Cited by 436T-cell and B-cell ImmunologyImmune Response and InflammationMultiple Sclerosis Research Studies

The DOI matches its Crossref record; 79 of the 81 references it cites were found in a registry or an index.

TLR-Activated B Cells Suppress T Cell-Mediated Autoimmunity

Lampropoulou, Vicky, Hoehlig, Kai, Roch, Toralf, Neves, Patricia, Gómez, Elisabeth Calderón, Sweenie, Claire H, Hao, Yi, Freitas, Antonio A, Steinhoff, Ulrich, Anderton, Stephen M, Fillatreau, Simon·2008·The Journal of Immunology

DOI 10.4049/jimmunol.180.7.4763

Open this paper in CoChat — free account

Abstract

TLR sense microbial infections, and control activation of immune responses. Dendritic cells, macrophages, and B lymphocytes express TLR and the TLR-signaling adaptor protein MyD88. The impact of TLR-activated B cells on T cell-mediated inflammation is unknown. In this study, we have used mice carrying B cell-restricted deficiencies in MyD88 or in distinct TLR to examine the impact of TLR-activated B cells on a T cell-mediated autoimmune disease, experimental autoimmune encephalomyelitis (EAE). We demonstrate that TLR-signaling in B cells suppresses inflammatory T cell responses (both Th1 and Th17), and stimulates recovery from EAE. Only certain TLR are required on B cells for resolution of EAE, and these are dispensable for disease initiation, indicating that a category of TLR agonists preferentially triggers a suppressive function in B cells and thereby limits autoimmune disease. The TLR agonists controlling the regulatory function of B cells are provided by components of Mycobacterium tuberculosis present in the adjuvant. Thus, MyD88 signaling in B cells antagonizes MyD88 signaling in other cells, which drives differentiation of Th17 cells and is required for induction of EAE. Altogether, our data indicate that B cells link recognition of microbial products via TLR to suppression of a T cell-mediated autoimmune disease.

Integrity signals

Registry

Crossref · 10.4049/jimmunol.180.7.4763

Cites

79 of 79 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Innate immune recognition
Janeway, C. A., & Medzhitov, R. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.083001.084359 · Cited by 8,394 · cited 1×
“TLR have conserved key functions in vertebrates’ innate immune system (13).”
Background
Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene
Poltorak, A., He, X., Smirnova, I., Liu, M.-Y., Huffel, C. V., Du, X., Birdwell, D., Alejos, E., Silva, M., Galanos, C., et al. (1998) · Science · doi:10.1126/science.282.5396.2085 · Cited by 7,631 · cited 1×
“Mammals possess at least 12 TLR that provide a powerful system to detect a broad range of pathogens including bacteria (2), mycobacteria (3), viruses (4), fungi (5), and helminths (6).”
Background
Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
Bettelli, E., Carrier, Y., Gao, W., Korn, T., Strom, T. B., Oukka, M., Weiner, H. L., & Kuchroo, V. K. (2006) · Nature · doi:10.1038/nature04753 · Cited by 6,992 · cited 16×
“IF N - γ (n g/ m l) MOG(35-55) (μg/ml) 0 20 30 40 10 0 20 40 50”
BackgroundMethodInfluential
A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
Medzhitov, R., Preston-Hurlburt, P., & Janeway, C. A. J. (1997) · Nature · doi:10.1038/41131 · Cited by 6,137 · cited 3×
“Following TLR stimulation, they up-regulate costimulatory molecules essential for T cell activation (1), and secrete cytokines releasing primed T cells from the suppressive effect of regulatory T cells (22).”
Background
A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
Park, H., Li, Z., Yang, X. O., Chang, S. H., Nurieva, R., Wang, Y.-H., Wang, Y., Hood, L., Zhu, Z., Tian, Q., et al. (2005) · Nature Immunology · doi:10.1038/ni1261 · Cited by 4,265 · cited 15×
“IF N - γ (n g/ m l) MOG(35-55) (μg/ml) 0 20 30 40 10 0 20 40 50”
BackgroundMethodInfluential
Recognition of Commensal Microflora by Toll-Like Receptors Is Required for Intestinal Homeostasis
Rakoff-Nahoum, S., Paglino, J., Eslami-Varzaneh, F., Edberg, S., & Medzhitov, R. (2004) · Cell · doi:10.1016/j.cell.2004.07.002 · Cited by 4,251 · cited 16×
“IF N - γ (n g/ m l) MOG(35-55) (μg/ml) 0 20 30 40 10 0 20 40 50”
BackgroundMethodInfluential
Approaching the asymptote? Evolution and revolution in immunology.Preprint
Janeway, C. (1989) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1989.054.01.003 · Cited by 3,396 · cited 1×
“Engagement of TLR can provide the accessory signals needed for activation of effective adaptive immune responses (1, 19, 20).”
Background
The Effect of Infections on Susceptibility to Autoimmune and Allergic Diseases
Bach, J. (2002) · New England Journal of Medicine · doi:10.1056/nejmra020100 · Cited by 2,723 · cited 1×
“Our data provide support for the “hygiene hypothesis”, which relates the sharp increase in incidence of autoimmune disorders (such as MS, type 1 diabetes, or inflammatory bowel disease) in western countries during the last 50 years to the concomitant reduction in incidence of certain infectious diseases (80).”
Result
CpG Motifs in Bacterial DNA and Their Immune Effects
Krieg, A. Μ. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.100301.064842 · Cited by 2,598 · cited 1×
“stimulate DC and macrophages, but fail to stimulate B cells, while type B(K) CpG oligonucleotides efficiently activate B cells (64).”
Background
Toll Pathway-Dependent Blockade of CD4 + CD25 + T Cell-Mediated Suppression by Dendritic Cells
Pasare, C., & Medzhitov, R. M. (2003) · Science · doi:10.1126/science.1078231 · Cited by 2,000 · cited 3×
“Following TLR stimulation, they up-regulate costimulatory molecules essential for T cell activation (1), and secrete cytokines releasing primed T cells from the suppressive effect of regulatory T cells (22).”
Background

Flagged first, then by citations

Show all 81 references

2 of the 81 references couldn’t be matched to a known paper.

