 · Cited by 211 · see citing works
Gorchs, L., Moro, C. F., Bankhead, P., Kern, K. P., Sadeak, I., Meng, Q., Rangelova, E. B., & Kaipe, H. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00847 · Cited by 193 · see citing works
Tumor stroma as targets for cancer therapy
Zhang, J., & Liu, J. (2012) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2012.10.003 · Cited by 185 · see citing works
Inducible Expression of B7-H1 (PD-L1) and Its Selective Role in Tumor Site Immune Modulation
Sanmamed, M. F., & Chen, L. (2014) · The Cancer Journal · doi:10.1097/ppo.0000000000000061 · Cited by 179 · see citing works
Fibroblasts Fuel Immune Escape in the Tumor Microenvironment
Jaeghere, E. A. D., Denys, H. G., & Wever, O. D. (2019) · Trends in cancer · doi:10.1016/j.trecan.2019.09.009 · Cited by 160 · see citing works
Servais, C., & Erez, N. (2012) · The Journal of Pathology · doi:10.1002/path.4103 · Cited by 152 · see citing works
Advances in cutaneous squamous cell carcinoma
Winge, M. C. G., Kellman, L. N., Guo, K., Tang, J. Y., Swetter, S. M., Aasi, S. Z., Sarin, K. Y., Chang, A. L. S., & Khavari, P. A. (2023) · Nature reviews. Cancer · doi:10.1038/s41568-023-00583-5 · Cited by 149 · see citing works
Immunosuppressive activity of cancer-associated fibroblasts in head and neck squamous cell carcinoma
Takahashi, H., Sakakura, K., Kawabata‐Iwakawa, R., Rokudai, S., Toyoda, M., Nishiyama, M., & Chikamatsu, K. (2015) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-015-1742-0 · Cited by 146 · see citing works
Preclinical murine tumor models: A structural and functional perspective
Guérin, M. V., Finisguerra, V., den Eynde, B. J. V., Bercovici, N., & Trautmann, A. (2020) · eLife · doi:10.7554/elife.50740 · Cited by 143 · see citing works
Exhaustion of T lymphocytes in the tumor microenvironment: Significance and effective mechanisms
Gholami, M. D., Kardar, G. A., Saeedi, Y., Heidari, S., Garssen, J., & Falak, R. (2017) · Cellular Immunology · doi:10.1016/j.cellimm.2017.10.002 · Cited by 140 · see citing works
Fibroblasts in the Tumor Microenvironment
Truffi, M., Sorrentino, L., & Corsi, F. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-37184-5_2 · Cited by 134 · see citing works
The role of the cell–cell interactions in cancer progression
Kaminska, K. H., Szczylik, C. A., Bielecka, Z. F., Bartnik, E., Porta, C., Lian, F., & Czarnecka, A. M. (2015) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.12408 · Cited by 132 · see citing works
Vicent, S., Sayles, L. C., Vaka, D., Khatri, P., Gevaert, O., Ron, C., Zheng, Y., Gillespie, A. K., Clarke, N., Xu, Y., et al. (2012) · Cancer Research · doi:10.1158/0008-5472.can-12-1097 · Cited by 130 · see citing works
Ziani, L., Safta, T. B., Gourbeix, J., Cavalcanti, A., Robert, C., Favre, G., Chouaı̈b, S., & Thiery, J. (2017) · Oncotarget · doi:10.18632/oncotarget.15540 · Cited by 128 · see citing works
Anti-programmed death-1 and anti-programmed death-ligand 1 antibodies in cancer therapy
Hamid, O., & Carvajal, R. D. (2013) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.2013.770836 · Cited by 122 · see citing works
Mechanisms of tumor escape from immune system: Role of mesenchymal stromal cells
Poggi, A. D., Musso, A., Dapino, I., & Zocchi, M. R. (2014) · Immunology Letters · doi:10.1016/j.imlet.2014.03.001 · Cited by 123 · see citing works
