The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
IFN Regulatory Factor Family Members Differentially Regulate the Expression of Type III IFN (IFN-λ) Genes
Abstract
Virus replication induces the expression of antiviral type I (IFN-αβ) and type III (IFN-λ1–3 or IL-28A/B and IL-29) IFN genes via TLR-dependent and -independent pathways. Although type III IFNs differ genetically from type I IFNs, their similar biological antiviral functions suggest that their expression is regulated in a similar fashion. Structural and functional characterization of the IFN-λ1 and IFN-λ3 gene promoters revealed them to be similar to IFN-β and IFN-α genes, respectively. Both of these promoters had functional IFN-stimulated response element and NF-κB binding sites. The binding of IFN regulatory factors (IRF) to type III IFN promoter IFN-stimulated response element sites was the most important event regulating the expression of these genes. Ectopic expression of the components of TLR7 (MyD88 plus IRF1/IRF7), TLR3 (Toll/IL-1R domain-containing adapter-inducing factor), or retinoic acid-inducible gene I (RIG-I) signal transduction pathways induced the activation of IFN-λ1 promoter, whereas the IFN-λ3 promoter was efficiently activated only by overexpression of MyD88 and IRF7. The ectopic expression of Pin1, a recently identified suppressor for IRF3-dependent antiviral response, decreased the IFN promoter activation induced by any of these three signal transduction pathways, including the MyD88-dependent one. To conclude, the data suggest that the IFN-λ1 gene is regulated by virus-activated IRF3 and IRF7, thus resembling that of the IFN-β gene, whereas IFN-λ2/3 gene expression is mainly controlled by IRF7, thus resembling those of IFN-α genes.
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Cites
Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses
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IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction
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Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus
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“Expression vectors for IRF1, IRF5 (variant 2, 498 aa) (34), IRF3 (35), IRF7 (36), p50, p65 (37), RIG-I, RIG-I (18), Cardif (33), IKK , and TBK1 (17) were described elsewhere.”
IRF family proteins and type I interferon induction in dendritic cells
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Cited by
Shared and Distinct Functions of Type I and Type III Interferons
Lazear, H. M., Schoggins, J. W., & Diamond, M. S. (2019) · Immunity · doi:10.1016/j.immuni.2019.03.025 · Cited by 1,138
The airway epithelium: soldier in the fight against respiratory viruses
Vareille, M., Kieninger, E., Edwards, M. R., & Regamey, N. (2011) · Clinical Microbiology Reviews · doi:10.1128/cmr.00014-10 · Cited by 655
Large-scale plasma proteomics comparisons through genetics and disease associations
Eldjarn, G. H., Ferkingstad, E., Lund, S. H., Helgason, H., Magnusson, O. T., Gunnarsdottir, K., Olafsdottir, T. A., Halldorsson, B. V., Olason, P. I., Zink, F., et al. (2023) · Nature · doi:10.1038/s41586-023-06563-x · Cited by 583
Cutting edge: Ku70 is a novel cytosolic DNA sensor that induces type III rather than type I IFN
Zhang, X., Brann, T. W., Zhou, M., Yang, J., Oguariri, R. M., Lidie, K. B., Imamichi, H., Huang, D.-W., Lempicki, R. A., Baseler, M. W., et al. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1003389 · Cited by 249
Österlund, P., Pirhonen, J., Ikonen, N., Rönkkö, E., Strengell, M., Mäkelä, S. M., Broman, M., Hamming, O. J., Hartmann, R., Ziegler, T., et al. (2010) · Journal of Virology · doi:10.1128/jvi.01619-09 · Cited by 162
Self-citation
Metadata
- Authors
- Österlund, P. I., Pietilä, T. E., Veckman, V., Kotenko, S. V., & Julkunen, I.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-09
- Volume
- 179
- Issue
- 6
- Pages
- 3434-3442
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2159803503
- Cited by
- 301
- References
- 8
- FWCI
- 4.72
- Type
- journal article
- Language
- en
- Open access
- closed
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- Österlund, P. I., Pietilä, T. E., Veckman, V., Kotenko, S. V., & Julkunen, I. (2007). IFN Regulatory Factor Family Members Differentially Regulate the Expression of Type III IFN (IFN-λ) Genes. The Journal of Immunology. https://doi.org/10.4049/jimmunol.179.6.3434
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