Research works printed but not linked: 80

1997, Nature, 394
1998, Science, 2085
1999, J. Immunol., 3920
2007, Semin. Immunol., 33
2006, Curr. Pharm. Des., 4195
2005, Int. Immunol., 1409
2007, Cell. Microbiol., 1891
2000, J. Immunol., 5392
2004, J. Immunol., 4463
2002, J. Immunol., 5997
2004, J. Clin. Invest., 1790
1996, Cell, 973
2002, Annu. Rev. Immunol., 197
2004, Science, 1014
1995, Infect. Immun., 3674
1995, Annu. Rev. Immunol., 437
2002, J. Immunol., 3863
2002, J. Immunol., 3869
1970, Science, 1042
1989, Cold Spring Harbor Symp. Quant. Biol., 1
1994, Immunity, 327
2003, Science, 1033
1999, Nat. Med., 702
2000, J. Immunol., 5683
2005, Nat. Med., 138
2007, Eur. J. Immunol., 2734
2007, Arthritis Rheum., 1618
2007, J. Neuroimmunol., 32
2007, J. Exp. Med., 1911
2000, J. Immunol., 6148
2002, Gastroenterology, 1428
1996, J. Exp. Med., 1389
2006, Immunity, 417
2006, Arthritis Rheum., 336
2007, Ann. Rheum. Dis., 905
2002, Nat. Immunol., 944
2002, Immunity, 219
2003, J. Exp. Med., 489
2004, J. Immunol., 3422
2007, J. Immunol., 6092
2003, J. Exp. Med., 195
1993, J. Immunol., 4371
2005, Nat. Immunol., 1133
2006, J. Clin. Invest., 456
2004, Cell, 229
2000, J. Exp. Med., 475
2005, J. Immunol., 4761
2007, J. Exp. Med., 105
2005, J. Immunol., 5601
2006, Eur. J. Immunol., 12
2007, J. Immunol., 7868
2006, Nature, 235
2007, Nature, 484
2007, Nat. Immunol., 1390
1999, J. Immunol., 4284
1998, J. Exp. Med., 537
2000, J. Neuroimmunol., 55
2003, J. Immunol., 5897
2001, J. Immunol., 1081
2007, J. Immunol., 3447
2005, J. Immunol., 3025
2007, Proc. Natl. Acad. Sci. USA, 14080
2006, J. Immunol., 4810
2002, Annu. Rev. Immunol., 709
2005, J. Exp. Med., 1715
2001, J. Exp. Med., 863
2001, Eur. J. Immunol., 3388
2006, J. Immunol., 1670
2005, Hepatology, 724
1998, Nat. Med., 627
2006, Neurology, 652
2001, Nat. Rev. Immunol., 20
1981, Acta Neurol. Scand., 131
1999, Neurology, 1588
1958, Nature, 1106
1992, J. Autoimmun., 675
2003, Clin. Diagn. Lab. Immunol., 564
1994, Proc. Natl. Acad. Sci. USA, 18
2004, J. Immunol., 6346
2002, N. Engl. J. Med., 911

