The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Cutting Edge: Membrane Nanotubes In Vivo: A Feature of MHC Class II+ Cells in the Mouse Cornea
Open accessAbstract
Membrane nanotubes are a recently discovered form of cellular protrusion between two or more cells whose functions include cell communication, environmental sampling, and protein transfer. Although clearly demonstrated in vitro, evidence of the existence of membrane nanotubes in mammalian tissues in vivo has until now been lacking. Confocal microscopy of whole-mount corneas from wild-type, enhanced GFP chimeric mice, and Cx3cr1gfp transgenic mice revealed long (>300 μm) and fine (<0.8 μm diameter) membrane nanotube-like structures on bone marrow-derived MHC class II+ cells in the corneal stroma, some of which formed distinct intercellular bridges between these putative dendritic cells. The frequency of these nanotubes was significantly increased in corneas subjected to trauma and LPS, which suggests that nanotubes have an important role in vivo in cell-cell communication between widely spaced dendritic cells during inflammation. Identification of these novel cellular processes in the mammalian cornea provides the first evidence of membrane nanotubes in vivo.
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Cutting Edge: Membrane Nanotubes Connect Immune Cells
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Corneal immunity is mediated by heterogeneous population of antigen-presenting cells
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Pasquier, J., Guerrouahen, B. S., Al Thawadi, H., Ghiabi, P., Maleki, M., Abu-Kaoud, N., Jacob, A., Mirshahi, M., Galas, L., Rafii, S., et al. (2013) · Journal of Translational Medicine · doi:10.1186/1479-5876-11-94 · Cited by 502
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Metadata
- Authors
- Chinnery, H. R., Pearlman, E., & McMenamin, P. G.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-05-01
- Volume
- 180
- Issue
- 9
- Pages
- 5779-5783
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1637952642
- Cited by
- 277
- References
- 25
- FWCI
- 5.96
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Cutting Edge: Membrane Nanotubes In Vivo: A Feature of MHC Class II+ Cells in the Mouse Cornea. https://app.cochat.ai/papers/10.4049/jimmunol.180.9.5779
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- Chinnery, H. R., Pearlman, E., & McMenamin, P. G. (2008). Cutting Edge: Membrane Nanotubes In Vivo: A Feature of MHC Class II+ Cells in the Mouse Cornea. The Journal of Immunology. https://doi.org/10.4049/jimmunol.180.9.5779
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