Perspectives on Chimeric Antigen Receptor T-Cell Immunotherapy for Solid Tumors
Kosti, P., Maher, J. F., & Arnold, J. N. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01104 · Cited by 118 · see citing works
Cancer-associated fibroblasts: key determinants of tumor immunity and immunotherapy
Barrett, R., & Puré, E. (2020) · Current Opinion in Immunology · doi:10.1016/j.coi.2020.03.004 · Cited by 117 · see citing works
Bankert, R. B., Balu‐Iyer, S. V., Odunsi, K. O., Shultz, L. D., Kelleher, R. J., Barnas, J. L., Simpson-Abelson, M. R., Parsons, R., & Yokota, S. J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024420 · Cited by 115 · see citing works
Self-citationCytokine regulation networks in the cancer microenvironment
Sheu, B. (2008) · Frontiers in bioscience · doi:10.2741/3152 · Cited by 113 · see citing works
Evolving landscape of PD-L2: bring new light to checkpoint immunotherapy
Wang, Y., Du, J., Gao, Z., Sun, H., Mei, M., Wang, Y., Ren, Y., & Zhou, X. (2022) · British Journal of Cancer · doi:10.1038/s41416-022-02084-y · Cited by 112 · see citing works
The Evolving Landscape of PD-1/PD-L1 Pathway in Head and Neck Cancer
Qiao, X., Jiang, J. D., Pang, X., Huang, M.-C., Tang, Y.-J., Liang, X., & Tang, Y. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01721 · Cited by 110 · see citing works
Cardiorenal complications of immune checkpoint inhibitors
Sury, K., Perazella, M. A., & Shirali, A. C. (2018) · Nature Reviews Nephrology · doi:10.1038/s41581-018-0035-1 · Cited by 106 · see citing works
Cancer-Associated Fibroblasts as Targets for Immunotherapy
Kakarla, S., Song, X., & Gottschalk, S. M. (2012) · Immunotherapy · doi:10.2217/imt.12.112 · Cited by 102 · see citing works
Fibroblast heterogeneity in solid tumors: From single cell analysis to whole-body imaging
Peltier, A., Seban, R., Buvat, I., Bidard, F., & Mechta‐Grigoriou, F. (2022) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2022.04.008 · Cited by 97 · see citing works
γδ T Cells and Tumor Microenvironment: From Immunosurveillance to Tumor Evasion
Presti, E. L., Pizzolato, G., Corsale, A. M., Caccamo, N., Sireci, G., Dieli, F., & Meraviglia, S. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01395 · Cited by 96 · see citing works
The Emerging Role of YAP/TAZ in Tumor Immunity
Pan, Z., Tian, Y., Cao, C., & Niu, G. (2019) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-19-0375 · Cited by 95 · see citing works
Negative immune checkpoints on T lymphocytes and their relevance to cancer immunotherapy
Śledzińska, A., Menger, L., Bergerhoff, K. F., Peggs, K. S., & Quezada, S. A. (2015) · Molecular Oncology · doi:10.1016/j.molonc.2015.10.008 · Cited by 93 · see citing works
Simpson-Abelson, M. R., Sonnenberg, G. F., Takita, H., Yokota, S. J., Conway, T. F., Kelleher, R. J., Shultz, L. D., Barcos, M. P., & Bankert, R. B. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.10.7009 · Cited by 94 · see citing works
Self-citationDezutter‐Dambuyant, C., Durand, I., Alberti, L., Bendriss‐Vermare, N., Valladeau‐Guilemond, J., Duc, A., Magron, A., Morel, A., Sisirak, V., Rodriguez, C., et al. (2015) · OncoImmunology · doi:10.1080/2162402x.2015.1091146 · Cited by 91 · see citing works
Programmed cell death-ligand 2: A neglected but important target in the immune response to cancer?