Sorted by citations

Inflammation and tumor progression: signaling pathways and targeted intervention
Zhao, H., Wu, L., Yan, G., Chen, Y., Zhou, M., Wu, Y., & Li, Y. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00658-5 · Cited by 3,058
Immune Regulatory Function of B Cells
Mauri, C., & Bosma, A. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-074934 · Cited by 1,298
Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination
Berer, K., Mues, M., Koutrolos, M., Rasbi, Z. A., Boziki, M., Johner, C., Wekerle, H., & Krishnamoorthy, G. (2011) · Nature · doi:10.1038/nature10554 · Cited by 1,251
IL-35-producing B cells are critical regulators of immunity during autoimmune and infectious diseases
Shen, P., Roch, T., Lampropoulou, V., O’Connor, R. A., Stervbo, U., Hilgenberg, E., Ries, S., Dang, V. D., Jaimes, Y., Daridon, C., et al. (2014) · Nature · doi:10.1038/nature12979 · Cited by 1,048
Self-citation
B cell depletion therapy ameliorates autoimmune disease through ablation of IL-6–producing B cells
Barr, T. A., Shen, P., Brown, S. L., Lampropoulou, V., Roch, T., Lawrie, S., Fan, B., O’Connor, R. A., Anderton, S. M., Bar‐Or, A., et al. (2012) · The Journal of Experimental Medicine · doi:10.1084/jem.20111675 · Cited by 673
“However, the production of IL-10 in mice (Lampropoulou et al., 2008; Barr et al., 2010; Neves et al., 2010) and humans (Bouaziz et al., 2010) is strongly augmented by TLR signals and, indeed, these innate signals are required in vivo for the full expression of regulatory activity (Lampropoulou et…”
BackgroundMethodResultInfluentialSelf-citation
Microbiota-Derived Metabolites Suppress Arthritis by Amplifying Aryl-Hydrocarbon Receptor Activation in Regulatory B Cells
Rosser, E. C., Piper, C. J. M., Matei, D. E., Blair, P. A., Rendeiro, A. F., Orford, M., Alber, D. G., Krausgruber, T., Catalan, D., Klein, N., et al. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.03.003 · Cited by 579
“Published by Elsevier Inc. 1 er the CC BY license (http://creativecommons.org/licenses/by/4.0/). levels of inflammatory cytokines, for example IFNa and/or IL-1b and IL-6, induce IL-10-producing Breg differentiation (Lampropoulou et al., 2008; Menon et al., 2016; Rosser et al., 2014).”
BackgroundInfluential
Interleukin-10-Producing Plasmablasts Exert Regulatory Function in Autoimmune Inflammation
Matsumoto, M., Baba, A., Yokota, T., Nishikawa, H., Ohkawa, Y., Kayama, H., Kallies, A., Nutt, S. L., Sakaguchi, S., Takeda, K., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.10.016 · Cited by 586
Abnormal B‐cell cytokine responses a trigger of T‐cell–mediated disease in MS?
Bar‐Or, A., Fawaz, L. M., Fan, B., Darlington, P. J., Rieger, A. M., Ghorayeb, C., Calabresi, P. A., Waubant, E. L., Hauser, S. L., Zhang, J., et al. (2009) · Annals of Neurology · doi:10.1002/ana.21939 · Cited by 519
“In recent years, the ‘2-signal’ model of normal human B-cell activation (involving BCR and CD40 engagement) has been extended to include ‘3rd signals’ that can modulate B-cell responses.(18,21,25,27,32) In relation to B-cell effector cytokine production, we previously reported that upon standard 2-signal activation, B…”
Background
Antibody-independent functions of B cells: a focus on cytokines
Shen, P., & Fillatreau, S. (2015) · Nature Reviews Immunology · doi:10.1038/nri3857 · Cited by 508
Self-citation
The Development and Function of Regulatory B Cells Expressing IL-10 (B10 Cells) Requires Antigen Receptor Diversity and TLR Signals
Yanaba, K., Bouaziz, J.-D., Matsushita, T., Tsubata, T., & Tedder, T. F. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0900270 · Cited by 503
“SJL mice are susceptible to EAE after myelin proteolipid protein immunization (38).”
BackgroundInfluential
B10 cells and regulatory B cells balance immune responses during inflammation, autoimmunity, and cancer
DiLillo, D. J., Matsushita, T., & Tedder, T. F. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.05137.x · Cited by 445
Regulatory B Cells (B10 Cells) and Regulatory T Cells Have Independent Roles in Controlling Experimental Autoimmune Encephalomyelitis Initiation and Late-Phase Immunopathogenesis
Matsushita, T., Horikawa, M., Iwata, Y., & Tedder, T. F. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1001307 · Cited by 394
“(44) have also shown that tissue culture supernatant fluid from LPS-stimulated spleen”
IL-10: A Multifunctional Cytokine in Viral Infections
Rojas, J. M., Avia, M., Martı́n, V., & Sevilla, N. (2017) · Journal of Immunology Research · doi:10.1155/2017/6104054 · Cited by 428
Reassessing B cell contributions in multiple sclerosis
Li, R., Patterson, K. R., & Bar‐Or, A. (2018) · Nature Immunology · doi:10.1038/s41590-018-0135-x · Cited by 417
Immunosuppressive Mechanisms of Regulatory B Cells
Catalán, D., Mansilla, M. A., Ferrier, A., Soto, L., Oļeiņika, K., Aguillón, J. C., & Aravena, O. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.611795 · Cited by 429
“This evidence, together with data showing that IL-10 B cells or plasmablasts inhibit Th1 and Th17-inducing DCs or induce tolerogenic DCs, in addition to direct inhibition of Th1 and Th17 cells, contribute to clarify the suppressive role of B10 in EAE and other inflammatory conditions (55, 92, 306, 307).”
BackgroundResult
Integration of B cell responses through Toll-like receptors and antigen receptors
Rawlings, D. J., Schwartz, M. A., Jackson, S. W., & Meyer‐Bahlburg, A. (2012) · Nature reviews. Immunology · doi:10.1038/nri3190 · Cited by 356
Role of B cells as antigen presenting cells
Rastogi, I., Jeon, D., Moseman, J. E., Muralidhar, A., Potluri, H. K., & McNeel, D. G. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.954936 · Cited by 352
“Several B cell subsets, such as immature B cells, plasmablasts and mature B cells, have been shown to differentiate into IL-10-producing Bregs, upon stimulation with toll-like receptors (TLRs) and/or CD40 activation (93, 94).”
Background
IL-10–Producing Regulatory B Cells in the Pathogenesis of Chronic Hepatitis B Virus Infection
Das, A., Ellis, G., Pallant, C., Lopes, A. R., Khanna, P., Peppa, D., Chen, A., Blair, P. A., Dusheiko, G. M., Gill, U. S., et al. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1103139 · Cited by 359
“PBMCs were stimulated with CpG, a TLR-9 agonist, relevant in the context of the DNA virus HBV, which was shown to potently induce B cell IL-10 release (14, 24, 25).”
Method
Not always the bad guys: B cells as regulators of autoimmune pathology
Fillatreau, S., Gray, D., & Anderton, S. M. (2008) · Nature reviews. Immunology · doi:10.1038/nri2315 · Cited by 292
