The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Cutting Edge: Membrane Nanotubes Connect Immune Cells
Abstract
We present evidence that nanotubular highways, or membrane nanotubes, facilitate a novel mechanism for intercellular communication in the immune system. Nanotubes were seen to connect multiple cells together and were readily formed between a variety of cell types, including human peripheral blood NK cells, macrophages, and EBV-transformed B cells. Nanotubes could be created upon disassembly of the immunological synapse, as cells move apart. Thus, nanotubular networks could be assembled from transient immunological synapses. Nanotubes were seen to contain GFP-tagged cell surface class I MHC protein expressed in one of the connected cells. Moreover, GPI-conjugated to GFP originating from one cell was transferred onto the surface of another at the connection with a nanotube. Thus, nanotubes can traffic cell surface proteins between immune cells over many tens of microns. Determining whether there are physiological functions for nanotubes is an intriguing new goal for cellular immunology.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Nanotubular Highways for Intercellular Organelle Transport
Rustom, A., Saffrich, R., Markovic, I., Walther, P., & Gerdes, H.-H. (2004) · Science · doi:10.1126/science.1093133 · Cited by 2,038
Two-Photon Imaging of Lymphocyte Motility and Antigen Response in Intact Lymph Node
Miller, M. J., Wei, S. H., Parker, I., & Cahalan, M. D. (2002) · Science · doi:10.1126/science.1070051 · Cited by 1,207
Bromley, S. K., Burack, W. R., Johnson, K. G., Somersalo, K., Sims, T. N., Sumen, C., Davis, M. M., Shaw, A. S., Allen, P. M., & Dustin, M. L. (2001) · Annual Review of Immunology · doi:10.1146/annurev.immunol.19.1.375 · Cited by 979
The Immunological Synapse of CTL Contains a Secretory Domain and Membrane Bridges
Stinchcombe, J. C., Bossi, G., Booth, S., & Griffiths, G. M. (2001) · Immunity · doi:10.1016/s1074-7613(01)00234-5 · Cited by 814
Dynamic Imaging of T Cell-Dendritic Cell Interactions in Lymph Nodes
Stoll, S., Delon, J., Brotz, T. M., & Germain, R. N. (2002) · Science · doi:10.1126/science.1071065 · Cited by 718
T-cell-antigen recognition and the immunological synapse
Huppa, J. B., & Davis, M. M. (2003) · Nature Reviews Immunology · doi:10.1038/nri1245 · Cited by 643
Ramírez-Weber, F.-A., & Kornberg, T. B. (1999) · Cell · doi:10.1016/s0092-8674(00)80771-0 · Cited by 612
TCR-Mediated Internalization of Peptide-MHC Complexes Acquired by T Cells
Huang, J.-F., Yang, Y., Sepulveda, H., Shi, W., Hwang, I., Peterson, P. A., Jackson, M. R., Sprent, J., & Cai, Z. (1999) · Science · doi:10.1126/science.286.5441.952 · Cited by 462
The human natural killer cell immune synapse
Davis, D. M., Chiu, I., Fassett, M., Cohen, G. B., Mandelboim, O., & Strominger, J. L. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.26.15062 · Cited by 416
Self-citationFuchs, A., Cella, M., Giurisato, E., Shaw, A. S., & Colonna, M. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.7.3994 · Cited by 358
Cited by
Mechanisms of mesenchymal stem/stromal cell function
Spees, J. L., Lee, R. H., & Gregory, C. A. (2016) · Stem Cell Research & Therapy · doi:10.1186/s13287-016-0363-7 · Cited by 891
Sowinski, S., Jolly, C., Berninghausen, O., Purbhoo, M. A., Chauveau, A., Köhler, K., Oddos, S., Eissmann, P., Brodsky, F. M., Hopkins, C., et al. (2008) · Nature Cell Biology · doi:10.1038/ncb1682 · Cited by 754
Self-citationMesenchymal stem cells avoid allogeneic rejection
Ryan, J. M., Barry, F. P., Murphy, J. M., & Mahon, B. P. (2005) · Journal of Inflammation · doi:10.1186/1476-9255-2-8 · Cited by 714
Prions hijack tunnelling nanotubes for intercellular spread
Gousset, K., Schiff, E., Langevin, C., Marijanovic, Z., Caputo, A., Browman, D. T., Chenouard, N., de Chaumont, F., Martino, A., Enninga, J., et al. (2009) · Nature Cell Biology · doi:10.1038/ncb1841 · Cited by 615
Avoiding the void: Cell-to-cell spread of human viruses
Sattentau, Q. (2008) · Nature Reviews Microbiology · doi:10.1038/nrmicro1972 · Cited by 614
Metadata
- Authors
- Önfelt, B., Nedvetzki, S., Yanagi, K., & Davis, D. M.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2004-08-01
- Volume
- 173
- Issue
- 3
- Pages
- 1511-1513
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1602326892
- Cited by
- 397
- References
- 22
- FWCI
- 7.12
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Cutting Edge: Membrane Nanotubes Connect Immune Cells. https://app.cochat.ai/papers/10.4049/jimmunol.173.3.1511
- The paper
- Önfelt, B., Nedvetzki, S., Yanagi, K., & Davis, D. M. (2004). Cutting Edge: Membrane Nanotubes Connect Immune Cells. The Journal of Immunology. https://doi.org/10.4049/jimmunol.173.3.1511
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