Solinas, C., Aiello, M. M., Rozali, E. N., Lambertini, M., Willard-Gallo, K. E., & Migliori, E. (2020) · Translational Oncology · doi:10.1016/j.tranon.2020.100811 · Cited by 90 · see citing works
Liu, X., Xu, J., Zhang, B., Liu, J., Liang, C., Meng, Q., Hua, J., Yu, X., & Shi, S. (2019) · Molecular Cancer · doi:10.1186/s12943-019-1117-9 · Cited by 84 · see citing works
Guo, L., Wei, R., Lin, Y., & Kwok, H. F. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01508 · Cited by 84 · see citing works
Immune Checkpoint Modulation in Colorectal Cancer: What’s New and What to Expect
Jacobs, J., Smits, E., Lardon, F., Pauwels, P., & Deschoolmeester, V. (2015) · Journal of Immunology Research · doi:10.1155/2015/158038 · Cited by 84 · see citing works
The Role of GSK-3 in Cancer Immunotherapy: GSK-3 Inhibitors as a New Frontier in Cancer Treatment
Augello, G., Emma, M. R., Cusimano, A., Azzolina, A., Montalto, G., McCubrey, J. A., & Cervello, M. (2020) · Cells · doi:10.3390/cells9061427 · Cited by 83 · see citing works
TLR4 Activation Enhances the PD-L1–Mediated Tolerogenic Capacity of Colonic CD90+ Stromal Cells
Beswick, E. J., Johnson, J. R., Saada, J. I., Humen, M. A., House, J., Dann, S. M., Qiu, S., Brasier, A. R., Powell, D. W., Reyes, V. E., et al. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1203441 · Cited by 82 · see citing works
Hirai, M., Kitahara, H., Kobayashi, Y., Kato, K., Bou–Gharios, G., Nakamura, H., & Kawashiri, S. (2016) · International Journal of Oncology · doi:10.3892/ijo.2016.3785 · Cited by 81 · see citing works
Immune evasion in cell-based immunotherapy: unraveling challenges and novel strategies
Li, Y.-R., Halladay, T., & Yang, L. (2024) · Journal of Biomedical Science · doi:10.1186/s12929-024-00998-8 · Cited by 80 · see citing works
Effects of Radiation on the Tumor Microenvironment
Monjazeb, A. M., Schalper, K. A., Villarroel‐Espíndola, F., Nguyen, A. T., Shiao, S. L., & Young, K. H. (2020) · Seminars in Radiation Oncology · doi:10.1016/j.semradonc.2019.12.004 · Cited by 81 · see citing works
PD-L1 Induction by Cancer-Associated Fibroblast-Derived Factors in Lung Adenocarcinoma Cells
Inoue, C., Miki, Y., Saito, R., Hata, S., Abe, J., Sato, I., Okada, Y., & Sasano, H. (2019) · Cancers · doi:10.3390/cancers11091257 · Cited by 78 · see citing works
Cancer-associated fibroblasts in digestive tumors
Huang, L., Xu, A., Liu, S., Liu, W., & Li, T.-J. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i47.17804 · Cited by 75 · see citing works
The importance of being CAFs (in cancer resistance to targeted therapies)
Rizzolio, S., Giordano, S., & Corso, S. (2022) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-022-02524-w · Cited by 74 · see citing works
Romano, V., Belviso, I., Venuta, A., Ruocco, M. R., Masone, S., Aliotta, F., Fiume, G., Montagnani, S., Avagliano, A., & Arcucci, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22105283 · Cited by 73 · see citing works
Umezu, D., Okada, N., Sakoda, Y., Adachi, K., Ojima, T., Yamaue, H., Eto, M., & Tamada, K. (2018) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-018-2263-4 · Cited by 73 · see citing works
Correlation Between PD-L2 Expression and Clinical Outcome in Solid Cancer Patients: A Meta-Analysis