Self-citation
Toll-like receptors (TLRs) and Nod-like receptors (NLRs) in inflammatory disorders
Fukata, M., Vamadevan, A. S., & Abreu, M. T. (2009) · Seminars in Immunology · doi:10.1016/j.smim.2009.06.005 · Cited by 326
Mechanisms of immune regulation in allergic diseases: the role of regulatory T and B cells
Palomares, Ó., Akdis, M., Martín‐Fontecha, M., & Akdiş, C. A. (2017) · Immunological Reviews · doi:10.1111/imr.12555 · Cited by 346
BCG-Induced Cross-Protection and Development of Trained Immunity: Implication for Vaccine Design
Covián, C., Fernández‐Fierro, A., Retamal-Díaz, A. R., Díaz, F. E., Vasquez, A. E., Lay, M. K., Riedel, C. A., González, P. A., Bueno, S. M., & Kalergis, A. M. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02806 · Cited by 342
“Also, TLR-signaling stimulated by mycobacterial components induces IL-10 secretion by B cells and consequent suppression of Th1 and Th17 activities, contributing to the suppression of autoimmune reactions (90).”
Background
Signaling via the MyD88 Adaptor Protein in B Cells Suppresses Protective Immunity during Salmonella typhimurium Infection
Neves, P., Lampropoulou, V., Calderón‐Gómez, E., Roch, T., Stervbo, U., Shen, P., Kühl, A. A., Loddenkemper, C., Haury, M., Nedospasov, S. A., et al. (2010) · Immunity · doi:10.1016/j.immuni.2010.10.016 · Cited by 327
“Alternatively, the recently identified role of MyD88 in the suppressive functions of B cells in EAE (Lampropoulou et al., 2008) suggests that ablation ofMyd88 specifically in B cells could unleash cell-mediated immune responses and improve protection against pathogens.”
InfluentialSelf-citation
Human CD19(+)CD25(high) B regulatory cells suppress proliferation of CD4(+) T cells and enhance Foxp3 and CTLA-4 expression in T-regulatory cells.
Kessel, A., Haj, T., Peri, R., Snir, A., Melamed, D., Sabo, E., & Toubi, E. (2012) · Autoimmunity Reviews · doi:10.1016/j.autrev.2011.11.018 · Cited by 291
“B cell expression of B7 (CD86) co-stimulatory molecule was proven to be necessary for B-cell mediated suppression of EAE [33].”
Influential
Transgenic Inhibition of Astroglial NF-κB Improves Functional Outcome in Experimental Autoimmune Encephalomyelitis by Suppressing Chronic Central Nervous System Inflammation
Brambilla, R., Persaud, T., Hu, X., Karmally, S., Shestopalov, V. I., Dvoriantchikova, G., Ivanov, D., Nathanson, L., Barnum, S. R., & Bethea, J. R. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0802954 · Cited by 279
“Specifically, IL-10-producing B cells stimulate resolution of EAE (37), and this appears to be linked to TLR activation (38).”
Background
Toll-like receptor signalling in B cells during systemic lupus erythematosus
Fillatreau, S., Manfroi, B., & Dörner, T. (2020) · Nature Reviews Rheumatology · doi:10.1038/s41584-020-00544-4 · Cited by 341
Self-citation
A Novel IL-10–Independent Regulatory Role for B Cells in Suppressing Autoimmunity by Maintenance of Regulatory T Cells via GITR Ligand
Ray, A., Basu, S., Williams, C. B., Salzman, N. H., & Dittel, B. N. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1103354 · Cited by 258
“In regard to TLR ligands, the TLR-signaling adaptor protein MyD88 was found to be essential for induction of EAE when globally knocked out, but not when deficient in B cells (52).”
Background
B cells as therapeutic targets in SLE
Sanz, I., & Lee, F. E. (2010) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2010.68 · Cited by 275
The Calcium Sensors STIM1 and STIM2 Control B Cell Regulatory Function through Interleukin-10 Production
Matsumoto, M., Fujii, Y., Baba, A., Hikida, M., Kurosaki, T., & Baba, Y. (2011) · Immunity · doi:10.1016/j.immuni.2011.03.016 · Cited by 279
IL‐10 produced by activated human B cells regulates CD4+ T‐cell activation in vitro
Bouaziz, J., Calbo, S., Maho-Vaillant, M., Saussine, A., Bagot, M., Bensussan, A., & Musette, P. (2010) · European Journal of Immunology · doi:10.1002/eji.201040673 · Cited by 261
Toll‐like receptors – sentries in the B‐cell response
Bekeredjian-Ding, I., & Jego, G. (2009) · Immunology · doi:10.1111/j.1365-2567.2009.03173.x · Cited by 249
Role of regulatory B cells in immune tolerance to allergens and beyond
van de Veen, W., Stanić, B., Wirz, O. F., Jansen, K., Głobińska, A., & Akdis, M. (2016) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2016.07.006 · Cited by 270
The Regulatory Role of IL-10 in Neurodegenerative Diseases
Porro, C., Cianciulli, A., & Panaro, M. A. (2020) · Biomolecules · doi:10.3390/biom10071017 · Cited by 247
“Consistent to this finding, previous studies reported that CD40 stimulation triggered continuous IL-10 production by human B cells in response to TLR stimulation correlating with B cell-mediated recovery from EAE by IL-10 production [48,49], promising a novel therapeutic approach for MS.”
Result
Regulatory B cells in autoimmune diseases
Yang, M., Rui, K., Wang, S., & Lu, L. (2013) · Cellular and Molecular Immunology · doi:10.1038/cmi.2012.60 · Cited by 202
Regulation of Toll-Like Receptor (TLR) Signaling Pathway by Polyphenols in the Treatment of Age-Linked Neurodegenerative Diseases: Focus on TLR4 Signaling
Azam, S., Jakaria, M., Kim, I., Kim, J.-S., Haque, M. E., & Choi, D. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01000 · Cited by 231
The Conserved Scavenger Receptor Cysteine-Rich Superfamily in Therapy and Diagnosis
Martínez, V. G., Moestrup, S. K., Holmskov, U., Mollenhauer, J., & Lozano, F. (2011) · Pharmacological Reviews · doi:10.1124/pr.111.004523 · Cited by 192
“…in the presence of microbial ligands of these PRRs has important consequences for the expansion and function of different T and B cell types, with effector as well as regulatory function (Netea et al., 2004; Caron et al., 2005; Liu et al., 2006; Lampropoulou et al., 2008; Yanaba et al., 2009).”
BackgroundResult
Modeling the heterogeneity of multiple sclerosis in animals
Simmons, S. B., Pierson, E. R., Lee, S. Y., & Goverman, J. M. (2013) · Trends in Immunology · doi:10.1016/j.it.2013.04.006 · Cited by 184
Periductal interleukin-17 production in association with biliary innate immunity contributes to the pathogenesis of cholangiopathy in primary biliary cirrhosis
Harada, K., Shimoda, S., Sato, Y., Isse, K., Ikeda, H., & Nakanuma, Y. (2009) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2009.03947.x · Cited by 179
Regulatory B cells in autoimmunity: developments and controversies
Mauri, C., & Blair, P. (2010) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2010.140 · Cited by 181
Regulatory B cells in cancer
Michaud, D. E., Steward, C. R., Mirlekar, B., & Pylayeva‐Gupta, Y. (2020) · Immunological Reviews · doi:10.1111/imr.12939 · Cited by 211
Aryl Hydrocarbon Receptor Contributes to the Transcriptional Program of IL-10-Producing Regulatory B Cells
Piper, C., Rosser, E. C., Oļeiņika, K., Nistala, K., Krausgruber, T., Rendeiro, A. F., Banos, A., Drozdov, I. A., Villa, M., Thomson, S., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.10.018 · Cited by 195
“B cell receptor (BCR) engagement, Toll-like receptor (TLR) agonists lipopolysaccharide (LPS; TLR2 and TLR4) (Lampropoulou et al., 2008; Tian et al., 2001), CpG oligo-deoxynucleotides (TLR9), and inflammatory cytokines such as IL-1b and IL-6 or IFN-a are all potent inducers of B cell-derived IL-10, suggesting an import…”
Background
Regulatory B Cells Shape the Development of Th2 Immune Responses in BALB/c Mice Infected with Leishmania major Through IL-10 Production
Ronet, C., Torre, Y. H.-L., Revaz-Breton, M., Mastelic, B., Tacchini-Cottier, F., Louis, J., & Launois, P. (2009) · Journal of Immunology · doi:10.4049/jimmunol.0901114 · Cited by 166
“Furthermore, in the EAE model, recovery was associated with the suppression of IL-12 production by DCs by IL-10 secreted by B cells (8, 45).”
Background
The immune potential and immunopathology of cytokine-producing B cell subsets: A comprehensive review
Bao, Y., & Cao, X. (2014) · Journal of Autoimmunity · doi:10.1016/j.jaut.2014.04.001 · Cited by 153
Human T cells induce their own regulation through activation of B cells.
Lemoine, S., Morva, A., Youinou, P., & Jamin, C. (2011) · Journal of Autoimmunity · doi:10.1016/j.jaut.2011.01.005 · Cited by 159
Toll-like receptors regulate B cell cytokine production in patients with diabetes
Jagannathan, M., McDonnell, M., Liang, Y., Hasturk, H., Hetzel, J., Rubin, D., Kantarci, A., Van Dyke, T. E., Ganley-Leal, L. M., & Nikolajczyk, B. S. (2010) · Diabetologia · doi:10.1007/s00125-010-1730-z · Cited by 156
“TLR engagement can activate B cell IL-10 production, which is critical for inflammatory disease resolution [26].”
Background
Tolerant Kidney Transplant Patients Produce B Cells with Regulatory Properties
Chesneau, M., Michel, L., Dugast, E., Chenouard, A., Baron, D., Pallier, A., Durand, J., Braza, F., Guérif, P., Laplaud, D. A., et al. (2015) · Journal of the American Society of Nephrology · doi:10.1681/asn.2014040404 · Cited by 181
Evaluating the role of Toll-like receptors in diseases of the central nervous system
Carty, M., & Bowie, A. (2011) · Biochemical Pharmacology · doi:10.1016/j.bcp.2011.01.003 · Cited by 151
“from B cells which prevents the release of IL-6 from DCs [57].”
Background
MHC class II–restricted antigen presentation by plasmacytoid dendritic cells inhibits T cell–mediated autoimmunity
Irla, M., Küpfer, N., Suter, T. B., Lissilaa, R., Benkhoucha, M., Skupsky, J., Lalive, P. H., Fontana, A., Reith, W., & Hugues, S. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20092627 · Cited by 153
“In accordance with previous studies (Fillatreau et al., 2002; Lampropoulou et al., 2008; by promoting the selective expansion of natural T reg cells.”
ResultInfluential
Regulation of B‐cell responses by Toll‐like receptors
Browne, E. P. (2012) · Immunology · doi:10.1111/j.1365-2567.2012.03587.x · Cited by 155
TLR-2–Activated B Cells Suppress Helicobacter-Induced Preneoplastic Gastric Immunopathology by Inducing T Regulatory-1 Cells
Sayi, A., Kohler, E., Toller, I., Flavell, R., Müller, W., Roers, A., & Müller, A. (2011) · Journal of Immunology · doi:10.4049/jimmunol.1002269 · Cited by 146
“All B cells can, in principle, produce IL-10 upon TLR-2, -4, or -9 stimulation or T cell-dependent activation (14, 15), with particularly strong production being attributed to CD5 peritoneal B-1a cells (16), intestinal CD19CD1d cells (9), and splenic CD1dCD5 “B10” cells (8).”
Background
Unique B Cell Differentiation Profile in Tolerant Kidney Transplant Patients
Chesneau, M., Pallier, A., Braza, F., Lacombe, G., Gallou, S. L., Baron, D., Giral, M., Danger, R., Guerif, P., Aubert-Wastiaux, H., et al. (2014) · American Journal of Transplantation · doi:10.1111/ajt.12508 · Cited by 144
Induction of a regulatory B cell population in experimental allergic encephalomyelitis by alteration of the gut commensal microflora
Ochoa‐Repáraz, J., Mielcarz, D. W., Haque-Begum, S., & Kasper, L. H. (2010) · Gut Microbes · doi:10.4161/gmic.1.2.11515 · Cited by 143
Regulatory functions of innate-like B cells
Zhang, X. (2013) · Cellular and Molecular Immunology · doi:10.1038/cmi.2012.63 · Cited by 136
Regulation of immunity and autoimmunity by B cells.
Mauri, C. (2010) · Current Opinion in Immunology · doi:10.1016/j.coi.2010.10.009 · Cited by 137
“These mice develop exacerbated EAE compared to wild-type mice [37].”
Background
Regulation of Interleukin-10 Expression
Rutz, S., & Ouyang, W. (2016) · Advances in experimental medicine and biology · doi:10.1007/978-94-024-0921-5_5 · Cited by 172
B cells and Autoimmunity
Pillai, S., Mattoo, H., & Cariappa, A. (2011) · Current Opinion in Immunology · doi:10.1016/j.coi.2011.10.007 · Cited by 132
“Since lupus pathogenesis is driven by chromatin derived autoantigens that can both engage the BCR and activate endosomal TLRs, auto-antigen specific B cell differentiation into long-lived plasma cells may occur more readily in this disease than in many other auto-immune disorders.”
BackgroundInfluential
Toll‐like Receptors in Autoimmunity
Fischer, M., & Ehlers, M. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1443.012 · Cited by 132
The Dynamics of B Cell Aging in Health and Disease
de Mol, J., Kuiper, J., Tsiantoulas, D., & Foks, A. C. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.733566 · Cited by 159
“In the adaptive pathway, BREGS present antigens to CD4 T cells and become activated through CD40-CD40L and IL-21 signals (77), whereas in the innate pathway, TLR2 and TLR9 signaling and IL-1b play important roles (78).”
Background
BAFF inhibition attenuates fibrosis in scleroderma by modulating the regulatory and effector B cell balance
Matsushita, T., Kobayashi, T., Mizumaki, K., Kano, M., Sawada, T., Tennichi, M., Okamura, A., Hamaguchi, Y., Iwakura, Y., Hasegawa, M., et al. (2018) · Science Advances · doi:10.1126/sciadv.aas9944 · Cited by 155
“The CD40-CD40L interaction and antigen-specific signals were reported to be essential for IL-10 production from B cells (3), while TLR signals strongly augment the production of IL-10 in mice (23) and humans (24).”
Background