Yang, H., Zhou, X., Sun, L., & Mao, Y. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.00047 · Cited by 73 · see citing works
Gorchs, L., Hellevik, T., Bruun, J., Camilio, K. A., Al‐Saad, S., Stuge, T. B., & Martínez-Zubiaurre, I. (2015) · Frontiers in Oncology · doi:10.3389/fonc.2015.00087 · Cited by 71 · see citing works
Wong, K.-Y., Cheung, A., Chen, B.-N., Chan, W.-N., Yu, J., Lo, K.-W., Kang, W., & To, K.-F. (2022) · International Journal of Cancer · doi:10.1002/ijc.34127 · Cited by 70 · see citing works
Gunderson, A. J., Yamazaki, T., McCarty, K., Phillips, M., Alice, A. F., Bambina, S., Zebertavage, L., Friedman, D. J., Cottam, B., Newell, P., et al. (2019) · PLoS ONE · doi:10.1371/journal.pone.0211117 · Cited by 70 · see citing works
CD84 regulates PD-1/PD-L1 expression and function in chronic lymphocytic leukemia
Lewinsky, H., Barak, A. F., Huber, V., Kramer, M. P., Radomir, L., Sever, L., Orr, I., Mirkin, V., Dezorella, N., Shapiro, M., et al. (2018) · Journal of Clinical Investigation · doi:10.1172/jci96610 · Cited by 69 · see citing works
Fibroblast activation protein and chronic liver disease
Wang, X. M. (2007) · Frontiers in bioscience · doi:10.2741/2918 · Cited by 69 · see citing works
Responsiveness of Stromal Fibroblasts to IFN-γ Blocks Tumor Growth via Angiostasis
Yu, L., Yang, W. C., Qin, C., Zhang, L., Deng, J., Liu, S., & Qin, Z. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0901073 · Cited by 69 · see citing works
Mo, R., Han, Z., Liang, Y., Ye, J., Wu, S., Lin, S. X. H., Zhang, Y., Song, S., Jiang, F., Zhong, W., et al. (2018) · International Journal of Cancer · doi:10.1002/ijc.32061 · Cited by 69 · see citing works
CXCR4 chemokine receptor antagonists: perspectives in SCLC
Burger, J. A., & Stewart, D. J. (2009) · Expert Opinion on Investigational Drugs · doi:10.1517/13543780902804249 · Cited by 68 · see citing works
Cancer-Associated Fibroblasts and T Cells: From Mechanisms to Outcomes
Baker, A. T., Abuwarwar, M. H., Poly, L., Wilkins, S., & Fletcher, A. L. (2021) · The Journal of Immunology · doi:10.4049/jimmunol.2001203 · Cited by 68 · see citing works
Cancer Associated Fibroblasts - An Impediment to Effective Anti-Cancer T Cell Immunity
Koppensteiner, L., Mathieson, L., O’Connor, R. A., & Akram, A. R. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.887380 · Cited by 66 · see citing works
Cancer immune exclusion: breaking the barricade for a successful immunotherapy
Bruni, S., Mercogliano, M. F., Mauro, F. L., Russo, R. I. C., & Schillaci, R. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1135456 · Cited by 66 · see citing works
Yang, L., Xue, R., & Pan, C. (2019) · OncoTargets and Therapy · doi:10.2147/ott.s190168 · Cited by 67 · see citing works
Domen, A., Quatannens, D., Zanivan, S. R., Deben, C., Audenaerde, J. R. M. V., Smits, E., Wouters, A., Lardon, F., Roeyen, G., Verhoeven, Y., et al. (2021) · Cancers · doi:10.3390/cancers13050987 · Cited by 63 · see citing works
MSC and Tumors: Homing, Differentiation, and Secretion Influence Therapeutic Potential
D’souza, N., Burns, J. S., Grisendi, G., Candini, O., Veronesi, E., Piccinno, M. S., Horwitz, E. M., Paolucci, P., Conte, P., & Dominici, M. (2012) · Advances in biochemical engineering, biotechnology · doi:10.1007/10_2012_150 · Cited by 62 · see citing works