Suppressive functions of activated B cells in autoimmune diseases reveal the dual roles of Toll‐like receptors in immunity
Lampropoulou, V., Calderon‐Gomez, E., Roch, T., Neves, P., Shen, P., Stervbo, U., Boudinot, P., Anderton, S. M., & Fillatreau, S. (2010) · Immunological Reviews · doi:10.1111/j.0105-2896.2009.00855.x · Cited by 130
“Naive B cells must first receive a specific signal before they can produce IL10 upon BCR ⁄CD40 stimulation.”
BackgroundInfluentialSelf-citation
Autocrine IL‐10 promotes human B‐cell differentiation into IgM‐ or IgG‐secreting plasmablasts
Heine, G., Drozdenko, G., Grün, J. R., Chang, H., Radbruch, A., & Worm, M. (2014) · European Journal of Immunology · doi:10.1002/eji.201343822 · Cited by 129
TLR‐mediated STAT3 and ERK activation controls IL‐10 secretion by human B cells
Liu, B.-S., Cao, Y., Huizinga, T., Hafler, D., & Toes, R. (2014) · European Journal of Immunology · doi:10.1002/eji.201344341 · Cited by 123
Regulatory B cells in ANCA-associated vasculitis
Wilde, B., Thewissen, M., Damoiseaux, J., Knippenberg, S., Hilhorst, M., van Paassen, P., Witzke, O., & Tervaert, J. C. (2013) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2012-202986 · Cited by 122
NFATc1 affects mouse splenic B cell function by controlling the calcineurin–NFAT signaling network
Bhattacharyya, S., Deb, J., Patra, A. K., Pham, D. A. T., Chen, W., Vaeth, M., Berberich‐Siebelt, F., Klein‐Hessling, S., Lamperti, E. D., Reifenberg, K., et al. (2011) · The Journal of Experimental Medicine · doi:10.1084/jem.20100945 · Cited by 129
“This suppressive effect of NFATc1/ B cells was markedly reduced by adding the IL-10–specific antibody JES5-2A5, which relieved IL-10–mediated inhibition of cytokine production of T cells by B cells (Lampropoulou et al., 2008).”
BackgroundMethodInfluential
From the regulatory functions of B cells to the identification of cytokine-producing plasma cell subsets
Dang, V. D., Hilgenberg, E., Ries, S., Shen, P., & Fillatreau, S. (2014) · Current Opinion in Immunology · doi:10.1016/j.coi.2014.02.009 · Cited by 128
Self-citation
Effector and regulatory B cells in immune-mediated kidney disease
Oļeiņika, K., Mauri, C., & Salama, A. D. (2018) · Nature Reviews Nephrology · doi:10.1038/s41581-018-0074-7 · Cited by 142
Killer B lymphocytes: the evidence and the potential
Lundy, S. K. (2009) · Inflammation Research · doi:10.1007/s00011-009-0014-x · Cited by 113
An age-related numerical and functional deficit in CD19+CD24hiCD38hi B cells is associated with an increase in systemic autoimmunity
Duggal, N. A., Upton, J., Phillips, A. C., Sapey, E., & Lord, J. (2013) · Aging Cell · doi:10.1111/acel.12114 · Cited by 110
“Expression of TLR1, TLR2, TLR4, TLR7 and TLR9 transcripts has been reported on B cells (Barr et al., 2007), and TLR-activated B cells are capable of resolving autoimmune disorders by inhibiting pathogenic T cells via IL10 production (Lampropoulou et al., 2008).”
Background
Cytokine-Defined B Cell Responses as Therapeutic Targets in Multiple Sclerosis
Li, R., Rezk, A., Healy, L. M., Muirhead, G., Prat, A., Gommerman, J. L., & Bar‐Or, A. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00626 · Cited by 107
“For example, innate signal-induced IL-10-producing B cells are able to down-regulate pathogenic T-cell responses indirectly through dendritic cells (14), whereas adaptive signal-induced IL-10-producing B cells directly down-regulate antigen-specific T-cell responses (15, 16).”
Background
Transcriptomics Identify CD9 as a Marker of Murine IL-10-Competent Regulatory B Cells
Sun, J., Wang, J., Pefanis, E., Chao, J. L., Rothschild, G., Tachibana, I., Chen, J. K., Ivanov, I. I., Rabadán, R., Takeda, Y., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.09.070 · Cited by 120
“Bregs are found enriched in phenotypically diverse B-cell subsets.”
BackgroundInfluential
B cells from glatiramer acetate-treated mice suppress experimental autoimmune encephalomyelitis
Kala, M., Rhodes, S. N., Piao, W.-H., Shi, F., Campagnolo, D. I., & Vollmer, T. L. (2009) · Experimental Neurology · doi:10.1016/j.expneurol.2009.10.015 · Cited by 103
Regulatory B cells: the cutting edge of immune tolerance in kidney transplantation
Peng, B., Ming, Y., & Yang, C. (2018) · Cell Death and Disease · doi:10.1038/s41419-017-0152-y · Cited by 114
Helminth Antigens Modulate Immune Responses in Cells from Multiple Sclerosis Patients through TLR2-Dependent Mechanisms
Correale, J. D., & Farez, M. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0900897 · Cited by 103
“TLR9 contributes to EAE severity (52) but has no influence on B cell-driven disease resolution (51).”
BackgroundInfluential
Cellular targets of regulatory B cell-mediated suppression
Rosser, E. C., Blair, P. A., & Mauri, C. (2014) · Molecular Immunology · doi:10.1016/j.molimm.2014.01.014 · Cited by 105
Prognostic and therapeutic role of tumor-infiltrating lymphocyte subtypes in breast cancer
Nelson, M. A., Ngamcherdtrakul, W., Luoh, S., & Yantasee, W. (2021) · Cancer and Metastasis Reviews · doi:10.1007/s10555-021-09968-0 · Cited by 119
Regulatory B cells in human inflammatory and autoimmune diseases: from mouse models to clinical research
Miyagaki, T., Fujimoto, M., & Sato, S. (2015) · International Immunology · doi:10.1093/intimm/dxv026 · Cited by 115
Donor-derived regulatory B cells are important for suppression of murine sclerodermatous chronic graft-versus-host disease.
Huu, D. L., Matsushita, T., Jin, G., Hamaguchi, Y., Hasegawa, M., Takehara, K., Tedder, T., & Fujimoto, M. (2013) · Blood · doi:10.1182/blood-2012-11-465658 · Cited by 97
The immunomodulatory properties of the CD5 lymphocyte receptor in health and disease
Soldevila, G., Raman, C., & Lozano, F. (2011) · Current Opinion in Immunology · doi:10.1016/j.coi.2011.03.003 · Cited by 97
“IL-10 producing B-cells have an important role in controlling mouse models of autoimmune diseases, such as EAE [34], collagen-induced arthritis (CIA) [35], inflammatory bowel disease (IBD) [36], contact hypersensivity (CHS) [33 ] and SLE [37].”
MethodInfluential
Schistosome egg antigens, including the glycoprotein IPSE/alpha-1, trigger the development of regulatory B cells
Haeberlein, S., Obieglo, K., Ozir-Fazalalikhan, A., Chayé, M. A. M., Veninga, H., van der Vlugt, L. E. P. M., Voskamp, A., Boon, L., den Haan, J. M. M., Westerhof, L. B., et al. (2017) · PLOS Pathogens · doi:10.1371/journal.ppat.1006539 · Cited by 96
Excessive CD11c + Tbet + B cells promote aberrant T FH differentiation and affinity-based germinal center selection in lupus