Miao, Y. R., Thakkar, K. N., Qian, J., Kariolis, M. S., Huang, W., Nandagopal, S., Yang, T. T. C., Diep, A. N., Cherf, G. M., Xu, Y., et al. (2021) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-20-0482 · Cited by 61 · see citing works
Wang, H., & Yang, Y. (2014) · Immunological Reviews · doi:10.1111/imr.12151 · Cited by 59 · see citing works
Teramoto, K., Igarashi, T., Kataoka, Y., Ishida, M., Hanaoka, J., Sumimoto, H., & Daigo, Y. (2019) · Lung Cancer · doi:10.1016/j.lungcan.2019.09.013 · Cited by 59 · see citing works
Liu, Y., Rao, P., Qian, H., Shi, Y., Chen, S., Lan, J., Mu, D., Chen, R., Zhang, X., Deng, C., et al. (2022) · Advanced Science · doi:10.1002/advs.202204998 · Cited by 58 · see citing works
The dilemmas and possible solutions for CAR-T cell therapy application in solid tumors
Wang, L., Zhang, L., Dunmall, L. C., Wang, Y. Y., Fan, Z., Cheng, Z., & Wang, Y. (2024) · Cancer Letters · doi:10.1016/j.canlet.2024.216871 · Cited by 58 · see citing works
Barnas, J. L., Simpson-Abelson, M. R., Yokota, S. J., Kelleher, R. J., & Bankert, R. B. (2010) · Cancer Microenvironment · doi:10.1007/s12307-010-0044-5 · Cited by 58 · see citing works
Self-citationBarnas, J. L., Simpson-Abelson, M. R., Brooks, S. P., Kelleher, R. J., & Bankert, R. B. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1000896 · Cited by 58 · see citing works
Self-citationPeyraud, F., Guégan, J., Rey, C., Lara, O., Odin, O., Castillo, M. D., Vanhersecke, L., Coindre, J., Clot, E., Brunet, M., et al. (2025) · Cell Reports Medicine · doi:10.1016/j.xcrm.2025.101934 · Cited by 58 · see citing works
- Authors
- Nazareth, M. R., Broderick, L., Simpson-Abelson, M. R., Kelleher, R. J., Yokota, S. J., & Bankert, R. B.
- Affiliations
- University at Buffalo, State University of New York (US)
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-05-01
- Volume
- 178
- Issue
- 9
- Pages
- 5552-5562
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2105055793
- Cited by
- 259
- References
- 72
- Citations by year
- 2026: 7 · 2025: 9 · 2024: 21 · 2023: 16 · 2022: 24 · 2021: 25 · 2020: 21 · 2019: 20 · 2018: 20 · 2017: 10 · 2016: 14 · 2015: 10 · 2014: 13 · 2013: 8 · 2012: 8
- FWCI
- 4.37
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- John R. Oishei Foundation
- U.S. Public Health Service
- National Cancer Institute (R01 CA 10897)
- Topics
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Keywords
- cancer-associated fibroblasts, non-small cell lung cancer, tumor microenvironment, tumor-associated T cells, T cell activation, PD-L1, PD-L2, myofibroblasts, interferon-gamma, TGF-β1, cytokine and chemokine production, stromal cells, immunosuppression, contact-dependent suppression
- MeSH terms
- Carcinoma, Non-Small-Cell Lung, Fibroblasts, Humans, Interferon-gamma, Lung Neoplasms, Lymphocyte Activation, Receptors, Antigen, T-Cell, T-Lymphocytes, Tumor Cells, Cultured, Biomarkers, Tumor, Antigens, CD, Cytokines, Transforming Growth Factor beta, B7-1 Antigen, Coculture Techniques, Chemokines, B7-H1 Antigen, Programmed Cell Death 1 Ligand 2 Protein
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