Zhang, W., Zhang, H., Liu, S., Xia, F., Kang, Z., Zhang, Y., Liu, Y., Xiao, H. Q., Chen, L., Huang, C., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1901340116 · Cited by 106
Transcriptional regulation of the anti-inflammatory cytokine IL-10 in acquired immune cells
Kubo, M., & Motomura, Y. (2012) · Frontiers in Immunology · doi:10.3389/fimmu.2012.00275 · Cited by 103
B cell immunosenescence: different features of naive and memory B cells in elderly
Buffa, S., Bulati, M., Pellicanò, M., Dunn‐Walters, D. K., Wu, Y.-C. B., Candore, G., Vitello, S., Caruso, C., & Colonna‐Romano, G. (2011) · Biogerontology · doi:10.1007/s10522-011-9353-4 · Cited by 104
“It has been demonstrated (Lampropoulou et al. 2008) that TLR2, TLR4 and TLR9 engagement induces IL-10”
Pathogen manipulation of B cells: the best defence is a good offence
Nothelfer, K., Sansonetti, P. J., & Phalipon, A. (2015) · Nature Reviews Microbiology · doi:10.1038/nrmicro3415 · Cited by 128
Insights into the heterogeneity of human B cells: diverse functions, roles in autoimmunity, and use as therapeutic targets
Anolik, J. H., Looney, R. J., Lund, F. E., Randall, T. D., & Sanz, I. (2009) · Immunologic Research · doi:10.1007/s12026-009-8096-7 · Cited by 88
“B cells may also directly suppress Th1 and Th17-mediated diseases (37).”
Background
A case for regulatory B cells in controlling the severity of autoimmune-mediated inflammation in experimental autoimmune encephalomyelitis and multiple sclerosis
Ray, A., Mann, M. K., Basu, S., & Dittel, B. N. (2010) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2010.10.037 · Cited by 73
“Furthermore, signaling through either TLR4 (LPS) or TLR9 (CpG) induced the expression of IL-10 in B cells, but only TLR2/4 expression by B cells regulated recovery from EAE (Lampropoulou et al., 2008).”
Influential
Th17 cells in central nervous system autoimmunity
Sie, C., Korn, T., & Mitsdoerffer, M. (2014) · Experimental Neurology · doi:10.1016/j.expneurol.2014.03.009 · Cited by 95
Targeting Poly(I:C) to the TLR3-Independent Pathway Boosts Effector CD8 T Cell Differentiation through IFN-α/β
Ngoi, S. M., Tovey, M. G., & Vella, A. T. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.11.7670 · Cited by 78
“Similarly, TLR ligand-activated B cells antagonized IFN- production by CD4 T cells through an IL-10-dependent mechanism (53).”
Background
Regulatory B cells: Phenotype, function and role in transplantation
Wortel, C. M., & Heidt, S. (2017) · Transplant Immunology · doi:10.1016/j.trim.2017.02.004 · Cited by 90
Regulatory functions of B cells in allergic diseases
Braza, F., Chesné, J., Castagnet, S., Magnan, A., & Brouard, S. (2014) · Allergy · doi:10.1111/all.12490 · Cited by 88
Role for MyD88, TLR2 and TLR9 but Not TLR1, TLR4 or TLR6 in Experimental Autoimmune Encephalomyelitis
Miranda-Hernandez, S., Gerlach, N., Fletcher, J., Biros, E., Mack, M., Körner, H., & Baxter, A. (2011) · Journal of Immunology · doi:10.4049/jimmunol.1001992 · Cited by 83
“The dependence of EAE induction on MyD88 signaling has been reported previously (32, 33, 67), as has the lack of an EAE phenotype in TLR6-deficient mice (33); the role of TLR1 in EAE has”
Background
Commensal gut flora and brain autoimmunity: a love or hate affair?
Berer, K., & Krishnamoorthy, G. (2012) · Acta Neuropathologica · doi:10.1007/s00401-012-0949-9 · Cited by 82
Regulation of autoimmune encephalomyelitis by toll-like receptors.
Marta, M., Meier, U., & Lobell, A. (2009) · Autoimmunity Reviews · doi:10.1016/j.autrev.2009.01.006 · Cited by 81
“In another study, clinical signs of MOG35–55-induced EAE in mice with TLR9−/− B cells were similar to mice with TLR9 B cells [24].”
BackgroundResult
B Cells and Immunological Tolerance
Manjarrez‐Orduño, N., Quách, T. D., & Sanz, I. (2009) · Journal of Investigative Dermatology · doi:10.1038/jid.2008.240 · Cited by 80
“Inhibition of Th1 and Th17 cells (TLR-mediated) (101)”
BackgroundInfluential
Immunological Perspective: Helicobacter pylori Infection and Gastritis
Yang, H., & Hu, B. (2022) · Mediators of Inflammation · doi:10.1155/2022/2944156 · Cited by 90
“TLR signaling in B cells inhibits inflammatory T cell response (both Th1 and Th17 cells), which can be controlled by TLR agonists [57].”
Background
B Cells Producing Type I IFN Modulate Macrophage Polarization in Tuberculosis
Bénard, A., Sakwa, I., Schierloh, P., Colom, A., Mercier, I., Tailleux, L., Jouneau, L., Boudinot, P., Saati, T. A., Lang, R., et al. (2017) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201707-1475oc · Cited by 89
“Because MyD88 signaling controls the production of IL-6 and IL-10 by B cells (49), we cannot exclude that these cytokines play a part in the observed phenotype.”
BackgroundSelf-citation
A regulatory CD9+B-cell subset inhibits HDM-induced allergic airway inflammation
Braza, F., Chesné, J., Durand, M., Dirou, S., Brosseau, C., Mahay, G., Cheminant, M., Magnan, A., & Brouard, S. (2015) · Allergy · doi:10.1111/all.12697 · Cited by 88
“Moreover, IL-10-secreting B cells can inhibit the production of IL-6 and IL-23 by dendritic cells in vitro, which might explain how Bregs can reduce TH17 responses in vivo (42).”
Background
B cells expressing CD11b effectively inhibit CD4+ T‐cell responses and ameliorate experimental autoimmune hepatitis in mice
Liu, X., Jiang, X., Liu, R., Wang, L., Qian, T., Zheng, Y., Deng, Y., Huang, E., Xu, F., Wang, J. O., et al. (2015) · Hepatology · doi:10.1002/hep.28001 · Cited by 81
Emerging concepts in autoimmune encephalomyelitis beyond the CD4/TH1 paradigm
Batoulis, H., Addicks, K., & Küerten, S. (2010) · Annals of Anatomy - Anatomischer Anzeiger · doi:10.1016/j.aanat.2010.06.006 · Cited by 72
B-cell linker protein expression contributes to controlling allergic and autoimmune diseases by mediating IL-10 production in regulatory B cells
Jin, G., Hamaguchi, Y., Matsushita, T., Hasegawa, M., Huu, D. L., Ishiura, N., Naka, K., Hirao, A., Takehara, K., & Fujimoto, M. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.01.044 · Cited by 89
“Nonetheless, activation through BCR and CD40 is also needed for the induction of IL-10–producing regulatory B cells to optimally suppress autoimmunity.(2,13,14,31) Thus, a 2-step activation model has been proposed.”
BackgroundMethod
Pathogenic and Protective Functions of TNF in Neuroinflammation Are Defined by Its Expression in T Lymphocytes and Myeloid Cells
Kruglov, A., Lampropoulou, V., Fillatreau, S., & Nedospasov, S. A. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100663 · Cited by 75
“Mice were scored daily, as described elsewhere (18).”
MethodSelf-citation

Authors: Lampropoulou, V., Hoehlig, K., Roch, T., Neves, P., Gómez, E. C., Sweenie, C. H., Hao, Y., Freitas, A. A., Steinhoff, U., Anderton, S. M., & Fillatreau, S.
Affiliations: German Rheumatism Research Centre (DE)
Deutsches Rheuma-ForschungsZentrum , Berlin ,
University of Edinburgh (GB)
Centre National de la Recherche Scientifique (FR)
Unité de Recherche Associée Centre National de la Recherche Scientifique 1961, Institut Pasteur , Paris ,
Max Planck Institute for Infection Biology (DE)
ORCID: Lampropoulou, Vicky
Hoehlig, Kai
Roch, Toralf
Hao, Yi
Steinhoff, Ulrich
Fillatreau, Simon
Venue: The Journal of Immunology
Publisher: Oxford University Press (OUP)
Published: 2008-04-01
Volume: 180
Issue: 7
Pages: 4763-4773
ISSN: 0022-1767 (ISSN-L)
1550-6606
DOI: 10.4049/jimmunol.180.7.4763
OpenAlex: W1918941126
Cited by: 436
References: 81
Citations by year: 2026: 11 · 2025: 7 · 2024: 11 · 2023: 13 · 2022: 17 · 2021: 23 · 2020: 13 · 2019: 17 · 2018: 24 · 2017: 24 · 2016: 41 · 2015: 31 · 2014: 34 · 2013: 40 · 2012: 33
FWCI: 13.45
Type: journal article
Language: en
Open access: closed
Licence: academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: The Journal of Immunology (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Max Planck Institute for Plasma Physics (submittedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
Keywords: MyD88, T cell-mediated autoimmunity, experimental autoimmune encephalomyelitis, Th17 cells, Th1 cells, B cell suppression, TLR agonists, dendritic cells, macrophages
MeSH terms: Animals, B-Lymphocytes, Dendritic Cells, Encephalomyelitis, Autoimmune, Experimental, Lymphocyte Activation, Mice, Inbred C57BL, Mycobacterium tuberculosis, T-Lymphocytes, Signal Transduction, Autoimmunity, Interleukin-10, Mice, Knockout, Toll-Like Receptors, Mice, Myeloid Differentiation Factor 88

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

TLR-Activated B Cells Suppress T Cell-Mediated Autoimmunity

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Metadata

Record

About these checks